Rebecca Fitzgerald

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Familial gastric cancer - clinical management
    Rebecca C Fitzgerald
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Best Pract Res Clin Gastroenterol 20:735-43. 2006
  2. pmc Acceptability and accuracy of a non-endoscopic screening test for Barrett's oesophagus in primary care: cohort study
    Sudarshan R Kadri
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge CB2 2XZ
    BMJ 341:c4372. 2010
  3. pmc Early diagnosis of oesophageal cancer
    E L Bird-Lieberman
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Br J Cancer 101:1-6. 2009
  4. pmc Gastro-esophageal reflux disease symptoms and demographic factors as a pre-screening tool for Barrett's esophagus
    Xinxue Liu
    MRC Cancer Unit, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 9:e94163. 2014
  5. doi request reprint Biomarkers in Barrett's oesophagus and oesophageal adenocarcinoma
    Anna L Paterson
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK 44 1223 763287 44 1223 763296
    Expert Opin Med Diagn 1:363-76. 2007
  6. doi request reprint Dissecting out the genetic origins of Barrett's oesophagus
    Rebecca C Fitzgerald
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, UK
    Gut 57:1033-4. 2008
  7. ncbi request reprint Barrett metaplasia: reassessment of treatment and follow-up
    R C Fitzgerald
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Curr Opin Oncol 16:372-7. 2004
  8. pmc Molecular basis of Barrett's oesophagus and oesophageal adenocarcinoma
    R C Fitzgerald
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
    Gut 55:1810-20. 2006
  9. pmc Barrett's oesophagus and oesophageal adenocarcinoma: how does acid interfere with cell proliferation and differentiation?
    R C Fitzgerald
    Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge CB2 2XZ, UK
    Gut 54:i21-6. 2005
  10. ncbi request reprint Genetics and prevention of oesophageal adenocarcinoma
    Rebecca C Fitzgerald
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, CB2 2XZ, UK
    Recent Results Cancer Res 166:35-46. 2005

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Familial gastric cancer - clinical management
    Rebecca C Fitzgerald
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Best Pract Res Clin Gastroenterol 20:735-43. 2006
    ..It is essential that experience of these rare families is pooled so that surveillance and treatment can be optimised in the future...
  2. pmc Acceptability and accuracy of a non-endoscopic screening test for Barrett's oesophagus in primary care: cohort study
    Sudarshan R Kadri
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge CB2 2XZ
    BMJ 341:c4372. 2010
    ..To determine the accuracy and acceptability to patients of non-endoscopic screening for Barrett's oesophagus, using an ingestible oesophageal sampling device (Cytosponge) coupled with immunocytochemisty for trefoil factor 3...
  3. pmc Early diagnosis of oesophageal cancer
    E L Bird-Lieberman
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Br J Cancer 101:1-6. 2009
    ..Understanding the pathogenesis of these cancers is vital to guide early diagnostic strategies...
  4. pmc Gastro-esophageal reflux disease symptoms and demographic factors as a pre-screening tool for Barrett's esophagus
    Xinxue Liu
    MRC Cancer Unit, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 9:e94163. 2014
    ..The current "gold-standard" for diagnosing BE is endoscopy which remains prohibitively expensive and impractical as a population screening tool. We aimed to develop a pre-screening tool to aid decision making for diagnostic referrals...
  5. doi request reprint Biomarkers in Barrett's oesophagus and oesophageal adenocarcinoma
    Anna L Paterson
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK 44 1223 763287 44 1223 763296
    Expert Opin Med Diagn 1:363-76. 2007
    ..This review aims to explore the potential roles of biomarkers in Barrett's oesophagus and oesophageal adenocarcinoma, focusing on the most extensively studied candidates and future novel developments...
  6. doi request reprint Dissecting out the genetic origins of Barrett's oesophagus
    Rebecca C Fitzgerald
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, UK
    Gut 57:1033-4. 2008
  7. ncbi request reprint Barrett metaplasia: reassessment of treatment and follow-up
    R C Fitzgerald
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Curr Opin Oncol 16:372-7. 2004
    ..However, adenocarcinoma will not develop in most patients with Barrett's esophagus. This review summarizes the data on the management of Barrett's esophagus that have been published since January 2003...
  8. pmc Molecular basis of Barrett's oesophagus and oesophageal adenocarcinoma
    R C Fitzgerald
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
    Gut 55:1810-20. 2006
  9. pmc Barrett's oesophagus and oesophageal adenocarcinoma: how does acid interfere with cell proliferation and differentiation?
