Julia C Knight

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1
    Julian C Knight
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Nat Genet 36:394-9. 2004
  2. pmc The human Major Histocompatibility Complex as a paradigm in genomics research
    Claire Vandiedonck
    Wellcome Trust Centre for Human Genetics WTCHG, University of Oxford, Oxford, UK
    Brief Funct Genomic Proteomic 8:379-94. 2009
  3. ncbi request reprint Polymorphisms in Tumor Necrosis Factor and Other Cytokines As Risks for Infectious Diseases and the Septic Syndrome
    Julian Knight
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Curr Infect Dis Rep 3:427-439. 2001
  4. doi request reprint Polymorphisms in tumor necrosis factor and other cytokines as risks for infectious diseases and the septic syndrome
    Julian Knight
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN, Headington, Oxford, UK
    Curr Infect Dis Rep 3:427-39. 2007
  5. pmc Transcriptomic profiling facilitates classification of response to influenza challenge
    Emma E Davenport
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
    J Mol Med (Berl) 93:105-14. 2015
  6. pmc An integrated approach to defining genetic and environmental determinants for major clinical outcomes involving vitamin D
    Antonio J Berlanga-Taylor
    CGAT, MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK
    Mol Diagn Ther 18:261-72. 2014
  7. pmc Chromatin profiling across the human tumour necrosis factor gene locus reveals a complex, cell type-specific landscape with novel regulatory elements
    Jennifer M Taylor
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Nucleic Acids Res 36:4845-62. 2008
  8. pmc Genetic determinants of HSP70 gene expression following heat shock
    Narelle Maugeri
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Hum Mol Genet 19:4939-47. 2010
  9. pmc Transcriptional repression and DNA looping associated with a novel regulatory element in the final exon of the lymphotoxin-β gene
    K Wicks
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Genes Immun 12:126-35. 2011
  10. pmc An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6
    Benjamin P Fairfax
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 19:720-30. 2010

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1
    Julian C Knight
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Nat Genet 36:394-9. 2004
    ..These findings provide a molecular model of how LTA expression may be genetically regulated by allele-specific recruitment of the transcriptional repressor ABF-1...
  2. pmc The human Major Histocompatibility Complex as a paradigm in genomics research
    Claire Vandiedonck
    Wellcome Trust Centre for Human Genetics WTCHG, University of Oxford, Oxford, UK
    Brief Funct Genomic Proteomic 8:379-94. 2009
    ..This review shows how the MHC continues to provide new insights and remains in the vanguard of contemporary research in human genomics...
  3. ncbi request reprint Polymorphisms in Tumor Necrosis Factor and Other Cytokines As Risks for Infectious Diseases and the Septic Syndrome
    Julian Knight
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Curr Infect Dis Rep 3:427-439. 2001
    ..An overview of genetic associations of cytokine genes with infectious disease is presented, together with discussion of recent studies in a number of infectious diseases including hepatitis, HIV, malaria, and sepsis...
  4. doi request reprint Polymorphisms in tumor necrosis factor and other cytokines as risks for infectious diseases and the septic syndrome
    Julian Knight
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN, Headington, Oxford, UK
    Curr Infect Dis Rep 3:427-39. 2007
    ..An overview of genetic associations of cytokine genes with infectious disease is presented, together with discussion of recent studies in a number of infectious diseases including hepatitis, HIV, malaria, and sepsis. ..
  5. pmc Transcriptomic profiling facilitates classification of response to influenza challenge
    Emma E Davenport
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
    J Mol Med (Berl) 93:105-14. 2015
    ..However, the major potential value is in the clinical trial setting by providing a more quantitative method to better classify symptomatic individuals post influenza challenge...
  6. pmc An integrated approach to defining genetic and environmental determinants for major clinical outcomes involving vitamin D
    Antonio J Berlanga-Taylor
    CGAT, MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK
    Mol Diagn Ther 18:261-72. 2014
    ..We highlight the challenges moving forward in this area and its importance for effective clinical translation of current research. ..
  7. pmc Chromatin profiling across the human tumour necrosis factor gene locus reveals a complex, cell type-specific landscape with novel regulatory elements
    Jennifer M Taylor
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Nucleic Acids Res 36:4845-62. 2008
    ....
  8. pmc Genetic determinants of HSP70 gene expression following heat shock
    Narelle Maugeri
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Hum Mol Genet 19:4939-47. 2010
    ..The work illustrates how analysis of a heritable induced expression phenotype can be highly informative in defining functionally important genetic variation...
