Gisli Jenkins

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. doi request reprint Novel approaches to pulmonary fibrosis
    Gisli Jenkins
    Centre for Respiratory Research, University of Nottingham, Nottingham, UK
    Clin Med (Lond) 14:s45-9. 2014
  2. doi request reprint In search of the fibrotic epithelial cell: opportunities for a collaborative network
    Gisli Jenkins
    Respiratory Biomedical Research Unit, University of Nottingham, Nottingham, UK
    Thorax 67:179-82. 2012
  3. doi request reprint The role of proteases in transforming growth factor-beta activation
    Gisli Jenkins
    University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Nottingham NG5 1PB, UK
    Int J Biochem Cell Biol 40:1068-78. 2008
  4. pmc Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression
    Amanda L Tatler
    From the Division of Respiratory Medicine, University of Nottingham, Nottingham University Hospitals, City Campus, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 291:9540-53. 2016
  5. doi request reprint TGF-β activation and lung fibrosis
    Amanda L Tatler
    Nottingham Respiratory Biomedical Research Unit, Nottingham University Hospitals, University of Nottingham, Hucknall Road, Nottingham, UK
    Proc Am Thorac Soc 9:130-6. 2012
  6. pmc Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis
    Amanda L Tatler
    Division of Respiratory Medicine City, University of Nottingham, Nottingham, United Kingdom
    PLoS ONE 11:e0158047. 2016
  7. doi request reprint αvβ6 integrin may be a potential prognostic biomarker in interstitial lung disease
    Gauri Saini
    Division of Respiratory Medicine, University of Nottingham, Nottingham, UK
    Eur Respir J 46:486-94. 2015
  8. pmc Influenza promotes collagen deposition via αvβ6 integrin-mediated transforming growth factor β activation
    Lisa Jolly
    From the Nottingham Respiratory Research Unit, University of Nottingham, Nottingham University Hospitals, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 289:35246-63. 2014
  9. pmc Caffeine inhibits TGFβ activation in epithelial cells, interrupts fibroblast responses to TGFβ, and reduces established fibrosis in ex vivo precision-cut lung slices
    Amanda L Tatler
    Division of Respiratory Medicine, Nottingham City Hospital, University of Nottingham, Nottingham, UK
    Thorax 71:565-7. 2016
  10. pmc Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma
    Amanda L Tatler
    Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Nottingham NG5 1PB, United Kingdom
    J Immunol 187:6094-107. 2011

