Roy W Jones
Affiliation: University of Bath
- Rates of cognitive change in Alzheimer disease: observations across a decade of placebo-controlled clinical trials with donepezilRoy W Jones
Research Institute for the Care of Older People, Royal United Hospital, Bath, UK
Alzheimer Dis Assoc Disord 23:357-64. 2009..This finding may have important potential implications for future clinical trial design...
- Dimebon disappointmentRoy W Jones
Research Institute for the Care of Older People, Royal United Hospital, Bath BA1 3NG, UK
Alzheimers Res Ther 2:25. 2010..The potential reasons for these disappointing results are discussed, as well as the implication for dimebon and drug treatment in Alzheimer's disease...
- Dementia, postcode prescribing and NICERoy W Jones
Age Ageing 33:331-2. 2004
- Safety and tolerability of once-daily versus twice-daily memantine: a randomised, double-blind study in moderate to severe Alzheimer's diseaseRoy W Jones
Research Institute for the Care of the Elderly RICE, Bath, UK
Int J Geriatr Psychiatry 22:258-62. 2007..To assess the safety and tolerability of three different dosing schedules of memantine in patients with moderate to severe Alzheimer's disease (AD)...
- Dependence in Alzheimer's disease and service use costs, quality of life, and caregiver burden: The DADE studyRoy W Jones
RICE The Research Institute for the Care of Older People, Royal United Hospital, Bath, UK Electronic address
Alzheimers Dement 11:280-90. 2015..Dependence has been proposed as a better marker for following disease progression...
- Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT)Linda Clare
School of Psychology, Bangor University, Bangor, Gwynedd LL57 2AS, UK
Trials 14:152. 2013..This study aims to establish whether CR is a clinically effective and cost-effective intervention for people with early-stage dementia and their carers...
- DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCTRob Jones
Section of Old Age Psychiatry, The University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
Trials 10:57. 2009..The aim of this trial is to establish the most effective drug option for people with AD who are progressing from moderate to severe dementia despite treatment with donepezil...
- Physicians and caregivers: ready and waiting for increased participation in clinical researchR W Jones
Rice, Royal United Hospital, Combe Park, Bath, UK
J Nutr Health Aging 14:563-8. 2010....
- Assessing attitudes and behaviours surrounding Alzheimer's disease in Europe: key findings of the Important Perspectives on Alzheimer's Care and Treatment (IMPACT) surveyR W Jones
RICE Centre, Royal United Hospital, Combe Park, Bath, UK
J Nutr Health Aging 14:525-30. 2010..Despite the prevalence of AD in the ageing population of Europe, the perception within each of the 5 countries surveyed is that AD is not viewed as a health care priority...
- Collaborative research between academia and industry using a large clinical trial database: a case study in Alzheimer's diseaseRoy Jones
Research Institute for the Care of Older People, Royal United Hospital, Combe Park, Bath BA1 3NG, UK
Trials 12:233. 2011..We present here a successful example of this type of collaboration in the field of dementia...
- The Atorvastatin/Donepezil in Alzheimer's Disease Study (LEADe): design and baseline characteristicsRoy W Jones
RICE The Research Institute for the Care of Older People, Royal United Hospital, Bath, United Kingdom
Alzheimers Dement 4:145-53. 2008....
- A review comparing the safety and tolerability of memantine with the acetylcholinesterase inhibitorsR W Jones
RICE The Research Institute for the Care of Older People, Royal United Hospital, Bath, UK
Int J Geriatr Psychiatry 25:547-53. 2010..This paper reviews the most recent safety data for memantine in comparison with the AChEIs...
- A multinational, randomised, 12-week study comparing the effects of donepezil and galantamine in patients with mild to moderate Alzheimer's diseaseRoy W Jones
Research Institute for the Care of the Elderly, St Martin s Hospital, Bath, UK
Int J Geriatr Psychiatry 19:58-67. 2004....
- The dementiasRoy W Jones
The Research Institute for the Care of the Elderly, St Martin s Hospital, Bath
Clin Med 3:404-8. 2003
- Have cholinergic therapies reached their clinical boundary in Alzheimer's disease?Roy W Jones
The Research Institute for the Care of the Elderly, St Martins Hospital, Bath, UK
Int J Geriatr Psychiatry 18:S7-S13. 2003..Trials are also being conducted in Mild Cognitive Impairment, other dementias and other conditions where cognitive impairment is a problem...
- Making errorless learning more active: self-generation in an error free learning context is superior to standard errorless learning of face-name associations in people with Alzheimer's diseaseAmanda J Laffan
Research Institute for the Care of Older People, Hillview Lodge, Royal United Hospital, Combe Park, Bath, Somerset, UK
Neuropsychol Rehabil 20:197-211. 2010..The implications of this research for individualised memory rehabilitation programmes are discussed...
- A direct comparison of errorless and errorful therapy for object name relearning in Alzheimer's diseaseKrist A Noonan
Research Institute for Care of Older People, Royal United Hospital, Bath, UK
Neuropsychol Rehabil 22:215-34. 2012..These results suggest that either EL or EF therapy can be used to alleviate word-finding problems in AD...
- Disordered memory awareness: recollective confabulation in two cases of persistent déjà vecuChristopher J A Moulin
The Research Institute for the Care of the Elderly, St Martin s Hospital, UK
Neuropsychologia 43:1362-78. 2005....