  9. pmc Transcriptional repression and DNA looping associated with a novel regulatory element in the final exon of the lymphotoxin-β gene
    K Wicks
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Genes Immun 12:126-35. 2011
    ..Our findings provide evidence of additional complexity in the transcriptional regulation of LTB with implications for coordinate expression of genes in this important genomic locus...
  10. pmc An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6
    Benjamin P Fairfax
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 19:720-30. 2010
    ..It also provides proof of concept for use of an integrated expression phenotype mapping approach...
  11. pmc Fine mapping genetic determinants of the highly variably expressed MHC gene ZFP57
    Katharine Plant
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Eur J Hum Genet 22:568-71. 2014
    ..The work highlights the role that ZFP57 may play in DNA methylation and epigenetic regulation beyond early development into adult life dependent on genetic background, with important potential implications for disease. ..
  12. pmc Genomic modulators of the immune response
    Julian C Knight
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Trends Genet 29:74-83. 2013
    ....
  13. pmc Resolving the variable genome and epigenome in human disease
    J C Knight
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
    J Intern Med 271:379-91. 2012
    ....
  14. ncbi request reprint Functional implications of genetic variation in non-coding DNA for disease susceptibility and gene regulation
    Julian C Knight
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Clin Sci (Lond) 104:493-501. 2003
    ..The strategic application of these functional approaches is discussed and illustrated by analysis of the role of genetic variation in the tumour necrosis factor promoter region in determining susceptibility to severe malaria...
  15. pmc Understanding human genetic variation in the era of high-throughput sequencing
    Julian C Knight
    Wellcome Trust Centre for Human Genetics at the University of Oxford, Oxford, UK
    EMBO Rep 11:650-2. 2010
    ....
  16. ncbi request reprint Allele-specific gene expression uncovered
    Julia C Knight
    Wellcome Trust Centre for Human Genetics, Universit of Oxford, Oxfoed, UK
    Trends Genet 20:113-6. 2004
    ..These new data provide evidence that differential expression is relatively common and that allelic differences are heritable and can be highly context specific...
  17. pmc Genetics and the general physician: insights, applications and future challenges
    J C Knight
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
    QJM 102:757-72. 2009
    ..There is also a need for a broader debate about the ethical implications of current advances in genetics for medicine and society...
  18. ncbi request reprint In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading
    Julian C Knight
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Nat Genet 33:469-75. 2003
    ..The haploChIP method may be useful in high-throughput screening for common DNA polymorphisms that affect gene regulation in vivo...
  19. pmc Regulatory polymorphisms underlying complex disease traits
    Julian C Knight
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
    J Mol Med (Berl) 83:97-109. 2005
    ....
  20. pmc A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, United Kingdom
    Genome Res 20:1352-60. 2010
    ..ChIP-seq determination of transcription factor binding, in combination with GWA data, provides a powerful approach to further understanding the molecular bases of complex diseases...
  21. ncbi request reprint Analysis of allele-specific gene expression
    Julian C Knight
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Methods Mol Biol 338:153-65. 2006
    ..These include analysis of the relative allelic abundance of transcribed RNA and of transcription factor recruitment and Pol II loading by chromatin immunoprecipitation...
  22. doi request reprint Multiple sclerosis and the major histocompatibility complex
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, UK
    Curr Opin Neurol 22:219-25. 2009
    ..We review here some of the recent findings of MS genetics with a particular focus on genes of the major histocompatibility complex (MHC)...
  23. pmc A common variant associated with dyslexia reduces expression of the KIAA0319 gene
    Megan Y Dennis
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    PLoS Genet 5:e1000436. 2009
    ..Our study thus pinpoints a common variant as altering the function of a dyslexia candidate gene and provides an illustrative example of the strategic approach needed to dissect the molecular basis of complex genetic traits...
  24. pmc Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 5:e1000369. 2009
    ..These findings support a connection between the main epidemiological and genetic features of this disease with major practical implications for studies of disease mechanism and prevention...
  25. ncbi request reprint The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration
    Silvia Paracchini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 15:1659-66. 2006
    ..2 down-regulates the KIAA0319 gene which is required for neuronal migration during the formation of the cerebral neocortex...
  26. pmc Leprosy and the adaptation of human toll-like receptor 1
    Sunny H Wong
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 6:e1000979. 2010
    ..These observations provide insight into the long standing host-pathogen relationship between human and mycobacteria and highlight the key role of the TLR pathway in infectious diseases...
  27. pmc HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility
    Michael J Chao
    Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 105:13069-74. 2008
    ....