Andrew D Johnson
Affiliation: University of Nottingham
- Evolution of predetermined germ cells in vertebrate embryos: implications for macroevolutionAndrew D Johnson
Division of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
Evol Dev 5:414-31. 2003..Moreover, our analysis suggests that germ plasm has evolved independently in several lineages of vertebrate embryos...
- Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissuesAndrew D Johnson
Department of Pharmacology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
Pharmacogenet Genomics 18:781-91. 2008..We have used AEI to discover and characterize regulatory polymorphisms in OPRM1, TPH2, MDR1, DRD2, and VKORC1. The objective of this study was to use AEI to determine the extent of cis-regulatory factors in pharmacogenetic genes...
- Primordial germ cells: the first cell lineage or the last cells standing?Andrew D Johnson
School of Life Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
Development 142:2730-9. 2015..We postulate that early germ line segregation liberates genetic regulatory networks for somatic development to evolve, and that it therefore emerged repeatedly in the animal kingdom in response to natural selection. ..
- Regulative germ cell specification in axolotl embryos: a primitive trait conserved in the mammalian lineageAndrew D Johnson
Department of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
Philos Trans R Soc Lond B Biol Sci 358:1371-9. 2003..Our results imply that germ plasm, as found in species such as frogs and teleosts, is the result of convergent evolution. We discuss the evolutionary implications of our findings...
- Evolution of the germ line-soma relationship in vertebrate embryosAndrew D Johnson
School of Biology, Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
Reproduction 141:291-300. 2011..We also present the correlation of preformation with enhanced species radiations, and we discuss the mutually exclusive trajectories influenced by germ plasm or pluripotency, which shaped chordate evolution...
- Stochastic specification of primordial germ cells from mesoderm precursors in axolotl embryosJodie Chatfield
School of Life Sciences, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
Development 141:2429-40. 2014..Before this, germline potential was maintained by MAP kinase signalling. We propose that this stochastic mechanism of PGC specification, from mesodermal precursors, is conserved in vertebrates...
- 5-hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate developmentRimple D Almeida
Wolfson Centre for Stem Cells, Tissue Engineering and Modelling STEM, School of Clinical Sciences, University of Nottingham, Nottingham, UK
Epigenetics 7:383-9. 2012..Our findings show that 5-hmC enrichment of non-committed cells is not a universal feature of vertebrate development and give insights both into evolution of embryonic pluripotency and the potential role of 5-hmC in its regulation...
- Epigenetic reprogramming of breast cancer cells with oocyte extractsCinzia Allegrucci
Centre for Genetics and Genomics, School of Biology, University of Nottingham, Queens Medical Centre, Nottingham, UK
Mol Cancer 10:7. 2011..In this study we apply the reprogramming capacity of oocytes to cancer cells in order to study breast oncogenesis...
- Epigenetic marks in somatic chromatin are remodelled to resemble pluripotent nuclei by amphibian oocyte extractsYuhong Bian
Division of Animal Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, UK
Epigenetics 4:194-202. 2009..The results demonstrate that axolotl oocyte extracts are a useful tool for studying epigenetic remodelling of somatic cells to a stem cell configuration, and for elucidating oocyte specific mechanisms of nuclear reprogramming...
- Semi-quantitative immunohistochemical detection of 5-hydroxymethyl-cytosine reveals conservation of its tissue distribution between amphibians and mammalsRimple D Almeida
Wolfson Centre for Stem Cells, Tissue Engineering and Modelling STEM, School of Clinical Sciences, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK
Epigenetics 7:137-40. 2012....
- Acquisition of germ plasm accelerates vertebrate evolutionTeri Evans
School of Life Sciences, University of Nottingham, Nottingham, NG7 2UH, UK
Science 344:200-3. 2014..Our results support the hypothesis that germ plasm liberates constraints on somatic development and that enhanced evolvability drives the evolution of germ plasm. ..
- A conserved mechanism for vertebrate mesoderm specification in urodele amphibians and mammalsGemma Swiers
Institute of Genetics, Queens Medical Centre, University of Nottingham, NG7 2UH, UK
Dev Biol 343:138-52. 2010....