- Alpha7 nicotinic acetylcholine receptor expression in Alzheimer's disease: receptor densities in brain regions of the APP(SWE) mouse model and in human peripheral blood lymphocytesIan W Jones
Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
J Mol Neurosci 30:83-4. 2006..We have undertaken a semiquantitative histological evaluation of alpha7 nAChR expression in a mouse model of AD pathology, as well as a comparison of alpha7 nAChR levels in lymphocytes from AD patients and control subjects...
- Music enhances category fluency in healthy older adults and Alzheimer's disease patientsR G Thompson
The Research Institute for the Care of the Elderly, Bath, UK
Exp Aging Res 31:91-9. 2005..In keeping with previous reports, the authors conclude that music enhances attentional processes, and that this can be demonstrated in Alzheimer's disease...
- The significance of dyslexia screening for the assessment of dementia in older peopleClaudia Metzler-Baddeley
The Research Institute for the Care of Older People RICE, Bath, UK
Int J Geriatr Psychiatry 23:766-8. 2008..These results highlight the importance of dyslexia screening for the assessment of dementia, not least because the choice of treatment is guided by the outcome of the assessment of the severity and the type of dementia...
- Cost effectiveness of memantine in Alzheimer's disease: an analysis based on a probabilistic Markov model from a UK perspectiveRoy W Jones
The Research Institute for the Care of the Elderly, St Martin s Hospital, Bath, UK
Drugs Aging 21:607-20. 2004..While these findings suggest that, compared with placebo, memantine provides cost savings, further analyses may help to quantify potential economic gains over a longer treatment period...
- Visual impairments in dementia with Lewy bodies and posterior cortical atrophyClaudia Metzler-Baddeley
Research Institute for the Care of Older People RICE, The RICE Centre, Royal United Hospital, Bath, BA1 3NG, United Kingdom
Neuropsychology 24:35-48. 2010..The latter suggests that both lower and higher level visual impairments contribute to the complex visual symptoms associated with PCA...
- Deficient acquisition and consolidation: intertrial free recall performance in Alzheimer's disease and mild cognitive impairmentChristopher J A Moulin
Research Institute for the Care of the Elderly, St Martin s Hospital, Bath, UK and School of Psychology, University of Leeds, Leeds, UK
J Clin Exp Neuropsychol 26:1-10. 2004..Finally, we showed strong correlations between our measure and dementia severity, suggesting that acquisition and consolidation both get worse as the dementia progresses...
- Recall of 9.11 in Alzheimer's disease: further evidence for intact flashbulb memoryR G Thompson
The Research Institute for the Care of the Elderly, St Martin s Hospital, Bath BA2 5RP, UK
Int J Geriatr Psychiatry 19:495-6. 2004
- Donepezil for the treatment of agitation in Alzheimer's diseaseRobert J Howard
Medical Research Council Neurogeneration Research Centre, Institute of Psychiatry, King s College London, London, United Kingdom
N Engl J Med 357:1382-92. 2007..Agitation is a common and distressing symptom in patients with Alzheimer's disease. Cholinesterase inhibitors improve cognitive outcomes in such patients, but the benefits of these drugs for behavioral disturbances are unclear...
- Deficits for semantics and the irregular past tense: a causal relationship?Lorraine K Tyler
Department of Experimental Psychology, University of Cambridge, Cambridge CB3 ODX, UK
J Cogn Neurosci 16:1159-72. 2004....
- Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trialClive Holmes
Division of Clinical Neurosciences, University of Southampton, Southampton, UK Moorgreen Hospital, Hampshire Partnership Trust, Southampton, UK
Lancet 372:216-23. 2008..Our aim was to assess the relation between Abeta(42) immune response, degree of plaque removal, and long-term clinical outcomes...
- How can we best assess the quality of life of people with dementia? the Bath Assessment of Subjective Quality of Life in Dementia (BASQID)Richard Trigg
Department of Psychology, World Health Organization Centre for the Study of Quality of Life, University of Bath, England
Gerontologist 47:789-97. 2007..The study aim was to develop a measure of self-reported quality of life (QoL) for people with mild to moderate dementia based on their views-the Bath Assessment of Subjective Quality of Life in Dementia (BASQID)...
- Can people with mild to moderate dementia provide reliable answers about their quality of life?Richard Trigg
Department of Psychology, WHO Centre for the Study of Quality of Life, University of Bath, UK
Age Ageing 36:663-9. 2007..However growing evidence suggests that people with mild to moderate dementia may be able to complete standardised questionnaire items and articulate feelings, providing reliable evaluations of their health and QoL...
- Memantine in moderate to severe Alzheimer's disease: a meta-analysis of randomised clinical trialsBengt Winblad
Karolinska Institutet, Stockholm, Sweden
Dement Geriatr Cogn Disord 24:20-7. 2007..Memantine was well tolerated, and the overall incidence rates of adverse events were comparable to placebo. This meta-analysis supports memantine's clinically relevant efficacy in patients with moderate to severe AD...
- A category-specific advantage for numbers in verbal short-term memory: evidence from semantic dementiaElizabeth Jefferies
University of Bristol, Bristol, UK
Neuropsychologia 42:639-60. 2004....
- Retrieval-induced forgetting in Alzheimer's diseaseChris J A Moulin
Department of Experimental Psychology, University of Bristol, Bristol, UK
Neuropsychologia 40:862-7. 2002..This suggests that a deficit in inhibitory processes during retrieval is not behind the high levels of intrusion errors made in recall in AD...