Laura Else

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. doi request reprint Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the fetal compartment (placenta and amniotic fluid)
    Laura J Else
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
    Antivir Ther 16:1139-47. 2011
  2. pmc Pharmacokinetics of lamivudine and lamivudine-triphosphate after administration of 300 milligrams and 150 milligrams once daily to healthy volunteers: results of the ENCORE 2 study
    Laura J Else
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom
    Antimicrob Agents Chemother 56:1427-33. 2012
  3. doi request reprint Validation of a rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) assay for the simultaneous determination of existing and new antiretroviral compounds
    Laura Else
    Department of Pharmacology and Therapeutics, University of Liverpool, Pharmacology Research Laboratories, Liverpool, UK
    J Chromatogr B Analyt Technol Biomed Life Sci 878:1455-65. 2010
  4. pmc Improved oral bioavailability of lopinavir in melt-extruded tablet formulation reduces impact of third trimester on lopinavir plasma concentrations
    L J Else
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom
    Antimicrob Agents Chemother 56:816-24. 2012
  5. doi request reprint Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the male and female genital tract
    Laura J Else
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
    Antivir Ther 16:1149-67. 2011
  6. doi request reprint Validation and clinical application of a method to quantify nevirapine in dried blood spots and dried breast-milk spots
    Adeniyi Olagunju
    Department of Molecular and Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Liverpool L69 3GF, UK Faculty of Pharmacy, Obafemi Awolowo University, Ile Ife, Nigeria
    J Antimicrob Chemother 70:2816-22. 2015
  7. doi request reprint Breast milk pharmacokinetics of efavirenz and breastfed infants' exposure in genetically defined subgroups of mother-infant pairs: an observational study
    Adeniyi Olagunju
    Department of Molecular and Clinical Pharmacology, University of Liverpool, United Kingdom Faculty of Pharmacy, Obafemi Awolowo University, Ile Ife, Nigeria
    Clin Infect Dis 61:453-63. 2015
  8. doi request reprint Dolutegravir and elvitegravir plasma concentrations following cessation of drug intake
    Emilie Elliot
    St Stephen s Centre, Chelsea and Westminster Hospital, London, UK University of Liverpool, Liverpool, UK
    J Antimicrob Chemother 71:1031-6. 2016
  9. pmc Plasma Tenofovir, Emtricitabine, and Rilpivirine and Intracellular Tenofovir Diphosphate and Emtricitabine Triphosphate Pharmacokinetics following Drug Intake Cessation
    Laura Dickinson
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom
    Antimicrob Agents Chemother 59:6080-6. 2015
  10. doi request reprint Development, validation and clinical application of a novel method for the quantification of efavirenz in dried breast milk spots using LC-MS/MS
    Adeniyi Olagunju
    Department of Molecular and Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Liverpool L69 3GF, UK Faculty of Pharmacy, Obafemi Awolowo University, Ile Ife, Nigeria
    J Antimicrob Chemother 70:555-61. 2015

