Genomes and Genes
David M Flavell
Affiliation: University College London
- Peroxisome proliferator-activated receptor alpha gene variants influence progression of coronary atherosclerosis and risk of coronary artery diseaseDavid M Flavell
Centre for Cardiovascular Genetics, Department of Medicine, Royal Free and University College of London Medical School, London, UK
Circulation 105:1440-5. 2002..Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates the expression of genes involved in lipid metabolism and inflammation, making it a candidate gene for atherosclerosis and ischemic heart disease (IHD)...
- Peroxisome proliferator-activated receptor alpha gene variation influences age of onset and progression of type 2 diabetesDavid M Flavell
Centre for Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, London, UK
Diabetes 54:582-6. 2005..4 +/- 1.5 and AC + CC 5.3 +/- 1.1 years, P = 0.002). These data indicate that PPARalpha gene variation influences the onset and progression of type 2 diabetes...
- A novel functional polymorphism in the PECAM-1 gene (53G>A) is associated with progression of atherosclerosis in the LOCAT and REGRESS studiesMohamed A Elrayess
The Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College Medical School, University College London, Rayne Building, 5 University Street, UK
Atherosclerosis 168:131-8. 2003..These data demonstrate that the PECAM-1 gene is responsive to shear stress in vitro and that decreased PECAM-1 gene expression in 53A carriers may influence reduced progression of vessel stenosis in patients with coronary artery disease...
- The lipoprotein lipase gene serine 447 stop variant influences hypertension-induced left ventricular hypertrophy and risk of coronary heart diseasePhilippa J Talmud
Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, The Rayne Building, Department of Medicine, Royal Free and University College Medical School, London, UK
Clin Sci (Lond) 112:617-24. 2007..007). In conclusion, hypertensive LPL X447 carriers have increased risk of LVH and CHD, suggesting that altered FA delivery constitutes a mechanism through which LVH and CHD are associated in hypertensive subjects...
- Progression of atherosclerosis is associated with variation in the alpha1-antitrypsin genePhilippa J Talmud
Centre for Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Rayne Building, Royal Free and University College Medical School, 5 University St, London WC1E 6JF, UK
Arterioscler Thromb Vasc Biol 23:644-9. 2003..Alpha1-Antitrypsin (AAT) protects elastic tissue and may play a role in atherogenesis. The association of atherosclerosis progression with common AAT variants was considered in 2 clinical trials...
- Variation in the lipoprotein lipase gene influences exercise-induced left ventricular growthDavid M Flavell
Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, University College London, London, UK
J Mol Med (Berl) 84:126-31. 2006..Change in blood pressure accounted for a proportion of LV growth. These data suggest that increased myocardial FA availability may reduce exercise-induced LV growth...
- Peroxisome proliferator--activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertensionYalda Jamshidi
Centre for Cardiovascular Genetics, Department of Medicine, University College London Medical School, London, UK
Circulation 105:950-5. 2002....
- Lipoprotein-associated phospholipase A2 A379V variant is associated with body composition changes in response to exercise trainingPeter T E Wootton
Centre for Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Rayne Building, Royal Free and University College London Medical School, 5 University Street, London WC1E 6JF, UK
Nutr Metab Cardiovasc Dis 17:24-31. 2007..51+/-1.17%) in percentage lean mass, compared to AV (1.64+/-0.38%) and AA (1.10+/-0.24%) recruits (p=0.02). The association of this genotype with changes in body composition after training suggests a novel role for Lp-PLA2...
- Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study IIWendy Putt
Division of Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, London, UK
Hum Mol Genet 13:1587-97. 2004..0002) on AUC TG and APOC3 -482C>T on plasma apoE levels (P=0.0012). Thus, in these healthy young men, variation in USF1 was the influencing feature of both glucose and lipid homeostasis showing case-control heterogeneity...
- IP receptor-dependent activation of PPARgamma by stable prostacyclin analoguesEmilia Falcetti
BHF Laboratories, Department of Medicine, Rayne Building, University College London, London WC1E 6JF, UK
Biochem Biophys Res Commun 360:821-7. 2007..We conclude that PPARgamma is activated through the IP receptor via a cyclic AMP-independent mechanism and contributes to the anti-growth effects of prostacyclin analogues...
- Response to micronized fenofibrate treatment is associated with the peroxisome-proliferator-activated receptors alpha G/C intron7 polymorphism in subjects with type 2 diabetesChristelle Foucher
Laboratoires Fournier S A Centre de Recherches, Department of Clinical Research and Medical Affairs, Daix, France
Pharmacogenetics 14:823-9. 2004....
- Identification of the PPARA locus on chromosome 22q13.3 as a modifier gene in familial combined hyperlipidemiaPetra M H Eurlings
Department of Internal Medicine, Laboratory of Molecular Metabolism and Endocrinology, Cardiovascular Research Institute Maastricht, University of Maastricht, PO Box 616, Maastricht, NL 6200 MD, The Netherlands
Mol Genet Metab 77:274-81. 2002..98%) compared to that in spouses (4.84%). These results clearly demonstrate the genetically complex nature of FCHL and identify the PPARA gene as a modifier of the FCHL phenotype...
- Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weightAlex Doney
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, United Kingdom
BMC Genet 3:21. 2002..Both rare alleles are in linkage disequilibrium and the independent associations of these two polymorphisms have not been addressed...
- Characterization of the human PPARalpha promoter: identification of a functional nuclear receptor response elementInes Pineda Torra
U 545 Institut National de la Santé et de la Recherche Médicale, Departement d Atherosclerose, Institut Pasteur de Lille, 59019 Lille, France
Mol Endocrinol 16:1013-28. 2002..Furthermore, these data demonstrate that the hPPARalpha gene is regulated by nuclear receptors, such as HNF-4, COUP-TFII, and PPARalpha...
- PPARalpha gene variation and physical performance in Russian athletesIldus I Ahmetov
Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, 2 Dynamo Street, 197110, St Petersburg, Russia
Eur J Appl Physiol 97:103-8. 2006..In conclusion, PPARalpha intron 7 G/C polymorphism was associated with physical performance in Russian athletes, and this may be explained, in part, by the association between PPARalpha genotype and muscle fiber type composition...