Mark A Holmes

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Evaluation of the evidence
    Mark A Holmes
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Vet Clin North Am Small Anim Pract 37:447-62. 2007
  2. doi request reprint Methicillin resistant S. aureus in human and bovine mastitis
    Mark A Holmes
    Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK
    J Mammary Gland Biol Neoplasia 16:373-82. 2011
  3. pmc Incidence and characterisation of methicillin-resistant Staphylococcus aureus (MRSA) from nasal colonisation in participants attending a cattle veterinary conference in the UK
    Gavin K Paterson
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, United Kingdom
    PLoS ONE 8:e68463. 2013
  4. pmc Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec gene
    Xiaoliang Ba
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    J Antimicrob Chemother 69:594-7. 2014
  5. pmc Old Drugs To Treat Resistant Bugs: Methicillin-Resistant Staphylococcus aureus Isolates with mecC Are Susceptible to a Combination of Penicillin and Clavulanic Acid
    Xiaoliang Ba
    Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    Antimicrob Agents Chemother 59:7396-404. 2015
  6. pmc Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mecA homologue mecC
    Ewan M Harrison
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    EMBO Mol Med 5:509-15. 2013
  7. pmc A novel hybrid SCCmec-mecC region in Staphylococcus sciuri
    Ewan M Harrison
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    J Antimicrob Chemother 69:911-8. 2014
  8. pmc Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission
    Gavin K Paterson
    Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK
    Nat Commun 6:6560. 2015
  9. pmc Genomic Analysis of Companion Rabbit Staphylococcus aureus
    Mark A Holmes
    Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 11:e0151458. 2016
  10. pmc A Staphylococcus xylosus isolate with a new mecC allotype
    Ewan M Harrison
    University of Cambridge, Department of Veterinary Medicine, Cambridge, United Kingdom
    Antimicrob Agents Chemother 57:1524-8. 2013

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Evaluation of the evidence
    Mark A Holmes
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Vet Clin North Am Small Anim Pract 37:447-62. 2007
    ..The types of errors that may lead to misinterpretation of evidence are discussed. This article includes descriptions of the main types of research performed in veterinary clinical research and notes on their advantages and disadvantages...
  2. doi request reprint Methicillin resistant S. aureus in human and bovine mastitis
    Mark A Holmes
    Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK
    J Mammary Gland Biol Neoplasia 16:373-82. 2011
    ..aureus and coagulase negative Staphylococcus species, which are the most common species associated with bovine intramammary infections and commonly carry antimicrobial resistance determinants...
  3. pmc Incidence and characterisation of methicillin-resistant Staphylococcus aureus (MRSA) from nasal colonisation in participants attending a cattle veterinary conference in the UK
    Gavin K Paterson
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, United Kingdom
    PLoS ONE 8:e68463. 2013
    ..Contact with livestock, including dairy cattle, may still be a risk factor for human colonisation with mecC-MRSA but occurs at a rate below the lower limit of detection available in this study. ..
  4. pmc Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec gene
    Xiaoliang Ba
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    J Antimicrob Chemother 69:594-7. 2014
    ..We identified four MRSA isolates that lacked mecA or mecC genes, but were still phenotypically resistant to pencillinase-resistant β-lactam antibiotics...
  5. pmc Old Drugs To Treat Resistant Bugs: Methicillin-Resistant Staphylococcus aureus Isolates with mecC Are Susceptible to a Combination of Penicillin and Clavulanic Acid
    Xiaoliang Ba
    Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    Antimicrob Agents Chemother 59:7396-404. 2015
    ..Thus, we demonstrate how the distinct biological differences between mecA- and mecC-encoded PBP2a and PBP2c have the potential to be exploited as a novel approach for the treatment of mecC-MRSA infections. ..
  6. pmc Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mecA homologue mecC
    Ewan M Harrison
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    EMBO Mol Med 5:509-15. 2013
    ..This study demonstrates that mecC-MRSA ST130 isolates are capable of transmission between animals and humans, and underscores the potential of WGS in epidemiological investigations and source tracking of bacterial infections...
  7. pmc A novel hybrid SCCmec-mecC region in Staphylococcus sciuri
    Ewan M Harrison
    Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    J Antimicrob Chemother 69:911-8. 2014
    ..In this study, we identified two Staphylococcus sciuri subsp. carnaticus isolates from bovine infections that harbour three different mecA homologues: mecA, mecA1 and mecC...
  8. pmc Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission
    Gavin K Paterson
    Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK
    Nat Commun 6:6560. 2015
    ..This study highlights the need for sequencing of multiple isolates from individuals to gain an accurate picture of transmission networks and to further understand the basis of pathogenesis. ..
  9. pmc Genomic Analysis of Companion Rabbit Staphylococcus aureus
    Mark A Holmes
    Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 11:e0151458. 2016
    ..The availability of S. aureus genome sequences from companion rabbits provides an important aid to understanding the pathogenesis of disease in this host and in the clinical management and surveillance of these infections. ..
  10. pmc A Staphylococcus xylosus isolate with a new mecC allotype
    Ewan M Harrison
    University of Cambridge, Department of Veterinary Medicine, Cambridge, United Kingdom
    Antimicrob Agents Chemother 57:1524-8. 2013
    ....
  11. pmc Use of Vitek 2 antimicrobial susceptibility profile to identify mecC in methicillin-resistant Staphylococcus aureus
    Edward J P Cartwright
    Department of Medicine, University of Cambridge, Cambridge, United Kingdom
    J Clin Microbiol 51:2732-4. 2013
    ..The presence of the mecC gene, determined by bacterial whole-genome sequencing, was used as the gold standard. This profile could provide a zero-cost screening method for identification of mecC-positive MRSA strains. ..
  12. pmc A shared population of epidemic methicillin-resistant Staphylococcus aureus 15 circulates in humans and companion animals
    Ewan M Harrison
    Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    MBio 5:e00985-13. 2014
    ....
  13. pmc Transmission of methicillin-resistant Staphylococcus aureus in long-term care facilities and their related healthcare networks
    Ewan M Harrison
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Box 157, Hills Road, Cambridge, CB2 0QQ, UK
    Genome Med 8:102. 2016
    ..Whole-genome sequencing (WGS) has been used successfully to understand MRSA epidemiology and transmission in hospitals and has the potential to identify transmission between these and LTCF...
  14. pmc Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study
    Laura García-Álvarez
    Department of Veterinary Medicine, University of Cambridge, UK
    Lancet Infect Dis 11:595-603. 2011
    ....
  15. pmc The emergence of mecC methicillin-resistant Staphylococcus aureus
    Gavin K Paterson
    Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK Electronic address
    Trends Microbiol 22:42-7. 2014
    ..The emergence of mecC MRSA is a topic of interest to human and veterinary microbiology, and we consider it timely to review here its discovery and subsequent investigation. ..
  16. ncbi request reprint Evidence for best veterinary practice: clinical veterinary research
    Mark A Holmes
    J Vet Intern Med 21:671-2. 2007