Deborah C I Goberdhan

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint The functions of insulin signaling: size isn't everything, even in Drosophila
    Deborah C I Goberdhan
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, United Kingdom
    Differentiation 71:375-97. 2003
  2. ncbi request reprint PTEN: tumour suppressor, multifunctional growth regulator and more
    Deborah C I Goberdhan
    Department of Human Anatomy and Genetics, University of Oxford, Oxford, UK
    Hum Mol Genet 12:R239-48. 2003
  3. ncbi request reprint PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids
    Deborah C I Goberdhan
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Development 132:2365-75. 2005
  4. pmc Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes
    Margret H Ogmundsdóttir
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e36616. 2012
  5. pmc Amino acid sensing and mTOR regulation: inside or out?
    Deborah C I Goberdhan
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Biochem Soc Trans 37:248-52. 2009
  6. pmc Drosophila expresses a CD98 transporter with an evolutionarily conserved structure and amino acid-transport properties
    Bruno Reynolds
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, U K
    Biochem J 420:363-72. 2009
  7. pmc mTOR: dissecting regulation and mechanism of action to understand human disease
    Deborah C I Goberdhan
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Rd, Oxford OX1 3QX, UK
    Biochem Soc Trans 37:213-6. 2009
  8. pmc Intracellular amino acid sensing and mTORC1-regulated growth: new ways to block an old target?
    Deborah C I Goberdhan
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK
    Curr Opin Investig Drugs 11:1360-7. 2010
  9. ncbi request reprint Insulin receptor-mediated organ overgrowth in Drosophila is not restricted by body size
    Deborah C I Goberdhan
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
    Dev Genes Evol 212:196-202. 2002
  10. pmc Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot
    Deborah C I Goberdhan
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, UK Electronic address
    Cell Metab 23:580-9. 2016

Collaborators

  • D Meredith
  • Adrian L Harris
  • Bruno Reynolds
  • Lawrence B Mensah
  • Margret H Ogmundsdóttir
  • Clive Wilson
  • Shubana Kazi
  • Noelia Pinal
  • John F Morris
  • Claire Davison
  • Shih Jung Fan
  • Sabine Heublein
  • Michael K Shaw
  • Shivanthy M Visvalingam
  • Pietro Roversi
  • C A Richard Boyd
  • Robert Laynes
  • Franck Pichaud
  • Lucy Collinson
  • Yasuyuki Fujita
  • Iain M Cox

Detail Information

Publications12

  1. ncbi request reprint The functions of insulin signaling: size isn't everything, even in Drosophila
    Deborah C I Goberdhan
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, United Kingdom
    Differentiation 71:375-97. 2003
    ....
  2. ncbi request reprint PTEN: tumour suppressor, multifunctional growth regulator and more
    Deborah C I Goberdhan
    Department of Human Anatomy and Genetics, University of Oxford, Oxford, UK
    Hum Mol Genet 12:R239-48. 2003
    ....
  3. ncbi request reprint PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids
    Deborah C I Goberdhan
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Development 132:2365-75. 2005
    ..As PATH is likely to be saturated in vivo, we propose that one specialised function of high-affinity PAT-related molecules is to maintain growth as local nutrient levels fluctuate during development...
  4. pmc Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes
    Margret H Ogmundsdóttir
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e36616. 2012
    ..In light of the recent identification of the vacuolar H(+)-ATPase as another Rag-interacting component, we propose a model in which PATs function as part of an AA-sensing engine that drives mTORC1 activation from LEL compartments...
  5. pmc Amino acid sensing and mTOR regulation: inside or out?
    Deborah C I Goberdhan
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Biochem Soc Trans 37:248-52. 2009
    ..The present review summarizes current ideas and suggests ways in which some of the models proposed might be unified to produce an amino acid detection system that can adapt to environmental change...
  6. pmc Drosophila expresses a CD98 transporter with an evolutionarily conserved structure and amino acid-transport properties
    Bruno Reynolds
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, U K
    Biochem J 420:363-72. 2009
    ..Therefore our results not only show that there is functional conservation of CD98hc System L transporters in flies, but also provide new insights into the structure, functions and regulation of heterodimeric amino acid transporters...
  7. pmc mTOR: dissecting regulation and mechanism of action to understand human disease
    Deborah C I Goberdhan
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Rd, Oxford OX1 3QX, UK
    Biochem Soc Trans 37:213-6. 2009
    ....
  8. pmc Intracellular amino acid sensing and mTORC1-regulated growth: new ways to block an old target?
    Deborah C I Goberdhan
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK
    Curr Opin Investig Drugs 11:1360-7. 2010
    ..In this review, recent mechanistic insights into how mTORC1 activity is controlled by amino acids and the potential for the selective targeting this regulatory input are discussed...
  9. ncbi request reprint Insulin receptor-mediated organ overgrowth in Drosophila is not restricted by body size
    Deborah C I Goberdhan
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
    Dev Genes Evol 212:196-202. 2002
    ..Given the evolutionarily conserved role of insulin receptor signalling in growth control, our data may also help to explain why this pathway is so frequently hyperactivated in mammalian tumours...
  10. pmc Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot
    Deborah C I Goberdhan
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, UK Electronic address
    Cell Metab 23:580-9. 2016
    ..We will discuss the implications of this for mTORC1 function in health and disease. ..
  11. pmc Fine-Tuning of PI3K/AKT Signalling by the Tumour Suppressor PTEN Is Required for Maintenance of Flight Muscle Function and Mitochondrial Integrity in Ageing Adult Drosophila melanogaster
    Lawrence B Mensah
    Department of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford, OX1 3QX, United Kingdom
    PLoS ONE 10:e0143818. 2015
    ....
  12. ncbi request reprint Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells
    Noelia Pinal
    Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit, Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT London, United Kingdom
    Curr Biol 16:140-9. 2006
    ..However, little is known about the mechanisms by which such apical factors might regulate the differentiation of the apical membrane into functional domains such as an apical-most stack of microvilli or more lateral sub-apical membrane...