Jörg Gsponer

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Tight regulation of unstructured proteins: from transcript synthesis to protein degradation
    Jörg Gsponer
    Medical Research Council MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Science 322:1365-8. 2008
  2. doi request reprint The rules of disorder or why disorder rules
    Jörg Gsponer
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom
    Prog Biophys Mol Biol 99:94-103. 2009
  3. ncbi request reprint Evolutionary selection for protein aggregation
    Natalia Sánchez de Groot
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, U K
    Biochem Soc Trans 40:1032-7. 2012
  4. doi request reprint Intrinsically disordered proteins: regulation and disease
    M Madan Babu
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, United Kingdom
    Curr Opin Struct Biol 21:432-40. 2011

Detail Information

Publications4

  1. pmc Tight regulation of unstructured proteins: from transcript synthesis to protein degradation
    Jörg Gsponer
    Medical Research Council MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Science 322:1365-8. 2008
    ..Fidelity in signaling may require that most IUPs be available in appropriate amounts and not present longer than needed...
  2. doi request reprint The rules of disorder or why disorder rules
    Jörg Gsponer
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom
    Prog Biophys Mol Biol 99:94-103. 2009
    ..In addition, we discuss how such properties, individually and in combination, facilitate combinatorial regulation and re-use of the same component in multiple biological processes...
  3. ncbi request reprint Evolutionary selection for protein aggregation
    Natalia Sánchez de Groot
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, U K
    Biochem Soc Trans 40:1032-7. 2012
    ..In the present review, we summarize the current knowledge of the advantages associated with aggregation-prone stretches in proteomes and the strategies that cellular systems have developed to control the aggregation process...
  4. doi request reprint Intrinsically disordered proteins: regulation and disease
    M Madan Babu
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, United Kingdom
    Curr Opin Struct Biol 21:432-40. 2011
    ..e., molecular titration), thereby causing an imbalance in signaling pathways. We discuss the regulation of IDPs, address implications for signaling, disease and drug development, and outline directions for future research...