A K Fielding
Affiliation: University College London
- Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 studyAdele K Fielding
Royal Free and University College London Medical School, and Christie Hospital National Health Service Trust, Manchester, UK
Blood 109:944-50. 2007..Prevention of recurrence is the best strategy for long-term survival in this disease...
- How I treat Philadelphia chromosome-positive acute lymphoblastic leukemiaAdele K Fielding
University College London, Royal Free Campus, Rowland Hill Street, London, United Kingdom
Blood 116:3409-17. 2010..My strongest recommendation is that all physicians who are treating this rare disease actively seek appropriate clinical trials for their patients wherever possible...
- The treatment of adults with acute lymphoblastic leukemiaAdele K Fielding
Royal Free and University College Medical School, London, UK
Hematology Am Soc Hematol Educ Program . 2008..In particular, the controversial subject of whether the superior outcome seen in younger patients is predicated on disease biology or therapeutic strategy is examined closely. Promising approaches under development are also discussed...
- Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era: results from the International ALL TAdele K Fielding
University College London, London, United Kingdom
Blood 113:4489-96. 2009..This prospective trial in adult Ph(+) ALL indicates a modest but significant benefit to alloHSCT. This trial has been registered with clinicaltrials.gov under identifier NCT00002514 and as ISRCTN77346223...
- Allogeneic haematopoietic stem cell transplant in Philadelphia-positive acute lymphoblastic leukaemiaA K Fielding
1Department of Haematology, Royal Free and University College Medical School, London, UK
Bone Marrow Transplant 41:447-53. 2008..We explore the burgeoning literature on the role of tyrosine kinase inhibitors in this disease and summarize their impact on the transplant practice...
- Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemiaA K Fielding
University College London, London, UK
Curr Hematol Malig Rep 8:98-108. 2013....
- Measles as a potential oncolytic virusAdele K Fielding
Department of Haematology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
Rev Med Virol 15:135-42. 2005....
- Antigen receptor gene rearrangements reflect on the heterogeneity of adult Acute Lymphoblastic Leukaemia (ALL) with implications of cell-origin of ALL subgroups - a UKALLXII studyLena Rai
Haematology Department, Royal Free Hospital, Pond Street, London, NW3 2QG, UK
Br J Haematol 148:394-401. 2010..0% at 4 years without, P = 0.05). The heterogeneity in clinical outcome is suggested by the basic molecular processes of antigen receptor gene rearrangements as shown in this work...
- High incidence of avascular necrosis in adolescents with acute lymphoblastic leukaemia: a UKALL XII analysisB Patel
Department of Haematology, Royal Free and University College Medical School, London, UK
Leukemia 22:308-12. 2008..00005). The actuarial incidence of AVN was 29% at 10 years in patients <20 years old compared to 8% at 10 years in those >20 years old; P=0.0004; odds ratio 0.28 (95% CI=0.14-0.56)...
- HLA-mismatched unrelated donors are a viable alternate graft source for allogeneic transplantation following alemtuzumab-based reduced-intensity conditioningAdam J Mead
Department of Haematology, University College London UCL Medical School, London, United Kingdom
Blood 115:5147-53. 2010..44). Mismatch occurred at the antigenic level in 40 cases. The outcome in these cases did not differ significantly from the rest of the cohort. We conclude that RIT using HLA-mismatched grafts is a viable option using FMC conditioning...
- Prognostic role of PET scanning before and after reduced-intensity allogeneic stem cell transplantation for lymphomaJonathan R Lambert
Department of Haematology, University College London Cancer Institute, London, UK
Blood 115:2763-8. 2010....
- In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/Anthony H Goldstone
North London Cancer Network, University College London Hospitals, London, United Kingdom
Blood 111:1827-33. 2008..There is no evidence that a single autologous transplantation can replace consolidation/maintenance in any risk group. This study is registered at http://clinicaltrials.gov as NCT00002514...
- Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trialAnthony V Moorman
Leukaemia Research Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, UK
Blood 109:3189-97. 2007....
- Neutrophils contribute to the measles virus-induced antitumor effect: enhancement by granulocyte macrophage colony-stimulating factor expressionDeanna Grote
Molecular Medicine Program, Mayo Clinic, Rochester, MN 55905, USA
Cancer Res 63:6463-8. 2003..The magnitude of the neutrophil response correlated well with tumor regression. Our studies suggest that therapy with replicating MV stimulates a strong neutrophil antitumor response, which can be cytokine-enhanced to improve oncolysis...
- An oncolytic measles virus engineered to enter cells through the CD20 antigenAmanda D Bucheit
Mayo Clinic Molecular Medicine Program, 200 First Street SW, Rochester, Minnesota 55902, USA
Mol Ther 7:62-72. 2003....
- Strength of envelope protein interaction modulates cytopathicity of measles virusRichard K Plemper
Molecular Medicine Program, Mayo Foundation, Rochester, Minnesota 55905, USA
J Virol 76:5051-61. 2002..Similar analyses of glycoproteins derived from MV strains with reduced cytopathicities confirm that the strength of H and F glycoprotein interaction is a modulator of viral fusogenicity...