Meng Chuan Lai

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. doi request reprint Identifying the lost generation of adults with autism spectrum conditions
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK Cambridge Lifespan Asperger Syndrome Service CLASS Clinic, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK Centre for Addiction and Mental Health, The Hospital for Sick Children, and Department of Psychiatry, University of Toronto, Toronto, ON, Canada Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan Electronic address
    Lancet Psychiatry 2:1013-27. 2015
  2. pmc Sex/gender differences and autism: setting the scene for future research
    Meng Chuan Lai
    National Taiwan University Hospital and College of Medicine, Taipei, Taiwan and the Autism Research Centre, University of Cambridge, Cambridge, UK Electronic address
    J Am Acad Child Adolesc Psychiatry 54:11-24. 2015
  3. doi request reprint Autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK Department of Psychiatry, College of Medicine, National Taiwan University, Taipei, Taiwan Electronic address
    Lancet 383:896-910. 2014
  4. pmc Biological sex affects the neurobiology of autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18B, Trumpington Road, Cambridge CB2 8AH, UK
    Brain 136:2799-815. 2013
  5. pmc Subgrouping the autism "spectrum": reflections on DSM-5
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK
    PLoS Biol 11:e1001544. 2013
  6. pmc Cognition in males and females with autism: similarities and differences
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e47198. 2012
  7. doi request reprint A shift to randomness of brain oscillations in people with autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, United Kingdom
    Biol Psychiatry 68:1092-9. 2010
  8. pmc A behavioral comparison of male and female adults with high functioning autism spectrum conditions
    Meng Chuan Lai
    Department of Psychiatry, Autism Research Centre, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e20835. 2011
  9. pmc Individual differences in brain structure underpin empathizing-systemizing cognitive styles in male adults
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge Douglas House, 18B, Trumpington Road, Cambridge CB2 8AH, UK
    Neuroimage 61:1347-54. 2012
  10. pmc Atypically rightward cerebral asymmetry in male adults with autism stratifies individuals with and without language delay
    Dorothea L Floris
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Hum Brain Mapp 37:230-53. 2016

