Colin D Kay

Summary

Affiliation: University of East Anglia
Country: UK

Publications

  1. doi request reprint Relative impact of flavonoid composition, dose and structure on vascular function: a systematic review of randomised controlled trials of flavonoid-rich food products
    Colin D Kay
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK
    Mol Nutr Food Res 56:1605-16. 2012
  2. doi request reprint The bioactivity of dietary anthocyanins is likely to be mediated by their degradation products
    Colin D Kay
    Institute of Food Research, Norwich Research Park, Norwich, UK
    Mol Nutr Food Res 53:S92-101. 2009
  3. doi request reprint The future of flavonoid research
    Colin D Kay
    School of Medicine, University of East Anglia, Norwich, UK
    Br J Nutr 104:S91-5. 2010
  4. doi request reprint Methods for isolating, identifying, and quantifying anthocyanin metabolites in clinical samples
    Rachel M de Ferrars
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, United Kingdom
    Anal Chem 86:10052-8. 2014
  5. pmc Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial
    Sara Hazim
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 103:694-702. 2016
  6. doi request reprint Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a (13)C-tracer study
    Charles Czank
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 97:995-1003. 2013
  7. doi request reprint Cardiovascular disease risk biomarkers and liver and kidney function are not altered in postmenopausal women after ingesting an elderberry extract rich in anthocyanins for 12 weeks
    PETER J CURTIS
    School of Medicine, University of East Anglia, Norwich, Norfolk, UK
    J Nutr 139:2266-71. 2009
  8. doi request reprint Anthocyanins remain stable during commercial blackcurrant juice processing
    Gary M Woodward
    School of Medicine, Univ of East Anglia, Norwich NR4 7TJ, UK
    J Food Sci 76:S408-14. 2011
  9. pmc Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells
    Hiren P Amin
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK
    Mol Nutr Food Res 59:1095-106. 2015
  10. pmc Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cells
    Emily F Warner
    Department of Nutrition, Norwich Medical School, and
    J Nutr 146:465-73. 2016

Collaborators

  • Aedin Cassidy
  • Qingzhi Zhang
  • Anne Marie Minihane
  • John F Potter
  • Eric B Rimm
  • Lee Hooper
  • Charles Czank
  • Gary M Woodward
  • Rachel M de Ferrars
  • PETER J CURTIS
  • Sara Hazim
  • Manuel Y Schär
  • Nigel P Botting
  • Paul A Kroon
  • Emily F Warner
  • David O'Hagan
  • Luisa M Ostertag
  • Maria A O'Connell
  • Saki Raheem
  • Michael Edwards
  • K Saki Raheem
  • Hiren P Amin
  • Jessica L di Gesso
  • Paul W Needs
  • Sai Krishna Yalamanchili
  • Jason S Kerr
  • Peter Curtis
  • Shikha Saha
  • Tom Preston
  • Douglas J Morrison
  • Danielle McCarthy
  • Danh Pham-Thanh
  • Rebecca Walls
  • Wendy J Hollands
  • Gail Jenkins

