Arun K Gupta

Summary

Affiliation: University Hospital Aintree
Country: UK

Publications

  1. ncbi request reprint Measuring brain tissue oxygenation compared with jugular venous oxygen saturation for monitoring cerebral oxygenation after traumatic brain injury
    A K Gupta
    Department of Anesthesia, University of Cambridge, Addenbrooke s Hospital, United Kingdom
    Anesth Analg 88:549-53. 1999
  2. ncbi request reprint Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method
    Arun K Gupta
    Department of Anaesthesia, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 96:263-8. 2002
  3. ncbi request reprint Monitoring the injured brain in the intensive care unit
    A K Gupta
    Department of Neuro Critical Care, Addenbrooke s Hospital, Cambridge, UK
    J Postgrad Med 48:218-25. 2002
  4. ncbi request reprint Direct comparison of cerebrovascular effects of norepinephrine and dopamine in head-injured patients
    Luzius A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 32:1049-54. 2004
  5. doi request reprint Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients
    Ivan Timofeev
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Brain 134:484-94. 2011
  6. ncbi request reprint Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury
    Andrew J Johnston
    University Department of Anaesthetics, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 33:189-95; discussion 255-7. 2005
  7. ncbi request reprint Effect of cerebral perfusion pressure augmentation with dopamine and norepinephrine on global and focal brain oxygenation after traumatic brain injury
    Andrew J Johnston
    Department of Anaesthetics, University of Cambridge, Addenbrooke s Hospital, Box 93, Cambridge CB2 2QQ, UK
    Intensive Care Med 30:791-7. 2004
  8. pmc Interaction between brain chemistry and physiology after traumatic brain injury: impact of autoregulation and microdialysis catheter location
    Ivan Timofeev
    Division of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurotrauma 28:849-60. 2011
  9. ncbi request reprint Cerebral oxygen and microdialysis monitoring during aneurysm surgery: effects of blood pressure, cerebrospinal fluid drainage, and temporary clipping on infarction
    Rupert Kett-White
    University Department of Neurosurgery and the Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 96:1013-9. 2002
  10. ncbi request reprint Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study
    Peter J Hutchinson
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    J Cereb Blood Flow Metab 22:735-45. 2002

