A K Fielding

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study
    Adele K Fielding
    Royal Free and University College London Medical School, and Christie Hospital National Health Service Trust, Manchester, UK
    Blood 109:944-50. 2007
  2. doi How I treat Philadelphia chromosome-positive acute lymphoblastic leukemia
    Adele K Fielding
    University College London, Royal Free Campus, Rowland Hill Street, London, United Kingdom
    Blood 116:3409-17. 2010
  3. doi The treatment of adults with acute lymphoblastic leukemia
    Adele K Fielding
    Royal Free and University College Medical School, London, UK
    Hematology Am Soc Hematol Educ Program . 2008
  4. pmc Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era: results from the International ALL T
    Adele K Fielding
    University College London, London, United Kingdom
    Blood 113:4489-96. 2009
  5. ncbi Allogeneic haematopoietic stem cell transplant in Philadelphia-positive acute lymphoblastic leukaemia
    A K Fielding
    1Department of Haematology, Royal Free and University College Medical School, London, UK
    Bone Marrow Transplant 41:447-53. 2008
  6. doi Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia
    A K Fielding
    University College London, London, UK
    Curr Hematol Malig Rep 8:98-108. 2013
  7. ncbi Measles as a potential oncolytic virus
    Adele K Fielding
    Department of Haematology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Rev Med Virol 15:135-42. 2005
  8. doi Antigen receptor gene rearrangements reflect on the heterogeneity of adult Acute Lymphoblastic Leukaemia (ALL) with implications of cell-origin of ALL subgroups - a UKALLXII study
    Lena Rai
    Haematology Department, Royal Free Hospital, Pond Street, London, NW3 2QG, UK
    Br J Haematol 148:394-401. 2010
  9. ncbi High incidence of avascular necrosis in adolescents with acute lymphoblastic leukaemia: a UKALL XII analysis
    B Patel
    Department of Haematology, Royal Free and University College Medical School, London, UK
    Leukemia 22:308-12. 2008
  10. doi HLA-mismatched unrelated donors are a viable alternate graft source for allogeneic transplantation following alemtuzumab-based reduced-intensity conditioning
    Adam J Mead
    Department of Haematology, University College London UCL Medical School, London, United Kingdom
    Blood 115:5147-53. 2010

