B H Hirst

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. pmc Secretin and the exposition of hormonal control
    Barry H Hirst
    Institute for Cell and Molecular Biosciences, University of Newcastle, Medical School, Nwecastle upon Tyne, UK
    J Physiol 560:339. 2004
  2. pmc K(+) recycling and gastric acid secretion
    Barry H Hirst
    Department of Physiological Sciences, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne NE2 4HH, UK
    J Physiol 540:1. 2002
  3. pmc Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein
    J Hunter
    Gastrointestinal Drug Delivery Research Centre, University of Newcastle upon Tyne, Medical School, UK
    Br J Cancer 64:437-44. 1991
  4. ncbi request reprint Exploiting M cells for drug and vaccine delivery
    M A Clark
    Department of Physiological Sciences, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    Adv Drug Deliv Rev 50:81-106. 2001
  5. ncbi request reprint Differential cytokeratin and glycoconjugate expression by the surface and crypt epithelia of human palatine tonsils
    M A Clark
    Department of Physiological Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Histochem Cell Biol 114:311-21. 2000
  6. pmc Substrate upregulation of the human small intestinal peptide transporter, hPepT1
    D Walker
    Department of Physiological Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    J Physiol 507:697-706. 1998
  7. ncbi request reprint Who's talking to whom? Epithelial-bacterial pathogen interactions
    Phillip D Aldridge
    Institute for Cell and Molecular Biosciences, University of Newcastle upon Tyne, The Medical School, Newcastle upon Tyne, NE2 4HH, UK
    Mol Microbiol 55:655-63. 2005
  8. ncbi request reprint Expression of the peptide transporter hPepT1 in human colon: a potential route for colonic protein nitrogen and drug absorption
    Dianne Ford
    School of Cell and Molecular Biosciences, The Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Histochem Cell Biol 119:37-43. 2003
  9. ncbi request reprint Glycine supply to human enterocytes mediated by high-affinity basolateral GLYT1
    G R Christie
    Department of Physiological Sciences, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne, England
    Gastroenterology 120:439-48. 2001
  10. pmc Angiotensin-converting enzyme (ACE) inhibitor transport in human intestinal epithelial (Caco-2) cells
    D T Thwaites
    Department of Physiological Sciences, University of Newcastle upon Tyne, Medical School
    Br J Pharmacol 114:981-6. 1995