Detail Information

Publications30

  1. ncbi request reprint Measuring brain tissue oxygenation compared with jugular venous oxygen saturation for monitoring cerebral oxygenation after traumatic brain injury
    A K Gupta
    Department of Anesthesia, University of Cambridge, Addenbrooke s Hospital, United Kingdom
    Anesth Analg 88:549-53. 1999
    ..Thus, monitoring of PbO2 is a useful addition to multimodal monitoring of patients with traumatic head injury...
  2. ncbi request reprint Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method
    Arun K Gupta
    Department of Anaesthesia, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 96:263-8. 2002
    ..The goal of this study was to validate the use of a new multiparameter sensor that measures brain tissue oxygenation and metabolism (Neurotrend) by comparing it with positron emission tomography (PET) scanning...
  3. ncbi request reprint Monitoring the injured brain in the intensive care unit
    A K Gupta
    Department of Neuro Critical Care, Addenbrooke s Hospital, Cambridge, UK
    J Postgrad Med 48:218-25. 2002
    ....
  4. ncbi request reprint Direct comparison of cerebrovascular effects of norepinephrine and dopamine in head-injured patients
    Luzius A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 32:1049-54. 2004
    ..To directly compare the cerebrovascular effects of norepinephrine and dopamine in patients with acute traumatic brain injury...
  5. doi request reprint Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients
    Ivan Timofeev
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Brain 134:484-94. 2011
    ..Whether treatment-related improvement in biochemistry translates into better outcome remains to be established...
  6. ncbi request reprint Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury
    Andrew J Johnston
    University Department of Anaesthetics, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 33:189-95; discussion 255-7. 2005
    ....
  7. ncbi request reprint Effect of cerebral perfusion pressure augmentation with dopamine and norepinephrine on global and focal brain oxygenation after traumatic brain injury
    Andrew J Johnston
    Department of Anaesthetics, University of Cambridge, Addenbrooke s Hospital, Box 93, Cambridge CB2 2QQ, UK
    Intensive Care Med 30:791-7. 2004
    ..To compare the effects of a cerebral perfusion pressure (CPP) intervention achieved with dopamine and norepinephrine after severe head injury...
  8. pmc Interaction between brain chemistry and physiology after traumatic brain injury: impact of autoregulation and microdialysis catheter location
    Ivan Timofeev
    Division of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurotrauma 28:849-60. 2011
    ..Decreases in perfusion and oxygenation were associated with deteriorating neurochemistry and these effects were more pronounced in perilesional tissue and when cerebrovascular reactivity was impaired...
  9. ncbi request reprint Cerebral oxygen and microdialysis monitoring during aneurysm surgery: effects of blood pressure, cerebrospinal fluid drainage, and temporary clipping on infarction
    Rupert Kett-White
    University Department of Neurosurgery and the Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 96:1013-9. 2002
    ....
  10. ncbi request reprint Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study
    Peter J Hutchinson
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    J Cereb Blood Flow Metab 22:735-45. 2002
    ..9 kPa resulted in a significant elevation of the OEF, in association with a reduction in glucose, but no significant elevation in the L/P ratio or glutamate...
  11. ncbi request reprint Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism
    Jonathan P Coles
    Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 35:568-78. 2007
    ..To determine whether hyperventilation exacerbates cerebral ischemia and compromises oxygen metabolism (CMRO2) following closed head injury...
  12. ncbi request reprint Hyperglycemia and brain tissue pH after traumatic brain injury
    David A Zygun
    Neuroscience Critical Care Unit and Department of Anaesthesia, University of Cambridge, Cambridge, England
    Neurosurgery 55:877-81; discussion 882. 2004
    ..We tested the hypothesis that blood glucose levels are associated with brain tissue pH (pH(b)) and that the correction of hyperglycemia would result in an improvement in pH(b)...
  13. ncbi request reprint Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: preliminary findings
    Jurgens Nortje
    University Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 36:273-81. 2008
    ..To determine the effect of normobaric hyperoxia on cerebral metabolism in patients with severe traumatic brain injury...
  14. ncbi request reprint Diffusion limited oxygen delivery following head injury
    David K Menon
    Division of Anaesthesia, and The Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 32:1384-90. 2004
    ..To use a range of techniques to explore diffusion limitation as a mechanism of cellular hypoxia in the setting of head injury...
  15. pmc Extracellular brain pH with or without hypoxia is a marker of profound metabolic derangement and increased mortality after traumatic brain injury
    Ivan Timofeev
    Academic Neurosurgery Unit, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 33:422-7. 2013
    ..993). The state 2 was a significant discriminator of mortality categories (P=0.031). Decreased pH(bt) is associated with impaired metabolism. Measuring pH(bt) with P(bt)O(2) is a more robust way of detecting metabolic derangements...
  16. doi request reprint The effect of red blood cell transfusion on cerebral oxygenation and metabolism after severe traumatic brain injury
    David A Zygun
    Department of Anaesthesia, University of Cambridge, Cambridge, United Kingdom
    Crit Care Med 37:1074-8. 2009