    R C Fitzgerald
    Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge CB2 2XZ, UK
    Gut 54:i21-6. 2005
    ..The other factors important in the aetiology of Barrett's oesophagus are poorly understood but probably include both genetic and environmental factors...
  10. ncbi request reprint Genetics and prevention of oesophageal adenocarcinoma
    Rebecca C Fitzgerald
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, CB2 2XZ, UK
    Recent Results Cancer Res 166:35-46. 2005
    ..Given the epidemic increase in oesophageal adenocarcinoma and the dismal 5-year mortality rate, a radical approach is necessary to prevent cancer development in individuals with pre-malignant lesions...
  11. pmc Clinical implications of E-cadherin associated hereditary diffuse gastric cancer
    R C Fitzgerald
    Hutchison MRC Research Centre, Cambridge, UK
    Gut 53:775-8. 2004
    ..This subset of gastric cancer has been termed hereditary diffuse gastric cancer (HDGC)...
  12. ncbi request reprint E-cadherin mutations and hereditary gastric cancer: prevention by resection?
    R C Fitzgerald
    Hutchison MRC Research Centre, Cambridge, UK
    Dig Dis 20:23-31. 2002
    ..There are many issues to be considered in order to determine whether prophylactic gastrectomy is the optimal management strategy for these patients...
  13. pmc Diversity in the oesophageal phenotypic response to gastro-oesophageal reflux: immunological determinants
    R C Fitzgerald
    Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
    Gut 50:451-9. 2002
    ..We investigated whether the inflammatory cell infiltrate and cytokine profiles of these clinical phenotypes merely vary in severity or are fundamentally different...
  14. pmc Inflammatory gradient in Barrett's oesophagus: implications for disease complications
    R C Fitzgerald
    Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, and Havering Hospitals NHS Trust, Romford, Essex, UK
    Gut 51:316-22. 2002
    ..We then investigated whether the inflammatory gradient is related to the distribution of metaplastic cell subtypes, epithelial exposure to the components of refluxate, or squamocolumnar cell interactions...
  15. ncbi request reprint National clinician scientist posts
    Rebecca Fitzgerald
    Hutchison Medical Research Council Research Centre, Addenbrooke s Hospital, Cambridge
    BMJ 325:S101. 2002
  16. doi request reprint Cellular mechanisms of Barrett's esophagus development
    Mariagnese Barbera
    Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK
    Surg Oncol Clin N Am 18:393-410. 2009
    ..The dramatic increase of esophageal adenocarcinoma incidence in the western world over the last two decades justifies the strong interest in BE and its development with the aim to improve preventative and therapeutic clinical strategies...
  17. ncbi request reprint In vitro acid exposure has a differential effect on apoptotic and proliferative pathways in a Barrett's adenocarcinoma cell line
    Claire Morgan
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
    Am J Gastroenterol 99:218-24. 2004
    ..The mechanisms underlying the hyperproliferative response are not well elucidated but may include alterations in Na(+)-H+ exchanger activity and MAPK signaling pathways...
  18. pmc Clinical puzzle: Barrett's oesophagus
    Massimiliano Di Pietro
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB20XZ, UK
    Dis Model Mech 1:26-31. 2008
    ..However, a number of in vitro model systems are ripe for further development into more physiologically complete systems...
  19. ncbi request reprint Cyclin A immunocytology as a risk stratification tool for Barrett's esophagus surveillance
    Pierre Lao-Sirieix
    Medical Research Council Cancer Cell Unit, Medical Research Council Hutchison Research Centre, Hills Road, Cambridge, UK
    Clin Cancer Res 13:659-65. 2007
    ..We hypothesized that cyclin A, which detects a proportion of proliferating cells, would be more specific. Because cytologic sampling has clinical advantages, we also evaluated the efficacy of cyclin A in endoscopic brushing samples...
  20. ncbi request reprint Surface expression of minichromosome maintenance proteins provides a novel method for detecting patients at risk for developing adenocarcinoma in Barrett's esophagus
    Pierre S Sirieix
    Medical Research Council Cancer Cell Unit, Hutchison Medical Research Council Research Centre, Cambridge CB2 2XZ, United Kingdom
    Clin Cancer Res 9:2560-6. 2003
    ....
  21. pmc Cell cycle phase abnormalities do not account for disordered proliferation in Barrett's carcinogenesis
    Pierre Lao-Sirieix
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
    Neoplasia 6:751-60. 2004
    ..Hence, the increased proliferation seen in Barrett's carcinogenesis is due to abnormal cell cycle entry or exit, rather than a primary abnormality within the cell cycle...
  22. pmc Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research
    Rebecca C Fitzgerald
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, UK
    J Med Genet 47:436-44. 2010
    ..Expert histopathological confirmation of these early lesions is recommended...
