A J Johnston

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Effect of cerebral perfusion pressure augmentation with dopamine and norepinephrine on global and focal brain oxygenation after traumatic brain injury
    Andrew J Johnston
    Department of Anaesthetics, University of Cambridge, Addenbrooke s Hospital, Box 93, Cambridge CB2 2QQ, UK
    Intensive Care Med 30:791-7. 2004
  2. ncbi request reprint Hyperoxia and the cerebral hemodynamic responses to moderate hyperventilation
    A J Johnston
    Department of Anaesthetics, Addenbrooke s Hospital, University of Cambridge, Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Acta Anaesthesiol Scand 47:391-6. 2003
  3. ncbi request reprint Cerebral oxygen vasoreactivity and cerebral tissue oxygen reactivity
    A J Johnston
    University of Cambridge Department of Anaesthetics, Box 93 and Academic Neurosurgery, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Br J Anaesth 90:774-86. 2003
  4. ncbi request reprint Effects of propofol on cerebral oxygenation and metabolism after head injury
    A J Johnston
    University of Cambridge Department of Anaesthesia, Box 93, Cambridge CB2 2QQ, UK
    Br J Anaesth 91:781-6. 2003
  5. ncbi request reprint Pharmacokinetics and pharmacodynamics of dopamine and norepinephrine in critically ill head-injured patients
    Andrew J Johnston
    University of Cambridge Department of Anaesthetics, Addenbrooke s Hospital, Box 93, Cambridge, CB2 2QQ, United Kingdom
    Intensive Care Med 30:45-50. 2004
  6. ncbi request reprint Imaging of cerebral blood flow and metabolism in brain injury in the ICU
    J D Pickard
    Wolfson Brain Imaging Centre, University of Cambridge, Addenbrookes Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:459-64. 2005
  7. ncbi request reprint Effects of moderate hyperventilation on cerebrovascular pressure-reactivity after head injury
    L A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:17-20. 2005
  8. ncbi request reprint Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury
    A S Cunningham
    Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, UK
    Brain 128:1931-42. 2005
  9. ncbi request reprint Predicting the response of intracranial pressure to moderate hyperventilation
    L A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, United Kingdom
    Acta Neurochir (Wien) 147:477-83; discussion 483. 2005
  10. doi request reprint Evaluation of the Sherlock 3CG Tip Confirmation System on peripherally inserted central catheter malposition rates
    A J Johnston
    John Farman Intensive Care Unit, Addenbrooke s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    Anaesthesia 69:1322-30. 2014

Detail Information

Publications26

  1. ncbi request reprint Effect of cerebral perfusion pressure augmentation with dopamine and norepinephrine on global and focal brain oxygenation after traumatic brain injury
    Andrew J Johnston
    Department of Anaesthetics, University of Cambridge, Addenbrooke s Hospital, Box 93, Cambridge CB2 2QQ, UK
    Intensive Care Med 30:791-7. 2004
    ..To compare the effects of a cerebral perfusion pressure (CPP) intervention achieved with dopamine and norepinephrine after severe head injury...
  2. ncbi request reprint Hyperoxia and the cerebral hemodynamic responses to moderate hyperventilation
    A J Johnston
    Department of Anaesthetics, Addenbrooke s Hospital, University of Cambridge, Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Acta Anaesthesiol Scand 47:391-6. 2003
    ..Hyperoxia is thought to modulate the production of lactic acid. This study examined the kinetics of middle cerebral artery flow velocity (MCA FV) reduction during hyperventilation, and its modulation by hyperoxia...
  3. ncbi request reprint Cerebral oxygen vasoreactivity and cerebral tissue oxygen reactivity
    A J Johnston
    University of Cambridge Department of Anaesthetics, Box 93 and Academic Neurosurgery, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Br J Anaesth 90:774-86. 2003
    ..This overview summarizes the available information in this area and suggests some avenues for further research...
