David C Harrowven

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi request reprint Total synthesis of cavicularin and riccardin C: addressing the synthesis of an arene that adopts a boat configuration
    David C Harrowven
    School of Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, UK
    Angew Chem Int Ed Engl 44:3899-901. 2005
  2. ncbi request reprint Medium ring synthesis by radical ipso-substitution
    David C Harrowven
    Department of Chemistry, The University of Southampton, Southampton, UK SO17 1BJ
    Chem Commun (Camb) . 2003
  3. ncbi request reprint Triggering apoptosis in cancer cells with an analogue of cribrostatin 6 that elevates intracellular ROS
    D J Asby
    Chemistry, University of Southampton, Southampton, SO17 1BJ, UK
    Org Biomol Chem 14:9322-9330. 2016
  4. ncbi request reprint KF-Silica as a stationary phase for the chromatographic removal of tin residues from organic compounds
    David C Harrowven
    Department of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK
    Chem Commun (Camb) . 2004
  5. ncbi request reprint (Bu3Sn)2-TBAF: a new combination reagent for the reduction and deuteration of aryl bromides and iodides
    David C Harrowven
    Department of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK
    Chem Commun (Camb) . 2004
  6. ncbi request reprint Intramolecular radical additions to pyridines
    David C Harrowven
    Department of Chemistry, University of Southampton, Southampton, UK
    Org Biomol Chem 1:4047-57. 2003
  7. doi request reprint The development of a short route to the API ropinirole hydrochloride
    Zeshan Yousuf
    Chemistry, University of Southampton, Highfield, Southampton, Hampshire SO17 1BJ, UK
    Org Biomol Chem 13:10532-9. 2015
  8. ncbi request reprint An Efficient Flow-Photochemical Synthesis of 5H-Furanones Leads to an Understanding of Torquoselectivity in Cyclobutenone Rearrangements
    David C Harrowven
    Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ UK
    Angew Chem Int Ed Engl 51:4405-8. 2012
  9. doi request reprint Potassium carbonate-silica: a highly effective stationary phase for the chromatographic removal of organotin impurities
    David C Harrowven
    School of Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, UK
    Chem Commun (Camb) 46:6335-7. 2010
  10. doi request reprint CH activation and CH2 double activation of indolines by radical translocation: understanding the chemistry of the indolinyl radical
    David C Harrowven
    School of Chemistry, University of Southampton, Highfield, Southampton, Hampshire, UK
    Org Biomol Chem 9:4882-5. 2011

Collaborators

  • Bruno Linclau
  • DENNIS CURRAN
  • Théo P Gonçalves
  • Mubina Mohamed
  • D J Asby
  • Zeshan Yousuf
  • Richard J Whitby
  • Emma Packard
  • Helen F Sneddon
  • Sarah L Kostiuk
  • A S Bienemann
  • D C Wilson
  • M E Light
  • F Cuda
  • A Tavassoli
  • C L L Chai
  • A Chen
  • M G Radigois
  • Andrew N Dwyer
  • Andrew K Richards
  • David D Pascoe
  • Jacques Maddaluno
  • Leo F Dudin
  • Peter D Howes
  • Timothy Woodcock

