Paul Kellam

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint The impact of different definitions on the estimated rate of transmitted HIV drug resistance in the United Kingdom
    Hannah Green
    HIV Group, Medical Research Council Clinical Trials Unit, 222 Euston Road, London, United Kingdom
    J Acquir Immune Defic Syndr 49:196-204. 2008
  2. pmc Consensus clustering and functional interpretation of gene-expression data
    Stephen Swift
    Department of Information Systems and Computing, Brunel University, Uxbridge UB8 3PH, UK
    Genome Biol 5:R94. 2004
  3. pmc Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation
    Janet Strath
    Institute of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK
    BMC Genomics 10:67. 2009
  4. pmc Characterization of monoclonal antibodies raised against the latent nuclear antigen of human herpesvirus 8
    P Kellam
    Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, United Kingdom
    J Virol 73:5149-55. 1999
  5. pmc Host-pathogen studies in the post-genomic era
    P Kellam
    Wohl Virion Centre, Department of Molecular Pathology, Windeyer Institute, University College London, London, W1P 6DB, UK
    Genome Biol 1:REVIEWS1009. 2000
  6. ncbi request reprint Post-genomic virology: the impact of bioinformatics, microarrays and proteomics on investigating host and pathogen interactions
    P Kellam
    Wohl Virion Centre, Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Rev Med Virol 11:313-29. 2001
  7. pmc Attacking pathogens through their hosts
    Paul Kellam
    Virus Genomics and Bioinformatics Group, Division of Infection and Immunity, University College London, London W1T 4JF, UK
    Genome Biol 7:201. 2006
  8. ncbi request reprint A statistical model for HIV-1 sequence classification using the subtype analyser (STAR)
    R E Myers
    Department of Immunology and Molecular Pathology, University College London, UK
    Bioinformatics 21:3535-40. 2005
  9. ncbi request reprint Virus bioinformatics: databases and recent applications
    Paul Kellam
    Wohl Virion Centre, Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, London, UK
    Appl Bioinformatics 1:37-42. 2002
  10. pmc Demonstration of sustained drug-resistant human immunodeficiency virus type 1 lineages circulating among treatment-naïve individuals
    Stephane Hue
    UCL MRC Centre for Medical Molecular Virology, University College London, Windeyer Building, 46 Cleveland Street, London W1T 4JF, United Kingdom
    J Virol 83:2645-54. 2009

Detail Information

Publications54

  1. doi request reprint The impact of different definitions on the estimated rate of transmitted HIV drug resistance in the United Kingdom
    Hannah Green
    HIV Group, Medical Research Council Clinical Trials Unit, 222 Euston Road, London, United Kingdom
    J Acquir Immune Defic Syndr 49:196-204. 2008
    ..The use of different lists of resistance mutations has resulted in estimates of transmitted HIV drug resistance (THDR) that are often not comparable...
  2. pmc Consensus clustering and functional interpretation of gene-expression data
    Stephen Swift
    Department of Information Systems and Computing, Brunel University, Uxbridge UB8 3PH, UK
    Genome Biol 5:R94. 2004
    ..When coupled with a statistically based gene functional analysis, our method allowed the identification of novel genes regulated by NFkappaB and the unfolded protein response in certain B-cell lymphomas...
  3. pmc Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation
    Janet Strath
    Institute of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK
    BMC Genomics 10:67. 2009
    ....
  4. pmc Characterization of monoclonal antibodies raised against the latent nuclear antigen of human herpesvirus 8
    P Kellam
    Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, United Kingdom
    J Virol 73:5149-55. 1999
    ..In situ immunocytochemistry of KS lesions with these antibodies show that LNA is extensively expressed in KS spindle cells...
  5. pmc Host-pathogen studies in the post-genomic era
    P Kellam
    Wohl Virion Centre, Department of Molecular Pathology, Windeyer Institute, University College London, London, W1P 6DB, UK
    Genome Biol 1:REVIEWS1009. 2000
    ..Several studies are starting to show the power of DNA microarrays to identify interactions between animal hosts and their pathogens, and have revealed interesting correlations between host responses to different infectious agents...
