Genomes and Genes
Affiliation: University of Edinburgh
- Ace-1 duplication in Anopheles gambiae: a challenge for malaria controlLuc Djogbenou
Institut de Recherche pour le Developpement, UR 016, Cotonou, Benin
Malar J 8:70. 2009..This mutation entails a large fitness cost. However, a resistant duplicated allele of the gene encoding AChE1 (ace-1), potentially associated to a lower fitness cost, recently appeared in An. gambiae...
- Forty years of erratic insecticide resistance evolution in the mosquito Culex pipiensPierrick Labbé
Equipe Génétique de l Adaptation, Institut des Sciences de l Evolution, CNRS Universite Montpellier 2, Montpellier, France
PLoS Genet 3:e205. 2007..Instead, resistance evolution has been an erratic combination of mutation, positive selection, and the rearrangement of existing variation leading to complex genetic architecture...
- ProPhenolOxidase in Daphnia magna: cDNA sequencing and expression in relation to resistance to pathogensPierrick Labbé
University of Edinburgh, IEB, Ashworth Laboratory, Kings Buildings, Edinburgh, UK
Dev Comp Immunol 33:674-80. 2009..This is the first evidence of a Daphnia immune response, and our observations raise the possibility that the PhenolOxidase (PO) cascade is involved in the defence against pathogenic gram-positive bacteria...
- Resistance Gene Replacement in the mosquito Culex pipiens: fitness estimation from long-term cline seriesPierrick Labbé
Universite de Montpellier, Montpellier Cedex 4, France
Genetics 182:303-12. 2009..e., with a large fitness variance across environments). More generally, we discuss how precise estimates of the strength of selection obtained from field data help us understand the process of amelioration of adaptation...
- An ancient immunity gene duplication in Daphnia magna: RNA expression and sequence analysis of two nitric oxide synthase genesPierrick Labbé
University of Edinburgh, Institute of Evolutionary Biology, School of Biological Sciences, Ashworth Laboratory, Kings Buildings, Edinburgh, UK
Dev Comp Immunol 33:1000-10. 2009..Thus, the function of NOS in Daphnia immunity remains uncertain, but the pattern of gene duplication and subsequent divergence suggests evolution via neo- or subfunctionalization...
- High incidence of ace-1 duplicated haplotypes in resistant Culex pipiens mosquitoes from AlgeriaHaoues Alout
Team Genetic of Adaptation, Laboratoire Genetique et Environnement, CNRS UMR 5554, Institut des Sciences de l Evolution, Universite Montpellier 2, Place E Bataillon, 34095 Montpellier Cedex 05, France
Insect Biochem Mol Biol 41:29-35. 2011..Finally, we discuss the mechanism at the origin of these duplicated haplotypes and their consequences on the management of insecticide resistance...
- Insecticide resistance in Culex pipiens quinquefasciatus and Aedes albopictus mosquitoes from La Réunion IslandMichaël Luciano Tantely
Universite Montpellier 2, UMR CNRS 5554, Institut des Sciences de l Evolution, Génétique de l Adaptation, Place Eugene Bataillon, Montpellier 05, France
Insect Biochem Mol Biol 40:317-24. 2010..Rdl selection in these two mosquito species discloses current insecticide pressures in urban areas, from unknown origins, that should be taken into account to develop vector control strategies...
- Independent duplications of the acetylcholinesterase gene conferring insecticide resistance in the mosquito Culex pipiensPierrick Labbé
Institut des Sciences de l Evolution UMR CNRS 5554, University Montpellier II, Montpellier, France
Mol Biol Evol 24:1056-67. 2007..The rate of duplication of ace-1 in C. pipiens is probably underestimated, but seems to be rather high...
- Novel AChE inhibitors for sustainable insecticide resistance managementHaoues Alout
Universités Montpellier 2 et 1, Montpellier, France
PLoS ONE 7:e47125. 2012..This study identifies the first compound class that preferentially targets OP-resistant mosquitoes, thus restoring OP-susceptibility, which validates a new prospect of sustainable insecticide resistance management...
