Ian P Hall

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. pmc The future of asthma
    I P Hall
    Department of Therapeutics, University Hospital, Nottingham
    BMJ 314:45-9. 1997
  2. ncbi request reprint Effects of growth factors and extracellular matrix on survival of human airway smooth muscle cells
    A M Freyer
    Division of Therapeutics and Institute of Cell Signalling, University Hospital, Nottingham, United Kingdom
    Am J Respir Cell Mol Biol 25:569-76. 2001
  3. ncbi request reprint Pharmacogenetics and asthma: false hope or new dawn?
    I P Hall
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, NG7 2UH, UK
    Eur Respir J 29:1239-45. 2007
  4. doi request reprint A biomechanical model of agonist-initiated contraction in the asthmatic airway
    B S Brook
    School of Mathematical Sciences, University Park, University of Nottingham, Nottingham, UK
    Respir Physiol Neurobiol 170:44-58. 2010
  5. ncbi request reprint Genetics of asthma
    I Hall
    Department of Therapeutics, University Hospital, Nottingham, United Kingdom
    IDrugs 2:754-5. 1999
  6. doi request reprint Efficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled corticosteroid treatment
    Ian P Hall
    Division of Respiratory Medicine, University of Nottingham, Nottingham, UK Electronic address
    Pulm Pharmacol Ther 32:37-44. 2015
  7. pmc Clonally expanded human airway smooth muscle cells exhibit morphological and functional heterogeneity
    Shailendra R Singh
    Division of Respiratory Medicine, University of Nottingham, Queen s Medical Centre, NG7 2UH Nottingham, United Kingdom
    Respir Res 15:57. 2014
  8. doi request reprint Stratified medicine: drugs meet genetics
    Ian P Hall
    Division of Therapeutics and Molecular Medicine, Queen s Medical Centre, Nottingham, UK
    Eur Respir Rev 22:53-7. 2013
  9. doi request reprint How will genetic approaches assist in the management of respiratory diseases?
    Ian P Hall
    Division of Therapeutics and Molecular Medicine, D Floor, South Block, QMC Campus, Nottingham University Hospitals, Nottingham NG7 2UH, UK
    Curr Opin Pharmacol 9:256-61. 2009
  10. ncbi request reprint Biosynthesized matrix provides a key role for survival signaling in bronchial epithelial cells
    Sam J Wadsworth
    Division of Therapeutics and Molecular Medicine, South Block, D Floor, University Hospital, Nottingham NG7 2UH, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 286:L596-603. 2004

Detail Information

Publications85

  1. pmc The future of asthma
    I P Hall
    Department of Therapeutics, University Hospital, Nottingham
    BMJ 314:45-9. 1997
    ..I have tried to explain the thinking behind some of the approaches under study. I discuss the potential contributions of genetic studies, immunological approaches, and new therapeutic approaches...
  2. ncbi request reprint Effects of growth factors and extracellular matrix on survival of human airway smooth muscle cells
    A M Freyer
    Division of Therapeutics and Institute of Cell Signalling, University Hospital, Nottingham, United Kingdom
    Am J Respir Cell Mol Biol 25:569-76. 2001
    ....
  3. ncbi request reprint Pharmacogenetics and asthma: false hope or new dawn?
    I P Hall
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, NG7 2UH, UK
    Eur Respir J 29:1239-45. 2007
    ..In addition, there is a shortage of well-designed, adequately powered clinical studies in this area. This series summarises the current state of knowledge and identifies areas for further research...
  4. doi request reprint A biomechanical model of agonist-initiated contraction in the asthmatic airway
    B S Brook
    School of Mathematical Sciences, University Park, University of Nottingham, Nottingham, UK
    Respir Physiol Neurobiol 170:44-58. 2010
    ..Such patterns of stress are likely to have important implications, from a mechano-transduction perspective, on contractility, short-term cytoskeletal adaptation and long-term airway remodelling in asthma...
  5. ncbi request reprint Genetics of asthma
    I Hall
    Department of Therapeutics, University Hospital, Nottingham, United Kingdom
    IDrugs 2:754-5. 1999
    ..The use of anti-IgE and anti-cytokine approaches to the treatment of asthma is also reviewed...
