Dominic F Kelly
Affiliation: University of Oxford
- Anti-polyribosylribitol phosphate antibody concentrations and avidities in children since the start of Haemophilus influenzae type b immunization of infants in the United KingdomDominic F Kelly
Oxford Vaccine Group, Oxford University Department of Paediatrics, Oxford, United Kingdom
Clin Vaccine Immunol 16:246-52. 2009..This study emphasizes the factors affecting anti-PRP antibody concentration following immunization with conjugate vaccines and the importance of these in long-term protection from invasive disease...
- An encephalitis primerDominic Kelly
Children s Hospital, Oxford, UK
Adv Exp Med Biol 764:133-40. 2013..This review focuses on encephalitis aetiology and investigation; HSV encephalitis; mycoplasma encephalitis; and flavivirus encephalitis as a globally important cause of disease...
- High-throughput bacterial SNP typing identifies distinct clusters of Salmonella Typhi causing typhoid in Nepalese childrenKathryn E Holt
Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
BMC Infect Dis 10:144. 2010..Kathmandu, the capital of Nepal, is an area of high incidence and the pediatric population appears to be at high risk of exposure and infection...
- The burden of vaccine-preventable invasive bacterial infections and pneumonia in children admitted to hospital in urban NepalDominic F Kelly
Department of Paediatrics, University of Oxford, Level 2, Room 02 46 03, Children s Hospital, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
Int J Infect Dis 15:e17-23. 2011..Nepal is one of many resource-poor nations with limited information on the epidemiology of childhood infections caused by these pathogens...
- Immunological memory: the role of B cells in long-term protection against invasive bacterial pathogensDominic F Kelly
University of Oxford Department of Paediatrics, Oxford, England
JAMA 294:3019-23. 2005..An improved understanding of the immunobiology of the B-cell response to these vaccines may direct development of immunization strategies that provide sustained protection...
- CRM197-conjugated serogroup C meningococcal capsular polysaccharide, but not the native polysaccharide, induces persistent antigen-specific memory B cellsDominic F Kelly
Department of Paediatrics, University of Oxford, Level 4, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
Blood 108:2642-7. 2006..Detection of peripheral blood memory B-cell responses after vaccination may be a useful signature of successful induction of immunologic memory during novel vaccine evaluation...
- The magnitude of the antibody and memory B cell responses during priming with a protein-polysaccharide conjugate vaccine in human infants is associated with the persistence of antibody and the intensity of booster responseGeraldine Blanchard Rohner
Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK
J Immunol 180:2165-73. 2008..These findings suggest that these two parameters are good markers of B cell responses to priming and can be used as predictors of long term humoral immunity induced by glycoconjugate vaccines received in early infancy...
- Serogroup C meningococcal glycoconjugate vaccine in adolescents: persistence of bactericidal antibodies and kinetics of the immune response to a booster vaccine more than 3 years after immunizationMatthew D Snape
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, OX3 7LJ, United Kingdom
Clin Infect Dis 43:1387-94. 2006....
- Haemophilus influenzae type b vaccine failure in children is associated with inadequate production of high-quality antibodyYeh Chen Lee
University Department of Paediatrics, University of Oxford, Oxford, UK
Clin Infect Dis 46:186-92. 2008....
- Persistence of serum bactericidal antibody one year after a booster dose of either a glycoconjugate or a plain polysaccharide vaccine against serogroup C Neisseria meningitidis given to adolescents previously immunized with a glycoconjugate vaccinePhilip C S de Whalley
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom
Pediatr Infect Dis J 30:e203-8. 2011..Adolescents are at particular risk from meningococcal disease, therefore they might benefit from a booster dose of vaccine. The duration of serologic response to such a booster in adolescents is unknown...
- Plasma and memory B-cell kinetics in infants following a primary schedule of CRM 197-conjugated serogroup C meningococcal polysaccharide vaccineDominic F Kelly
Oxford Vaccine Group, Department of Paediatrics, Oxford University, Oxford, UK
Immunology 127:134-43. 2009..This study provides data on B-cell kinetics following a primary schedule of immunization in young infants upon which to base further studies of the underlying cellular mechanism of humoral immunity...
- The B-cell response to a primary and booster course of MenACWY-CRM₁₉₇ vaccine administered at 2, 4 and 12 months of ageGeraldine Blanchard-Rohner
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK
Vaccine 31:2441-8. 2013....
- Seroprevalence and placental transmission of maternal antibodies specific for Neisseria meningitidis Serogroups A, C, Y and W135 and influence of maternal antibodies on the immune response to a primary course of MenACWY-CRM vaccine in the United KingdomGeraldine Blanchard-Rohner
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom
Pediatr Infect Dis J 32:768-76. 2013..We also assessed the impact of maternal antibody present at 2 months of age on the immune response to a primary course of quadrivalent meningococcal conjugate vaccine (MenACWY-CRM197) given at 2 and 4 months of age...
