Lesley A Houghton

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint Effects of cilomilast, a selective phosphodiesterase 4 inhibitor, on esophageal motility and pH, and orocecal and colonic transit: two single-center, randomized, double-blind, placebo-controlled, two-part crossover studies in healthy volunteers
    Lesley A Houghton
    Neurogastroenterology Unit, Wythenshawe Hospital, Manchester, United Kingdom
    Clin Ther 28:569-81. 2006
  2. ncbi request reprint Relationship of abdominal bloating to distention in irritable bowel syndrome and effect of bowel habit
    Lesley A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK
    Gastroenterology 131:1003-10. 2006
  3. pmc Effect of a second-generation alpha2delta ligand (pregabalin) on visceral sensation in hypersensitive patients with irritable bowel syndrome
    L A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, University of Manchester, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK
    Gut 56:1218-25. 2007
  4. doi request reprint 5-hydroxytryptamine signalling in irritable bowel syndrome with diarrhoea: effects of gender and menstrual status
    L A Houghton
    Neurogastroenterology Unit, School of Translational Medicine GI Sciences, University of Manchester, Wythenshawe Hospital, Manchester, UK
    Aliment Pharmacol Ther 30:919-29. 2009
  5. ncbi request reprint Sigmoid-colonic motility in health and irritable bowel syndrome: a role for 5-hydroxytryptamine
    L A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, Wythenshawe Hospital, Manchester, UK
    Neurogastroenterol Motil 19:724-31. 2007
  6. ncbi request reprint Towards a better understanding of abdominal bloating and distension in functional gastrointestinal disorders
    L A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, Wythenshawe Hospital, Manchester, UK
    Neurogastroenterol Motil 17:500-11. 2005
  7. doi request reprint Bloating and distention in irritable bowel syndrome: the role of visceral sensation
    Anurag Agrawal
    Neurogastroenterology Unit, University of Manchester, Manchester, United Kingdom
    Gastroenterology 134:1882-9. 2008
  8. doi request reprint A novel approach to studying the relationship between subjective and objective measures of cough
    Angela Kelsall
    Respiratory Research Group, Nuerogastroenterology Unit, University of Manchester, 2nd Floor Education and Research Centre, University Hospital of South Manchester, Southmoor Rd, Manchester M23 9LT, England
    Chest 139:569-75. 2011
  9. doi request reprint Rome III functional constipation and irritable bowel syndrome with constipation are similar disorders within a spectrum of sensitization, regulated by serotonin
    Chander Shekhar
    Neurogastroenterology Unit, University of Manchester, Manchester, UK
    Gastroenterology 145:749-57; quiz e13-4. 2013
  10. ncbi request reprint Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome
    Wendy Atkinson
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, University Hospital of South Manchester, Manchester, United Kingdom
    Gastroenterology 130:34-43. 2006

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Effects of cilomilast, a selective phosphodiesterase 4 inhibitor, on esophageal motility and pH, and orocecal and colonic transit: two single-center, randomized, double-blind, placebo-controlled, two-part crossover studies in healthy volunteers
    Lesley A Houghton
    Neurogastroenterology Unit, Wythenshawe Hospital, Manchester, United Kingdom
    Clin Ther 28:569-81. 2006
    ....
  2. ncbi request reprint Relationship of abdominal bloating to distention in irritable bowel syndrome and effect of bowel habit
    Lesley A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK
    Gastroenterology 131:1003-10. 2006
    ..The aim of this study was to use the technique of abdominal inductance plethysmography to compare diurnal variation in girth in IBS patients and healthy volunteers, relating these changes to the sensation of bloating...
  3. pmc Effect of a second-generation alpha2delta ligand (pregabalin) on visceral sensation in hypersensitive patients with irritable bowel syndrome
    L A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, University of Manchester, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK
    Gut 56:1218-25. 2007
    ..Pre-clinical studies suggest that the alpha(2)delta ligand pregabalin reduces both visceral allodynia and hyperalgesia, but is inactive on basal sensitivity...
  4. doi request reprint 5-hydroxytryptamine signalling in irritable bowel syndrome with diarrhoea: effects of gender and menstrual status
    L A Houghton
    Neurogastroenterology Unit, School of Translational Medicine GI Sciences, University of Manchester, Wythenshawe Hospital, Manchester, UK
    Aliment Pharmacol Ther 30:919-29. 2009
    ..Symptomatology and physiology differ between men and women and across the menstrual cycle in irritable bowel syndrome (IBS). Ovarian hormones influence 5-hydroxytryptamine (5-HT), an amine known to play a role in gut motor-sensory function...