  6. doi request reprint Efficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled corticosteroid treatment
    Ian P Hall
    Division of Respiratory Medicine, University of Nottingham, Nottingham, UK Electronic address
    Pulm Pharmacol Ther 32:37-44. 2015
    ..37% (1.57%) for montelukast (p = 0.0050 and p = 0.0657, respectively). These findings suggest that BI 671800 is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on ICS...
  7. pmc Clonally expanded human airway smooth muscle cells exhibit morphological and functional heterogeneity
    Shailendra R Singh
    Division of Respiratory Medicine, University of Nottingham, Queen s Medical Centre, NG7 2UH Nottingham, United Kingdom
    Respir Res 15:57. 2014
    ....
  8. doi request reprint Stratified medicine: drugs meet genetics
    Ian P Hall
    Division of Therapeutics and Molecular Medicine, Queen s Medical Centre, Nottingham, UK
    Eur Respir Rev 22:53-7. 2013
    ..This knowledge can then potentially be used to stratify patient groups within (or even across) disease boundaries and then to target therapy more effectively...
  9. doi request reprint How will genetic approaches assist in the management of respiratory diseases?
    Ian P Hall
    Division of Therapeutics and Molecular Medicine, D Floor, South Block, QMC Campus, Nottingham University Hospitals, Nottingham NG7 2UH, UK
    Curr Opin Pharmacol 9:256-61. 2009
    ..The aim of this review is to assess the current state of our knowledge of these areas of research...
  10. ncbi request reprint Biosynthesized matrix provides a key role for survival signaling in bronchial epithelial cells
    Sam J Wadsworth
    Division of Therapeutics and Molecular Medicine, South Block, D Floor, University Hospital, Nottingham NG7 2UH, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 286:L596-603. 2004
    ..These data indicate that bronchial epithelial cell survival is dependent both on soluble growth factors and on a variety of ECM-derived signals...
  11. pmc Expression profiling: fishing and chips
    I P Hall
    Division of Therapeutics and Molecular Medicine, D Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Gut 53:917-8. 2004
    ..However, there are many pitfalls which need to be considered in the design of experiments of this kind and in considering interpretation of data from such studies. Some of these are discussed...
  12. ncbi request reprint Beta2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study
    Ian P Hall
    Division of Therapeutics and Molecular Medicine, University of Nottingham, UK
    Lancet 368:771-9. 2006
    ..We aimed to relate the long-term prevalence of asthma or wheeze to functional coding region polymorphisms in the ADRB2 gene...
  13. ncbi request reprint Pharmacogenetics of asthma
    Ian P Hall
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham NG7 2UH, UK
    Chest 130:1873-8. 2006
    ..A number of examples of possible pharmacogenetic approaches that may prove of value in the management of asthma are discussed...
  14. pmc Pharmacogenetics, pharmacogenomics and airway disease
    Ian P Hall
    Queens Medical Centre, Nottingham, UK
    Respir Res 3:10. 2002
    ..This review describes recent advances in pharmacogenetics and pharmacogenomics with regard to airway disease...
  15. ncbi request reprint The beta-agonist controversy revisited
    Ian P Hall
    Division of Therapeutics and Molecular Medicine, Queen s Medical Centre, University Hospital, NG7 2UH, Nottingham, UK
    Lancet 363:183-4. 2004
  16. pmc Interleukin-4 receptor alpha gene variants and allergic disease
    I P Hall
    Division of Therapeutics, University Hospital of Nottingham, Nottingham, UK
    Respir Res 1:6-8. 2000
    ....
  17. doi request reprint Conference scene: UK pharmacogenetics and stratified medicine network
    Ian Hall
    University of Nottingham Medical School, Nottingham, NG7 2UH, UK
    Pharmacogenomics 13:19-20. 2012
    ..Around 95 individuals from a wide range of backgrounds including research councils, academia and industry attended the meeting...
  18. pmc GSTCD and INTS12 regulation and expression in the human lung
    Ma en Obeidat
    Division of Respiratory Medicine, University of Nottingham, Queen s Medical Center, Nottingham, United Kingdom James Hogg Research Centre, Institute for Heart and Lung Health, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 8:e74630. 2013
    ..Future work is warranted to fully define the functions of INTS12 and GSTCD. ..
