- Optimal placement of origins for DNA replicationJens Karschau
Institute for Complex Systems and Mathematical Biology, SUPA, King s College, University of Aberdeen, Aberdeen 24 3UE, United Kingdom
Phys Rev Lett 108:058101. 2012..We show that under some conditions the minimization of replication time leads to the grouping of origins, and relate this to experimental data in a number of species showing origin grouping...
- A matter of life or death: modeling DNA damage and repair in bacteriaJens Karschau
Institute of Complex Systems and Mathematical Biology, SUPA, King s College, University of Aberdeen, Aberdeen, United Kingdom
Biophys J 100:814-21. 2011..We verify our analytical results by simulating the stochastic dynamics of DNA damage and repair. Finally, we also perform an experiment with Escherichia coli cells to test one of the predictions of our model...