Detail Information

Publications16

  1. ncbi request reprint Total synthesis of cavicularin and riccardin C: addressing the synthesis of an arene that adopts a boat configuration
    David C Harrowven
    School of Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, UK
    Angew Chem Int Ed Engl 44:3899-901. 2005
  2. ncbi request reprint Medium ring synthesis by radical ipso-substitution
    David C Harrowven
    Department of Chemistry, The University of Southampton, Southampton, UK SO17 1BJ
    Chem Commun (Camb) . 2003
    ..A new approach to eight and nine membered ring synthesis is described in which a radical ipso-substitution reaction features as a key step...
  3. ncbi request reprint Triggering apoptosis in cancer cells with an analogue of cribrostatin 6 that elevates intracellular ROS
    D J Asby
    Chemistry, University of Southampton, Southampton, SO17 1BJ, UK
    Org Biomol Chem 14:9322-9330. 2016
    ..Our results demonstrate the potential for targeting tumors with molecules that enhance intracellular oxidative stress...
  4. ncbi request reprint KF-Silica as a stationary phase for the chromatographic removal of tin residues from organic compounds
    David C Harrowven
    Department of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK
    Chem Commun (Camb) . 2004
    ....
  5. ncbi request reprint (Bu3Sn)2-TBAF: a new combination reagent for the reduction and deuteration of aryl bromides and iodides
    David C Harrowven
    Department of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK
    Chem Commun (Camb) . 2004
    ..The combination of (Bu(3)Sn)(2) and TBAF has been shown to reduce aromatic bromides and iodides in excellent yields under mild conditions. When the residual water in TBAF is exchanged for D(2)O, the halogen is replaced by a deuterium atom...
  6. ncbi request reprint Intramolecular radical additions to pyridines
    David C Harrowven
    Department of Chemistry, University of Southampton, Southampton, UK
    Org Biomol Chem 1:4047-57. 2003
    ..All attempts to effect 5-exolendo-trig cyclisations failed. Tributyltin hydride, tris(trimethylsilyl)silane, tris(trimethylsilyl)germane and, in part, samarium(II) iodide can each be employed as mediators of the reaction...
  7. doi request reprint The development of a short route to the API ropinirole hydrochloride
    Zeshan Yousuf
    Chemistry, University of Southampton, Highfield, Southampton, Hampshire SO17 1BJ, UK
    Org Biomol Chem 13:10532-9. 2015
    ..Key features of the synthesis are a regioselective Birch reduction and an ozonolysis with concomitant ring closure to induce the required ring contraction. ..
  8. ncbi request reprint An Efficient Flow-Photochemical Synthesis of 5H-Furanones Leads to an Understanding of Torquoselectivity in Cyclobutenone Rearrangements
    David C Harrowven
    Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ UK
    Angew Chem Int Ed Engl 51:4405-8. 2012
    ..Selectivity in the photochemical rearrangement is due a dichotomous reactivity of the (E)- and (Z)-vinylketene intermediates...
  9. doi request reprint Potassium carbonate-silica: a highly effective stationary phase for the chromatographic removal of organotin impurities
    David C Harrowven
    School of Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, UK
    Chem Commun (Camb) 46:6335-7. 2010
    ..Organotin impurities in product mixtures can be reduced from stoichiometric levels to approximately 15 parts per million by column chromatography using 10% w/w anhydrous potassium carbonate-silica as a stationary phase...
  10. doi request reprint CH activation and CH2 double activation of indolines by radical translocation: understanding the chemistry of the indolinyl radical
    David C Harrowven
    School of Chemistry, University of Southampton, Highfield, Southampton, Hampshire, UK
    Org Biomol Chem 9:4882-5. 2011
    ..The fate of the C2 indolinyl radical is dictated by the substitution at C3. Fragmentation, cyclisation and tandem cyclisation reactions leading to indole, azaheterocycle and azapropellane formation, respectively, are reported...
  11. doi request reprint Macrocylic bisbibenzyl natural products and their chemical synthesis
    David C Harrowven
    Chemistry, University of Southampton, Southampton, SO17 1BJ, UK
    Nat Prod Rep 29:223-42. 2012
    ..Prod. Rep. 1995, 12, 69-75) and largely focuses on new additions to the family and the strategies used to effect their chemical synthesis...
  12. doi request reprint Unified syntheses of cavicularin and riccardin C: addressing the synthesis of an arene adopting a boat configuration
    Sarah L Kostiuk
    Chemistry, University of Southampton, Highfield, Southampton, Hampshire, SO17 1BJ, UK
    Chemistry 17:10906-15. 2011
    ....
  13. doi request reprint New insights into cyclobutenone rearrangements: a total synthesis of the natural ROS-generating anti-cancer agent cribrostatin 6
    Mubina Mohamed
    Chemistry, University of Southampton, Highfield, Southampton, Hampshire, SO17 1BJ, UK
    Chemistry 17:13698-705. 2011
    ..A short and efficient total synthesis of cribrostatin 6, an anti-neoplastic and anti-microbial agent, provides a topical demonstration of the value of this method...
  14. doi request reprint Exploring Diradical Chemistry: A Carbon-Centered Radical May Act as either an Anion or Electrophile through an Orbital Isomer
    Théo P Gonçalves
    Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ UK
    Angew Chem Int Ed Engl 54:4531-4. 2015
    ..For example, it can be used to shut down radical pathways and to give access to aryl carbonates and tetrasubstituted quinones. ..
  15. ncbi request reprint Total synthesis of (-)-colombiasin A and (-)-elisapterosin B
    David C Harrowven
    School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK
    Angew Chem Int Ed Engl 44:1221-2. 2005
  16. pmc Organoytterbium ate complexes extend the value of cyclobutenediones as isoprene equivalents
    Emma Packard
    Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ United Kingdom
    Angew Chem Int Ed Engl 52:13076-9. 2013
    ..Tf=trifluoromethanesulfonyl. ..