  6. ncbi request reprint Post-genomic virology: the impact of bioinformatics, microarrays and proteomics on investigating host and pathogen interactions
    P Kellam
    Wohl Virion Centre, Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Rev Med Virol 11:313-29. 2001
    ..Such research should ultimately result in new methods for diagnosing and treating infectious diseases...
  7. pmc Attacking pathogens through their hosts
    Paul Kellam
    Virus Genomics and Bioinformatics Group, Division of Infection and Immunity, University College London, London W1T 4JF, UK
    Genome Biol 7:201. 2006
    ..This new antimicrobial strategy has proved effective in the laboratory and in the clinic, and it has great potential for the future...
  8. ncbi request reprint A statistical model for HIV-1 sequence classification using the subtype analyser (STAR)
    R E Myers
    Department of Immunology and Molecular Pathology, University College London, UK
    Bioinformatics 21:3535-40. 2005
    ..We have produced a program, Subtype Analyser (STAR) that rapidly and accurately subtypes HIV-1. Here we have determined a robust and statistically validated model for subtype assignment...
  9. ncbi request reprint Virus bioinformatics: databases and recent applications
    Paul Kellam
    Wohl Virion Centre, Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, London, UK
    Appl Bioinformatics 1:37-42. 2002
    ..Here we will review some of these recent advances focusing mainly on the herpesvirus...
  10. pmc Demonstration of sustained drug-resistant human immunodeficiency virus type 1 lineages circulating among treatment-naïve individuals
    Stephane Hue
    UCL MRC Centre for Medical Molecular Virology, University College London, Windeyer Building, 46 Cleveland Street, London W1T 4JF, United Kingdom
    J Virol 83:2645-54. 2009
    ..These findings provide new insights for the planning and management of treatment programs in resource-rich and developing countries...
  11. pmc Phylogenetic surveillance of viral genetic diversity and the evolving molecular epidemiology of human immunodeficiency virus type 1
    Robert J Gifford
    Department of Infection, University College London, London, United Kingdom
    J Virol 81:13050-6. 2007
    ..The framework implemented here takes advantage of the vast amount of routinely generated HIV-1 sequence data and can provide epidemiological insights not readily obtainable through standard surveillance methods...
  12. pmc X-box binding protein 1 contributes to induction of the Kaposi's sarcoma-associated herpesvirus lytic cycle under hypoxic conditions
    Lucy Dalton-Griffin
    Department of Infection, UCL, London, United Kingdom
    J Virol 83:7202-9. 2009
    ..Hypoxia also induces active XBP-1s, and here, we show that both transcription factors contribute to the induction of RTA expression, leading to the production of infectious KSHV under hypoxic conditions...
  13. pmc The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin
    Claire Pardieu
    MRC Centre for Medical Molecular Virology, University College London, London, United Kingdom
    PLoS Pathog 6:e1000843. 2010
    ..Taken together our results demonstrate that K5 is a mechanistically distinct viral countermeasure to tetherin-mediated restriction, and that herpesvirus particle release is sensitive to this mode of antiviral inhibition...
  14. pmc Genome-wide innate immune responses in HIV-1-infected macrophages are preserved despite attenuation of the NF-kappa B activation pathway
    Mahdad Noursadeghi
    Infection and Immunity, University College London, London, United Kingdom
    J Immunol 182:319-28. 2009
    ..Unexpectedly, our data suggest innate immune responses are broadly preserved with limited exceptions, and pave the way for further study of the complex relationship between HIV-1 and immunological pathways within macrophages...
  15. pmc Specific capture and whole-genome sequencing of viruses from clinical samples
    Daniel P Depledge
    Division of Infection and Immunity, University College London, London, United Kingdom
    PLoS ONE 6:e27805. 2011
    ..Moreover, we show the specificity of the method enables the study of viral population structures and their diversity within a range of clinical samples types...
