Despina Eleftheriou

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Treatment strategies for childhood stroke
    Despina Eleftheriou
    Institute of Child Health and Great Ormond St Hospital, Department of Paediatric Rheumatology, 30 Guilford Street, WC1N 1EH, London, UK
    Expert Opin Pharmacother 9:2955-67. 2008
  2. doi request reprint Vasculitis in children
    Despina Eleftheriou
    Department of Paediatric Rheumatology, Institute of Child Health and Great Ormond St Hospital for Children, London, UK
    Best Pract Res Clin Rheumatol 23:309-23. 2009
  3. doi request reprint Controversies in childhood arterial ischemic stroke and cerebral venous sinus thrombosis
    Despina Eleftheriou
    Department of Paediatric Rheumatology, Institute of Child Health and Great Ormond Street Hospital, London, UK
    Expert Rev Cardiovasc Ther 7:853-61. 2009
  4. pmc Endothelial injury in childhood stroke with cerebral arteriopathy: a cross-sectional study
    Despina Eleftheriou
    Paediatric Rheumatology Department, Institute of Child Health and Great Ormond St Hospital for Children, London, UK
    Neurology 79:2089-96. 2012
  5. doi request reprint Biologic therapy in refractory chronic non-bacterial osteomyelitis of childhood
    Despina Eleftheriou
    Department of Rheumatology, Institute of Child Health and Great Ormond Street Hospital, London WC1N 1EH, UK
    Rheumatology (Oxford) 49:1505-12. 2010
  6. doi request reprint Investigation of childhood central nervous system vasculitis: magnetic resonance angiography versus catheter cerebral angiography
    Despina Eleftheriou
    Department of Paediatric Rheumatology, Institute of Child Health, London, UK
    Dev Med Child Neurol 52:863-7. 2010
  7. doi request reprint Biologic therapy in primary systemic vasculitis of the young
    Despina Eleftheriou
    Rheumatology Department, Institute of Child Health, London, UK
    Rheumatology (Oxford) 48:978-86. 2009
  8. doi request reprint Advances in childhood vasculitis
    Despina Eleftheriou
    Department of Paediatric Rheumatology, Institute of Child Health and Great Ormond St Hospital for Children, London, UK
    Curr Opin Rheumatol 21:411-8. 2009
  9. doi request reprint Systemic polyarteritis nodosa in the young: a single-center experience over thirty-two years
    Despina Eleftheriou
    Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
    Arthritis Rheum 65:2476-85. 2013
  10. pmc Takayasu arteritis in childhood: retrospective experience from a tertiary referral centre in the United Kingdom
    Despina Eleftheriou
    UCL Institute of Child Health, 30 Guilford Street and Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N1EH, UK
    Arthritis Res Ther 17:36. 2015

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Treatment strategies for childhood stroke
    Despina Eleftheriou
    Institute of Child Health and Great Ormond St Hospital, Department of Paediatric Rheumatology, 30 Guilford Street, WC1N 1EH, London, UK
    Expert Opin Pharmacother 9:2955-67. 2008
    ..Ischaemic stroke (arterial ischaemic stroke and cerebral sinovenous thrombosis) is increasingly recognised in childhood and has a significant attendant morbidity and mortality...
  2. doi request reprint Vasculitis in children
    Despina Eleftheriou
    Department of Paediatric Rheumatology, Institute of Child Health and Great Ormond St Hospital for Children, London, UK
    Best Pract Res Clin Rheumatol 23:309-23. 2009
    ..International multicenter collaboration is of utmost importance in order for us to further advance our understanding and improve the treatment and outcome of systemic vasculitis in the young...
  3. doi request reprint Controversies in childhood arterial ischemic stroke and cerebral venous sinus thrombosis
    Despina Eleftheriou
    Department of Paediatric Rheumatology, Institute of Child Health and Great Ormond Street Hospital, London, UK
    Expert Rev Cardiovasc Ther 7:853-61. 2009
    ..In this article, we review some of the current concepts and controversies in the investigation and management of AIS and CVST in children...
  4. pmc Endothelial injury in childhood stroke with cerebral arteriopathy: a cross-sectional study
    Despina Eleftheriou
    Paediatric Rheumatology Department, Institute of Child Health and Great Ormond St Hospital for Children, London, UK
    Neurology 79:2089-96. 2012
    ..We tested the hypothesis that these indices differ between children with cerebral arteriopathy and arterial ischemic stroke (AIS) recurrence, and those with a single event...
  5. doi request reprint Biologic therapy in refractory chronic non-bacterial osteomyelitis of childhood
    Despina Eleftheriou
    Department of Rheumatology, Institute of Child Health and Great Ormond Street Hospital, London WC1N 1EH, UK
    Rheumatology (Oxford) 49:1505-12. 2010
    ..We report on our clinical experience of using biologic therapy to treat children with these conditions...