  19. ncbi request reprint Functional polymorphism and differential regulation of CYSLTR1 transcription in human airway smooth muscle and monocytes
    Nathalie P Duroudier
    Division of Therapeutics and Molecular Medicine, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Cell Biochem Biophys 47:119-30. 2007
    ....
  20. ncbi request reprint A major functional role for phosphodiesterase 4D5 in human airway smooth muscle cells
    Charlotte K Billington
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Queens Medical Centre, Nottingham, UK
    Am J Respir Cell Mol Biol 38:1-7. 2008
    ..These data suggest that PDE4D5, despite being a minor component of the tissue PDE pool, is the key physiological regulator of beta(2)AR-induced cAMP turnover within human airway smooth muscle...
  21. doi request reprint Association of the cysteinyl leukotriene receptor 1 gene with atopy in the British 1958 birth cohort
    Nathalie P Duroudier
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, United Kingdom
    J Allergy Clin Immunol 124:566-72, 572.e1-3. 2009
    ..However, data on the contribution of genetic variability of the cysteinyl leukotriene receptor 1 gene (CYSLTR1) in asthma and atopy remain conflicting...
  22. pmc ORAI and store-operated calcium influx in human airway smooth muscle cells
    Samantha E Peel
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Queens Medical Centre, Nottingham, UK
    Am J Respir Cell Mol Biol 38:744-9. 2008
    ..These data extend the major tissue types in which these proteins appear to be major determinants of SOC influx, and suggest that modulation of these pathways may prove useful in the treatment of bronchoconstriction...
  23. ncbi request reprint Temporal characteristics of cAMP response element-mediated gene transcription: requirement for sustained cAMP production
    Jillian G Baker
    Institute of Cell Signaling, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    Mol Pharmacol 65:986-98. 2004
    ..g., several clinically used "beta-blockers") may cause more substantial gene transcription than previously believed...
  24. ncbi request reprint Extracellular matrix modulates beta2-adrenergic receptor signaling in human airway smooth muscle cells
    Anette M Freyer
    Division of Therapeutics and Molecular Biology, University of Nottingham, D Floor, South Block, Queens Medical Centre, Nottingham NG7 2UH, UK
    Am J Respir Cell Mol Biol 31:440-5. 2004
    ..We conclude therefore that ECM modulates Galphai activity in human airway smooth muscle cells, and propose that these changes could contribute to the fixed airway obstruction seen in patients with chronic asthma...
  25. ncbi request reprint Agonist actions of "beta-blockers" provide evidence for two agonist activation sites or conformations of the human beta1-adrenoceptor
    Jillian G Baker
    Institute of Cell Signaling, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Mol Pharmacol 63:1312-21. 2003
    ..The different responses to beta-blockers seen in the clinic may therefore be caused in part by these beta-blocker agonist responses and the differential activation of the two sites or conformations...
  26. pmc Salmeterol and cytokines modulate inositol-phosphate signalling in human airway smooth muscle cells via regulation at the receptor locus
    Natalie Smith
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
    Respir Res 8:68. 2007
    ..The aim of the current study was to clarify the effect of proinflammatory cytokines and asthma medication on primary human airway smooth muscle (ASM) inositol phosphate (IPx) signalling and define the regulatory loci involved...
  27. ncbi request reprint Pharmacogenetic approaches in the treatment of asthma
    Ian Sayers
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, D Floor, South Block, Nottingham, NG7 2UH, UK
    Curr Allergy Asthma Rep 5:101-8. 2005
    ..In this review, we discuss the current understanding of asthma pharmacogenetics, focusing on the main three classes of drugs currently used clinically...
  28. pmc Pharmacology and direct visualisation of BODIPY-TMR-CGP: a long-acting fluorescent beta2-adrenoceptor agonist
    Jillian G Baker
    Institute of Cell Signalling, C Floor, Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Br J Pharmacol 139:232-42. 2003
    ..5 BODIPY-TMR-CGP is therefore a long-acting fluorescent beta(2)-adrenoceptor agonist that can be used to label beta(2)-adrenoceptors in the plasma membrane of living cells...