- 5-Carboxylcytosine is localized to euchromatic regions in the nuclei of follicular cells in axolotl ovaryAnthony Alioui
School of Biology, University of Nottingham, Nottingham, UK
Nucleus 3:565-9. 2012..Our results suggest that 5-carboxylcytosine may play a distinct functional role in certain biological contexts...
- Reprogramming somatic cells into stem cellsRamiro Alberio
School of Biosciences University of Nottingham, Loughborough, NG2 5RD, UK
Reproduction 132:709-20. 2006..We also overview reprogramming events after somatic cell nuclear transfer (SCNT), as they may further instruct ex ovo strategies for cellular manipulation...
- Axolotl Nanog activity in mouse embryonic stem cells demonstrates that ground state pluripotency is conserved from urodele amphibians to mammalsJames E Dixon
Institute of Genetics, School of Biology, University of Nottingham, Queens Medical Centre, Nottingham NG2 2UH, UK
Development 137:2973-80. 2010..Our results show that protein interactions mediated by Nanog dimerization promote proliferation. More importantly, they demonstrate that the mechanisms governing pluripotency are conserved from urodele amphibians to mammals...
- Transient accumulation of 5-carboxylcytosine indicates involvement of active demethylation in lineage specification of neural stem cellsLee M Wheldon
Medical Molecular Sciences, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK
Cell Rep 7:1353-61. 2014..Our data suggest that active demethylation contributes to epigenetic reprogramming determining lineage specification in embryonic brain. ..
- Stepwise evolution of Elk-1 in early deuterostomesJanice Saxton
School of Life Sciences, University of Nottingham, UK
FEBS J 283:1025-38. 2016..The role of TCF was acquired later, but presumably prior to the whole genome duplications in the basal vertebrate lineage. Thus its evolutionary origins link Elk-1 to the appearance of mesoderm. ..
- Differential nuclear remodeling of mammalian somatic cells by Xenopus laevis oocyte and egg cytoplasmRamiro Alberio
Animal Development and Biotechnology Group, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leics, LE12 5RD, UK
Exp Cell Res 307:131-41. 2005....
- Inferring developmental constraint and constraint release: primordial germ cell determination mechanisms as examplesBrian I Crother
Southeastern Louisiana University, Hammond, LA 70402, USA
J Theor Biol 248:322-30. 2007..Our results corroborate previous conclusions that the induced mode is the constraint and the predetermined mode is the release and we speculate on the importance of these two processes in terms of robustness and evolvability...
- Gene expression in the axolotl germ line: Axdazl, Axvh, Axoct-4, and AxkitRosemary F Bachvarova
Department of Cell Biology and Development, Weill Medical College of Cornell University, New York, New York, USA
Dev Dyn 231:871-80. 2004..We conclude that PGCs are restricted to the germ line later in urodeles than in mice or lack migration and proliferation programs...
- An XML-based system for synthesis of data from disparate databasesTahsin Kurc
Biomedical Informatics Department, Ohio State University, 3184 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA
J Am Med Inform Assoc 13:289-301. 2006..The data management system also allows collaborators to share data in a uniform way and supports complex queries that target data sets...
- Large scale genotype-phenotype correlation analysis based on phylogenetic treesFarhat Habib
Department of Physics, The Ohio State University, Columbus, OH 43210, USA
Bioinformatics 23:785-8. 2007..We use these methods to find SNPs correlated with resistance to Bacillus anthracis in inbred mouse strains. Our findings are consistent with the current biological literature, and also suggest potential novel candidate genes...
- Polymorphisms affecting gene regulation and mRNA processing: broad implications for pharmacogeneticsAndrew D Johnson
Integrated Biomedical Sciences Graduate Program, Department of Pharmacology, College of Medicine and Public Health, The Ohio State University, 5072 Graves Hall, 333 W 10th Avenue, Columbus, OH 43210 1239, USA
Pharmacol Ther 106:19-38. 2005..Current methods and challenges associated with the identification and characterization of functional polymorphisms are also discussed...