Detail Information

Publications16

  1. ncbi Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study
    Adele K Fielding
    Royal Free and University College London Medical School, and Christie Hospital National Health Service Trust, Manchester, UK
    Blood 109:944-50. 2007
    ..Prevention of recurrence is the best strategy for long-term survival in this disease...
  2. doi How I treat Philadelphia chromosome-positive acute lymphoblastic leukemia
    Adele K Fielding
    University College London, Royal Free Campus, Rowland Hill Street, London, United Kingdom
    Blood 116:3409-17. 2010
    ..My strongest recommendation is that all physicians who are treating this rare disease actively seek appropriate clinical trials for their patients wherever possible...
  3. doi The treatment of adults with acute lymphoblastic leukemia
    Adele K Fielding
    Royal Free and University College Medical School, London, UK
    Hematology Am Soc Hematol Educ Program . 2008
    ..In particular, the controversial subject of whether the superior outcome seen in younger patients is predicated on disease biology or therapeutic strategy is examined closely. Promising approaches under development are also discussed...
  4. pmc Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era: results from the International ALL T
    Adele K Fielding
    University College London, London, United Kingdom
    Blood 113:4489-96. 2009
    ..This prospective trial in adult Ph(+) ALL indicates a modest but significant benefit to alloHSCT. This trial has been registered with clinicaltrials.gov under identifier NCT00002514 and as ISRCTN77346223...
  5. ncbi Allogeneic haematopoietic stem cell transplant in Philadelphia-positive acute lymphoblastic leukaemia
    A K Fielding
    1Department of Haematology, Royal Free and University College Medical School, London, UK
    Bone Marrow Transplant 41:447-53. 2008
    ..We explore the burgeoning literature on the role of tyrosine kinase inhibitors in this disease and summarize their impact on the transplant practice...
  6. doi Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia
    A K Fielding
    University College London, London, UK
    Curr Hematol Malig Rep 8:98-108. 2013
    ....
  7. ncbi Measles as a potential oncolytic virus
    Adele K Fielding
    Department of Haematology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Rev Med Virol 15:135-42. 2005
    ....
  8. doi Antigen receptor gene rearrangements reflect on the heterogeneity of adult Acute Lymphoblastic Leukaemia (ALL) with implications of cell-origin of ALL subgroups - a UKALLXII study
    Lena Rai
    Haematology Department, Royal Free Hospital, Pond Street, London, NW3 2QG, UK
    Br J Haematol 148:394-401. 2010
    ..0% at 4 years without, P = 0.05). The heterogeneity in clinical outcome is suggested by the basic molecular processes of antigen receptor gene rearrangements as shown in this work...
  9. ncbi High incidence of avascular necrosis in adolescents with acute lymphoblastic leukaemia: a UKALL XII analysis
    B Patel
    Department of Haematology, Royal Free and University College Medical School, London, UK
    Leukemia 22:308-12. 2008
    ..00005). The actuarial incidence of AVN was 29% at 10 years in patients <20 years old compared to 8% at 10 years in those >20 years old; P=0.0004; odds ratio 0.28 (95% CI=0.14-0.56)...
  10. doi HLA-mismatched unrelated donors are a viable alternate graft source for allogeneic transplantation following alemtuzumab-based reduced-intensity conditioning
    Adam J Mead
    Department of Haematology, University College London UCL Medical School, London, United Kingdom
    Blood 115:5147-53. 2010
    ..44). Mismatch occurred at the antigenic level in 40 cases. The outcome in these cases did not differ significantly from the rest of the cohort. We conclude that RIT using HLA-mismatched grafts is a viable option using FMC conditioning...
  11. doi Prognostic role of PET scanning before and after reduced-intensity allogeneic stem cell transplantation for lymphoma
    Jonathan R Lambert
    Department of Haematology, University College London Cancer Institute, London, UK
    Blood 115:2763-8. 2010
    ....
  12. ncbi In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/
    Anthony H Goldstone
    North London Cancer Network, University College London Hospitals, London, United Kingdom
    Blood 111:1827-33. 2008
    ..There is no evidence that a single autologous transplantation can replace consolidation/maintenance in any risk group. This study is registered at http://clinicaltrials.gov as NCT00002514...
  13. ncbi Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial
    Anthony V Moorman
    Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, UK
    Blood 109:3189-97. 2007
    ....
  14. ncbi Neutrophils contribute to the measles virus-induced antitumor effect: enhancement by granulocyte macrophage colony-stimulating factor expression
    Deanna Grote
    Molecular Medicine Program, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Res 63:6463-8. 2003
    ..The magnitude of the neutrophil response correlated well with tumor regression. Our studies suggest that therapy with replicating MV stimulates a strong neutrophil antitumor response, which can be cytokine-enhanced to improve oncolysis...
  15. ncbi An oncolytic measles virus engineered to enter cells through the CD20 antigen
    Amanda D Bucheit
    Mayo Clinic Molecular Medicine Program, 200 First Street SW, Rochester, Minnesota 55902, USA
    Mol Ther 7:62-72. 2003
    ....
  16. pmc Strength of envelope protein interaction modulates cytopathicity of measles virus
    Richard K Plemper
    Molecular Medicine Program, Mayo Foundation, Rochester, Minnesota 55905, USA
    J Virol 76:5051-61. 2002
    ..Similar analyses of glycoproteins derived from MV strains with reduced cytopathicities confirm that the strength of H and F glycoprotein interaction is a modulator of viral fusogenicity...