Affiliation: University of Cambridge
- Tight regulation of unstructured proteins: from transcript synthesis to protein degradationJörg Gsponer
Medical Research Council MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Science 322:1365-8. 2008..Fidelity in signaling may require that most IUPs be available in appropriate amounts and not present longer than needed...
- The rules of disorder or why disorder rulesJörg Gsponer
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom
Prog Biophys Mol Biol 99:94-103. 2009..In addition, we discuss how such properties, individually and in combination, facilitate combinatorial regulation and re-use of the same component in multiple biological processes...
- Evolutionary selection for protein aggregationNatalia Sánchez de Groot
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, U K
Biochem Soc Trans 40:1032-7. 2012..In the present review, we summarize the current knowledge of the advantages associated with aggregation-prone stretches in proteomes and the strategies that cellular systems have developed to control the aggregation process...
- Intrinsically disordered proteins: regulation and diseaseM Madan Babu
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, United Kingdom
Curr Opin Struct Biol 21:432-40. 2011..e., molecular titration), thereby causing an imbalance in signaling pathways. We discuss the regulation of IDPs, address implications for signaling, disease and drug development, and outline directions for future research...