Simon J Foster

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. pmc The effect of skin fatty acids on Staphylococcus aureus
    Yvonne Neumann
    Department of Molecular Biology and Biotechnology, The Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK
    Arch Microbiol 197:245-67. 2015
  2. pmc Clonal expansion during Staphylococcus aureus infection dynamics reveals the effect of antibiotic intervention
    Gareth McVicker
    Krebs Institute, University of Sheffield, Western Bank, Sheffield, United Kingdom Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, United Kingdom
    PLoS Pathog 10:e1003959. 2014
  3. pmc A privileged intraphagocyte niche is responsible for disseminated infection of Staphylococcus aureus in a zebrafish model
    Tomasz K Prajsnar
    Krebs Institute, University of Sheffield, Western Bank, Sheffield, UK
    Cell Microbiol 14:1600-19. 2012
  4. pmc Burkholderia Hep_Hag autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis
    Rachaneeporn Tiyawisutsri
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    BMC Microbiol 7:19. 2007
  5. pmc Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)
    Roy R Chaudhuri
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK
    BMC Genomics 10:291. 2009
  6. pmc Characterization of IsaA and SceD, two putative lytic transglycosylases of Staphylococcus aureus
    Melanie R Stapleton
    Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, UK
    J Bacteriol 189:7316-25. 2007
  7. ncbi Analysis of the open and closed conformations of the GTP-binding protein YsxC from Bacillus subtilis
    Sergey N Ruzheinikov
    Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    J Mol Biol 339:265-78. 2004
  8. ncbi The Staphylococcus aureus surface protein IsdA mediates resistance to innate defenses of human skin
    Simon R Clarke
    Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Cell Host Microbe 1:199-212. 2007
  9. pmc Iron-regulated surface determinant protein A mediates adhesion of Staphylococcus aureus to human corneocyte envelope proteins
    Simon R Clarke
    Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom
    Infect Immun 77:2408-16. 2009
  10. pmc Catalase (KatA) and alkyl hydroperoxide reductase (AhpC) have compensatory roles in peroxide stress resistance and are required for survival, persistence, and nasal colonization in Staphylococcus aureus
    Kate Cosgrove
    Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom
    J Bacteriol 189:1025-35. 2007

Collaborators

Detail Information

Publications41

  1. pmc The effect of skin fatty acids on Staphylococcus aureus
    Yvonne Neumann
    Department of Molecular Biology and Biotechnology, The Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK
    Arch Microbiol 197:245-67. 2015
    ..In particular, members of the SaeRS regulon had highly reduced expression, and the use of specific mutants revealed that the effect on toxin production is likely mediated via SaeRS. ..
  2. pmc Clonal expansion during Staphylococcus aureus infection dynamics reveals the effect of antibiotic intervention
    Gareth McVicker
    Krebs Institute, University of Sheffield, Western Bank, Sheffield, United Kingdom Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, United Kingdom
    PLoS Pathog 10:e1003959. 2014
    ..Our results have key implications for the design of effective treatment regimes to limit the spread of antimicrobial resistance, where inappropriate usage leading to resistance may reduce the efficacy of life-saving drugs. ..
  3. pmc A privileged intraphagocyte niche is responsible for disseminated infection of Staphylococcus aureus in a zebrafish model
    Tomasz K Prajsnar
    Krebs Institute, University of Sheffield, Western Bank, Sheffield, UK
    Cell Microbiol 14:1600-19. 2012
    ..These findings add credence to the argument that S. aureus control regimes should recognize both the intracellular as well as extracellular facets of the S. aureus life cycle...
  4. pmc Burkholderia Hep_Hag autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis
    Rachaneeporn Tiyawisutsri
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    BMC Microbiol 7:19. 2007
    ..Genomic and epidemiological studies have shown that B. mallei is a recently emerged, host restricted clone of B. pseudomallei...
  5. pmc Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)
    Roy R Chaudhuri
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK
    BMC Genomics 10:291. 2009
    ..An important starting point for the development of new antimicrobial drugs is the identification of "essential" genes that are important for bacterial survival and growth...