  5. ncbi request reprint Sigmoid-colonic motility in health and irritable bowel syndrome: a role for 5-hydroxytryptamine
    L A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, Wythenshawe Hospital, Manchester, UK
    Neurogastroenterol Motil 19:724-31. 2007
    ..402; P = 0.003) and fed (r = 0.439; P = 0.001) conditions. These data show a possible relationship between endogenous concentrations of 5-HT and sigmoid-colonic motility recorded in both IBS and healthy subjects...
  6. ncbi request reprint Towards a better understanding of abdominal bloating and distension in functional gastrointestinal disorders
    L A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, Wythenshawe Hospital, Manchester, UK
    Neurogastroenterol Motil 17:500-11. 2005
    ..Treatment options are currently rather limited but include dietary changes, pharmacological approaches, probiotics and hypnotherapy...
  7. doi request reprint Bloating and distention in irritable bowel syndrome: the role of visceral sensation
    Anurag Agrawal
    Neurogastroenterology Unit, University of Manchester, Manchester, United Kingdom
    Gastroenterology 134:1882-9. 2008
    ..A number of mechanisms have been postulated for bloating and distention, but the role of visceral sensation, which is often abnormal in IBS, has not been previously investigated, and this study aimed to address this question...
  8. doi request reprint A novel approach to studying the relationship between subjective and objective measures of cough
    Angela Kelsall
    Respiratory Research Group, Nuerogastroenterology Unit, University of Manchester, 2nd Floor Education and Research Centre, University Hospital of South Manchester, Southmoor Rd, Manchester M23 9LT, England
    Chest 139:569-75. 2011
    ..Because patients anecdotally report reductions in cough severity while undergoing esophageal testing, we aimed to address these issues by assessing objective and subjective measures of cough with and without an esophageal catheter...
  9. doi request reprint Rome III functional constipation and irritable bowel syndrome with constipation are similar disorders within a spectrum of sensitization, regulated by serotonin
    Chander Shekhar
    Neurogastroenterology Unit, University of Manchester, Manchester, UK
    Gastroenterology 145:749-57; quiz e13-4. 2013
    ..We investigated relationships between platelet-depleted plasma concentrations of serotonin, gastrointestinal symptoms, and motor-sensory function in patients with FC or IBS-C compared with healthy volunteers (controls)...
  10. ncbi request reprint Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome
    Wendy Atkinson
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, University Hospital of South Manchester, Manchester, United Kingdom
    Gastroenterology 130:34-43. 2006
    ..The ratio of plasma 5-HIAA:5-HT and platelet stores was also assessed...
  11. doi request reprint Bloating and distension in irritable bowel syndrome: the role of gastrointestinal transit
    Anurag Agrawal
    Neurogastroenterology Unit, Gastrointestinal Sciences, School of Translational Medicine, University of Manchester, Manchester, UK
    Am J Gastroenterol 104:1998-2004. 2009
    ..Because constipation is often associated with delayed gastrointestinal transit, this study aimed at establishing whether patients with delayed transit show more distension and bloating than do those with normal transit...
  12. doi request reprint GERD-related cough: pathophysiology and diagnostic approach
    Jaclyn A Smith
    Respiratory Research Group, University of Manchester, ERC Building, Second Floor, Wythenshawe Hospital, Manchester M23 9LT, UK
    Curr Gastroenterol Rep 13:247-56. 2011
    ..Particular mechanisms to be explored include laryngopharyngeal reflux, microaspiration, and neuronal cross-organ sensitization. Finally, diagnostic approaches are considered...
  13. doi request reprint Measurement of serotonin in platelet depleted plasma by liquid chromatography tandem mass spectrometry
    Phillip J Monaghan
    Department of Clinical Biochemistry, South Manchester University Hospital Trust, Manchester, M23 9LT, United Kingdom
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2163-7. 2009
    ..91 (HPLC)-0.83, r(2)=0.97, n=80. Bland Altman analysis showed general agreement, with a mean bias of 3.3 nmol/L. We have developed a simple and robust assay for PDP 5-HT that will increase throughput for clinical trials...
  14. ncbi request reprint The rationale, efficacy and safety evidence for tegaserod in the treatment of irritable bowel syndrome
    John McLaughlin
    Department of Gastroenterology, Hope Hospital, Salford, Manchester, M6 8HD, UK
    Expert Opin Drug Saf 5:313-27. 2006
    ..The authors review the evidence for 5-HT in the aetiology of IBS and its symptoms, and the data available concerning the partial 5-HT4 receptor agonist tegaserod, in terms of rationale, efficacy and safety...
  15. pmc Increased platelet depleted plasma 5-hydroxytryptamine concentration following meal ingestion in symptomatic female subjects with diarrhoea predominant irritable bowel syndrome
    L A Houghton
    Academic Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Gut 52:663-70. 2003
    ....