  16. pmc Identification of new herpesvirus gene homologs in the human genome
    Ria Holzerlandt
    Wohl Virion Centre, Department of Immunology and Molecular Pathology, University College London, London W1T 4JF, United Kingdom
    Genome Res 12:1739-48. 2002
    ....
  17. ncbi request reprint Viral bioinformatics: computational views of host and pathogen
    Paul Kellam
    Virus Genomics and Bioinformatics Group, Department of Immunology and Molecular Pathology, University College, Windeyer Institute of Medical Sciences, 46 Cleveland Street, London W1T4JF, UK
    Novartis Found Symp 254:234-47; discussion 247-52. 2003
    ..Ultimately, microbiology and immunology will tend towards a systems-level view of how host and pathogen interact...
  18. doi request reprint Microarray-based determination of the lytic cascade of human herpesvirus 6B
    Edward H Tsao
    Department of Infection, Division of Infection and Immunity, Royal Free and University College Medical School of UCL, London, UK
    J Gen Virol 90:2581-91. 2009
    ..Clustering of genes with similar expression profiles implied a shared function, thus revealing possible roles of previously uncharacterized HHV-6B genes...
  19. doi request reprint Epidemiology of non-B clade forms of HIV-1 in men who have sex with men in the UK
    Julie Fox
    Department of HIV, Guys and St Thomas NHS Trust Kings College London, St Thomas Hospital, London, UK
    AIDS 24:2397-401. 2010
    ..To describe the frequency and risk factors of non-B HIV-1 subtypes in men who have sex with men (MSM) in the UK...
  20. pmc Gene3D: comprehensive structural and functional annotation of genomes
    Corin Yeats
    UCL, Department of Molecular Biology and Biochemistry, Darwin Building, Gower St, London, UK
    Nucleic Acids Res 36:D414-8. 2008
    ..Currently Gene3D contains over 3.5 million domain assignments for nearly 5 million proteins including 527 completed genomes. This is available at: http://gene3d.biochem.ucl.ac.uk/..
  21. pmc X box binding protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency
    Sam J Wilson
    Department of Infection, UCL, 46 Cleveland Street, London W1T 4JF, United Kingdom
    J Virol 81:13578-86. 2007
    ..This links B-cell terminal differentiation to KSHV lytic reactivation...
  22. ncbi request reprint Robust Selection of Predictive Genes via a Simple Classifier
    Veronica Vinciotti
    School of Information Systems, Computing and Mathematics, Brunel University, Uxbridge, UK
    Appl Bioinformatics 5:1-11. 2006
    ..The method has been shown to be capable of selecting genes known to be associated with prostate cancer and viral infections...
  23. doi request reprint The effect of transmitted HIV-1 drug resistance on pre-therapy viral load
    Linda Harrison
    HIV and Infections Group, MRC Clinical Trials Unit, London, UK
    AIDS 24:1917-22. 2010
    ..Reduced replication capacity of viruses expressing drug resistant mutations implies that patients with transmitted drug resistance (TDR) could have lower HIV RNA viral load than those infected with wild-type virus...
  24. ncbi request reprint Assessment of automated genotyping protocols as tools for surveillance of HIV-1 genetic diversity
    Robert Gifford
    Department of Infection, University College London, UK
    AIDS 20:1521-9. 2006
    ..However, it is not clear how reliable standard genotyping of these sequences is for describing HIV-1 genetic variation and for detecting novel genetic variants and epidemiological trends...
  25. pmc KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming
    Amy Hansen
    Cancer Research UK Viral Oncology Group, University College London Cancer Institute, University College London, London WC1E 6BT, United Kingdom
    Genes Dev 24:195-205. 2010
    ..These findings demonstrate that viral miRNAs could influence the differentiation status of infected cells, and thereby contribute to KSHV-induced oncogenesis...