  4. ncbi request reprint Effects of propofol on cerebral oxygenation and metabolism after head injury
    A J Johnston
    University of Cambridge Department of Anaesthesia, Box 93, Cambridge CB2 2QQ, UK
    Br J Anaesth 91:781-6. 2003
    ..We have used a step increase in target plasma propofol concentration in head injured patients to explore flow-metabolism coupling in these patients...
  5. ncbi request reprint Pharmacokinetics and pharmacodynamics of dopamine and norepinephrine in critically ill head-injured patients
    Andrew J Johnston
    University of Cambridge Department of Anaesthetics, Addenbrooke s Hospital, Box 93, Cambridge, CB2 2QQ, United Kingdom
    Intensive Care Med 30:45-50. 2004
    ..To explore the pharmacokinetics and pharmacodynamics of dopamine and norepinephrine...
  6. ncbi request reprint Imaging of cerebral blood flow and metabolism in brain injury in the ICU
    J D Pickard
    Wolfson Brain Imaging Centre, University of Cambridge, Addenbrookes Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:459-64. 2005
    ..New modelling and analytical approaches have been developed...
  7. ncbi request reprint Effects of moderate hyperventilation on cerebrovascular pressure-reactivity after head injury
    L A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:17-20. 2005
    ..Our data suggest that the response of pressure reactivity to hyperventilation is heterogeneous. This could be due to hyperventilation-induced changes in cerebral metabolism, or the change in CPP...
  8. ncbi request reprint Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury
    A S Cunningham
    Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, UK
    Brain 128:1931-42. 2005
    ..At a voxel-based level, however (and in common with ischaemic stroke), the extent of irreversible tissue damage cannot be accurately predicted by early abnormalities of any single physiological variable...
  9. ncbi request reprint Predicting the response of intracranial pressure to moderate hyperventilation
    L A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, United Kingdom
    Acta Neurochir (Wien) 147:477-83; discussion 483. 2005
    ..We investigated the ability of pre-hyperventilation ICP and cerebrospinal compensatory reserve to predict the reduction in ICP achievable with moderate hyperventilation in head injured patients...
  10. doi request reprint Evaluation of the Sherlock 3CG Tip Confirmation System on peripherally inserted central catheter malposition rates
    A J Johnston
    John Farman Intensive Care Unit, Addenbrooke s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    Anaesthesia 69:1322-30. 2014
    ..5%; 95% CI 16-26%) catheters were malpositioned. These malposition rates are significantly lower than our own historical data, which used a 'blind' anthropometric technique to guide peripherally inserted central catheter insertion. ..
  11. doi request reprint Defining peripherally inserted central catheter tip position and an evaluation of insertions in one unit
    A J Johnston
    John Farman Intensive Care Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    Anaesthesia 68:484-91. 2013
    ..Malposition rates were significantly higher in ICU patients. Emerging technologies may assist in reducing these high rates...
  12. ncbi request reprint Influence of improved teaching on medical students' acquisition and retention of drug administration skills
    D W Wheeler
    University Department of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Br J Anaesth 96:48-52. 2006
    ..Lack of education about drug administration appears to be a causative factor. We devised an online teaching module for medical students and assessed its short- and long-term efficacy...
  13. ncbi request reprint Validation of a tonometric noninvasive arterial blood pressure monitor in the intensive care setting
    L A Steiner
    University Department of Anaesthesia and Academic Neurosurgery, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Anaesthesia 58:448-54. 2003
    ..Furthermore, there was a tendency to underestimate low pressures and overestimate high pressures. In our opinion, the Colin CBM-7000 cannot be recommended for continuous blood pressure monitoring in the intensive care setting...
  14. ncbi request reprint Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury
    Andrew J Johnston
    University Department of Anaesthetics, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 33:189-95; discussion 255-7. 2005
    ....
  15. ncbi request reprint Sustained moderate reductions in arterial CO2 after brain trauma time-course of cerebral blood flow velocity and intracranial pressure
    Luzius A Steiner
    Department of Anaesthesia, University Hospital Basel, 4031 Basel, Switzerland
    Intensive Care Med 30:2180-7. 2004
    ..We investigated the time-course of changes in middle cerebral artery mean flow velocity (FVm) and intracranial pressure (ICP) in head-injured patients during sustained moderate reductions in arterial partial pressure of CO(2) (PaCO(2))...