    ..To understand the acute effect of packed red blood cell transfusion on cerebral oxygenation and metabolism in patients with sTBI...
  17. ncbi request reprint The effects of large-dose propofol on cerebrovascular pressure autoregulation in head-injured patients
    Luzius A Steiner
    Academic Neurosurgery, University Department of Anaesthesia, Addenbrooke s Hospital, Cambridge, United Kingdom
    Anesth Analg 97:572-6, table of contents. 2003
    ..We propose that large doses of propofol should be used cautiously in head-injured patients, because there is the potential to increase the injured brain's vulnerability to secondary insults...
  18. ncbi request reprint Adverse cerebral events detected after subarachnoid hemorrhage using brain oxygen and microdialysis probes
    Rupert Kett-White
    Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, England
    Neurosurgery 50:1213-21; discussion 1221-2. 2002
    ..A prospective observational study was conducted to investigate whether episodes of ischemia are detected by continuous cerebral monitoring and whether such episodes are related to clinical outcome...
  19. ncbi request reprint Advanced monitoring in the neurology intensive care unit: microdialysis
    Andrew J Johnston
    Neuro Critical Care Unit, Addenbrooke s Hospital, Cambridge, UK
    Curr Opin Crit Care 8:121-7. 2002
    ..The advantages and disadvantages of microdialysis are discussed, as is its future potential...
  20. ncbi request reprint Effect of hyperventilation on cerebral blood flow in traumatic head injury: clinical relevance and monitoring correlates
    Jonathan P Coles
    Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 30:1950-9. 2002
    ..To investigate the effect of hyperventilation on cerebral blood flow in traumatic brain injury...
  21. ncbi request reprint Pharmacokinetics and pharmacodynamics of dopamine and norepinephrine in critically ill head-injured patients
    Andrew J Johnston
    University of Cambridge Department of Anaesthetics, Addenbrooke s Hospital, Box 93, Cambridge, CB2 2QQ, United Kingdom
    Intensive Care Med 30:45-50. 2004
    ..To explore the pharmacokinetics and pharmacodynamics of dopamine and norepinephrine...
  22. ncbi request reprint Non-neurological organ dysfunction in neurocritical care
    David A Zygun
    Neuroscience Critical Care Unit, Addengrooke s Hospital, Cambridge, UK
    J Crit Care 18:238-44. 2003
    ..To determine the incidence of non-neurological organ dysfunction in patients with severe neurological injury...
  23. ncbi request reprint The effect of drug concentration expression on epinephrine dosing errors: a randomized trial
    Daniel W Wheeler
    Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Ann Intern Med 148:11-4. 2008
    ..The expression of drug concentration as a ratio may cause dosing errors...
  24. pmc Optimizing cerebral glucose in severe traumatic brain injury: still some way to go
    Cameron Zahed
    Addenbrooke s Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 2QQ, UK
    Crit Care 13:131. 2009
    ..Some of the mechanisms of cerebral glucose control are explored, including the impact of intensive insulin therapy on cerebral metabolism...
  25. doi request reprint Retesting the Hypothesis of a Clinical Randomized Controlled Trial in a Simulation Environment to Validate Anesthesia Simulation in Error Research (the VASER Study)
    Alan F Merry
    From the Department of Anaesthesiology, Faculty of Medical and Health Sciences A F M, J A H, J T, Centre for Medical and Health Sciences Education, Faculty of Medical and Health Sciences C S W, J M W, University of Auckland, Auckland, New Zealand Anaesthetic Department, St Mary s Hospital, London, United Kingdom K E E Department of Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, New Zealand C F University Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom D W W Department of Anaesthesia, Cambridge University Hospitals, Cambridge, United Kingdom A K G and Anaesthesia and Critical Care, Division of Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom R P M, R E
    Anesthesiology . 2017
    ..We asked "would results of a simulation-based study justify the same principal conclusions as those of a larger clinical study?"..
  26. pmc Consensus statement from the 2014 International Microdialysis Forum
    Peter J Hutchinson
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Box 167, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK
    Intensive Care Med 41:1517-28. 2015
    ....
  27. doi request reprint Plasma renin activity for monitoring vesicoureteric reflux therapy: mid-term observations
    Minu Bajpai
    Department of Paediatric Surgery, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    J Pediatr Urol 4:60-4. 2008
    ..To study plasma renin activity (PRA) as an early marker for monitoring treatment of vesicoureteric reflux (VUR)...
  28. ncbi request reprint Transmural intrathoracic lipoma with intraspinal extension
    Vishesh Jain
    Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India
    J Pediatr Surg 42:2120-2. 2007
    ..Complete excision was curative. The chest wall defect was repaired with Prolene mesh. Only one similar case has been previously reported in the English literature...
  29. ncbi request reprint Prenatally diagnosed unilateral hydronephrosis: prognostic significance of plasma renin activity
    Minu Bajpai
    Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India
    J Urol 178:2580-4. 2007
    ..In this descriptive study we quantify plasma renin activity as an additional measure to evaluate renal outcome...
  30. ncbi request reprint Extracellular Brain pH and Outcome following Severe Traumatic Brain Injury
    Arun K Gupta
    Neuroscience Critical Care Unit, University of Cambridge Department of Anaesthesia, UK
    J Neurotrauma 21:678-84. 2004
    ..pH(b) differentiated between survivors and non-survivors. Measurement of pH(b) may be a useful indicator of outcome in patients with TBI...