  26. pmc No evidence of XMRV or related retroviruses in a London HIV-1-positive patient cohort
    Eleanor R Gray
    Department of Infection and Immunity, University College London, London, United Kingdom
    PLoS ONE 6:e18096. 2011
    ..It has also been suggested that the virus can be found circulating amongst the general population. The discovery has been controversial, with conflicting results from attempts to reproduce the original studies...
  27. ncbi request reprint Genotyping Hepatitis B virus from whole- and sub-genomic fragments using position-specific scoring matrices in HBV STAR
    Richard Myers
    Division of Infection and Immunity, Royal Free and University College Medical School, The Windeyer Building, 46 Cleveland Street, London W1T 4JF, UK
    J Gen Virol 87:1459-64. 2006
    ..A web interface to hbv star is available at http://www.vgb.ucl.ac.uk/starn.shtml...
  28. pmc Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection
    A Ross Lopes
    Division of Infection and Immunity and Centre for Sexual Health and HIV Research, University College London, London, United Kingdom
    J Clin Invest 118:1835-45. 2008
    ..We therefore postulate that Bim-mediated attrition of HBV-specific CD8(+) T cells contributes to the inability of these cell populations to persist and control viral replication...
  29. pmc Transcriptional and functional defects of dendritic cells derived from the MUTZ-3 leukaemia line
    Jane Rasaiyaah
    Division of Infection and Immunity, University College London, London, UK
    Immunology 127:429-41. 2009
    ..These results have important implications for studies using MUTZ-3 as a model of MDDC or for cancer immunotherapy...
  30. doi request reprint HIV type-1 drug resistance in antiretroviral treatment-naive adults infected with non-B subtype virus in the United Kingdom
    Daniella N Chilton
    Medical Research Council Clinical Trials Unit, London, UK
    Antivir Ther 15:985-91. 2010
    ..We examined the characteristics of HIV-1 drug resistance in antiretroviral treatment (ART)-naive individuals migrating to the UK...
  31. pmc Assessment of a 44 gene classifier for the evaluation of chronic fatigue syndrome from peripheral blood mononuclear cell gene expression
    Daniel Frampton
    Department of Infection, Division of Infection and Immunity, University College London, London, United Kingdom
    PLoS ONE 6:e16872. 2011
    ..We conclude many of the previously identified reporter genes are study-specific and thus cannot be used as a broad CFS diagnostic...
  32. ncbi request reprint Infectogenomics: insights from the host genome into infectious diseases
    Paul Kellam
    MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London W1T 4JF, UK
    Cell 124:695-7. 2006
    ..This "infectogenomics" approach should yield further insights into both diagnostic and therapeutic advances, as well as normal cellular function...
  33. pmc Analysis of XMRV integration sites from human prostate cancer tissues suggests PCR contamination rather than genuine human infection
    Jeremy A Garson
    MRC Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland St, London W1T 4JF, UK
    Retrovirology 8:13. 2011
    ..We propose that the patient-derived sites are the result of PCR contamination. This observation further undermines the notion that XMRV is a genuine human pathogen...
  34. pmc Human immunodeficiency virus Tat associates with a specific set of cellular RNAs
    Russell D Bouwman
    MRC Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London WC1E 6BT, UK
    Retrovirology 11:53. 2014
    ..HIV-1 Tat has also been shown to alter the expression of host genes during infection, contributing to viral pathogenesis but, whether Tat also interacts with cellular RNAs is unknown...
  35. doi request reprint Patient-specific simulation as a basis for clinical decision-making
    S Kashif Sadiq
    Centre for Computational Science, Department of Chemistry, University College London, London WC1H 0AJ, UK
    Philos Trans A Math Phys Eng Sci 366:3199-219. 2008
    ..We describe systems that enable such priority computing...
