Genomes and Genes
Affiliation: University College London
- Large-scale pathways-based association study in amyotrophic lateral sclerosisDalia Kasperaviciute
Department of Neurodegenerative Disease, Institute of Neurology, University College London, London, UK
Brain 130:2292-301. 2007..It is reliable for large scale genotyping studies of diseases such as ALS, where DNA sample collections are limited because of low disease prevalence and short survival time...
- Analysis of European case-control studies suggests that common inherited variation in mitochondrial DNA is not involved in susceptibility to amyotrophic lateral sclerosisCatherine J E Ingram
The Centre for Genetic Anthropology, University College London Genetics Institute, Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK
Amyotroph Lateral Scler 13:341-6. 2012..Combining the data with other studies will allow meta-analysis to look for variants with modest effect sizes. The sequencing of complete mitochondrial genomes will be required to assess the role of rare mutations...
- Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1ADalia Kasperaviciute
1 NIHR University College London Hospitals Biomedical Research Centre, Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
Brain 136:3140-50. 2013....
- Common genetic variation and susceptibility to partial epilepsies: a genome-wide association studyDalia Kasperaviciute
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
Brain 133:2136-47. 2010..Data emerging from genome-wide association-studies will be valuable during the next serious challenge of interpreting all the genetic variation emerging from whole-genome sequencing studies...
- Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of dataJennifer C Schymick
Laboratory of Neurogenetics, National Institute on Aging, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
Lancet Neurol 6:322-8. 2007..We sought to identify genetic variants associated with an increased or decreased risk for developing ALS in a cohort of American sporadic cases...