- Multiple duplications of the rare ace-1 mutation F290V in Culex pipiens natural populationsHaoues Alout
Team Genomic of Adaptation, CNRS UMR 5554, Institut des Sciences de l Evolution, C C 065, Universite Montpellier 2, Place E Bataillon, 34095 Montpellier, France
Insect Biochem Mol Biol 39:884-91. 2009..Evolutionary forces driving the large number of F290V ace-1 alleles and their low frequency in Mediterranean countries are discussed...
- The ace-1 Locus Is Amplified in All Resistant Anopheles gambiae Mosquitoes: Fitness Consequences of Homogeneous and Heterogeneous DuplicationsBenoît S Assogba
Institut des Sciences de l Evolution de Montpellier UMR 5554, CNRS UM IRD EPHE, Universite de Montpellier, Place Eugene Bataillon, Montpellier, France
PLoS Biol 14:e2000618. 2016..This impressive adaptability could have a major impact on vector control in Africa...
- Stable coexistence of incompatible Wolbachia along a narrow contact zone in mosquito field populationsCelestine M Atyame
CNRS, ISEM UMR 5554, Montpellier, France University La Réunion CRVOI, Ste Clotilde, Reunion Island, France University Montpellier 2, Montpellier, France
Mol Ecol 24:508-21. 2015..pipiens probably play major roles. This study highlights the need of understanding CI dynamics in natural populations to design effective and sustainable Wolbachia-based control strategies. ..
- GENE-dosage effects on fitness in recent adaptive duplications: ace-1 in the mosquito Culex pipiensPierrick Labbé
CNRS, Universite Montpellier 2, ISEM UMR 5554, 34065, Montpellier, France
Evolution 68:2092-101. 2014....
- Wolbachia divergence and the evolution of cytoplasmic incompatibility in Culex pipiensCelestine M Atyame
CNRS, University Montpellier 2, ISEM UMR 5554, Montpellier, France
PLoS ONE 9:e87336. 2014..This study indicates a clear correlation between Wolbachia genotypes and CI properties, paving the way toward the identification of the molecular basis of CI through comparative genomics. ..
- Relating fitness to long-term environmental variations in naturaPascal Milesi
Institut des Sciences de l Evolution de Montpellier UMR 5554, CNRS UM IRD EPHE, Universite de Montpellier, Place Eugene Bataillon, 34095, Montpellier, Cedex 5, France
Mol Ecol 25:5483-5499. 2016..Our study also emphasizes the necessity of long-term surveys in evolutionary ecology...
- An ace-1 gene duplication resorbs the fitness cost associated with resistance in Anopheles gambiae, the main malaria mosquitoBenoît S Assogba
CNRS, IRD, ISEM UMR 5554, Montpellier, France
Sci Rep 5:14529. 2015..It provides malaria mosquito with a new evolutionary path that could hamper resistance management. ..
- Successfully resisting a pathogen is rarely costly in Daphnia magnaPierrick Labbé
University of Edinburgh, Institute of Evolutionary Biology, King s Buildings, Edinburgh, EH9 3JT, UK
BMC Evol Biol 10:355. 2010..We sought to study inducible costs in depth using the crustacean Daphnia magna and its bacterial parasite Pasteuria ramosa...
- Multiple insecticide resistances in the disease vector Culex p. quinquefasciatus from Western Indian OceanNicolas Pocquet
Institut de Recherche pour le Developpement, Unité mixte de recherche MIVEGEC IRD 224 CNRS 5290 UM1 UM2, Montpellier, France
PLoS ONE 8:e77855. 2013..It thus becomes urgent to find alternatives to control populations of Cx. p. quinquefasciatus in the Indian Ocean. ..
- Wolbachia age-sex-specific density in Aedes albopictus: a host evolutionary response to cytoplasmic incompatibility?Pablo Tortosa
Institut des Sciences de l Evolution, CNRS UMR 5554, Universite Montpellier 2, Montpellier, France
PLoS ONE 5:e9700. 2010..Here, we assess the density dynamics of Wolbachia infections in males and females of the mosquito Aedes albopitcus, an important vector of human pathogens, and interpret the results within an evolutionary framework...