Collaborators

Detail Information

Publications18

  1. pmc Secretin and the exposition of hormonal control
    Barry H Hirst
    Institute for Cell and Molecular Biosciences, University of Newcastle, Medical School, Nwecastle upon Tyne, UK
    J Physiol 560:339. 2004
  2. pmc K(+) recycling and gastric acid secretion
    Barry H Hirst
    Department of Physiological Sciences, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne NE2 4HH, UK
    J Physiol 540:1. 2002
  3. pmc Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein
    J Hunter
    Gastrointestinal Drug Delivery Research Centre, University of Newcastle upon Tyne, Medical School, UK
    Br J Cancer 64:437-44. 1991
    ....
  4. ncbi request reprint Exploiting M cells for drug and vaccine delivery
    M A Clark
    Department of Physiological Sciences, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    Adv Drug Deliv Rev 50:81-106. 2001
    ..Further definition of M cell development and function should permit exploitation of their high transcytotic capacity for safe and reliable mucosal delivery...
  5. ncbi request reprint Differential cytokeratin and glycoconjugate expression by the surface and crypt epithelia of human palatine tonsils
    M A Clark
    Department of Physiological Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Histochem Cell Biol 114:311-21. 2000
    ..These findings establish a basis for future studies to investigate histochemical changes in tonsil epithelia that are associated with or predispose to local and/or systemic disease...
  6. pmc Substrate upregulation of the human small intestinal peptide transporter, hPepT1
    D Walker
    Department of Physiological Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    J Physiol 507:697-706. 1998
    ..The signalling pathway between increased dietary peptide and hPepT1 upregulation, therefore, involves direct action on the enterocyte, independent of hormonal and/or neural control...
  7. ncbi request reprint Who's talking to whom? Epithelial-bacterial pathogen interactions
    Phillip D Aldridge
    Institute for Cell and Molecular Biosciences, University of Newcastle upon Tyne, The Medical School, Newcastle upon Tyne, NE2 4HH, UK
    Mol Microbiol 55:655-63. 2005
    ..These studies highlight the need for further multidisciplinary studies into how the host differentiates between pathogenic and commensal bacteria...
  8. ncbi request reprint Expression of the peptide transporter hPepT1 in human colon: a potential route for colonic protein nitrogen and drug absorption
    Dianne Ford
    School of Cell and Molecular Biosciences, The Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Histochem Cell Biol 119:37-43. 2003
    ..We conclude that distal regions of the bowel express hPepT1, which may provide a mechanism for colonic protein-nitrogen absorption and for absorption of therapeutically important peptidomimetic drugs...
  9. ncbi request reprint Glycine supply to human enterocytes mediated by high-affinity basolateral GLYT1
    G R Christie
    Department of Physiological Sciences, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne, England
    Gastroenterology 120:439-48. 2001
    ..The primary aim of this study was to characterize the mechanism of postabsorptive (basolateral) glycine acquisition by the enterocyte...
  10. pmc Angiotensin-converting enzyme (ACE) inhibitor transport in human intestinal epithelial (Caco-2) cells
    D T Thwaites
    Department of Physiological Sciences, University of Newcastle upon Tyne, Medical School
    Br J Pharmacol 114:981-6. 1995
    ..These observations are consistent with the greater oral availability and time-dependent absorption profile of enalapril maleate and captopril, compared to lisinopril...
  11. ncbi request reprint Targeting polymerised liposome vaccine carriers to intestinal M cells
    M A Clark
    Department of Physiological Sciences, Medical School, University of Newcastle, NE2 4HH, Newcastle upon Tyne, UK
    Vaccine 20:208-17. 2001
    ..Lectin-mediated M cell targeting may thus permit the efficacy of mucosal vaccines to be enhanced if cellular relationship between particle binding and immune outcome can be established...
  12. ncbi request reprint Increased expression of specific intestinal amino acid and peptide transporter mRNA in rats fed by TPN is reversed by GLP-2
    Alison Howard
    Institute for Cell and Molecular Biosciences, University of Newcastle Medical School, Newcastle upon Tyne, UK
    J Nutr 134:2957-64. 2004
    ..The importance of maintaining amino acid supply for intestinal mucosal cells is illustrated...
  13. ncbi request reprint Active intestinal secretion of the fluoroquinolone antibacterials ciprofloxacin, norfloxacin and pefloxacin; a common secretory pathway?
    N M Griffiths
    Department of Physiological Sciences, Medical School, University of Newcastle upon Tyne, United Kingdom
    J Pharmacol Exp Ther 269:496-502. 1994
    ..Pefloxacin may interact with a brush-border carrier for which norfloxacin and ciprofloxacin are poor substrates, enhancing the absorptive flux of this fluoroquinolone...
  14. ncbi request reprint The novel avian protein, AWAK, contains multiple domains with homology to protease inhibitory modules
    Christopher J Nile
    Institute for Cell and Molecular Biosciences, Kings Walk, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 7RU, UK
    Mol Immunol 43:388-94. 2006
    ..The presence of WAP and Kunitz modules suggests that AWAK has proteinase inhibitor activity. RT-PCR analyses demonstrated expression of the AWAK gene in the chicken intestine...
  15. ncbi request reprint Co-integration and expression of bacterial and genomic transgenes in the pancreatic and intestinal tissues of transgenic mice
    S Ali
    Department of Biological and Nutritional Sciences, University of Newcastle upon Tyne, UK
    Gene 202:203-8. 1997
    ..Thus permissive integration or rescue may be general, but the overall level of rescue is often insubstantial compared to the endogenous expression of the transgene genomic DNA...
  16. pmc Autocrine stimulation of growth of AR4-2J rat pancreatic tumour cells by gastrin
    M Blackmore
    Gastrointestinal Drug Delivery Research Centre, University of Newcastle upon Tyne, Medical School, UK
    Br J Cancer 66:32-8. 1992
    ..This study highlights that gastrin receptor antagonists warrant further investigation as agents to control growth of tumours, such as those from the gastrointestinal tract, which express gastrin receptors...
  17. ncbi request reprint P-glycoprotein potentiates CYP3A4-mediated drug disappearance during Caco-2 intestinal secretory detoxification
    Lauretta M S Chan
    Institute for Cell and Molecular Biosciences, University of Newcastle Medical School, Newcastle upon Tyne NE2 4HH, UK
    J Drug Target 12:405-13. 2004
    ..Thus, evidence is provided for Pgp/CYP3A4 co-substrates, Pgp potentiates CYP3A4-mediated drug disappearance during intestinal secretory detoxification...
  18. ncbi request reprint The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability
    Lauretta M S Chan
    Laboratory of Pharmacology and Chemistry, Natinal Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Eur J Pharm Sci 21:25-51. 2004
    ..This review addresses the progress to date on what is known about the role and regulation of drug efflux mechanisms in the intestine and liver...