  16. ncbi request reprint Inter-digestive and post-prandial antro-pyloro-duodenal motor activity in humans: effect of 5-hydroxytryptamine 1 receptor agonism
    E L Calvert
    Academic Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Aliment Pharmacol Ther 19:805-15. 2004
    ..Little is known about the effect of 5-hydroxytryptamine 1 (5-HT(1)) receptor agonism on the co-ordinated motor activity of the gastric antrum, pylorus and duodenum under fasting and fed conditions...
  17. pmc The oesophagus and cough: laryngo-pharyngeal reflux, microaspiration and vagal reflexes
    Jaclyn A Smith
    Respiratory and Allergy Centre, The University of Manchester, University Hospital of South Manchester, Manchester, UK
    Cough 9:12. 2013
    ..How recent evidence might shed light on the failure of acid suppressing therapies and suggest new approaches to treating reflux related cough are also discussed...
  18. doi request reprint Editorial: breaking the sound barrier? Pitfalls and benefits of acoustic cough monitoring
    Lesley A Houghton
    1 Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Jacksonville, USA 2 Respiratory Research Group, Faculty of Medicine and Human Sciences, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK
    Am J Gastroenterol 107:1833-6. 2012
    ..This editorial examines both the findings of Kavitt et al. and discusses the pitfalls and benefits of validated accurate documentation of cough...
  19. doi request reprint Acoustic cough-reflux associations in chronic cough: potential triggers and mechanisms
    Jaclyn A Smith
    Respiratory Research Group, The University of Manchester, Manchester, UK
    Gastroenterology 139:754-62. 2010
    ....
  20. ncbi request reprint Effect of the NK(3) receptor antagonist, talnetant, on rectal sensory function and compliance in healthy humans
    L A Houghton
    Neurogastroenterology Unit, Wythenshawe Hospital, Academic Division of Medicine and Surgery, University of Manchester, Manchester, UK
    Neurogastroenterol Motil 19:732-43. 2007
    ..At the doses tested, talnetant has no effect on rectal compliance or distension-induced rectal sensation in healthy participants...
  21. pmc Ambulatory abdominal inductance plethysmography: towards objective assessment of abdominal distension in irritable bowel syndrome
    M J Lewis
    Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Gut 48:216-20. 2001
    ..Furthermore, it should aid research into the pathogenesis of this symptom for which no satisfactory explanation has yet emerged...
  22. ncbi request reprint Alosetron, a 5-HT3 receptor antagonist, delays colonic transit in patients with irritable bowel syndrome and healthy volunteers
    L A Houghton
    Department of Medicine, University Hospital of South Manchester, Manchester, UK
    Aliment Pharmacol Ther 14:775-82. 2000
    ..Alosetron is a potent and selective 5-HT3 receptor antagonist, which has been shown to be beneficial in the treatment of female patients with non-constipated irritable bowel syndrome...
  23. ncbi request reprint Diagnostic criteria for irritable bowel syndrome: utility and applicability in clinical practice
    R Lea
    Medical Academic Department, South Manchester University Hospitals, Manchester, UK
    Digestion 70:210-3. 2004
    ..It was the aim of this study to assess the applicability of the Manning, Rome I and Rome II criteria in the clinical setting and to ascertain how often hospital specialists and general practitioners (GPs) use them...
  24. ncbi request reprint Validation of the measurement of low concentrations of 5-hydroxytryptamine in plasma using high performance liquid chromatography
    Wendy Atkinson
    Department of Medicine, South Manchester University Hospitals NHS Trust, UK
    J Chromatogr B Analyt Technol Biomed Life Sci 832:173-6. 2006
    ..The limit of detection and quantification were 1 and 3 nmol/l, respectively, and the calibration curve linear between 1 and 1000 nmol/l. The within-day and between-day precision were 4.3 and <13.6%, respectively...
  25. ncbi request reprint Functional bowel disorders
    George F Longstreth
    Kaiser Permanente Medical Care Program, San Diego, California 92120, USA
    Gastroenterology 130:1480-91. 2006
    ..Treatment of FBDs is based on an individualized evaluation, explanation, and reassurance. Alterations in diet, drug treatment aimed at predominant symptoms, and psychotherapy may be beneficial...
  26. doi request reprint First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome
    Johannes Kapeller
    Department of Human Molecular Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Hum Mol Genet 17:2967-77. 2008
    ..This is the first example indicating micro RNA-related expression regulation of a serotonin receptor gene with a cis-regulatory variant affecting this regulation and appearing to be associated with female IBS-D...
  27. ncbi request reprint Hypnotherapy in irritable bowel syndrome: a large-scale audit of a clinical service with examination of factors influencing responsiveness
    Wendy M Gonsalkorale
    Department of Medicine, University Hospital of South Manchester, United Kingdom
    Am J Gastroenterol 97:954-61. 2002
    ..This study presents an audit on the first 250 unselected patients treated, and these large numbers have also allowed analysis of data in terms of a variety of other factors, such as gender and bowel habit type, that might affect outcome...