Affiliation: University of Cambridge
- Structural basis of hepatocyte growth factor/scatter factor and MET signallingErmanno Gherardi
Medical Research Council Centre and Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
Proc Natl Acad Sci U S A 103:4046-51. 2006....
- Engineering the NK1 fragment of hepatocyte growth factor/scatter factor as a MET receptor antagonistMark Youles
Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, UK
J Mol Biol 377:616-22. 2008..These NK1 variants have no detectable agonistic activity on, behave as bona fide receptor antagonists by blocking cell migration and DNA synthesis in target cells and have strong prospects as therapeutics for human cancer...
- Targeting MET in cancer: rationale and progressErmanno Gherardi
Medical Research Council MRC Centre, Hills Road, Cambridge CB2 2QH, UK
Nat Rev Cancer 12:89-103. 2012..In this Review, we discuss these advances, as well as results from recent clinical studies that demonstrate that inhibiting MET signalling in several types of solid human tumours has major therapeutic value...
- The sema domainErmanno Gherardi
MRC Centre, Hills Road, Cambridge CB2 2QH, UK
Curr Opin Struct Biol 14:669-78. 2004....
- Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factorErmanno Gherardi
Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom
Proc Natl Acad Sci U S A 100:12039-44. 2003..Our studies provide 3D models and a functional map of the MET ectodomain. They have broad implications for structure-function of the MET receptor and the related semaphorin and plexin proteins...
- Crystal structure of the beta-chain of human hepatocyte growth factor-like/macrophage stimulating proteinFederico Carafoli
MRC Centre, Hills Road, Cambridge, UK
FEBS J 272:5799-807. 2005....
- Interactions of hepatocyte growth factor/scatter factor with various glycosaminoglycans reveal an important interplay between the presence of iduronate and sulfate densityKrista R Catlow
Cancer Research UK Glyco Oncology Group, School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, United Kingdom
J Biol Chem 283:5235-48. 2008....
- X-ray and neutron small-angle scattering analysis of the complex formed by the Met receptor and the Listeria monocytogenes invasion protein InlBHartmut H Niemann
Division of Structural Biology, Helmholtz Center for Infection Research, Inhoffenstrasse 7, D 38124 Braunschweig, Germany
J Mol Biol 377:489-500. 2008....
- Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlBHartmut H Niemann
Division of Structural Biology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, D 38124 Braunschweig, Germany
Cell 130:235-46. 2007..Thus, although it elicits a similar cellular response, InlB is not a structural mimic of HGF/SF...
- A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonistW David Tolbert
Laboratory of Structural Sciences, Van Andel Research Institute, 333 Bostwick Avenue, Grand Rapids, MI 49503, USA
Proc Natl Acad Sci U S A 104:14592-7. 2007..This strategy of antagonist design may be applicable for other growth factor receptors by selectively abolishing the receptor activation ability but not the receptor binding of the growth factors...
- A new crystal form of the NK1 splice variant of HGF/SF demonstrates extensive hinge movement and suggests that the NK1 dimer originates by domain swappingKeiichi Watanabe
Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
J Mol Biol 319:283-8. 2002....
- The interactions of hepatocyte growth factor/scatter factor and its NK1 and NK2 variants with glycosaminoglycans using a modified gel mobility shift assay. Elucidation of the minimal size of binding and activatory oligosaccharidesMalcolm Lyon
Cancer Research UK, University of Manchester, Christie Hospital National Health Service Trust, Wilmslow Road, M20 4BX
J Biol Chem 279:43560-7. 2004..The binding and activity of tetrasaccharides put constraints upon the possible interactions and molecular geometry within the ternary signaling complex...
- Met, metastasis, motility and moreCarmen Birchmeier
Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13122 Berlin, Germany
Nat Rev Mol Cell Biol 4:915-25. 2003
- Hepatocyte growth factor/scatter factor can induce angiogenesis independently of vascular endothelial growth factorShiladitya Sengupta
Angiogenesis Laboratory, Department of Pharmacology, University of Cambridge, Cambridge, England
Arterioscler Thromb Vasc Biol 23:69-75. 2003..The present study was designed to delineate the HGF/SF and VEGF signaling cascades during angiogenesis by using PTK787, a selective VEGF receptor antagonist...
- Targeting of mitogen-activated protein kinases and phosphatidylinositol 3 kinase inhibits hepatocyte growth factor/scatter factor-induced angiogenesisShiladitya Sengupta
Angiogenesis Laboratory, Department of Pharmacology, University of Cambridge, Cambridge, United Kingdo
Circulation 107:2955-61. 2003..However, the treatment strategies have mostly been unsuccessful. The present study is the first to evaluate the possible targeting of downstream signals for the inhibition of HGF/SF-induced angiogenesis...
- Aromatic amino acids at the surface of InlB are essential for host cell invasion by Listeria monocytogenesMatthias P Machner
Department of Structural Biology, German Research Centre for Biotechnology GBF, Mascheroder Weg 1, D 38124 Braunschweig, Germany
Mol Microbiol 48:1525-36. 2003..We conclude that InlB binds to Met through its concave surface of the LRR domain, and that aromatic amino acids are critical for binding and signalling before invasion...
- Cyclooxygenase-2-selective nonsteroidal anti-inflammatory drugs inhibit hepatocyte growth factor/scatter factor-induced angiogenesisShiladitya Sengupta
Department of Pharmacology, Glaxo Institute of Applied Pharmacology, University of Cambridge, Cambridge, United Kingdom
Cancer Res 63:8351-9. 2003..Few therapeutic options currently exist for HGF/SF-induced pathological angiogenesis, and the vast knowledge on COX-2 inhibitors can be harnessed to design a newer therapeutic approach...
- Diverse and potent activities of HGF/SF in skin wound repairDamon Bevan
School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
J Pathol 203:831-8. 2004..The results demonstrate that HGF/SF affects and sustains all key cellular processes responsible for wound repair and point to a unique potential of this molecule for the therapy of chronic skin wounds...
- Computer-assisted mass spectrometric analysis of naturally occurring and artificially introduced cross-links in proteins and protein complexesLeo J de Koning
Biomolecular Mass Spectrometry group, Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
FEBS J 273:281-91. 2006..The program is freely available upon request...
- Hepatocyte growth factor/scatter factor and MET are involved in arterial repair and atherogenesisHeather McKinnon
Department of Pathology, University of Cambridge, Cambridge, United Kingdom
Am J Pathol 168:340-8. 2006..These results demonstrate that MET is induced in migrating and proliferating SMCs and that HGF/SF and MET are key mediators of the SMC response in atherogenesis...
- Nitric oxide modulates hepatocyte growth factor/scatter factor-induced angiogenesisShiladitya Sengupta
Department of Pharmacology, Angiogenesis Laboratory, Babraham Institute, Cambridge, UK
Angiogenesis 7:285-94. 2004..The current study is the first to evaluate the possible involvement of NOS-NO cascade in HGF-induced angiogenesis...