  6. pmc Characterization of IsaA and SceD, two putative lytic transglycosylases of Staphylococcus aureus
    Melanie R Stapleton
    Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, UK
    J Bacteriol 189:7316-25. 2007
    ..An isaA sceD mutant is attenuated for virulence, while SceD is essential for nasal colonization in cotton rats, thus demonstrating the importance of cell wall dynamics in host-pathogen interactions...
  7. ncbi Analysis of the open and closed conformations of the GTP-binding protein YsxC from Bacillus subtilis
    Sergey N Ruzheinikov
    Department of Molecular Biology and Biotechnology, Krebs Institute for Biomolecular Research, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    J Mol Biol 339:265-78. 2004
    ....
  8. ncbi The Staphylococcus aureus surface protein IsdA mediates resistance to innate defenses of human skin
    Simon R Clarke
    Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Cell Host Microbe 1:199-212. 2007
    ..A purified human skin fatty acid was effective in treating systemic and topical infections of S. aureus suggesting that our natural defense mechanisms can be exploited to combat drug-resistant pathogens...
  9. pmc Iron-regulated surface determinant protein A mediates adhesion of Staphylococcus aureus to human corneocyte envelope proteins
    Simon R Clarke
    Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom
    Infect Immun 77:2408-16. 2009
    ..The NEAT domain also was found to be required for S. aureus whole-cell binding to the ligands as well as to human nasal cells. Thus, IsdA is an important adhesin to human ligands, which predominate in its primary ecological niche...
  10. pmc Catalase (KatA) and alkyl hydroperoxide reductase (AhpC) have compensatory roles in peroxide stress resistance and are required for survival, persistence, and nasal colonization in Staphylococcus aureus
    Kate Cosgrove
    Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom
    J Bacteriol 189:1025-35. 2007
    ..Thus, oxidative-stress resistance is an important factor in the ability of S. aureus to persist in the hospital environment and so contribute to the spread of human disease...
  11. ncbi IsdA of Staphylococcus aureus is a broad spectrum, iron-regulated adhesin
    Simon R Clarke
    Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK
    Mol Microbiol 51:1509-19. 2004
    ..Thus for S. aureus, iron is an important marker for the host environment, to which the bacterium responds by differential regulation of at least one element of its adhesive strategy...
  12. pmc YsxC, an essential protein in Staphylococcus aureus crucial for ribosome assembly/stability
    Elizabeth L Cooper
    Department of Molecular Biology and Microbiology, University of Sheffield, Sheffield S10 2TN, UK
    BMC Microbiol 9:266. 2009
    ..They are also attractive targets for the development of new antibiotics. YsxC is a member of a family of GTPases highly conserved across eubacteria with a possible ribosome associated function...
  13. doi The iron-regulated surface proteins IsdA, IsdB, and IsdH are not required for heme iron utilization in Staphylococcus aureus
    Alexander F Hurd
    Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, UK
    FEMS Microbiol Lett 329:93-100. 2012
    ..Also using a mouse septic arthritis model of S. aureus systemic disease, no significant difference in bacterial load was observed for the triple mutant, compared with its otherwise isogenic parent...
  14. pmc PheP, a putative amino acid permease of Staphylococcus aureus, contributes to survival in vivo and during starvation
    Malcolm J Horsburgh
    Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom
    Infect Immun 72:3073-6. 2004
    ..A pheP mutation led to poor growth after microaerobic or anaerobic incubation on pig serum agar, which was recovered by phenylalanine addition. Genetic complementation of pheP restored growth and starvation survival...
  15. ncbi Invertebrates as animal models for Staphylococcus aureus pathogenesis: a window into host-pathogen interaction
    Jorge Garcia-Lara
    Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    FEMS Immunol Med Microbiol 43:311-23. 2005
    ..aureus interaction as well as a high throughput method for antimicrobial screening...
  16. pmc Characterization of LytH, a differentiation-associated peptidoglycan hydrolase of Bacillus subtilis involved in endospore cortex maturation
    Gavin J Horsburgh
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, United Kingdom
    J Bacteriol 185:3813-20. 2003
    ..The lack of di- or tripeptides in a lytH mutant reveals the enzyme is an endopeptidase...
  17. pmc Identification of antigenic components of Staphylococcus epidermidis expressed during human infection
    Mohammad R Pourmand
    Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, United Kingdom
    Infect Immun 74:4644-54. 2006
    ..Vaccination of mice with recombinant antigens stimulated an immune response which in vitro opsonized S. epidermidis. In this study we identified prospective candidate antigens for prophylaxis or immunotherapy to control disease...
