David J P Ferguson

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Toxoplasma gondii and sex: essential or optional extra?
    David J P Ferguson
    Nuffield Dept of Pathology, Oxford University, John Radcliffe Hospital, Oxford, UK OX3 9DU
    Trends Parasitol 18:355-9. 2002
  2. doi request reprint Congenital toxoplasmosis: continued parasite proliferation in the fetal brain despite maternal immunological control in other tissues
    David J P Ferguson
    Nuffield Department of Clinical Laboratory Science, Oxford University Hospital, UK
    Clin Infect Dis 56:204-8. 2013
  3. pmc Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection
    Gretchen Hermes
    Department of Ophthalmology, University of Chicago, Chicago, IL, USA
    J Neuroinflammation 5:48. 2008
  4. ncbi request reprint Use of molecular and ultrastructural markers to evaluate stage conversion of Toxoplasma gondii in both the intermediate and definitive host
    D J P Ferguson
    Nuffield Department of Pathology, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Int J Parasitol 34:347-60. 2004
  5. ncbi request reprint The development of the macrogamete and oocyst wall in Eimeria maxima: immuno-light and electron microscopy
    D J P Ferguson
    Nuffield Department of Pathology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Int J Parasitol 33:1329-40. 2003
  6. ncbi request reprint Toxoplasma gondii: 1908-2008, homage to Nicolle, Manceaux and Splendore
    David J P Ferguson
    Nuffield Department of Clinical Laboratory Science, Oxford University, John Radcliffe Hospital, Oxford, UK
    Mem Inst Oswaldo Cruz 104:133-48. 2009
  7. doi request reprint Identification of faecal transmission of Toxoplasma gondii: Small science, large characters
    D J P Ferguson
    Nuffield Department of Clinical Laboratory Science, Oxford University, John Radcliffe Hospital, UK
    Int J Parasitol 39:871-5. 2009
  8. pmc Enzymes of type II fatty acid synthesis and apicoplast differentiation and division in Eimeria tenella
    D J P Ferguson
    Nuffield Department of Pathology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Int J Parasitol 37:33-51. 2007
  9. pmc Maternal inheritance and stage-specific variation of the apicoplast in Toxoplasma gondii during development in the intermediate and definitive host
    David J P Ferguson
    Department of Pathology, University of Oxford, John Radcliffe Hospital, United Kingdom
    Eukaryot Cell 4:814-26. 2005
  10. ncbi request reprint PfEMP1 expression is reduced on the surface of knobless Plasmodium falciparum infected erythrocytes
    Paul Horrocks
    Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK
    J Cell Sci 118:2507-18. 2005

Detail Information

Publications44

  1. ncbi request reprint Toxoplasma gondii and sex: essential or optional extra?
    David J P Ferguson
    Nuffield Dept of Pathology, Oxford University, John Radcliffe Hospital, Oxford, UK OX3 9DU
    Trends Parasitol 18:355-9. 2002
    ..Is this a realistic assumption? It is possible, for different reasons, that the theory may not to be applicable to either malaria parasites or Toxoplasma gondii...
  2. doi request reprint Congenital toxoplasmosis: continued parasite proliferation in the fetal brain despite maternal immunological control in other tissues
    David J P Ferguson
    Nuffield Department of Clinical Laboratory Science, Oxford University Hospital, UK
    Clin Infect Dis 56:204-8. 2013
    ..Congenital toxoplasmosis is a serious condition but little is known of the natural history of parasite development and associated fetal tissue destruction...
  3. pmc Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection
    Gretchen Hermes
    Department of Ophthalmology, University of Chicago, Chicago, IL, USA
    J Neuroinflammation 5:48. 2008
    ..Worldwide, approximately two billion people are chronically infected with Toxoplasma gondii with largely unknown consequences...
  4. ncbi request reprint Use of molecular and ultrastructural markers to evaluate stage conversion of Toxoplasma gondii in both the intermediate and definitive host
    D J P Ferguson
    Nuffield Department of Pathology, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Int J Parasitol 34:347-60. 2004
    ..In conclusion, it was possible using a combination of molecular markers to identify tachyzoite, bradyzoite and coccidian development in tissue sections...