Collaborators

Detail Information

Publications18

  1. doi request reprint Novel approaches to pulmonary fibrosis
    Gisli Jenkins
    Centre for Respiratory Research, University of Nottingham, Nottingham, UK
    Clin Med (Lond) 14:s45-9. 2014
    ..In this review we will discuss the recent developments in this field and review how this knowledge has been translated into clinical trials and a paradigm shift in our approach to patients with IPF. ..
  2. doi request reprint In search of the fibrotic epithelial cell: opportunities for a collaborative network
    Gisli Jenkins
    Respiratory Biomedical Research Unit, University of Nottingham, Nottingham, UK
    Thorax 67:179-82. 2012
    ..The central themes discussed in the workshop have been compiled as the proceedings of the ECIPF...
  3. doi request reprint The role of proteases in transforming growth factor-beta activation
    Gisli Jenkins
    University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Nottingham NG5 1PB, UK
    Int J Biochem Cell Biol 40:1068-78. 2008
    ..This review describes the mechanism of protease driven TGF-beta activation, and discusses the physiological and pathological relevance of this process...
  4. pmc Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression
    Amanda L Tatler
    From the Division of Respiratory Medicine, University of Nottingham, Nottingham University Hospitals, City Campus, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 291:9540-53. 2016
    ..Moreover, Elk1 dysregulation is present in epithelium from patients with IPF. These data reveal a novel role for Elk1 regulating ITGB6 expression and highlight how dysregulation of Elk1 can contribute to human disease. ..
  5. doi request reprint TGF-β activation and lung fibrosis
    Amanda L Tatler
    Nottingham Respiratory Biomedical Research Unit, Nottingham University Hospitals, University of Nottingham, Hucknall Road, Nottingham, UK
    Proc Am Thorac Soc 9:130-6. 2012
    ..This article describes the mechanisms through which epithelial cells activate TGF-β by the αvβ6 integrin and mesenchymal cells activate TGF-β by the αvβ5 integrin, and highlights their roles in lung fibrosis...
  6. pmc Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis
    Amanda L Tatler
    Division of Respiratory Medicine City, University of Nottingham, Nottingham, United Kingdom
    PLoS ONE 11:e0158047. 2016
    ..Active TGFβ1 amplifies this pathway both in vitro and in vivo, which may promote fibrosis. ..
  7. doi request reprint αvβ6 integrin may be a potential prognostic biomarker in interstitial lung disease
    Gauri Saini
    Division of Respiratory Medicine, University of Nottingham, Nottingham, UK
    Eur Respir J 46:486-94. 2015
    ..There was no association with the other markers measured.Our data suggest high levels of αvβ6 integrin may identify a specific endotype of progressive fibrotic lung disease. ..
  8. pmc Influenza promotes collagen deposition via αvβ6 integrin-mediated transforming growth factor β activation
    Lisa Jolly
    From the Nottingham Respiratory Research Unit, University of Nottingham, Nottingham University Hospitals, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 289:35246-63. 2014
    ....
  9. pmc Caffeine inhibits TGFβ activation in epithelial cells, interrupts fibroblast responses to TGFβ, and reduces established fibrosis in ex vivo precision-cut lung slices
    Amanda L Tatler
    Division of Respiratory Medicine, Nottingham City Hospital, University of Nottingham, Nottingham, UK
    Thorax 71:565-7. 2016
    ..Together, these findings suggest that there is merit in further investigating the potential use of caffeine, or its analogues, as antifibrotic agents in the lung. ..
  10. pmc Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma
    Amanda L Tatler
    Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Nottingham NG5 1PB, United Kingdom
    J Immunol 187:6094-107. 2011
    ..These data highlight a mechanism of TGF-β activation in asthma and support the hypothesis that bronchoconstriction promotes airway remodeling via integrin mediated TGF-β activation...
  11. pmc Secretory leukocyte protease inhibitor gene deletion alters bleomycin-induced lung injury, but not development of pulmonary fibrosis
    Anthony N Habgood
    Nottingham Respiratory Research Unit, University of Nottingham, Nottingham, England
    Lab Invest 96:623-31. 2016
    ..However, these changes do not prevent the development of lung fibrosis. Overall, these data suggest that the absence of Slpi does not markedly modify the development of lung fibrosis following bleomycin-induced lung injury. ..
  12. pmc Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma
    David M L Lilburn
    Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom
    Magn Reson Med 76:1224-35. 2016
    ..In this work, a straightforward laboratory method is advanced to probe dynamic changes in gas inhalation patterns by using an ex vivo small animal ovalbumin (OVA) model of human asthma...
  13. pmc Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q)
    Ming Yan Xu
    Centre for Respiratory Research, University of Nottingham, Nottingham, NG5 1PB, UK
    Am J Pathol 174:1264-79. 2009
    ....
  14. pmc A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis
    William R Coward
    Division of Respiratory Medicine and Nottingham Respiratory Biomedical Research Unit, University of Nottingham, City Hospital, Nottingham, UK and
    FASEB J 28:3183-96. 2014
    ..Coward, W. R., Feghali-Bostwick, C. A., Jenkins, G., Knox, A. J., Pang, L. A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis. ..
  15. doi request reprint The pathogenesis of idiopathic pulmonary fibrosis
    William R Coward
    Nottingham Respiratory Biomedical Research Unit, Clinical Sciences Building, Nottingham City Campus, Nottingham, UK
    Ther Adv Respir Dis 4:367-88. 2010
    ..The resulting deposition of excess disrupted matrix by these myofibroblasts leads to the development of IPF...
  16. doi request reprint Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis
    Amanda L Tatler
    Centre for Respiratory Research, Clinical Sciences Building, City Hospital, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK
    Biochem Biophys Res Commun 370:239-42. 2008
    ..The results indicate that tryptase activates TGFbeta via a PAR2-independent proteolytic mechanism in human ASM cells and may help understanding the role of tryptase in asthma...
  17. doi request reprint Role of integrin-mediated TGFbeta activation in the pathogenesis of pulmonary fibrosis
    Amanda Goodwin
    Centre for Respiratory Research, Nottingham Biomedical Research Unit, Nottingham NG5 1PB, UK
    Biochem Soc Trans 37:849-54. 2009
    ..Therefore the molecular pathways that lead to integrin-mediated TGFbeta activation must be precisely defined to identify and fully exploit novel therapeutic targets that might ultimately improve the prognosis for patients with IPF...
  18. pmc Repression of IP-10 by interactions between histone deacetylation and hypermethylation in idiopathic pulmonary fibrosis
    William R Coward
    Division of Respiratory Medicine, Centre for Respiratory Research and Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, United Kingdom
    Mol Cell Biol 30:2874-86. 2010
    ....