  29. doi request reprint Can lineage-specific markers be identified to characterize mesenchyme-derived cell populations in the human airways?
    Shailendra R Singh
    Univ of Nottingham, Queen s Medical Centre, UK
    Am J Physiol Lung Cell Mol Physiol 299:L169-83. 2010
    ..Ex vivo studies in human airway tissue sections identified high-molecular weight caldesmon and alpha-smooth muscle actin as being expressed in smooth muscle bundles, whereas ITGA8 and TBXAS1 were absent from these...
  30. doi request reprint Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα
    Caroline Swan
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK
    Gut 62:985-94. 2013
    ..The authors hypothesised that polymorphisms in genes whose expression were altered by gastroenteritis might be linked to IBS with diarrhoea (IBS-D) which closely resembles PI-IBS...
  31. pmc Reverse mode Na+/Ca2+ exchange mediated by STIM1 contributes to Ca2+ influx in airway smooth muscle following agonist stimulation
    Bo Liu
    Division of Therapeutics and Molecular Medicine, Respiratory Biomedical Research Unit, Queens Medical Centre, Nottingham, UK
    Respir Res 11:168. 2010
    ..The aim of this study was to characterise the expression and physiological function of the Na+/Ca2+ exchanger in cultured human bronchial smooth muscle cells and determine its contribution to agonist induced Ca2+ influx into these cells...
  32. pmc Real time analysis of β(2)-adrenoceptor-mediated signaling kinetics in human primary airway smooth muscle cells reveals both ligand and dose dependent differences
    Charlotte K Billington
    Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, Floor D, South Block, University Hospital of Nottingham, The University of Nottingham, Nottingham, NG7 2UH, UK
    Respir Res 12:89. 2011
    ....
  33. pmc A key role for STIM1 in store operated calcium channel activation in airway smooth muscle
    Samantha E Peel
    Division of Therapeutics and Molecular Medicine, University Hospital, Queens Medical Centre, Nottingham, UK
    Respir Res 7:119. 2006
    ..The mechanism underlying SOC activation following depletion of intracellular Ca2+ stores in smooth muscle has not been identified...
  34. ncbi request reprint The effect of beta2-adrenoceptor agonists on phospholipase C (beta1) signalling in human airway smooth muscle cells
    Ian Sayers
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, NG7 2UH, UK
    Eur J Pharmacol 531:9-12. 2006
    ..05). Therefore, beta2-adrenoceptor agonists can augment spasmogen responses in airway smooth muscle but not via a G-protein/PLC-beta1 mediated mechanism...
  35. pmc PLAUR polymorphisms and lung function in UK smokers
    Ceri E Stewart
    Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham, UK
    BMC Med Genet 10:112. 2009
    ..In the current study we tested the hypothesis that PLAUR single nucleotide polymorphisms (SNPs) determine baseline lung function and contribute to the development of Chronic Obstructive Pulmonary Disease (COPD) in smokers...
  36. pmc Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome)
    Mark Glover
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, U K
    Clin Sci (Lond) 126:721-6. 2014
    ..As a third of our non-WNK FHHt families do not have plausible CUL3 or KLHL3 variants, there are probably additional, as yet undiscovered, regulators of the thiazide-sensitive pathways. ..
  37. pmc Meta-analysis of genome-wide linkage studies of asthma and related traits
    Samuel Denham
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
    Respir Res 9:38. 2008
    ....
  38. ncbi request reprint Alternative promoter use and splice variation in the human histamine H1 receptor gene
    Caroline Swan
    Division of Therapeutics and Molecular Medicine, D Floor, South Block, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    Am J Respir Cell Mol Biol 35:118-26. 2006
    ..7% and 4.4%, respectively. These data suggest the use of alternative promoters directing human H1 receptor gene expression, both within and between cell types...
  39. ncbi request reprint Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling
    Jillian G Baker
    Institute of Cell Signaling, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Mol Pharmacol 64:1357-69. 2003
    ..These data suggest that propranolol can simultaneously act as an inverse agonist through a Gs-coupled mechanism while stimulating the p42/44-MAP kinase pathway through an alternative G-protein-independent mechanism...