Detail Information

Publications15

  1. doi request reprint Relative impact of flavonoid composition, dose and structure on vascular function: a systematic review of randomised controlled trials of flavonoid-rich food products
    Colin D Kay
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK
    Mol Nutr Food Res 56:1605-16. 2012
    ..The aim of the present study was to examine the relative impact of composition, flavonoid structure and dose...
  2. doi request reprint The bioactivity of dietary anthocyanins is likely to be mediated by their degradation products
    Colin D Kay
    Institute of Food Research, Norwich Research Park, Norwich, UK
    Mol Nutr Food Res 53:S92-101. 2009
    ..Future efforts to establish the biological activities of anthocyanins should therefore include the investigation of phenolic acid and aldehyde products of degradation, along with their respective metabolites...
  3. doi request reprint The future of flavonoid research
    Colin D Kay
    School of Medicine, University of East Anglia, Norwich, UK
    Br J Nutr 104:S91-5. 2010
    ..The future of flavonoid research will undoubtedly depend upon the resolve of these issues, and although the field has shown continuous progress for many years, progress will likely slow if these challenges are not met...
  4. doi request reprint Methods for isolating, identifying, and quantifying anthocyanin metabolites in clinical samples
    Rachel M de Ferrars
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, United Kingdom
    Anal Chem 86:10052-8. 2014
    ....
  5. pmc Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial
    Sara Hazim
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 103:694-702. 2016
    ..Although cross-sectional and retrospective data support favorable associations between the equol producer (EP) phenotype and cardiometabolic health, few studies have prospectively recruited EPs to confirm this association...
  6. doi request reprint Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a (13)C-tracer study
    Charles Czank
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 97:995-1003. 2013
    ..Evidence suggests that the consumption of anthocyanin-rich foods beneficially affects cardiovascular health; however, the absorption, distribution, metabolism, and elimination (ADME) of anthocyanin-rich foods are relatively unknown...
  7. doi request reprint Cardiovascular disease risk biomarkers and liver and kidney function are not altered in postmenopausal women after ingesting an elderberry extract rich in anthocyanins for 12 weeks
    PETER J CURTIS
    School of Medicine, University of East Anglia, Norwich, Norfolk, UK
    J Nutr 139:2266-71. 2009
    ..02). In conclusion, these data suggest that chronic consumption of 500 mg/d of elderberry extract for 12 wk is apparently safe, but ineffective in altering biomarkers of CVD risk in healthy postmenopausal women...
  8. doi request reprint Anthocyanins remain stable during commercial blackcurrant juice processing
    Gary M Woodward
    School of Medicine, Univ of East Anglia, Norwich NR4 7TJ, UK
    J Food Sci 76:S408-14. 2011
    ....
  9. pmc Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells
    Hiren P Amin
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK
    Mol Nutr Food Res 59:1095-106. 2015
    ....
  10. pmc Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cells
    Emily F Warner
    Department of Nutrition, Norwich Medical School, and
    J Nutr 146:465-73. 2016
    ....
  11. doi request reprint Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function
    Michael Edwards
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    J Agric Food Chem 63:2423-31. 2015
    ..Anthocyanin metabolites may therefore modulate vascular reactivity by inducing HO-1 and modulating NOX activity, resulting in reduced superoxide production and improved NO bioavailability. ..
  12. pmc Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes
    Jessica L di Gesso
    School of Pharmacy, University of East Anglia, Norwich, UK
    Mol Nutr Food Res 59:1143-54. 2015
    ..Using a unique study design, we investigated the potential for singular or additive anti-inflammatory effects of flavonoid metabolites relative to their precursor structures...
  13. pmc Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease
    Manuel Y Schär
    From the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 101:931-8. 2015
    ..However, insufficient randomized controlled trial data limit our understanding of the mechanisms by which flavanones and their metabolites potentially reduce cardiovascular risk factors...
  14. doi request reprint Anthocyanin-derived phenolic acids form glucuronides following simulated gastrointestinal digestion and microsomal glucuronidation
    Gary M Woodward
    School of Medicine, University of East Anglia, Norwich, UK
    Mol Nutr Food Res 55:378-86. 2011
    ..Current research indicates that anthocyanins are primarily degraded to form phenolic acid products. However, no studies have yet demonstrated the metabolic conjugation of these anthocyanin-derived phenolic acids in humans...
  15. doi request reprint Phenolic metabolites of anthocyanins following a dietary intervention study in post-menopausal women
    Rachel M de Ferrars
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK
    Mol Nutr Food Res 58:490-502. 2014
    ..Numerous studies feeding anthocyanin-rich foods report limited bioavailability of the parent anthocyanins. The present study explores the identity and concentration of the phenolic metabolites of anthocyanins in humans...