Affiliation: University Hospital Aintree
- Conus peptides and neuroprotectionChristine E Heading
Department of Biological Sciences, The Open University, Milton Keynes, UK
Curr Opin Investig Drugs 3:915-20. 2002..The poor pharmacokinetic profile of the peptides remains a challenge...
- Ziconotide (Elan Pharmaceuticals)C E Heading
IDrugs 4:339-50. 2001..This included patients who had failed morphine therapy, or who had become intolerant of therapy due to side-effects. The drug was safe and well tolerated over periods as long as 3 years ...
- TA-CD. XenovaChristine E Heading
Department of Biological Sciences, The Open University, Walton Hall, Milton Keynes, MK7 6AA, UK
IDrugs 5:1070-4. 2002..It was renamed TA-CD when ownership was transferred to Cantab , . By April 2002, a second phase IIa dose escalation trial was underway , which was ongoing in September 2002 ...
- Common ground in therapy of substance abuseC E Heading
Faculty of Science, The Open University, Parsifal College, 527 Finchley Road, London, NW3 7BG
IDrugs 4:1266-74. 2001..A simple working framework for classifying approaches to drug development is suggested, and four distinct pharmacological approaches applicable both to established and potential products are identified...
- Siramesine H LundbeckC Heading
Curr Opin Investig Drugs 2:266-70. 2001..Phase III trials are expected to take place in 2002 . A series of compounds have been synthesized by Lundbeck, the most potent of which may serve as a backup compound ...
- Drug evaluation: CYT-002-NicQb, a therapeutic vaccine for the treatment of nicotine addictionChristine E Heading
The Open University in the North, Faculty of Science, Eldon House, Regent Centre, Gosforth, Newcastle upon Tyne NE3 3PW, UK
Curr Opin Investig Drugs 8:71-7. 2007..A phase II trial was initiated in Switzerland in January 2005 and in February 2006, Cytos Biotechnology announced that it planned to begin a phase IIb/III trial in 2007...
- Vivitrex (Alkermes/Cephalon)Christine E Heading
Faculty of Science, The Open University in the North, Eldon House, Regent Centre, Gosforth, Newcastle upon Tyne NE3 3PW, UK
Curr Opin Investig Drugs 7:81-8. 2006..Alkermes and Cephalon are currently awaiting Food and Drug Administration review of the Vivitrex new drug application, which was granted Priority Review in May 2005...
- Conus toxins: targets and propertiesChristine E Heading
The Open University, Department of Biological Sciences, Walton Hall, Milton Keynes, MK7 6AA UK
IDrugs 7:1011-6. 2004..In turn, this presents problems of bioavailability, while the potency is a potential source of toxicity...
- NicVAX (Nabi Biopharmaceuticals)Christine E Heading
The Open University, Department of Biological Sciences, Walton Hall, Milton Keynes MK7 6AA, UK
IDrugs 6:1178-81. 2003..Nabi Biopharmaceuticals is developing NicVAX, a proprietary vaccine designed as a potential therapeutic to prevent and treat nicotine addiction...
- Recent advances against substance abuseChristine E Heading
The Open University, Department of Biological Sciences, Walton Hall, Milton Keynes, MK7 6AA, UK
IDrugs 6:681-7. 2003..For cocaine abuse, the main focus is on products targeting the dopamine reuptake system...
- Gender issues and the pharmacotherapy of substance abuseChristine E Heading
Faculty of Science, The Open University in the North, Eldon House Regent Centre, Gosforth, Newcastle upon Tyne, NE3 3PW, UK
IDrugs 11:428-32. 2008..Some gender differences will have more clinical significance than others, but any difference related to gender has the potential to complicate clinical trials and other studies...