  40. pmc The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro
    Suzanne Miller
    Division of Respiratory Medicine, University of Nottingham, Nottingham, United Kingdom
    PLoS ONE 11:e0164041. 2016
    ....
  41. ncbi request reprint Airway myofibroblasts and their relationship with airway myocytes and fibroblasts
    Shailendra R Singh
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, NG7 2UH, UK
    Proc Am Thorac Soc 5:127-32. 2008
    ....
  42. ncbi request reprint Personalised prescribing for asthma--is pharmacogenetics the answer?
    Jane C Dewar
    Division of Respiratory Medicine, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham, NG5 1PB, UK
    J Pharm Pharmacol 55:279-89. 2003
    ..The pharmacogenetics of the main asthma treatment groups will then be reviewed in detail. Finally, the impact of pharmacogenetics on the pharmaceutical industry, and clinical practice in the future will be discussed...
  43. ncbi request reprint Bradykinin activates calcium-dependent potassium channels in cultured human airway smooth muscle cells
    Bo Liu
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham NG7 2UH, UK
    Am J Physiol Lung Cell Mol Physiol 292:L898-907. 2007
    ..In summary, BK activates BKCa, SKCa, CACC, and I(CAT) via IP3-sensitive stores in human ASM...
  44. ncbi request reprint Influence of agonist efficacy and receptor phosphorylation on antagonist affinity measurements: differences between second messenger and reporter gene responses
    Jillian G Baker
    Institute of Cell Signaling, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Mol Pharmacol 64:679-88. 2003
    ....
  45. doi request reprint A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom
    Yize I Wan
    Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham, United Kingdom
    J Allergy Clin Immunol 127:223-31, 231.e1-3. 2011
    ..A genetic component in the development of atopy has been identified. However, numerous heritability models have been proposed with inconsistent replication of susceptibility loci and genes...
  46. doi request reprint Effects of atopy and grass pollen season on histamine H₄ receptor expression in human leukocytes
    Emily Hodge
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Queen s Medical Centre, Nottingham, United Kingdom
    Ann Allergy Asthma Immunol 111:38-44. 2013
    ..The histamine H4 receptor (H4R) is a novel therapeutic target to treat allergic inflammation...
  47. pmc HTR4 gene structure and altered expression in the developing lung
    Emily Hodge
    Division of Respiratory Medicine, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Respir Res 14:77. 2013
    ....
  48. pmc A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample
    Ma en Obeidat
    Nottingham Respiratory Biomedical Research Unit, Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, United Kingdom
    PLoS ONE 6:e19382. 2011
    ..Recently, we undertook a meta-analysis of Genome Wide Association Study (GWAS) results for lung function measures in 20,288 individuals from the general population (the SpiroMeta consortium)...
  49. ncbi request reprint Expression of transient receptor potential C6 and related transient receptor potential family members in human airway smooth muscle and lung tissue
    Randolph L Corteling
    Division of Therapeutics, University Hospital, Queens Medical Centre, Nottingham NG7 2UH, UK
    Am J Respir Cell Mol Biol 30:145-54. 2004
    ..TRPC homologs may provide an important novel target for the treatment of airway disease...
  50. pmc Novel cAMP signalling paradigms: therapeutic implications for airway disease
    Charlotte K Billington
    Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, The University of Nottingham, Nottingham, UK
    Br J Pharmacol 166:401-10. 2012
    ..LINKED ARTICLES This article is part of a themed section on Novel cAMP Signalling Paradigms. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2012.166.issue-2...
  51. pmc Pharmacological characterization of CGP 12177 at the human beta(2)-adrenoceptor
    Jillian G Baker
    Institute of Cell Signalling, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH
    Br J Pharmacol 137:400-8. 2002
    ....
  52. pmc Pharmacogenetic characterization of indacaterol, a novel beta 2-adrenoceptor agonist
    I Sayers
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
    Br J Pharmacol 158:277-86. 2009
    ..The aim of this study was to investigate the comparative pharmacology of indacaterol in recombinant cells expressing the common polymorphic variants of the human beta(2)-adrenoceptor and in human primary airway smooth muscle (ASM) cells...
