- Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritisMaría C de Andrés
Bone and Joint Research Group, University of Southampton Medical School, Southampton, UK
Biochem Biophys Res Commun 407:54-9. 2011..In addition, SOCS2 protein production was assessed and the CpG methylation status of the SOCS2 promoter was analyzed to determine the role of epigenetics in its regulation...
- Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytesMaría C de Andrés
University of Southampton Medical School, Southampton, UK
Arthritis Rheum 65:732-42. 2013..To investigate whether the abnormal expression of inducible nitric oxide synthase (iNOS) by osteoarthritic (OA) human chondrocytes is associated with changes in the DNA methylation status in the promoter and/or enhancer elements of iNOS...
- Epigenetic regulation during fetal femur development: DNA methylation mattersMaría C de Andrés
Bone and Joint Research Group, University of Southampton, Southampton, United Kingdom
PLoS ONE 8:e54957. 2013..In conclusion, these findings demonstrate the role of epigenetic regulation, specifically DNA methylation, in bone development, informing and opening new possibilities in development of strategies for bone repair/tissue engineering...