S G Grant
Affiliation: University of Edinburgh
- The molecular evolution of the vertebrate behavioural repertoireSeth G N Grant
Centre for Clinical Brain Science, Edinburgh University, Chancellors Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
Philos Trans R Soc Lond B Biol Sci 371:20150051. 2016..These molecular mechanisms have general importance for understanding the repertoire of behaviours in different species and for human behavioural disorders arising from synapse gene mutations. ..
- Comparative study of human and mouse postsynaptic proteomes finds high compositional conservation and abundance differences for key synaptic proteinsAlex Bayes
Molecular Physiology of the Synapse Laboratory, Institut de Recerca de l Hospital de la Santa Creu i Sant Pau, UAB, Barcelona, Catalonia, Spain
PLoS ONE 7:e46683. 2012..Understanding synapse proteome diversity within and between species will be important to further our understanding of brain complexity and disease...
- The subtype of GluN2 C-terminal domain determines the response to excitotoxic insultsMarc Andre Martel
Centre for Integrative Physiology, University of Edinburgh School of Biomedical Sciences, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
Neuron 74:543-56. 2012..Dependence of NMDAR excitotoxicity on the GluN2 CTD subtype can be overcome by inducing high levels of NMDAR activity. Thus, the identity (2A versus 2B) of the GluN2 CTD controls the toxicity dose-response to episodes of NMDAR activity...
- Synaptopathies: diseases of the synaptomeSeth G N Grant
Genes to Cognition Programme, Centre for Clinical Brain Sciences, The University of Edinburgh, Chancellors Building, 47 Little France Crescent, Edinburgh EH16 4SB, United Kingdom
Curr Opin Neurobiol 22:522-9. 2012..Classifying synaptic disease phenotypes with genetic and proteome data provides a new brain disease classification system based on molecular etiology and pathogenesis...
- Proteomics of multiprotein complexes: answering fundamental questions in neuroscienceS G Grant
Dept of Neuroscience, University of Edinburgh, UK
Trends Biotechnol 19:S49-54. 2001..Simultaneous analysis of multiple proteins enables the development of new concepts and approaches for neuroscience research...
- Proteomics in neuroscience: from protein to networkS G Grant
Department of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom
J Neurosci 21:8315-8. 2001..Here we will discuss the technology of proteomics and its applications to the nervous system...
- Multiprotein complex signaling and the plasticity problemS G Grant
Department of Neuroscience, University of Edinburgh, EH8 9JZ, Edinburgh, UK
Curr Opin Neurobiol 11:363-8. 2001....
- Systems biology in neuroscience: bridging genes to cognitionSeth G N Grant
Division of Neuroscience, 1 George Square, Edinburgh EH8 9JZ, UK
Curr Opin Neurobiol 13:577-82. 2003..A neuroscience systems biology programme, organized as a consortium, is proposed...
- Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 proteinM Migaud
Centre for Genome Research, University of Edinburgh, UK
Nature 396:433-9. 1998..PSD-95 thus appears to be important in coupling the NMDA receptor to pathways that control bidirectional synaptic plasticity and learning...
- Isolation of 2000-kDa complexes of N-methyl-D-aspartate receptor and postsynaptic density 95 from mouse brainH Husi
Department of Neuroscience, University of Edinburgh, Edinburgh, UK
J Neurochem 77:281-91. 2001..These methods can be used to define the structure of the complexes at different synapses and in mice carrying gene mutations as well as new tools for drug discovery...
- SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptorNoboru H Komiyama
Division of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom
J Neurosci 22:9721-32. 2002..A comparison of SynGAP and PSD-95 mutants suggests that PSD-95 couples NMDARs to multiple downstream signaling pathways with very different roles in LTP and learning...
- Neurone specific regulation of dendritic spines in vivo by post synaptic density 95 protein (PSD-95)Catherine A Vickers
Department of Pre Clinical Veterinary Sciences, RDSVS Summerhall, University of Edinburgh, Edinburgh EH9 1QH, UK
Brain Res 1090:89-98. 2006..Thus, PSD-95 is an important regulator of neuronal structure as well as plasticity in vivo...
- Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant miceS G Grant
Center for Genome Research, University of Edinburgh, UK
Genes Dev 9:1909-21. 1995..Tyrosine phosphorylation is a critical regulator of FAK, and impairments in FAK signal transduction in fyn mutants may contribute to the mutant neural phenotype...
- Proteomics of the nervous systemH Husi
Dept of Neuroscience, University of Edinburgh, 1 George Square, Edinburgh, UK, EH9 9JZ
Trends Neurosci 24:259-66. 2001..This article reviews the impact of and outlines the application of proteomic analysis in the field of neuroscience, illustrating this with the example of NMDA receptor complexes...
- Neuropathic sensitization of behavioral reflexes and spinal NMDA receptor/CaM kinase II interactions are disrupted in PSD-95 mutant miceEmer M Garry
Division of Preclinical Veterinary Sciences, R D SVS, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
Curr Biol 13:321-8. 2003..Disruption of CaM kinase II docking to the NMDA receptor and activation may be responsible for the lack of neuropathic behavioral reflex sensitization in PSD-95 mutant mice...
- Dynamic distribution of endoplasmic reticulum in hippocampal neuron dendritic spinesHakan Toresson
Division of Neuroscience, College of Medicine and Veterinary Medicine, University of Edinburgh, 1 George Square, Edinburgh, UK
Eur J Neurosci 22:1793-8. 2005....
- Synaptic Ras GTPase activating protein regulates pattern formation in the trigeminal system of miceMark W Barnett
Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
J Neurosci 26:1355-65. 2006....
- Analyses of murine postsynaptic density-95 identify novel isoforms and potential translational control elementsMatthew Bence
Division of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, UK
Brain Res Mol Brain Res 133:143-52. 2005..The variety of mRNA isoforms and regulatory elements identified provides for a high degree of diversity in the structure and function of PSD-95 proteins...
- The proteomes of neurotransmitter receptor complexes form modular networks with distributed functionality underlying plasticity and behaviourAndrew J Pocklington
School of Informatics, Edinburgh University, Edinburgh, UK
Mol Syst Biol 2:2006.0023. 2006..These studies of synapse proteome organisation suggest that molecular networks with simple design principles underpin synaptic signalling properties with important roles in physiology, behaviour and disease...
- Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategiesPeter C Cuthbert
Wellcome Trust Sanger Institute, Cambridge CB10 1SA, United Kingdom
J Neurosci 27:2673-82. 2007..This provides a mechanism for discriminating patterns of synaptic activity that lead to long-lasting changes in synaptic strength as well as distinct aspects of cognition in the mammalian nervous system...
- Recording long-term potentiation of synaptic transmission by three-dimensional multi-electrode arraysMaksym V Kopanitsa
Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK
BMC Neurosci 7:61. 2006....
- Inhibition of the dopamine D1 receptor signaling by PSD-95Jingping Zhang
Department of Psychiatry, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA
J Biol Chem 282:15778-89. 2007..These studies demonstrate a role for a glutamatergic scaffold in dopamine receptor signaling and trafficking and identify a new potential target for the modulation of abnormal dopaminergic function...
- Clustered gene expression changes flank targeted gene loci in knockout miceLuis M Valor
Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Cambridge, United Kingdom
PLoS ONE 2:e1303. 2007..Gene expression profiling using microarrays is a powerful technology widely used to study regulatory networks. Profiling of mRNA levels in mutant organisms has the potential to identify genes regulated by the mutated protein...
- Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memoriesNiels Plath
Molecular Neurobiology, Department of Biology Chemistry Pharmacy, Freie Universitat Berlin, 14195 Berlin, Germany
Neuron 52:437-44. 2006..In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage...
- Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signalingMichela Fagiolini
Neuronal Circuit Development, Institute of Physical and Chemical Research, RIKEN, Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
Proc Natl Acad Sci U S A 100:2854-9. 2003..Taken together, our results demonstrate that the cellular basis generating individual sensory response properties is separable in the developing neocortex...