  53. pmc Regulation of proliferation of human colonic subepithelial myofibroblasts by mediators important in intestinal inflammation
    T M Jobson
    Division of Therapeutics, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    J Clin Invest 101:2650-7. 1998
    ..2-fold over control and produces a dose-related inhibition of platelet-derived growth factor-driven proliferation with a maximum inhibition of 33% at 1 microM...
  54. ncbi request reprint Severe hyponatraemia in medical in-patients: aetiology, assessment and outcome
    J A Clayton
    Division of Therapeutics and Molecular Medicine, Queen s Medical Centre, Nottingham NG7 2UH
    QJM 99:505-11. 2006
    ..Hyponatraemia is the most commonly identified electrolyte abnormality. Published data on severe hyponatraemia in general medical in-patients is lacking...
  55. ncbi request reprint Asthma
    A E Tattersfield
    Division of Respiratory Medicine, Clinical Sciences Building, City Hospital, Nottingham, UK
    Lancet 360:1313-22. 2002
    ..However, a better understanding of the mechanisms underlying asthma and the genetic and environmental factors that predispose individuals to asthma should lead to better preventative strategies and new therapeutic approaches...
  56. pmc Thiazide diuretic prescription and electrolyte abnormalities in primary care
    J A Clayton
    Division of Therapeutics and Molecular Medicine, University Hospital, Queen s Medical Centre, Nottingham, UK
    Br J Clin Pharmacol 61:87-95. 2006
    ..Thiazide diuretics have a number of well-documented metabolic adverse effects. The aim of this study was to estimate the frequency of hyponatraemia and hypokalaemia amongst patients taking a thiazide diuretic in primary care...
  57. doi request reprint Cigarette Smoke and the Induction of Urokinase Plasminogen Activator Receptor In Vivo: Selective Contribution of Isoforms to Bronchial Epithelial Phenotype
    Michael A Portelli
    1 Division of Respiratory Medicine, University of Nottingham, Queen s Medical Centre, Nottingham, United Kingdom and
    Am J Respir Cell Mol Biol 53:174-83. 2015
    ..These findings provide further insight into how cigarette smoke may influence changes in the airways of importance to airway remodeling and obstructive lung disease progression. ..
  58. ncbi request reprint Glucocorticoids increase repair potential in a novel in vitro human airway epithelial wounding model
    Samuel J Wadsworth
    Division of Therapeutics and Molecular Medicine, D Floor, South Block, Queens Medical Centre, University Hospital, Nottingham, NG7 2UH, United Kingdom
    J Clin Immunol 26:376-87. 2006
    ..We suggest part of the beneficial effects of glucocorticoids in asthma is related to this ability to prolong repair potential following repeated episodes of epithelial injury...
  59. pmc Current progress in pharmacogenetics
    John D Blakey
    Respiratory Biomedical Research Unit, City Hospital Campus, Nottingham, UK
    Br J Clin Pharmacol 71:824-31. 2011
    ..In the final sections we discuss contemporary challenges for both researchers and clinicians...
  60. ncbi request reprint Are beta2-adrenoceptor polymorphisms important in asthma--an unravelling story
    A E Tattersfield
    Respiratory Division, Nottingham City Hospital NHS Trust, Nottingham, NG5 1PB, UK
    Lancet 364:1464-6. 2004
  61. ncbi request reprint Interleukin-1beta and rhinovirus sensitize adenylyl cyclase in human airway smooth-muscle cells
    C K Billington
    Division of Therapeutics and Institute of Cell Signalling, and Public Health Laboratory, University Hospital of Nottingham, Nottingham, United Kingdom
    Am J Respir Cell Mol Biol 24:633-9. 2001
    ..We suggest that the sensitization of AC observed after exposure to IL-1beta or RV infection is a cellular defense mechanism to promote pathways that induce relaxation in the inflamed airway...
  62. doi request reprint Traditional and emerging indicators of cardiovascular risk in chronic obstructive pulmonary disease
    Michelle John
    Nottingham Respiratory Research Unit and Division of Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham, UK
    Chron Respir Dis 13:247-55. 2016
    ..The traditional CV prediction scores used in the general population were not statistically different. We provide new data to suggest that alternative approaches for optimal CV risk detection should be employed in COPD management. ..