  5. ncbi request reprint The development of the macrogamete and oocyst wall in Eimeria maxima: immuno-light and electron microscopy
    D J P Ferguson
    Nuffield Department of Pathology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Int J Parasitol 33:1329-40. 2003
    ..Thus, oocyst wall formation in E. maxima represents a sequential release of the contents of the veil forming bodies, wall forming bodies types 1 and 2 and this may be controlled at the level of the rough endoplasmic reticulum/Golgi body...
  6. ncbi request reprint Toxoplasma gondii: 1908-2008, homage to Nicolle, Manceaux and Splendore
    David J P Ferguson
    Nuffield Department of Clinical Laboratory Science, Oxford University, John Radcliffe Hospital, Oxford, UK
    Mem Inst Oswaldo Cruz 104:133-48. 2009
    ..In this review a number of the historical advances will be mentioned and combined with a description of the basic biology of the parasite...
  7. doi request reprint Identification of faecal transmission of Toxoplasma gondii: Small science, large characters
    D J P Ferguson
    Nuffield Department of Clinical Laboratory Science, Oxford University, John Radcliffe Hospital, UK
    Int J Parasitol 39:871-5. 2009
    ..This personal review describes the scientist (W.M. Hutchison) and the background to the initial discovery and covers the period to the complete elucidation of the life cycle of T. gondii...
  8. pmc Enzymes of type II fatty acid synthesis and apicoplast differentiation and division in Eimeria tenella
    D J P Ferguson
    Nuffield Department of Pathology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Int J Parasitol 37:33-51. 2007
    ..Apicoplast division results in the simultaneous formation of multiple fragments. The division mechanism is unknown, but is independent of nuclear division and occurs prior to daughter formation...
  9. pmc Maternal inheritance and stage-specific variation of the apicoplast in Toxoplasma gondii during development in the intermediate and definitive host
    David J P Ferguson
    Department of Pathology, University of Oxford, John Radcliffe Hospital, United Kingdom
    Eukaryot Cell 4:814-26. 2005
    ..Thus, it is shown that apicoplasts are present and contain ENR in all T. gondii life cycle stages except microgametes, which will result in maternal inheritance of the organelle...
  10. ncbi request reprint PfEMP1 expression is reduced on the surface of knobless Plasmodium falciparum infected erythrocytes
    Paul Horrocks
    Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK
    J Cell Sci 118:2507-18. 2005
    ..However, despite this reduction, the gross distribution of PfEMP1 in K(-) IEs appears unaltered. These data impact on our current interpretation of the role of knobs in adhesion and the mechanism of trafficking PfEMP1 to the IE surface...
  11. ncbi request reprint Evidence for nuclear localisation of two stage-specific isoenzymes of enolase in Toxoplasma gondii correlates with active parasite replication
    David J P Ferguson
    Nuffield Department of Pathology, John Radcliffe Hospital, University of Oxford, OX3 9DU, Oxford
    Int J Parasitol 32:1399-410. 2002
    ....
  12. pmc Can cytoplasmic nucleophosmin be detected by immunocytochemical staining of cell smears in acute myeloid leukemia?
    Goran Mattsson
    1Leukaemia Research Immunodiagnostics Unit, Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Haematologica 95:670-3. 2010
    ..Due to the high false positive and negative rates for cNPM in cell smears, this method should not be used as a surrogate for NPM1 mutations in AML...
  13. pmc Novel type IV secretion system involved in propagation of genomic islands
    Mario Juhas
    Clinical Microbiology and Infectious Diseases, Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Headington, OX3 9DU Oxford, United Kingdom
    J Bacteriol 189:761-71. 2007
    ..Moreover, the expression of this T4SS was found to be positively regulated by one of its components, the tfc24 gene. We concluded that this gene cluster represents a novel family of T4SSs involved in propagation of genomic islands...
  14. doi request reprint Haemophilus influenzae biofilms: hypothesis or fact?