  18. doi A novel vertebrate model of Staphylococcus aureus infection reveals phagocyte-dependent resistance of zebrafish to non-host specialized pathogens
    Tomasz K Prajsnar
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Western Bank, Sheffield S102TN, UK
    Cell Microbiol 10:2312-25. 2008
    ..Zebrafish are a new addition to the tools available for the study of S. aureus pathogenesis, and may provide insights into the interactions of bacterial and host genomes in determining the outcome of infection...
  19. doi Identification of conserved antigens from staphylococcal and streptococcal pathogens
    Melanie R Stapleton
    The Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, UK
    J Med Microbiol 61:766-79. 2012
    ..aureus and Strep. agalactiae thereby increasing their phagocytic uptake by human neutrophils. The conserved antigenic domains therefore represent potential cross-protective vaccine candidates...
  20. doi Multiple essential roles for EzrA in cell division of Staphylococcus aureus
    Victoria R Steele
    The Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Mol Microbiol 80:542-55. 2011
    ....
  21. pmc Cell wall peptidoglycan architecture in Bacillus subtilis
    Emma J Hayhurst
    Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, United Kingdom
    Proc Natl Acad Sci U S A 105:14603-8. 2008
    ..We propose a coiled-coil model for peptidoglycan architecture encompassing our data and recent evidence concerning the biosynthetic machinery for this essential polymer...
  22. ncbi Role of the hprT-ftsH locus in Staphylococcus aureus
    James K Lithgow
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK
    Microbiology 150:373-81. 2004
    ..Both hprT-lacZ and ftsH-lacZ gene fusions are expressed maximally in the post-exponential phase of growth. Although secretion of exoproteins is not affected, an ftsH mutant is attenuated in a murine skin lesion model of pathogenicity...
  23. pmc Cell wall elongation mode in Gram-negative bacteria is determined by peptidoglycan architecture
    Robert D Turner
    Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK
    Nat Commun 4:1496. 2013
    ..We present a consolidated model of growth via architecture-regulated insertion, where we propose only the more porous regions of the peptidoglycan network that are permissive for synthesis...
  24. ncbi The role and regulation of the extracellular proteases of Staphylococcus aureus
    Lindsey Shaw
    Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Microbiology 150:217-28. 2004
    ..It is likely the attenuation observed in the sspA strain is due to polarity on the sspB gene...
  25. ncbi Drosophila melanogaster as a model host for Staphylococcus aureus infection
    Andrew J Needham
    Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Microbiology 150:2347-55. 2004
    ..The disease model also allowed the effect of antibiotic treatment on the flies to be determined. D. melanogaster is a genetically tractable model host for high-throughput analysis of S. aureus virulence determinants...
  26. pmc IsdA protects Staphylococcus aureus against the bactericidal protease activity of apolactoferrin
    Simon R Clarke
    Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, United Kingdom
    Infect Immun 76:1518-26. 2008
    ..Recombinant IsdA was a competitive inhibitor of lactoferrin protease activity. Reciprocally, antibody reactive to IsdA enhanced killing of S. aureus. Thus, IsdA can protect S. aureus against lactoferrin and acts as a protease inhibitor...
  27. pmc Zebrafish as a novel vertebrate model to dissect enterococcal pathogenesis
    Tomasz K Prajsnar
    Krebs Institute, University of Sheffield, Sheffield, United Kingdom
    Infect Immun 81:4271-9. 2013
    ..Our results reveal that the zebrafish is a novel, powerful model for studying E. faecalis pathogenesis, enabling us to dissect the mechanism of enterococcal virulence. ..
  28. ncbi Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage
    Simon R Clarke
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom
    J Infect Dis 193:1098-108. 2006
    ..aureus to human desquamated nasal epithelial cells and is required for nasal colonization in the cotton rat model. Thus, vaccination with these antigens may prevent S. aureus carriage and reduce the prevalence of human disease...
  29. doi Super-resolution microscopy reveals cell wall dynamics and peptidoglycan architecture in ovococcal bacteria
    Richard Wheeler
    Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Mol Microbiol 82:1096-109. 2011
    ..The ovococci have a unique peptidoglycan architecture and growth mode not observed in other model organisms...