  63. ncbi request reprint β2 Agonists
    Charlotte K Billington
    Division of Respiratory Medicine, University of Nottingham, Nottingham, NG7 2RD, UK
    Handb Exp Pharmacol . 2016
    ..Finally we comment on what the future may hold for the use of β agonists in respiratory disease...
  64. pmc Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized (83)Kr
    Joseph S Six
    Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham NG7 2RD, UK School of Medicine, University of Nottingham, Nottingham NG7 2UH, UK
    Magn Reson Imaging 32:48-53. 2014
    ..The T1 weighted hyperpolarized (83)Kr MRI provided a first demonstration of surface quadrupolar relaxation (SQUARE) pulmonary MRI contrast...
  65. ncbi request reprint Molecular and phenotypic analyses of human embryonic stem cell-derived cardiomyocytes: opportunities and challenges for clinical translation
    Gareth Goh
    Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham, UK
    Thromb Haemost 94:728-37. 2005
    ..This review evaluates the opportunities presented by hESC-derived cardiomyocytes and the progress towards surmounting the challenges of clinical translation...
  66. ncbi request reprint Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter
    Ivan R Le Jeune
    Division of Therapeutics and Institute of Cell Signalling, University Hospital, Nottingham NG7 2UH, United Kingdom
    J Biol Chem 277:35980-9. 2002
    ..We present evidence for cAMP-driven PDE4D5 up-regulation in hASMs and suggest a CRE-containing, isoform-specific promoter as the primary mechanism...
  67. pmc Control of cyclic AMP levels in primary cultures of human tracheal smooth muscle cells
    I P Hall
    Department of Therapeutics, University Hospital of Nottingham
    Br J Pharmacol 107:422-8. 1992
    ....
  68. pmc Complications and mortality in hereditary hemorrhagic telangiectasia: A population-based study
    James W Donaldson
    From the Divisions of Epidemiology and Public Health J W D, T M M, R B H, A W F and Therapeutics and Molecular Medicine I P H, University of Nottingham, UK
    Neurology 84:1886-93. 2015
    ..However, most published cohorts derive from specialist centers, which may be susceptible to bias...
  69. pmc A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation?
    JENNIFER BARBER
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, NG7 2UH, UK
    Br J Clin Pharmacol 79:566-77. 2015
    ..We sought to review and analyze all published cases of this important condition...
  70. pmc Genetics of complex respiratory diseases: implications for pathophysiology and pharmacology studies
    Ma en Obeidat
    Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University of Nottingham, UK
    Br J Pharmacol 163:96-105. 2011
    ..The implications of these approaches for studies of asthma and Chronic Obstructive Pulmonary Disease are covered in this review...
  71. pmc The role of inflammation resolution speed in airway smooth muscle mass accumulation in asthma: insight from a theoretical model
    Igor L Chernyavsky
    School of Mathematical Sciences, University of Nottingham, Nottingham, United Kingdom
    PLoS ONE 9:e90162. 2014
    ..This ASM growth model should prove useful for designing new experiments or as a building block of more detailed multi-cellular tissue-level models. ..
  72. ncbi request reprint Identification of the autoantigen SART-1 as a candidate gene for the development of atopy
    Amanda P Wheatley
    Division of Therapeutics and Institute of Genetics, University Hospital of Nottingham, Queen s Medical Centre, UK
    Hum Mol Genet 11:2143-6. 2002
    ..We therefore hypothesize that polymorphic variation within the SART-1 gene may account for individuals developing atopy...
  73. ncbi request reprint Cell adhesion and mechanical properties of a flexible scaffold for cardiac tissue engineering
    L A Hidalgo-Bastida
    Division of Drug Delivery and Tissue Engineering, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK
    Acta Biomater 3:457-62. 2007
    ..This porous material has the potential to be used for cardiac tissue engineering as well as for other soft tissue applications...
  74. pmc Contribution of ADAM33 polymorphisms to the population risk of asthma
    J Blakey
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
    Thorax 60:274-6. 2005
    ..It has a postulated role in myogenesis, airway modelling, and signalling via protein shedding. Concerns over the methodology of the initial study have led to several attempts at replication, with inconsistent results...