  23. doi request reprint Barrett's oesophagus: an ideal model to study cancer genetics
    Massimiliano Di Pietro
    Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Hum Genet 126:233-46. 2009
    ..Here, we review the knowledge acquired so far on the genetic and molecular alterations along the oesophageal metaplasia-dysplasia-carcinoma sequence...
  24. doi request reprint Barrett's esophagus
    Elizabeth L Bird-Lieberman
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK
    Gastroenterol Clin North Am 37:921-42, x. 2008
    ..In association with these advances in risk stratification, progress is being made in the endoscopic treatment of Barrett's. Chemoprevention is also an area of interest and trials are underway...
  25. doi request reprint Cellular origin of Barrett's metaplasia and oesophageal stem cells
    Mariagnese Barbera
    Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    Biochem Soc Trans 38:370-3. 2010
    ..Locating stem cells in human squamous oesophagus could have important implications for our understanding of Barrett's oesophagus and remarkably improve our future strategies for its prevention...
  26. doi request reprint Nitric oxide-mediated invasion in Barrett's high-grade dysplasia and adenocarcinoma
    Nicholas J Clemons
    Medical Research Council Cancer Cell Unit, Hutchison Medical Research Council Centre, Hills Road, Cambridge, CB2 0XZ, UK
    Carcinogenesis 31:1669-75. 2010
    ..Thus, NO may play a role in Barrett's carcinogenesis through deregulating MMP and TIMP expression to enhance invasive potential...
  27. ncbi request reprint The pathogenesis of Barrett's esophagus
    Rebecca C Fitzgerald
    Cancer Cell Unit, Hutchison MRC Research Centre Cambridge CB2 2XZ, UK
    Gastrointest Endosc Clin N Am 13:233-55. 2003
    ..With the advent of the genomic era and an explosion in studies in BE, significant progress can be made...
  28. ncbi request reprint Complex diseases in gastroenterology and hepatology: GERD, Barrett's, and esophageal adenocarcinoma
    Rebecca C Fitzgerald
    Medical Research Council Cancer Cell Unit, Hutchinson MRC Research Center, Cambridge, United Kingdom
    Clin Gastroenterol Hepatol 3:529-37. 2005
    ..At the current time, genetics does not influence routine clinical management of patients with gastroesophageal reflux disease, Barrett's esophagus, or esophageal adenocarcinoma...
  29. ncbi request reprint In vivo and in vitro evidence for transforming growth factor-beta1-mediated epithelial to mesenchymal transition in esophageal adenocarcinoma
    Jonathan R E Rees
    Medical Research Council Cancer Cell Unit, Hutchison Medical Research Council Research Centre, Hills Road, Cambridge CB2 2XZ, United Kingdom
    Cancer Res 66:9583-90. 2006
    ..These functional changes were reversed by BMP7 and SMAD4 RNA interference in vitro. These data suggest that TGF-beta1-mediated EMT may be relevant in esophageal carcinogenesis...
  30. doi request reprint Randomized crossover study comparing efficacy of transnasal endoscopy with that of standard endoscopy to detect Barrett's esophagus
    M Kareem Shariff
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, United Kingdom
    Gastrointest Endosc 75:954-61. 2012
    ..Unsedated transnasal endoscopy (TNE) may be safer and less expensive than standard endoscopy (SE) for detecting Barrett's esophagus (BE). Emerging technologies require robust evaluation before routine use...
  31. pmc Selective loss of TGFbeta Smad-dependent signalling prevents cell cycle arrest and promotes invasion in oesophageal adenocarcinoma cell lines
    Benjamin A Onwuegbusi
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, United Kingdom
    PLoS ONE 2:e177. 2007
    ..However, TGFbeta can promote PAI and uPA expression and invasion through MAPK pathways. These data would support a dual role for TGFbeta in oesophageal adenocarcinoma...
  32. ncbi request reprint Effect of inflammation on cyclooxygenase (COX)-2 expression in benign and malignant oesophageal cells
    Salem I Abdalla
    Cancer Cell Unit, Hutchison, MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK
    Carcinogenesis 26:1627-33. 2005
    ..In addition, there was no correlation between COX-2 and CD45 in AC. COX-2 protein expression in the oesophagus appears to be independent of the degree of inflammation...
  33. ncbi request reprint Effect of acid suppression on molecular predictors for esophageal cancer
    Pierre Lao-Sirieix
    Medical Research Council Cancer Cell Unit, Hutchison Medical Research Council Research Centre, Hills Road, Cambridge CB2 2XZ, United Kingdom
    Cancer Epidemiol Biomarkers Prev 15:288-93. 2006
    ..Aim: To study the differential effect of complete compared with incomplete acid suppression on proliferation, apoptosis, and COX-2. Patients and..