Collaborators

Detail Information

Publications31

  1. doi request reprint Identifying the lost generation of adults with autism spectrum conditions
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK Cambridge Lifespan Asperger Syndrome Service CLASS Clinic, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK Centre for Addiction and Mental Health, The Hospital for Sick Children, and Department of Psychiatry, University of Toronto, Toronto, ON, Canada Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan Electronic address
    Lancet Psychiatry 2:1013-27. 2015
    ..The creation of supportive, accepting, and autism-friendly social and physical environments is important and requires a coordinated effort across agencies and needs support from government policies. ..
  2. pmc Sex/gender differences and autism: setting the scene for future research
    Meng Chuan Lai
    National Taiwan University Hospital and College of Medicine, Taipei, Taiwan and the Autism Research Centre, University of Cambridge, Cambridge, UK Electronic address
    J Am Acad Child Adolesc Psychiatry 54:11-24. 2015
    ..To better understand the implications from existing research and to help design future studies, we propose a 4-level conceptual framework to clarify the embedded themes...
  3. doi request reprint Autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK Department of Psychiatry, College of Medicine, National Taiwan University, Taipei, Taiwan Electronic address
    Lancet 383:896-910. 2014
    ..Drugs can reduce comorbid symptoms, but do not directly improve social communication. Creation of a supportive environment that accepts and respects that the individual is different is crucial. ..
  4. pmc Biological sex affects the neurobiology of autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18B, Trumpington Road, Cambridge CB2 8AH, UK
    Brain 136:2799-815. 2013
    ..Future research should stratify by biological sex to reduce heterogeneity and to provide greater insight into the neurobiology of autism. ..
  5. pmc Subgrouping the autism "spectrum": reflections on DSM-5
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK
    PLoS Biol 11:e1001544. 2013
    ..But making progress in research, and ultimately improving clinical practice, will require identifying subgroups within the autism spectrum...
  6. pmc Cognition in males and females with autism: similarities and differences
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e47198. 2012
    ..However, in specific non-social cognitive domains, performance within ASC depends on sex. This suggests that in specific domains, cognitive profiles in ASC are modulated by sex...
  7. doi request reprint A shift to randomness of brain oscillations in people with autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, United Kingdom
    Biol Psychiatry 68:1092-9. 2010
    ..5) to ordered (H = 1). Shifts in fractal scaling of physiological time series have been associated with neurological and cardiac conditions...
  8. pmc A behavioral comparison of male and female adults with high functioning autism spectrum conditions
    Meng Chuan Lai
    Department of Psychiatry, Autism Research Centre, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e20835. 2011
    ..We discuss the importance of the superficially better socio-communication ability in adult females with ASC in terms of why females with ASC may more often go under-recognized, and receive their diagnosis later, than males...
  9. pmc Individual differences in brain structure underpin empathizing-systemizing cognitive styles in male adults
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge Douglas House, 18B, Trumpington Road, Cambridge CB2 8AH, UK
    Neuroimage 61:1347-54. 2012
    ..These results suggest an underlying neuroanatomical basis linked to the discrepancy between these two important dimensions of individual differences in cognitive style...
  10. pmc Atypically rightward cerebral asymmetry in male adults with autism stratifies individuals with and without language delay
    Dorothea L Floris
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Hum Brain Mapp 37:230-53. 2016
    ..We conclude that atypical cerebral structural asymmetry is a potential candidate neurophenotype of ASC...
  11. pmc Fetal programming effects of testosterone on the reward system and behavioral approach tendencies in humans
    Michael V Lombardo
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 72:839-47. 2012
    ....
  12. pmc Neuroanatomy of Individual Differences in Language in Adult Males with Autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge CB2 8AH, UK Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei 10051, Taiwan
    Cereb Cortex 25:3613-28. 2015
    ..This underscores the importance of including both developmental and current language as specifiers for ASC, to help clarify heterogeneity. ..
  13. doi request reprint Creating a platform to bridge service and research for early psychosis
    Chen Chung Liu
    Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan
    J Formos Med Assoc 109:543-9. 2010
    ..It seems that setting up a special clinic to provide a service for at risk subjects, combined with certain campaigns, could facilitate their engagement in a longitudinal prospective study for early psychosis...
  14. doi request reprint Imaging sex/gender and autism in the brain: Etiological implications
    Meng Chuan Lai
    Child and Youth Mental Health Collaborative at the Centre for Addiction and Mental Health and The Hospital for Sick Children, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    J Neurosci Res 95:380-397. 2017
    ..These together help delineate the different roles of sex and gender in relation to risk vs. protective mechanisms. © 2016 Wiley Periodicals, Inc...
  15. pmc From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition
    Adam M H Young
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, UK School of Clinical Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, UK
    Mol Autism 7:9. 2016
    ..This is complemented with a number of neuroimaging and neuropathological studies describing microglial activation. Implications for treatment are discussed. ..
  16. pmc Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits
    Dorothea L Floris
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK Department of Child and Adolescent Psychiatry, The Child Study Center, New York University Langone Medical Center, New York, NY USA
    Mol Autism 7:35. 2016
    ..Motor deficits are among the earliest and most prominent symptoms in individuals with ASC and precede core social and communicative symptoms...
  17. pmc Personality traits in adults with attention-deficit hyperactivity disorder and their unaffected first-degree relatives
    Valentino Antonio Pironti
    PhD, Department of Psychiatry, University of Cambridge, Cambridge, UK, and MRC Wellcome Trust Behavioural and Clinical Neuroscience Institute BCNI, University of Cambridge, Cambridge, UK, and Adult ADHD Clinic, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK
    BJPsych Open 2:280-285. 2016
    ..However, personality traits are not well understood in adults with ADHD, and it is unclear whether they are predisposing factors or phenotypical facets of the condition...