  75. ncbi request reprint Peripheral blood neutrophils are hyperresponsive to IL-8 and Gro-alpha in cryptogenic fibrosing alveolitis
    P C Glynn
    Division of Therapeutics, University Hospital of Nottingham, UK
    Eur Respir J 18:522-9. 2001
    ..Selective CXCR2 antagonists may be useful to block the Gro-alpha-induced priming response whilst preserving neutrophil functions mediated by CXCR1, the alternative neutrophil receptor for interleukin-8...
  76. ncbi request reprint Beta(2)-adrenoceptor polymorphism determines vascular reactivity in humans
    J R Cockcroft
    School of Medical and Surgical Sciences, Division of Therapeutics, University of Nottingham Medical School, Queen s Medical Centre, Nottingham, UK
    Hypertension 36:371-5. 2000
    ..Further studies are necessary to establish whether beta(2)-adrenoceptor polymorphisms are important in the genesis of hypertension...
  77. pmc The arginine-16 beta2-adrenoceptor polymorphism predisposes to bronchoprotective subsensitivity in patients treated with formoterol and salmeterol
    Daniel K C Lee
    Asthma and Allergy Research Group, Department of Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Br J Clin Pharmacol 57:68-75. 2004
    ..The relationship between beta2-adrenoceptor polymorphisms and bronchoprotective response with long-acting beta2-adrenoceptor agonists is unknown...
  78. pmc Pharmacogenetics of asthma
    A Fenech
    Department of Clinical Pharmacology and Therapeutics, University of Malta, Msida MSD 06, Malta
    Br J Clin Pharmacol 53:3-15. 2002
    ..Genetic variability in both of these genes may account in part for interindividual variability in treatment response. Finally, a number of key targets within the airways remain to be adequately screened for polymorphic variation...
  79. ncbi request reprint 5-Lipoxygenase polymorphism and in-vivo response to leukotriene receptor antagonists
    Stephen J Fowler
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Eur J Clin Pharmacol 58:187-90. 2002
    ..To determine whether genetic polymorphisms of the core promoter region of the 5-lipoxygenase gene contribute to the clinical response to leukotriene receptor antagonists...
  80. ncbi request reprint ADRB2 polymorphisms and beta2 agonists
    D Robin Taylor
    Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Lancet 370:2075-6. 2007
  81. ncbi request reprint Novel polymorphisms influencing transcription of the human CHRM2 gene in airway smooth muscle
    Anthony G Fenech
    Department of Clinical Pharmacology and Therapeutics, University of Malta, Msida, Malta
    Am J Respir Cell Mol Biol 30:678-86. 2004
    ..We present functional data to show that the CA repeat may influence the transcription of the gene in HASM and BEAS-2B cells...
  82. ncbi request reprint Pharmacogenetics and ethnicity: more complexities of personalized prescribing
    Ian P Hall
    Am J Respir Crit Care Med 171:535-6. 2005
  83. ncbi request reprint Eosinophil-mediated cholinergic nerve remodeling
    Niamh Durcan
    Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    Am J Respir Cell Mol Biol 34:775-86. 2006
    ..Together these data suggest that eosinophil localization to cholinergic nerves induces neural remodeling, promoting a cholinergic phenotype...
  84. pmc Airway smooth muscle in bronchial tone, inflammation, and remodeling: basic knowledge to clinical relevance
    Reynold A Panettieri
    Airway Biology and Disease Program, Division of Lung Diseases, National Heart, Lung, and Blood Institute, Two Rockledge Center, Suite 10042, 6701 Rockledge Drive, MSC 7952, Bethesda, MD 20892 7952, USA
    Am J Respir Crit Care Med 177:248-52. 2008
    ....
  85. ncbi request reprint Tryptase's potent mitogenic effects in human airway smooth muscle cells are via nonproteolytic actions
    James K Brown
    Pulmonary and Critical Care Medicine Section, Medical Service, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Am J Physiol Lung Cell Mol Physiol 282:L197-206. 2002
    ..We conclude that beta-tryptase is a potent mitogenic serine protease in cultured human airway smooth muscle cells. However, its growth stimulatory effects in these cells occur predominantly via nonproteolytic actions...