  36. pmc X-box binding protein 1 induces the expression of the lytic cycle transactivator of Kaposi's sarcoma-associated herpesvirus but not Epstein-Barr virus in co-infected primary effusion lymphoma
    Imogen Yi Chun Lai
    University College London, MRC Centre for Molecular Virology, Department of Infection, Division of Infection and Immunity, Windeyer Institute of Medical Science, 46 Cleveland Street, London W1T 4JF, UK
    J Gen Virol 92:421-31. 2011
    ..Finally, chemical inducers of KSHV and EBV lytic replication in PEL, including HDAC inhibitors, do not lead to XBP-1 activation. We conclude that XBP-1 specifically reactivates the KSHV lytic cycle in dually infected PELs...
  37. ncbi request reprint Specific gene expression profiles in systemic juvenile idiopathic arthritis
    Emma Mary Ogilvie
    University College London, London, UK
    Arthritis Rheum 56:1954-65. 2007
    ..The purpose of this study was to compare gene expression profiles in peripheral blood mononuclear cells (PBMCs) from patients with active and inactive systemic JIA to define and better understand the cause of active disease...
  38. pmc Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile
    Richard G Jenner
    Wohl Virion Centre, Department of Immunology and Molecular Pathology, Windeyer Institute, University College London, London W1T 4JF, United Kingdom
    Proc Natl Acad Sci U S A 100:10399-404. 2003
    ..Similar to malignant plasma cells, all PEL samples tested express the vitamin D receptor and are sensitive to the vitamin D analogue drug EB 1089 (Seocalcitol)...
  39. pmc Kaposi's sarcoma-associated herpesvirus latent and lytic gene expression as revealed by DNA arrays
    R G Jenner
    Wohl Virion Centre, Department of Immunology and Molecular Pathology, Windeyer Institute, University College London, London W1T 4JF, United Kingdom
    J Virol 75:891-902. 2001
    ..Furthermore, latent and lytic genes thought to be functionally related cluster into groups. The correlation between gene expression and function also infers possible roles for KSHV genes yet to be characterized...
  40. pmc Phylogenetic studies of transmission dynamics in generalized HIV epidemics: an essential tool where the burden is greatest?
    Ann M Dennis
    Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC Department of Microbiology, University of Washington, Seattle, WA Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom Wellcome Trust Sanger Institute, Cambridge, United Kingdom Division of Infection and Immunity, University College London, London, United Kingdom Wellcome Trust Africa Centre for Health and Population Studies, University of Kwazula Natal, ZA and Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    J Acquir Immune Defic Syndr 67:181-95. 2014
    ..Finally, we review logistic and technical challenges inherent to large-scale molecular epidemiological studies of generalized epidemics and suggest potential solutions...
  41. pmc Disease-associated XMRV sequences are consistent with laboratory contamination
    Stephane Hue
    MRC Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland St, London W1T 4JF, UK
    Retrovirology 7:111. 2010
    ..Controversy has arisen from the failure of some studies to detect XMRV in PC or CFS patients and from inconsistent detection of XMRV in healthy controls...
  42. pmc Gammaherpesvirus lytic gene expression as characterized by DNA array
    Joo Wook Ahn
    Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, United Kingdom
    J Virol 76:6244-56. 2002
    ..This fundamental characterization furthers the development of this model and provides an experimental basis for continued investigation of gammaherpesvirus pathology...
  43. pmc Global Conformational Dynamics of HIV-1 Reverse Transcriptase Bound to Non-Nucleoside Inhibitors
    David W Wright
    Centre for Computational Science, Department of Chemistry, University College London, London, WC1H 0AJ, UK
    Biology (Basel) 1:222-44. 2012
    ..We further suggest a plausible path for conformational and dynamic changes to be communicated from the vicinity of the NNRTI binding pocket to the RNaseH at the other end of the enzyme. ..
  44. pmc RNA-seq analysis of host and viral gene expression highlights interaction between varicella zoster virus and keratinocyte differentiation
    Meleri Jones
    Division of Infection and Immunity, University College London, London, United Kingdom
    PLoS Pathog 10:e1003896. 2014
    ..These studies highlight the intimate host-pathogen interaction following VZV infection of skin and provide insight into the mechanisms by which VZV remodels the epidermal environment to promote its own replication and spread. ..
