Affiliation: University of Oxford
- Pre-clinical development of a multi-CTL epitope-based DNA prime MVA boost vaccine for AIDST Hanke
Institute of Molecular Medicine, University of Oxford, The John Radcliffe Hospital, UK
Immunol Lett 66:177-81. 1999..Thus, a vaccination regimen for an effective elicitation of CTL has been developed which might facilitate evaluation of the role(s) that these lymphocytes play in the control of SIV and HIV infections...
- Immunogenicities of intravenous and intramuscular administrations of modified vaccinia virus Ankara-based multi-CTL epitope vaccine for human immunodeficiency virus type 1 in miceT Hanke
Molecular Immunology Group, Institute of Molecular Medicine, University of Oxford, The John Radcliffe, UK
J Gen Virol 79:83-90. 1998..Also, the correct processing and presentation of some HLA-restricted epitopes in human cells was confirmed...
- Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus AnkaraJ Schneider
Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, UK
Nat Med 4:397-402. 1998..DNA priming followed by MVA boosting may provide a general immunization regime for induction of high levels of CD8+ T cells...
- Effective induction of HIV-specific CTL by multi-epitope using gene gun in a combined vaccination regimeT Hanke
Molecular Immunology Group, Institute of Molecular Medicine, University of Oxford, The John Radcliffe Hospital, Headington, UK
Vaccine 17:589-96. 1999..Thus particular sequences of routes or vaccine vehicles rather than simple prime-boost delivery of a single vaccine is critical for an effective elicitation of CTL...
- Effective induction of simian immunodeficiency virus-specific cytotoxic T lymphocytes in macaques by using a multiepitope gene and DNA prime-modified vaccinia virus Ankara boost vaccination regimenT Hanke
Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom
J Virol 73:7524-32. 1999..The advantages of the DNA prime-MVA boost regimen as well as the correlations of tetramer staining of peripheral blood lymphocytes with CTL killing in vitro and postchallenge control of viremia are discussed...
- Vehicles for genetic vaccines against human immunodeficiency virus: induction of T cell-mediated immune responsesT Hanke
MRC Human Immunology Unit, Institute of Molecular Medicine, The John Radcliffe, Oxford, UK
Curr Mol Med 1:123-35. 2001..In any case, a successful vaccination strategy against HIV as well as other chronic viral infections has to elicit better immune responses than the natural infections do...
- Prospect of a prophylactic vaccine for HIVT Hanke
MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
Br Med Bull 58:205-18. 2001..With a series of new technologies and increased political and financial commitments, a growing momentum in the field of HIV-vaccine development promises exciting years ahead...
- Engineering RENTA, a DNA prime-MVA boost HIV vaccine tailored for Eastern and Central AfricaJ P Nkolola
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, The John Radcliffe, Oxford, UK
Gene Ther 11:1068-80. 2004..RENTA and MVA.RENTA vaccines in mice. Furthermore, we demonstrated in mice and rhesus monkeys broadening of HIVA-elicited T-cell responses by a parallel induction of HIVA- and RENTA-specific responses recognizing multiple HIV epitopes...
- Lack of toxicity and persistence in the mouse associated with administration of candidate DNA- and modified vaccinia virus Ankara (MVA)-based HIV vaccines for KenyaT Hanke
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, The John Radcliffe, Oxford OX3 9DS, UK
Vaccine 21:108-14. 2002..Thus, both the vaccines alone and in a combination were considered safe and suitable for the use in phase I trials in humans...
- Prospects for an effective T cell-based immunoprophylaxis against mother-to-child transmission of HIV-1T Hanke
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, The John Radcliffe, Oxford, United Kingdom
Folia Biol (Praha) 50:100-6. 2004..This review discusses prospects of the T-cell approach for development of a paediatric HIV-1 vaccine...
- Specific proliferative T cell responses and antibodies elicited by vaccination with simian immunodeficiency virus Nef do not confer protection against virus challengeA M Wade-Evans
Division of Retrovirology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, EN6 3QG, UK
AIDS Res Hum Retroviruses 17:1517-26. 2001..If Nef-based vaccines are to be beneficial in controlling infection with immunodeficiency viruses, then it will be necessary to develop more effective immunization protocols that elicit potent CD8(+) cell responses reproducibly...
- S-adenosylmethionine decarboxylase from Leishmania infantum promastigotes: molecular cloning and differential expressionS Taladriz
Centro de Investigaciones Biologicas, CSIC, Madrid, Spain
Parasitol Res 88:421-6. 2002..The gene expression shows variations between the distinct phases of the parasite, being higher in the most infective one. This fact may be related to the multiple defense mechanism of the protozoon against the macrophage action...
- Viral infections induce abundant numbers of senescent CD8 T cellsD Voehringer
Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany
J Immunol 167:4838-43. 2001..Thus, this study demonstrates that senescent CD8 T cells are induced in abundant numbers during viral infections in vivo...
- Cumulative inhibition of NK cells and T cells resulting from engagement of multiple inhibitory Ly49 receptorsT Hanke
Institute for Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany
J Immunol 166:3002-7. 2001..They have intriguing implications concerning NK cell tolerance and reactivity toward cells with extinguished expression of a limited number of class I molecules...
- Expression of natural killer receptor alleles at different Ly49 loci occurs independently and is regulated by major histocompatibility complex class I moleculesD M Tanamachi
Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California at Berkeley, Berkeley, California 94720, USA
J Exp Med 193:307-15. 2001..Thus, biallelic expression of Ly49 genes is regulated by interactions of NK cell progenitors with MHC class I molecules...
- EAE in beta-2 microglobulin-deficient mice: axonal damage is not dependent on MHC-I restricted immune responsesRalf A Linker
Department of Neurology, Clinical Research Group for Multiple Sclerosis, Julius Maximilians Universitat Wurzburg, Josef Schneider Str 11, D 97080 Wurzburg, Germany
Neurobiol Dis 19:218-28. 2005..Enhanced axonal damage speaks for pathways of tissue damage independent of CD8+ T-cells and neuronal MHC-I expression...