Jeffrey K Huang

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. doi Regenerative medicine in multiple sclerosis: identifying pharmacological targets of adult neural stem cell differentiation
    Jeffrey K Huang
    MRC Centre for Stem Cell Biology and Regenerative Medicine and Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Neurochem Int 59:329-32. 2011
  2. pmc BDNF promotes target innervation of Xenopus mandibular trigeminal axons in vivo
    Jeffrey K Huang
    Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK
    BMC Dev Biol 7:59. 2007
  3. pmc Myelin regeneration in multiple sclerosis: targeting endogenous stem cells
    Jeffrey K Huang
    MRC Cambridge Centre for Stem Cell Biology and Regenerative Medicine, and Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, United Kingdom
    Neurotherapeutics 8:650-8. 2011
  4. pmc Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination
    Yasir A Syed
    Wellcome Trust and MRC Cambridge Stem Cell Institute, and Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, West Forvie Building, Forvie Site, Robinson Way, Cambridge, UK Department of Neurosurgery, Medical University Vienna, Vienna, Austria Max Planck Institute for Experimental Medicine, Department of Neurogenetics, Goettingen, Germany
    EMBO Mol Med 5:1918-34. 2013
  5. pmc Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation
    Alerie Guzman de la Fuente
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK
    J Cell Biol 211:975-85. 2015
  6. doi Current status of myelin replacement therapies in multiple sclerosis
    Jeffrey K Huang
    Wellcome Trust and MRC, Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK
    Prog Brain Res 201:219-31. 2012
  7. doi Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis
    Alberto Camacho
    Institute of Metabolic Science, University of Cambridge, Cambridge, UK
    Eur J Neurosci 38:2672-83. 2013
  8. pmc Accelerated axonal loss following acute CNS demyelination in mice lacking protein tyrosine phosphatase receptor type Z
    Jeffrey K Huang
    Wellcome Trust and MRC Cambridge Stem Cell Institute, University of Cambridge, United Kingdom
    Am J Pathol 181:1518-23. 2012
  9. pmc Retinoid X receptor gamma signaling accelerates CNS remyelination
    Jeffrey K Huang
    MRC Centre for Stem Cell Biology and Regenerative Medicine and Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Nat Neurosci 14:45-53. 2011

Collaborators

Detail Information

Publications9

  1. doi Regenerative medicine in multiple sclerosis: identifying pharmacological targets of adult neural stem cell differentiation
    Jeffrey K Huang
    MRC Centre for Stem Cell Biology and Regenerative Medicine and Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Neurochem Int 59:329-32. 2011
    ..We discuss the role of LINGO-1, Notch, Wnt, and retinoid X receptor (RXR) signaling, and how they might be useful pharmacological targets to overcoming remyelination failure in MS...
  2. pmc BDNF promotes target innervation of Xenopus mandibular trigeminal axons in vivo
    Jeffrey K Huang
    Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK
    BMC Dev Biol 7:59. 2007
    ..Brain derived neurotrophic factor, BDNF is known to stimulate axon outgrowth and branching. The goal of this study is to determine whether BDNF functions as the proposed target recognition signal in the Xenopus cement gland...
  3. pmc Myelin regeneration in multiple sclerosis: targeting endogenous stem cells
    Jeffrey K Huang
    MRC Cambridge Centre for Stem Cell Biology and Regenerative Medicine, and Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, United Kingdom
    Neurotherapeutics 8:650-8. 2011
    ..We highlight recent studies on factors that influence endogenous remyelination and potential promising pharmacological targets that may be considered for enhancing central nervous system remyelination...
  4. pmc Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination
    Yasir A Syed
    Wellcome Trust and MRC Cambridge Stem Cell Institute, and Anne McLaren Laboratory for Regenerative Medicine, University of Cambridge, West Forvie Building, Forvie Site, Robinson Way, Cambridge, UK Department of Neurosurgery, Medical University Vienna, Vienna, Austria Max Planck Institute for Experimental Medicine, Department of Neurogenetics, Goettingen, Germany
    EMBO Mol Med 5:1918-34. 2013
    ..These data reveal a novel approach to therapeutic enhancement of remyelination amenable to pharmacological intervention and hence with significant potential for translation. ..
  5. pmc Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation
    Alerie Guzman de la Fuente
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0AH, England, UK
    J Cell Biol 211:975-85. 2015
    ..We also show expression of VDR in OLG lineage cells in multiple sclerosis. Our data reveal a role for vitamin D in the regenerative component of demyelinating disease and identify a new target for remyelination medicines. ..
  6. doi Current status of myelin replacement therapies in multiple sclerosis
    Jeffrey K Huang
    Wellcome Trust and MRC, Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK
    Prog Brain Res 201:219-31. 2012
    ..In this chapter, in addition to describing why remyelination therapies are important, we review both these approaches, outlining their current status and future developments...
  7. doi Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis
    Alberto Camacho
    Institute of Metabolic Science, University of Cambridge, Cambridge, UK
    Eur J Neurosci 38:2672-83. 2013
    ..Although PGC1a is involved in lipid biosynthesis, we concluded that altered lipid composition in the PGC1a mutant did not directly affect central nervous system myelin morphology. ..
  8. pmc Accelerated axonal loss following acute CNS demyelination in mice lacking protein tyrosine phosphatase receptor type Z
    Jeffrey K Huang
    Wellcome Trust and MRC Cambridge Stem Cell Institute, University of Cambridge, United Kingdom
    Am J Pathol 181:1518-23. 2012
    ....
  9. pmc Retinoid X receptor gamma signaling accelerates CNS remyelination
    Jeffrey K Huang
    MRC Centre for Stem Cell Biology and Regenerative Medicine and Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Nat Neurosci 14:45-53. 2011
    ..Our results indicate that RXR-╬│ is a positive regulator of endogenous oligodendrocyte precursor cell differentiation and remyelination and might be a pharmacological target for regenerative therapy in the CNS...