  34. ncbi request reprint Nitric oxide and acid induce double-strand DNA breaks in Barrett's esophagus carcinogenesis via distinct mechanisms
    Nicholas J Clemons
    MRC Cancer Cell Unit, Hutchison MRC Centre, Cambridge, United Kingdom
    Gastroenterology 133:1198-209. 2007
    ..The luminal microenvironment including acid and nitric oxide (NO) has been implicated in Barrett's esophagus carcinogenesis. We investigated the ability of acid and NO to induce DNA damage in esophageal cells...
  35. pmc Retinoic acid-induced glandular differentiation of the oesophagus
    Chih Long Chang
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, UK
    Gut 56:906-17. 2007
    ..The bile acid lithocholic acid (LCA) competes for the retinoid X receptor retinoid binding site. Hence, RA pathways may be implicated in Barrett's oesophagus...
  36. doi request reprint Genetic predisposition to gastro-oesophageal cancer
    Pierre Lao-Sirieix
    Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Curr Opin Genet Dev 20:210-7. 2010
    ....
  37. doi request reprint Role of the micro-environment in Barrett's carcinogenesis
    Pierre Lao-Sirieix
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    Biochem Soc Trans 38:327-30. 2010
    ..As sequelae to this, it is possible that the niches created by the micro-environment may influence genetic epithelial diversity observed within the Barrett's oesophagus segment...
  38. ncbi request reprint Gastrin-induced cyclooxygenase-2 expression in Barrett's carcinogenesis
    Salem I Abdalla
    Cancer Cell Unit Hutchison MRC Research Centre, Cambridge, United Kingdom
    Clin Cancer Res 10:4784-92. 2004
    ..The evidence for increased COX-2 in the malignant progression of Barrett's esophagus is contradictory. We hypothesize that COX-2 expression may be causally affected by the gastrin status via the cholecystokinin 2 (CCK(2)) receptor...
  39. ncbi request reprint Epidemiologic risk factors for Barrett's esophagus and associated adenocarcinoma
    Angela Wong
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge CB2 2XZ, UK
    Clin Gastroenterol Hepatol 3:1-10. 2005
    ..An understanding of the factors that predispose to the development and progression of Barrett's esophagus is crucial to the implementation of effective screening and prevention programs...
  40. pmc Testing the utility of an integrated analysis of copy number and transcriptomics datasets for inferring gene regulatory relationships
    Xin Yi Goh
    Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, United Kingdom
    PLoS ONE 8:e63780. 2013
    ..Three additional predicted ERBB2 regulated interactions were confirmed, as well as interactions regulated by ARPC1A and FANCG. Overall, two thirds of experimentally tested predictions were confirmed...
  41. ncbi request reprint Familial gastric cancer - aetiology and pathogenesis
    Miriam Barber
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Best Pract Res Clin Gastroenterol 20:721-34. 2006
    ..It is hoped that understanding the genetic basis for familial gastric cancer will facilitate the development of clinically useful screening and preventative procedures...
  42. pmc Biomarkers in Barrett's esophagus and esophageal adenocarcinoma: predictors of progression and prognosis
    Chin Ann J Ong
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Box 197 Hills Road, Cambridge, CB20XZ, United Kingdom
    World J Gastroenterol 16:5669-81. 2010
    ..This review aims to highlight the most promising predictive and prognostic biomarkers in Barrett's esophagus and EA and to discuss what is required to move the field forward towards clinical application...
  43. ncbi request reprint Gastrin-induced hyperproliferation in Barrett's esophagus
    Rebecca C Fitzgerald
    Gastroenterology 125:1921; author reply 1921-2. 2003
  44. pmc Non-endoscopic immunocytological screening test for Barrett's oesophagus
    Pierre Lao-Sirieix
    Gut 56:1033-4. 2007
  45. ncbi request reprint Short segment columnar-lined oesophagus: an underestimated cancer risk? A large cohort study of the relationship between Barrett's columnar-lined oesophagus segment length and adenocarcinoma risk
    Piers A C Gatenby
    Department of Surgery, UK National Barrett s Oesophagus Registry, Royal Free and University College Medical School London, UK
    Eur J Gastroenterol Hepatol 19:969-75. 2007
    ..This study establishes adenocarcinoma risk in CLO by segment length...
  46. ncbi request reprint Significance of acid exposure in Barrett's esophagus
    Rebecca C Fitzgerald
    Am J Gastroenterol 98:699-700. 2003