Collaborators

Detail Information

Publications13

  1. doi request reprint Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the fetal compartment (placenta and amniotic fluid)
    Laura J Else
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
    Antivir Ther 16:1139-47. 2011
    ..More comprehensive in vivo pharmacokinetic data are required to justify the potential use of these agents as safe and effective options during pregnancy...
  2. pmc Pharmacokinetics of lamivudine and lamivudine-triphosphate after administration of 300 milligrams and 150 milligrams once daily to healthy volunteers: results of the ENCORE 2 study
    Laura J Else
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom
    Antimicrob Agents Chemother 56:1427-33. 2012
    ..68 to 0.99), and 0.70 (0.61 to 0.82), respectively. We found that 3TC at 150 mg is not bioequivalent to the standard regimen of 300 mg, indicating that saturation of cytosine phosphorylation pathways is not achieved at a dose of 150 mg...
  3. doi request reprint Validation of a rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) assay for the simultaneous determination of existing and new antiretroviral compounds
    Laura Else
    Department of Pharmacology and Therapeutics, University of Liverpool, Pharmacology Research Laboratories, Liverpool, UK
    J Chromatogr B Analyt Technol Biomed Life Sci 878:1455-65. 2010
    ..The method described is being successfully applied to measure plasma antiretroviral concentrations from samples obtained from clinical pharmacokinetic studies...
  4. pmc Improved oral bioavailability of lopinavir in melt-extruded tablet formulation reduces impact of third trimester on lopinavir plasma concentrations
    L J Else
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom
    Antimicrob Agents Chemother 56:816-24. 2012
    ....
  5. doi request reprint Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the male and female genital tract
    Laura J Else
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
    Antivir Ther 16:1149-67. 2011
    ....
  6. doi request reprint Validation and clinical application of a method to quantify nevirapine in dried blood spots and dried breast-milk spots
    Adeniyi Olagunju
    Department of Molecular and Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Liverpool L69 3GF, UK Faculty of Pharmacy, Obafemi Awolowo University, Ile Ife, Nigeria
    J Antimicrob Chemother 70:2816-22. 2015
    ..The validation and clinical application of an LC-MS/MS method for the quantification of nevirapine in dried blood spots (DBS) and dried breast-milk spots (DBMS) are presented...
  7. doi request reprint Breast milk pharmacokinetics of efavirenz and breastfed infants' exposure in genetically defined subgroups of mother-infant pairs: an observational study
    Adeniyi Olagunju
    Department of Molecular and Clinical Pharmacology, University of Liverpool, United Kingdom Faculty of Pharmacy, Obafemi Awolowo University, Ile Ife, Nigeria
    Clin Infect Dis 61:453-63. 2015
    ..Evaluating its safety requires an understanding of its breast milk pharmacokinetics, level of breastfed infants' exposure, and potential influence of polymorphisms in drug disposition genes...
  8. doi request reprint Dolutegravir and elvitegravir plasma concentrations following cessation of drug intake
    Emilie Elliot
    St Stephen s Centre, Chelsea and Westminster Hospital, London, UK University of Liverpool, Liverpool, UK
    J Antimicrob Chemother 71:1031-6. 2016
    ..To evaluate dolutegravir and elvitegravir/cobicistat pharmacokinetics in HIV-negative volunteers up to 10 days after drug cessation...
  9. pmc Plasma Tenofovir, Emtricitabine, and Rilpivirine and Intracellular Tenofovir Diphosphate and Emtricitabine Triphosphate Pharmacokinetics following Drug Intake Cessation
    Laura Dickinson
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom
    Antimicrob Agents Chemother 59:6080-6. 2015
    ..The trial was conducted in accordance with the Declaration of Helsinki [EudraCT 2012-002781-13].). ..
  10. doi request reprint Development, validation and clinical application of a novel method for the quantification of efavirenz in dried breast milk spots using LC-MS/MS
    Adeniyi Olagunju
    Department of Molecular and Clinical Pharmacology, University of Liverpool, 70 Pembroke Place, Liverpool L69 3GF, UK Faculty of Pharmacy, Obafemi Awolowo University, Ile Ife, Nigeria
    J Antimicrob Chemother 70:555-61. 2015
    ..This manuscript describes the development, validation and clinical application of a novel method for the quantification of the antiretroviral drug efavirenz in dried breast milk spots using LC-MS...
  11. doi request reprint Effect of intermittent rifampicin on the pharmacokinetics and safety of raltegravir
    Helen E Reynolds
    Royal Liverpool and Broadgreen University Hospitals NHS Trust, Prescot Street, Liverpool, UK
    J Antimicrob Chemother 70:550-4. 2015
    ..Previous studies of raltegravir and rifampicin have not studied the interaction when rifampicin is dosed intermittently. This study aimed to assess the pharmacokinetics of twice daily raltegravir and intermittently dosed rifampicin...
  12. pmc Sequential population pharmacokinetic modeling of lopinavir and ritonavir in healthy volunteers and assessment of different dosing strategies
    Laura Dickinson
    Department of Pharmacology, University of Liverpool, Pharmacology Research Laboratories, Block H, First Floor, 70 Pembroke Place, Liverpool L693GF, United Kingdom
    Antimicrob Agents Chemother 55:2775-82. 2011
    ..The model allows a better understanding of the interaction between lopinavir and ritonavir and may allow a better prediction of lopinavir concentrations and assessments of different dosing strategies...
  13. doi request reprint The importance of drug-drug interactions in the DAA era
    David Back
    Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK Electronic address
    Dig Liver Dis 45:S343-8. 2013
    ....