- Phosphatidylinositol 3-kinase regulates the induction of long-term potentiation through extracellular signal-related kinase-independent mechanismsPatricio Opazo
Department of Physiology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, USA
J Neurosci 23:3679-88. 2003..Together, our results indicate that the role of PI3-kinase in LTP is not limited to its role as an upstream regulator of MAPK signaling but also includes signaling through ERK-independent pathways that regulate LTP induction...
- Differential expression of two NMDA receptor interacting proteins, PSD-95 and SynGAP during mouse developmentKaren Porter
Centre for Neuroscience Research, University of Edinburgh, Edinburgh UK
Eur J Neurosci 21:351-62. 2005..These data support the model that synaptic signalling complexes are heterogeneous and individual components show temporal and spatial specificity during development...
- Clustering of neuronal potassium channels is independent of their interaction with PSD-95Matthew N Rasband
Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
J Cell Biol 159:663-72. 2002..These data suggest that the primary function of PSD-95 at juxtaparanodes lies outside of its accepted role in mediating the high density clustering of Kv1 potassium channels at these sites...
- Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticityWei Dong Yao
Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Neuron 41:625-38. 2004..Our findings uncover a previously unappreciated role of PSD-95 in psychostimulant action and identify a molecular and cellular mechanism shared between drug-related plasticity and learning...
- A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stabilityFrancesca Zalfa
Dipartimento di Biologia, Universita Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy
Nat Neurosci 10:578-87. 2007..Through our functional analysis of this FMRP target we provide evidence that dysregulation of mRNA stability may contribute to the cognitive impairments in individuals with FXS...
- NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840Jary Y Delgado
Interdepartmental PhD Program for Neuroscience, University of California, Los Angeles, 90095, USA
J Neurosci 27:13210-21. 2007..Together, our results show that GluR1 phosphorylation at T840 is regulated by NMDA receptor activation and suggest that decreases in GluR1 phosphorylation at T840 may have a role in LTD...
- Toward a molecular catalogue of synapsesSeth G N Grant
Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton, Cambridge, Cambridgeshire, UK
Brain Res Rev 55:445-9. 2007..A case will be made for developing approaches that can be used to generate a general catalogue of synapse types based on molecular markers, which should have wide application...
- Network activity-independent coordinated gene expression program for synapse assemblyLuis M Valor
Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
Proc Natl Acad Sci U S A 104:4658-63. 2007..Thus, two distinct sequentially active gene expression programs underlie the genomic programs of synapse function...
- The role of neuronal complexes in human X-linked brain diseasesFrederic Laumonnier
Genes to Cognition Programme, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, UK
Am J Hum Genet 80:205-20. 2007..We propose that systematic studies of PSD and NRC/MASC genes in mice and humans will give a high yield of novel genes important for human disease and new mechanistic insights into higher cognitive functions...
- Identification of PSD-93 as a substrate for the Src family tyrosine kinase FynShigeyuki Nada
Department of Oncogene Research, Research Institute for Microbial Disease, Osaka University, Suita, Osaka 565 0871, Japan
J Biol Chem 278:47610-21. 2003..These results suggest that PSD-93 serves as a membrane-anchored substrate of Fyn and plays a role in the regulation of Fyn-mediated modification of NMDA receptor function...
- AMPA receptor trafficking and GluR1Seth G N Grant
Science 310:234-5; author reply 234-5. 2005
- Proteomics in postgenomic neuroscience: the end of the beginningJyoti Choudhary
Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK
Nat Neurosci 7:440-5. 2004..The combination of proteomics with other global functional genomic approaches at the levels of genome and transcriptome, together with network biology, will provide important bridges between genes, physiology and pathology...
- Synapse signalling complexes and networks: machines underlying cognitionSeth G N Grant
Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB1D 1SA, UK
Bioessays 25:1229-35. 2003..Supplementary material for this article can be found on the BioEssays website http://www.interscience.wiley.com/jpages/0265-9247/suppmat/index.html...
- Synapse proteomics of multiprotein complexes: en route from genes to nervous system diseasesSeth G N Grant
Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK
Hum Mol Genet 14:R225-34. 2005..genes2cognition.org) that links human and mouse genetics with proteomic studies...