    E Richard Moxon
    University of Oxford Department of Paediatrics, Oxford OX3 9DS, UK
    Trends Microbiol 16:95-100. 2008
    ..Uncritical acceptance of a distinctive NTHi biofilm phenotype has the potential to mislead and could confuse and compromise research efforts aimed at improving management and prevention of NTHi diseases of the human respiratory tract...
  15. pmc Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis
    Rebecca A Dragovic
    Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Nanomedicine 7:780-8. 2011
    ..By combining NTA with fluorescence measurement we have demonstrated that vesicles can be labeled with specific antibody-conjugated quantum dots, allowing their phenotype to be determined...
  16. pmc MORN1 has a conserved role in asexual and sexual development across the apicomplexa
    David J P Ferguson
    Nuffield Department of Pathology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Eukaryot Cell 7:698-711. 2008
    ..These observations suggest a conserved role for MORN1 in both asexual and sexual development across the Apicomplexa...
  17. ncbi request reprint Human serum haptoglobin is toxic to Plasmodium falciparum in vitro
    Heather Imrie
    Peter Medawar Building for Pathogen Research, Department of Zoology, University of Oxford, OX1 3SY Oxford, UK
    Mol Biochem Parasitol 133:93-8. 2004
    ..This effect is phenotype dependent and occurs during the trophozoite phase of the asexual life cycle. We propose that the increased levels of haptoglobin seen in the acute phase response may be protective against malaria in humans...
  18. pmc Autophagy Controls Acquisition of Aging Features in Macrophages
    Amanda J Stranks
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
    J Innate Immun 7:375-91. 2015
    ..Thus, autophagy modulation may prevent excess inflammation and preserve macrophage function during aging, improving immune responses and reducing the morbidity and mortality associated with inflamm-aging...
  19. doi request reprint TRAP1 regulates proliferation, mitochondrial function, and has prognostic significance in NSCLC
    Jackeline Agorreta
    Authors Affiliations Oncology Division, Center for Applied Medical Research CIMA, University of Navarra, Pamplona 2Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Madrid, Spain 3Nuffield Department of Clinical Laboratory Sciences 4Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital 5Department of Medical Oncology, University of Oxford, The Churchill Hospital, Oxford, United Kingdom 6Department of Rheumatology and Immunology, Shandong Provincial Hospital, Shandong University, Jinan, China and 7Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
    Mol Cancer Res 12:660-9. 2014
    ..008; multivariate analysis, HR: 2.554; 95% confidence interval, 1.085-6.012; P = 0.03). In conclusion, these results demonstrate that TRAP1 impacts the viability of NSCLC cells, and that its expression is prognostic in NSCLC...
  20. pmc Detection of genetic alterations by immunoFISH analysis of whole cells extracted from routine biopsy material
    Goran Mattsson
    Haematology Department, Level 4, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Mol Diagn 9:479-89. 2007
    ..This procedure represents a novel methodology, which in some settings offers clear advantages over analysis of tissue sections...
  21. doi request reprint Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells
    Elena Favaro
    Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Cell Metab 16:751-64. 2012
    ..Thus, glycogen metabolism is a key pathway induced by hypoxia, necessary for optimal glucose utilization, which represents a targetable mechanism of metabolic adaptation...
  22. pmc Sequence and functional analyses of Haemophilus spp. genomic islands
    Mario Juhas
    Clinical Microbiology and Infectious Diseases, NDCLS, University of Oxford, Headley Way, Oxford OX3 9DU, UK
    Genome Biol 8:R237. 2007
    ..More clarity comes from this comparative analysis of seven complete sequences of the ICEHin1056 genomic island subfamily...
  23. doi request reprint Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1{alpha} localization in erythroblasts
    Raffaele Renella
    Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Blood 117:6928-38. 2011
    ..Cdan1(gt/gt) homozygotes die in utero before the onset of primitive erythropoiesis, suggesting that Cdan1 has other critical roles during embryogenesis...