- Hospital-based surveillance of invasive pneumococcal disease among young children in urban NepalEleri J Williams
Department of Paediatrics, University of Oxford, Oxford, United Kingdom
Clin Infect Dis 48:S114-22. 2009..The aims of this study were to determine the prevalence and serotype distribution of invasive pneumococcal disease among young children hospitalized in urban Nepal...
- Haemophilus influenzae type b conjugate vaccinesDominic F Kelly
Department of Paediatrics, John Radcliffe Hospital, University of Oxford, Headington, Oxford, UK
Immunology 113:163-74. 2004..However, the burden of disease remains highest in resource-poor countries and urgent efforts are needed to provide the benefits of this vaccine for children living in regions where it cannot be used for economic and logistical reasons...
- Prevalence and genetic analysis of phenotypically Vi- negative Salmonella typhi isolates in children from Kathmandu, NepalAnoop S Pulickal
Oxford Vaccine Group, Department of Pediatrics, University of Oxford, Oxford, Oxfordshire, OX3 7LE, UK
J Trop Pediatr 59:317-20. 2013..These data suggest that phenotypically acapsulate S.Typhi may not have a genetic basis for the same. ..
- Streptococcus pneumoniae carriage prevalence in Nepal: evaluation of a method for delayed transport of samples from remote regions and implications for vaccine implementationSarah Hanieh
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom Patan Academy Paediatric Research Unit, Patan Academy of Health Sciences, Kathmandu, Nepal
PLoS ONE 9:e98739. 2014..Pneumococcal disease is a significant cause of morbidity and mortality in young children in Nepal, and currently available pneumococcal conjugate vaccines offer moderate coverage of invasive disease isolates...
- Lack of serum bactericidal activity in preschool children two years after a single dose of serogroup C meningococcal polysaccharide-protein conjugate vaccineMatthew D Snape
Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, United Kingdom
Pediatr Infect Dis J 24:128-31. 2005..A serum bactericidal titer of <1/8 correlates with susceptibility to invasive meningococcal disease. We assessed this correlate of protection in a cohort of children approximately 2 years after a single dose of vaccine...
- Baseline polysaccharide-specific antibodies may not consistently inhibit booster antibody responses in infants to a serogroup C meningococcal protein-polysaccharide conjugate vaccineGeraldine Blanchard-Rohner
Oxford Vaccine Group and the NIHR Oxford Biomedical Research Centre, University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine, Oxford, UK
Vaccine 30:4153-9. 2012..That an inhibitory effect of baseline antibody cannot be assumed a priori is supported by observations in animal models, which show that baseline antibody can both suppress or enhance the antibody response to a specific antigen...
- Comparison of two-dose priming plus 9-month booster with a standard three-dose priming schedule for a ten-valent pneumococcal conjugate vaccine in Nepalese infants: a randomised, controlled, open-label, non-inferiority trialMainga Hamaluba
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, UK
Lancet Infect Dis 15:405-14. 2015....
- The seroepidemiology of Haemophilus influenzae type b prior to introduction of an immunization programme in Kathmandu, NepalAndrew S J Marshall
Oxford Vaccine Group, Oxford University, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom
PLoS ONE 9:e85055. 2014..Only 20% of children under 5 years old had levels considered protective (>0.15 µg/ml), rising to 83% of 15-54 year-olds. Prior to introduction of Hib vaccine in Kathmandu, the majority of young children were susceptible to disease. ..
- Evaluation of haemophilus influenzae type b vaccine for routine immunization in Nepali infantsJane Astrid Metz
Department of Pediatrics, Oxford Vaccine Group, University of Oxford, UK
Pediatr Infect Dis J 31:e66-72. 2012..Hib conjugate vaccines (HibCV) do not have uniform immunogenicity between populations. We determined the immunogenicity of HibCV in Nepali infants, before its introduction into the routine immunization schedule...
- Identification of antigen-specific B cell receptor sequences using public repertoire analysisJohannes Trück
Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the National Institute for Health Research Oxford Biomedical Research Centre, Oxford OX3 7LE, United Kingdom
J Immunol 194:252-61. 2015..If this finding is confirmed, the public repertoire could be used for rapid and direct identification of protective Ag-specific BCR sequences from peripheral blood. ..
- Multi-serotype pneumococcal nasopharyngeal carriage prevalence in vaccine naïve Nepalese children, assessed using molecular serotypingRama Kandasamy
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom
PLoS ONE 10:e0114286. 2015....
- Reverse vaccinology and vaccines for serogroup B Neisseria meningitidisDominic F Kelly
Department of Paediatrics, University of Oxford, John Radcliffe Hospital, United Kingdom
Adv Exp Med Biol 568:217-23. 2005..Despite the advantages of the approach, development in conventional areas of vaccinology remains important to support the process of producing vaccines from genome-derived antigens...
- Studying the antibody repertoire after vaccination: practical applicationsJacob D Galson
Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK Electronic address
Trends Immunol 35:319-31. 2014....