  18. pmc Psychosis in autism: comparison of the features of both conditions in a dually affected cohort
    Felicity V Larson
    Felicity V Larson, PhD, Department of Psychiatry, University of Cambridge, Cambridge, Department of Psychology, University of Birmingham, Birmingham and Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham, UK Adam P Wagner, PhD, Department of Psychiatry, University of Cambridge, Cambridge, National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care, East of England, Norwich Medical School, University of East Anglia, Norwich, UK Peter B Jones, MD, PhD, Department of Psychiatry, University of Cambridge, Cambridge, National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care, East of England, Cambridge and Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK Digby Tantam, BM, BCH, PhD, School of Health and Related Research, University of Sheffield, Sheffield, UK Meng Chuan Lai, MD PhD, Department of Psychiatry, University of Cambridge, Cambridge, Child and Youth Mental Health Collaborative at the Centre for Addiction and Mental Health and The Hospital for Sick Children, and Department of Psychiatry, University of Toronto, Toronto, Nursing Systems
    Br J Psychiatry . 2016
    ..There is limited information on the presentation and characteristics of psychotic illness experienced by people with autism spectrum disorder (ASD)...
  19. pmc The "Reading the Mind in the Eyes" Test: Complete Absence of Typical Sex Difference in ~400 Men and Women with Autism
    Simon Baron-Cohen
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom CLASS Clinic, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom
    PLoS ONE 10:e0136521. 2015
    ..Females with autism also showed stronger coherence between self-reported dispositional traits and Eyes test performance than all other groups. ..
  20. pmc Are power calculations useful? A multicentre neuroimaging study
    John Suckling
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom Cambridge and Peterborough Foundation NHS Trust, Cambridge, United Kingdom
    Hum Brain Mapp 35:3569-77. 2014
    ..In summary, power calculations offer a validated, quantitative means of making informed choices on important factors that influence the outcome of studies that consume significant resources...
  21. pmc A meta-analysis of sex differences in human brain structure
    Amber N V Ruigrok
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge CB2 8AH, United Kingdom Electronic address
    Neurosci Biobehav Rev 39:34-50. 2014
    ..Together, these results suggest candidate regions for investigating the asymmetric effect that sex has on the developing brain, and for understanding sex-biased neurological and psychiatric conditions. ..
  22. pmc Attenuation of typical sex differences in 800 adults with autism vs. 3,900 controls
    Simon Baron-Cohen
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom Cambridge Lifespan Asperger Syndrome Service CLASS Clinic, Cambridgeshire and Peterborough National Health Service Foundation Trust, Cambridge, United Kingdom
    PLoS ONE 9:e102251. 2014
    ..Further, normative sex differences are attenuated but not abolished in adults with autism. The findings provide strong support for the EMB theory of autism, and highlight differences between males and females with autism. ..
  23. doi request reprint The loss of asymmetry and reduced interhemispheric connectivity in adolescents with autism: a study using diffusion spectrum imaging tractography
    Yu Chun Lo
    Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan
    Psychiatry Res 192:60-6. 2011
    ..Our results warrant further investigation by combining developmental and neurocognitive data...
  24. doi request reprint Follow-up of subjects with suspected pre-psychotic state in Taiwan
    Chen Chung Liu
    Department of Psychiatry, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan
    Schizophr Res 126:65-70. 2011
    ..To describe the outcomes of subjects with suspected pre-psychotic state in Taiwan...
  25. pmc Self-referential and social cognition in a case of autism and agenesis of the corpus callosum
    Michael V Lombardo
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge CB2 8AH, UK
    Mol Autism 3:14. 2012
    ..Here we examine agenesis of the corpus callosum (AgCC) as a model at the level of neuroanatomy that may be relevant for understanding self-referential and social-cognitive difficulties in ASC...
  26. pmc Mirror-Touch Synaesthesia Is Not Associated with Heightened Empathy, and Can Occur with Autism
    Simon Baron-Cohen
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 11:e0160543. 2016
    ..Our findings dispute the views that MT synaesthesia is linked with enhanced empathy, is less likely to occur with ASC or elevated autistic traits, and is specific to seeing a person being touched. ..
  27. doi request reprint Altered resting-state frontoparietal control network in children with attention-deficit/hyperactivity disorder
    Hsiang Yuan Lin
    1Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan
    J Int Neuropsychol Soc 21:271-84. 2015
    ..The findings support potential integration of the disconnection model and the executive dysfunction model for ADHD. Atypical frontoparietal control network may play a pivotal role in the pathophysiology of ADHD...
  28. doi request reprint Differential propensity in recognition of prepsychotic phenomena among psychiatrists, clinical psychologists and school counsellors
    Chen Chung Liu
    Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan
    Early Interv Psychiatry 4:275-82. 2010
    ..This study was conducted to assess differences among three types of mental health professionals in the recognition of prepsychotic phenomena...
  29. pmc Testing the 'Extreme Female Brain' Theory of Psychosis in Adults with Autism Spectrum Disorder with or without Co-Morbid Psychosis
    Felicity V Larson
    Cambridge Intellectual and Development Disabilities Research Group, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 10:e0128102. 2015
    ..The opposite cognitive profile, an 'extreme of the typical female brain', has been proposed to be linked to conditions such as psychosis and mania/hypomania...
  30. pmc Neuroanatomical abnormalities and cognitive impairments are shared by adults with attention-deficit/hyperactivity disorder and their unaffected first-degree relatives
    Valentino Antonio Pironti
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom Medical Research Council Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom Adult ADHD Clinic, Cambridgeshire and Peterborough National Health Service Foundation Trust, Cambridge, United Kingdom Electronic address
    Biol Psychiatry 76:639-47. 2014
    ..In this study, we tested for neuroanatomical and cognitive endophenotypes in a group of adults with ADHD, their unaffected first-degree relatives, and typically developing control subjects...
  31. doi request reprint Correlates of gender dysphoria in Taiwanese university students
    Meng Chuan Lai
    Department of Psychiatry, National Taiwan University Hospital, No 7, Chung Shan South Road, 10002, Taipei, Taiwan
    Arch Sex Behav 39:1415-28. 2010
    ..This implies the importance of attention and specific measures to offset psychiatric conditions and to promote mental well-being of this population...