  16. ncbi request reprint Problems encountered with a pilot online attendance record and feedback scheme for medical students
    Daniel W Wheeler
    University Department of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Educ Health (Abingdon) 19:369-74. 2006
  17. ncbi request reprint Does induced hypertension reduce cerebral ischaemia within the traumatized human brain?
    Jonathan P Coles
    Division of Anaesthesia, Addenbrooke s Hospital, Cambridge, UK
    Brain 127:2479-90. 2004
    ..It also remains unclear whether CPP values below 65 mmHg can be safely used in this population. Clarification of the significance of a reduction in CMRO2 and neuronal electrical function will require further study...
  18. ncbi request reprint Direct comparison of cerebrovascular effects of norepinephrine and dopamine in head-injured patients
    Luzius A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 32:1049-54. 2004
    ..To directly compare the cerebrovascular effects of norepinephrine and dopamine in patients with acute traumatic brain injury...
  19. ncbi request reprint Incidence and mechanisms of cerebral ischemia in early clinical head injury
    Jonathan P Coles
    The Division of Anaesthesia, and The Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 24:202-11. 2004
    ..The ischemic burden represented by this "traumatic penumbra" is poorly detected by bedside clinical monitors and has significant associations with outcome...
  20. ncbi request reprint Measuring cerebral autoregulation in stroke patients
    Andrew J Johnston
    Stroke 34:e39-40; author reply e39-40. 2003
  21. ncbi request reprint Responses of posttraumatic pericontusional cerebral blood flow and blood volume to an increase in cerebral perfusion pressure
    Luzius A Steiner
    Wolfson Brain Imaging Centre, University Department of Anesthesia, Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 23:1371-7. 2003
    ..Pericontusional oedema on computed tomography was associated with lower absolute values of CBF and CBV but did not differ from nonoedematous tissue in the relative response to CPP elevation...
  22. ncbi request reprint The effects of large-dose propofol on cerebrovascular pressure autoregulation in head-injured patients
    Luzius A Steiner
    Academic Neurosurgery, University Department of Anaesthesia, Addenbrooke s Hospital, Cambridge, United Kingdom
    Anesth Analg 97:572-6, table of contents. 2003
    ..We propose that large doses of propofol should be used cautiously in head-injured patients, because there is the potential to increase the injured brain's vulnerability to secondary insults...
  23. ncbi request reprint Assessment of cerebrovascular autoregulation in head-injured patients: a validation study
    Luzius A Steiner
    Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, UK
    Stroke 34:2404-9. 2003
    ..Cerebrovascular autoregulation is frequently measured in head-injured patients. We attempted to validate 4 bedside methods used for assessment of autoregulation...
  24. ncbi request reprint Hyperglycemia and brain tissue pH after traumatic brain injury
    David A Zygun
    Neuroscience Critical Care Unit and Department of Anaesthesia, University of Cambridge, Cambridge, England
    Neurosurgery 55:877-81; discussion 882. 2004
    ..We tested the hypothesis that blood glucose levels are associated with brain tissue pH (pH(b)) and that the correction of hyperglycemia would result in an improvement in pH(b)...
  25. ncbi request reprint Extracellular Brain pH and Outcome following Severe Traumatic Brain Injury
    Arun K Gupta
    Neuroscience Critical Care Unit, University of Cambridge Department of Anaesthesia, UK
    J Neurotrauma 21:678-84. 2004
    ..pH(b) differentiated between survivors and non-survivors. Measurement of pH(b) may be a useful indicator of outcome in patients with TBI...
  26. ncbi request reprint Advanced monitoring in the neurology intensive care unit: microdialysis
    Andrew J Johnston
    Neuro Critical Care Unit, Addenbrooke s Hospital, Cambridge, UK
    Curr Opin Crit Care 8:121-7. 2002
    ..The advantages and disadvantages of microdialysis are discussed, as is its future potential...