  30. ncbi Surface adhesins of Staphylococcus aureus
    Simon R Clarke
    Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK
    Adv Microb Physiol 51:187-224. 2006
    ..Here, we describe the current knowledge of the molecular features of the adhesive components of S. aureus, mechanisms of adhesion and the impact that these have on host-pathogen interaction...
  31. ncbi Staphylococcus aureus: the search for novel targets
    Jorge Garcia-Lara
    Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, UK, S10 2TN
    Drug Discov Today 10:643-51. 2005
    ..Several promising cellular targets are now being developed in the quest to control such a life-threatening pathogen...
  32. doi Peptidoglycan architecture can specify division planes in Staphylococcus aureus
    Robert D Turner
    Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Nat Commun 1:26. 2010
    ..We propose that this epigenetic information is used to enable S. aureus to divide in sequentially orthogonal planes, explaining how a spherical organism can maintain division plane localization with fidelity over many generations...
  33. ncbi LytG of Bacillus subtilis is a novel peptidoglycan hydrolase: the major active glucosaminidase
    Gavin J Horsburgh
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, S10 2TN, United Kingdom
    Biochemistry 42:257-64. 2003
    ..Despite sequence homology suggesting muramidase activity, LytG is a novel glucosaminidase with exoenzyme activity and may form part of a novel family of autolysins. It is involved in cell division, lysis, and motility on swarm plates...
  34. ncbi Role and regulation of the superoxide dismutases of Staphylococcus aureus
    Michail H Karavolos
    Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Microbiology 149:2749-58. 2003
    ..In a mouse abscess model of infection, isogenic sodA, sodM and sodA sodM mutants had reduced virulence compared to the parental strain, showing the importance of the enzymic scavenging system for the survival of the pathogen...
  35. pmc Role of a cysteine synthase in Staphylococcus aureus
    James K Lithgow
    Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    J Bacteriol 186:1579-90. 2004
    ..aureus to recover from starvation in amino acid- or phosphate-limiting conditions, indicating a role for cysteine in the S. aureus stress response and survival mechanisms...
  36. pmc Staphylococcus aureus induces eosinophil cell death mediated by α-hemolysin
    Lynne R Prince
    Department of Infection and Immunity, University of Sheffield, Sheffield, United Kingdom
    PLoS ONE 7:e31506. 2012
    ..We conclude that S. aureus Hla induces aberrant eosinophil cell death in vitro and that this may increase tissue injury in allergic disease...
  37. doi Desiccation tolerance in Staphylococcus aureus
    Plykaeow Chaibenjawong
    Department of Molecular Biology and Biotechnology, Krebs Institute, University of Sheffield, Sheffield S10 2TN, UK
    Arch Microbiol 193:125-35. 2011
    ..Understanding the molecular mechanisms that govern desiccation tolerance may determine the break points to be exploited to prevent the spread of this dangerous pathogen in hospitals and communities...
  38. ncbi Expression, purification, crystallization and preliminary crystallographic analysis of a putative GTP-binding protein, YsxC, from Bacillus subtilis
    Sanjan K Das
    The Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, England
    Acta Crystallogr D Biol Crystallogr 60:166-8. 2004
    ..Both crystal forms diffract to beyond 2.0 A resolution and are suitable for structure determination...
  39. pmc Analysis of Ebh, a 1.1-megadalton cell wall-associated fibronectin-binding protein of Staphylococcus aureus
    Simon R Clarke
    Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, United Kingdom
    Infect Immun 70:6680-7. 2002
    ..aureus infections were found to contain anti-Ebh antibodies. Localization studies revealed Ebh to be cell envelope associated and is proposed to form a specialized surface structure involved in cellular adhesion...
  40. pmc Different walls for rods and balls: the diversity of peptidoglycan
    Robert D Turner
    The Krebs Institute, Department of Molecular Biology and Biotechnology, Firth Court, Western Bank, The University of Sheffield, Sheffield, S10 2TN, UK
    Mol Microbiol 91:862-74. 2014
    ....
  41. doi A ruthenium(II) polypyridyl complex for direct imaging of DNA structure in living cells
    Martin R Gill
    Department of Chemistry, University of Sheffield, Sheffield, UK
    Nat Chem 1:662-7. 2009
    ....