  45. pmc A systematic review of definitions of extreme phenotypes of HIV control and progression
    Deepti Gurdasani
    aWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton bStrangeways Research Laboratory, Department of Public Health and Primary Care, University of Cambridge, Wort s Causeway, Cambridge cMedical Research Council, Clinical Trials Unit, Aviation House, London, UK dCentre for the AIDS Programme of Research in South Africa CAPRISA, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, South Africa eWellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford fImperial College Healthcare NHS Trust, London gCambridge University Hospitals NHS Foundation Trust, Department of Infectious Diseases, Addenbrooke s Hospital, Cambridge hKing s College London, Weston Education Centre iDivision of Infection and Immunity, University College London, London, UK
    AIDS 28:149-62. 2014
    ..In this context, we were able to identify common components in existing definitions that may provide a framework for developing consensus definitions for these phenotypes in HIV infection. ..
  46. pmc Infectious causes of cancer and their detection
    Lucy Dalton-Griffin
    Department of Infection, University College London, Cleveland Street, London W1T 4JF, UK
    J Biol 8:67. 2009
    ..Identifying a causal infectious agent helps in understanding the biology of these cancers and can lead ultimately to the development of antimicrobial drugs and vaccines for their treatment and prevention...
  47. ncbi request reprint Development of a novel human immunodeficiency virus type 1 subtyping tool, Subtype Analyzer (STAR): analysis of subtype distribution in London
    Catherine V Gale
    Department of Infection, University College London, London W1T 4JF, UK
    AIDS Res Hum Retroviruses 20:457-64. 2004
    ..STAR was used to classify HIV-1 PR-RT sequences from 843 HIV-1 clinical isolates submitted for drug resistance profiling in London. Within this dataset 26.9% of sequences were classified by STAR as non-B subtypes...
  48. ncbi request reprint Rabbit endogenous retrovirus-H encodes a functional protease
    Cécile Voisset
    Wohl Virion Centre, Windeyer Institute of Medical Sciences, University College London, 46 Cleveland Street, London W1T 4JF, UK
    J Gen Virol 84:215-25. 2003
    ..A structural model of the RERV-H protease was constructed that, together with the activity data, confirms that this is a retroviral aspartic protease...
  49. pmc Genomewide function conservation and phylogeny in the Herpesviridae
    M M Alba
    Wohl Virion Centre, Department of Immunology and Molecular Pathology, University College London, London W1T 4JF, UK
    Genome Res 11:43-54. 2001
    ..These trees agreed with molecular-sequence-derived trees and allowed greater insight into the phylogeny of ungulate and murine gammaherpesviruses...
  50. doi request reprint HIV-1 drug resistance in HIV-1-infected children in the United Kingdom from 1998 to 2004
    Rana Chakraborty
    Paediatric Infectious Diseases Unit, St George s Hospital, London
    Pediatr Infect Dis J 27:457-9. 2008
    ..Three-class resistance was noted in 42 samples (14.1%). Our study also highlighted underutilization of testing and the need for prompt genotyping after drug discontinuation which may have lead to an underestimation of HIV-1 resistance...
  51. ncbi request reprint Poxvirus genomes: a phylogenetic analysis
    Caroline Gubser
    Department of Virology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    J Gen Virol 85:105-17. 2004
    ..This suggests that CPV-BR and GRI-90 should be separate species...
  52. ncbi request reprint PFDB: a generic protein family database integrating the CATH domain structure database with sequence based protein family resources
    Adrian J Shepherd
    Department of Biochemistry and Molecular Biology, University College, London, Gower Street, London WC1E 6BT
    Bioinformatics 18:1666-72. 2002
    ....
  53. pmc LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration
    Ming Chieh Shun
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 21:1767-78. 2007
    ..Akin to yeast retrotransposons, disrupting the lentiviral targeting mechanism significantly perturbs overall integration...