  24. doi request reprint SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis
    Hedia Chagraoui
    Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    Blood 118:723-35. 2011
    ..Our study provides a mechanistic link between a major hematopoietic transcriptional regulator, cell-cycle progression, and megakaryocytic differentiation...
  25. ncbi request reprint Characterization of the pathway for transport of the cytoadherence-mediating protein, PfEMP1, to the host cell surface in malaria parasite-infected erythrocytes
    Neline Kriek
    Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, Headington, Oxford, OX3 9DS, UK
    Mol Microbiol 50:1215-27. 2003
    ..Thus, we have delineated some important aspects of the unusual trafficking mechanism for delivery of this critical parasite virulence factor to the erythrocyte surface...
  26. ncbi request reprint Stimulation of osteoclast formation by inflammatory synovial fluid
    Iannis E Adamopoulos
    Institute of Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK
    Virchows Arch 449:69-77. 2006
    ....
  27. ncbi request reprint Mitochondrial clearance by autophagy in developing erythrocytes: clearly important, but just how much so?
    Monika Mortensen
    Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Cell Cycle 9:1901-6. 2010
    ..This review will therefore focus on comparing the different studies of mitophagy in erythroid development and highlight some of the remaining controversial points...
  28. ncbi request reprint Efficient characterisation of human cell-bioceramic interactions in vitro and in vivo by using enhanced GFP-labelled mesenchymal stem cells
    Zhidao Xia
    BotnarResearch Centre, Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, UK
    Biomaterials 26:5790-800. 2005
    ..This is of great value in prospective assessments of these cell populations for use in tissue engineering applications...
  29. ncbi request reprint Host vascular endothelial growth factor is trophic for Plasmodium falciparum-infected red blood cells
    Navakanit Sachanonta
    Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Asian Pac J Allergy Immunol 26:37-45. 2008
    ..We conclude that P. falciparum iRBC can bind host VEGF-R on the erythrocyte membrane and accumulate host VEGF within the parasitophorous vacuole, which may have a trophic effect on parasite growth...
  30. ncbi request reprint An ultrastructural study of the brain in fatal Plasmodium falciparum malaria
    Emsri Pongponratn
    Department of Tropical Pathology, and Wellcome Trust Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 69:345-59. 2003
    ..7) than in NCM patients (median = 6.9) (P = 0.042). The degree of sequestration of P. falciparum-infected erythrocytes in cerebral microvessels is quantitatively associated with pre-mortem coma...
  31. ncbi request reprint The coccidian oocyst: a tough nut to crack!
    Sabina I Belli
    Institute for the Biotechnology of Infectious Diseases, University of Technology, Sydney, Australia
    Trends Parasitol 22:416-23. 2006
    ..Here, we revisit the early work and combine it with newer molecular data to describe our present understanding of the coccidian oocyst wall...
  32. ncbi request reprint Immunohistochemical study of acute and chronic toxoplasmosis in experimentally infected mice
    Phuangphet Waree
    Department of Protozoology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 38:223-31. 2007
    ..Double immunocytochemical labelling confirmed the exclusive presence of tachyzoites during the acute phase and bradyzoites during the chronic phase...
  33. pmc Plasmodium falciparum Pf34, a novel GPI-anchored rhoptry protein found in detergent-resistant microdomains
    Nicholas I Proellocks
    NHMRC Program in Malaria, Department of Microbiology, Monash University, VIC 3800, Australia
    Int J Parasitol 37:1233-41. 2007
    ..Pf34 is exposed to the human immune system during infection and is recognised by human immune sera collected from residents of malaria endemic areas of Vietnam and Papua New Guinea...
  34. pmc Carbohydrate metabolism in the Toxoplasma gondii apicoplast: localization of three glycolytic isoenzymes, the single pyruvate dehydrogenase complex, and a plastid phosphate translocator
    Tobias Fleige
    Institute of Medical Microbiology, University of Gottingen, Kreuzbergring 57, D 37075 Gottingen, Germany
    Eukaryot Cell 6:984-96. 2007
    ..Based on these localization studies, a model is proposed that explains the supply of the apicoplast with ATP and the reduction power, as well as the exchange of metabolites between the cytosol and the apicoplast...
