Affiliation: University College London
- Nematode ageing: Putting metabolic theories to the testD Gems
Department of Biology, University College London, 4 Stephenson Way, London, NW1 2HE, UK
Curr Biol 9:R614-6. 1999..New findings support the former, but not the latter interpretation...
- Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegansD Gems
The Galton Laboratory, Department of Biology, University College London, England
Genetics 154:1597-610. 2000..This variability was reduced when dead bacteria were used as food. Maintenance on dead bacteria extended both male and hermaphrodite longevity...
- Insulin/IGF signalling and ageing: seeing the bigger pictureD Gems
Department of Biology, University College London, 4 Stephenson Way, NW1 2HE, London, UK
Curr Opin Genet Dev 11:287-92. 2001..The focus now is on how this pathway is regulated, how it controls nematode ageing, and how this relates to the ageing process in higher animals...
- Defining wild-type life span in Caenorhabditis elegansD Gems
Department of Biology, University College London, England
J Gerontol A Biol Sci Med Sci 55:B215-9. 2000..We infer that the longest-lived N2 variant best resembles the original N2 isolate. This is the N2 male stock currently distributed by the Caenorhabditis Genetics Center...
- An integrated theory of ageing in the nematode Caenorhabditis elegansD Gems
Department of Biology, University College London, UK
J Anat 197:521-8. 2000..This tripartite theory of ageing gives rise to a number of predictions that may be tested experimentally...
- Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate proteinD J Clancy
Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
Science 292:104-6. 2001..The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved...
- Longevity and ageing in parasitic and free-living nematodesD Gems
Department of Biology, University College London, 4 Stephenson Way, London NW1 2HE, UK
Biogerontology 1:289-307. 2000..The possible evolutionary and mechanistic causes of such differences in ageing are discussed...
- An abundant, trans-spliced mRNA from Toxocara canis infective larvae encodes a 26-kDa protein with homology to phosphatidylethanolamine-binding proteinsD Gems
Wellcome Research Centre for Parasitic Infections, Department of Biology, Imperial College of Science, Technology and Medicine, London, United Kingdom
J Biol Chem 270:18517-22. 1995..Assays with the T. canis recombinant 26-kDa protein expressed as a fusion with maltose-binding protein have confirmed phosphatidylethanolamine-binding specificity for this novel product...