  35. pmc Genesis of and trafficking to the Maurer's clefts of Plasmodium falciparum-infected erythrocytes
    Cornelia Spycher
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Socinstrasse 57, CH 4002 Basel, Switzerland
    Mol Cell Biol 26:4074-85. 2006
    ..The data suggest that the Maurer's clefts bud from the parasitophorous vacuole membrane and diffuse within the erythrocyte cytoplasm before taking up residence at the cell periphery...
  36. ncbi request reprint Eimeria maxima TRAP family protein EmTFP250: subcellular localisation and induction of immune responses by immunisation with a recombinant C-terminal derivative
    David M Witcombe
    Institute for the Biotechnology of Infectious Diseases, University of Technology Sydney, Westbourne St, Gore Hill, Sydney, NSW 2065, Australia
    Int J Parasitol 34:861-72. 2004
    ..This study is further suggestive of a functional importance for EmTFP250 and underscores its potential as a candidate for a recombinant vaccine targeting coccidiosis in chickens...
  37. ncbi request reprint Food vacuole-associated lipid bodies and heterogeneous lipid environments in the malaria parasite, Plasmodium falciparum
    Katherine E Jackson
    Department of Biochemistry, La Trobe University, Melbourne 3086, Victoria, Australia
    Mol Microbiol 54:109-22. 2004
    ..Ratiometric imaging revealed more subtle variations in the lipid environments within the parasite membrane network...
  38. ncbi request reprint A novel rhoptry protein in Toxoplasma gondii bradyzoites and merozoites
    Jodi A Schwarz
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    Mol Biochem Parasitol 144:159-66. 2005
    ..Since we also observed that BRP1 is expressed in the merozoite stages in the gut of infected cats, the coccidian phase of the life cycle may be where BRP1 plays its most important role...
  39. ncbi request reprint Autocrine and paracrine nitric oxide regulate attachment of human osteoclasts
    Beatrice B Yaroslavskiy
    Department of Pathology, University of Pittsburgh, and Veteran s Affairs Medical Center, Pittsburgh, Pennsylvania 15243, USA
    J Cell Biochem 91:962-72. 2004
    ..We conclude that NO is produced by human osteoclasts and regulates acid secretion and cellular motility, in keeping with autocrine and paracrine NO regulation of the resorption cycle...
  40. ncbi request reprint A quantitative ultrastructural study of the liver and the spleen in fatal falciparum malaria
    Oranan Prommano
    Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 36:1359-70. 2005
    ..This observation reveals that the spleen plays a major role in malaria parasite clearance, and is associated with host defence mechanisms against malaria...
  41. ncbi request reprint A quantitative ultrastructural study of renal pathology in fatal Plasmodium falciparum malaria
    Sudarat Nguansangiam
    Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Trop Med Int Health 12:1037-50. 2007
    ..To use electron microscopy to examine the role of parasitized red blood cell (PRBC) sequestration in the pathogenesis of acute renal failure in severe falciparum malaria...
  42. ncbi request reprint The Drosophila ortholog of the endolysosomal membrane protein, endolyn, regulates cell proliferation
    Guang Qian Zhou
    Centre for Cancer Research and Cell Biology, Queen s University of Belfast, Belfast, UK
    J Cell Biochem 99:1380-96. 2006
    ..Taken together, these results demonstrate that endolyn is an evolutionarily conserved sialomucin fundamentally involved in cell proliferation in both the human and Drosophila melanogaster...
  43. pmc Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages
    Yun M Ling
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, and Core Research Laboratories, Rhode Island Hospital, Providence, RI 02912, USA
    J Exp Med 203:2063-71. 2006
    ..These observations outline a series of mechanisms used by effector cells to redirect the fate of a classically nonfusogenic intracellular pathogen toward a path of immune elimination...
  44. ncbi request reprint Toxoplasma gondii MAG1 protein expression
    David J P Ferguson
    Trends Parasitol 18:482. 2002