  6. doi request reprint Investigation of childhood central nervous system vasculitis: magnetic resonance angiography versus catheter cerebral angiography
    Despina Eleftheriou
    Department of Paediatric Rheumatology, Institute of Child Health, London, UK
    Dev Med Child Neurol 52:863-7. 2010
    ..We compared the clinical utility of magnetic resonance angiography (MRA) to catheter cerebral angiography (CA) in the investigation of children with suspected central nervous system (CNS) vasculitis...
  7. doi request reprint Biologic therapy in primary systemic vasculitis of the young
    Despina Eleftheriou
    Rheumatology Department, Institute of Child Health, London, UK
    Rheumatology (Oxford) 48:978-86. 2009
    ..To describe the biologic treatment regimens and report the efficacy and safety of biologic therapies in a multicentre series of children with primary systemic vasculitis (PSV)...
  8. doi request reprint Advances in childhood vasculitis
    Despina Eleftheriou
    Department of Paediatric Rheumatology, Institute of Child Health and Great Ormond St Hospital for Children, London, UK
    Curr Opin Rheumatol 21:411-8. 2009
    ..To provide an update on new developments in paediatric vasculitis...
  9. doi request reprint Systemic polyarteritis nodosa in the young: a single-center experience over thirty-two years
    Despina Eleftheriou
    Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
    Arthritis Rheum 65:2476-85. 2013
    ..Polyarteritis nodosa (PAN) is a rare disease of childhood. The aims of this study were to describe the clinical features, treatment, and outcome of systemic childhood PAN and to identify predictors of relapse...
  10. pmc Takayasu arteritis in childhood: retrospective experience from a tertiary referral centre in the United Kingdom
    Despina Eleftheriou
    UCL Institute of Child Health, 30 Guilford Street and Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N1EH, UK
    Arthritis Res Ther 17:36. 2015
    ..Although the disease rarely affects children, it does occur, even in infants. The objective of this study was to evaluate the clinical features, disease activity, treatment and outcome of childhood TA in a tertiary UK centre...
  11. doi request reprint Efficacy and safety of canakinumab therapy in paediatric patients with cryopyrin-associated periodic syndrome: a single-centre, real-world experience
    Ricardo A G Russo
    Department of Rheumatology, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Rheumatology (Oxford) 53:665-70. 2014
    ..The aim of this study was to determine the short- and long-term efficacy and safety of 8-weekly canakinumab therapy in children with cryopyrin-associated periodic syndromes (CAPS) in routine clinical practice...
  12. pmc Medium-size-vessel vasculitis
    Michael J Dillon
    Nephrourology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Pediatr Nephrol 25:1641-52. 2010
    ..Greater understanding of the pathogenetic mechanisms involved in these three types of vasculitis and better long-term follow-up data will lead to improved therapy and prediction of prognosis...
  13. pmc Small vessel vasculitis
    Paul Brogan
    Department of Rheumatology, Institute of Child Health, 30 Guilford St, London, WC1N1EH, UK
    Pediatr Nephrol 25:1025-35. 2010
    ..Lastly, long-term outcome data are lacking in survivors of pediatric small vessel vasculitis...
  14. doi request reprint Deficiency of Adenosine Deaminase Type 2: A Description of Phenotype and Genotype in Fifteen Cases
    Sira Nanthapisal
    University College London Institute of Child Health and Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
    Arthritis Rheumatol 68:2314-22. 2016
    ..To describe the clinical features, genotype, and treatment in a series of subjects with confirmed adenosine deaminase 2 (ADA2) deficiency...
  15. pmc Impaired function of endothelial progenitor cells in children with primary systemic vasculitis
    Ying Hong
    Infection, Immunity, Immunology and Physiological Medicine, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK
    Arthritis Res Ther 17:292. 2015
    ..investigate the relationship between disease activity and EPC function in children with SV; and 2. study the influence of systemic inflammation on EPC function by investigating the effects of hyperthermia and TNF-α on EPC function...
  16. pmc Anti-neutrophil cytoplasmic antibodies stimulate release of neutrophil microparticles
    Ying Hong
    Infectious Diseases and Microbiology Unit, 30 Guilford Street, London WC1N 1EH, United Kingdom
    J Am Soc Nephrol 23:49-62. 2012
    ..Taken together, these results support a role for neutrophil microparticles in the pathogenesis of ANCA-associated vasculitis, potentially providing a target for future therapeutics...
  17. pmc Paediatric Behçet's disease: a UK tertiary centre experience
    Sira Nanthapisal
    Infection, Inflammation and Rheumatology Section, UCL Institute of Child Health and Great Ormond Street Hospital NHS Foundation Trust, 30 Guilford Street, London, WC1N 1EH, UK
    Clin Rheumatol 35:2509-16. 2016
    ..Diagnostic delay is common. The majority of our patients required systemic therapy; anti-TNFα was reserved for severe cases and has largely superseded the use of thalidomide. ..
  18. doi request reprint Granulomatosis with polyangiitis mimicking infective endocarditis in an adolescent male
    Giulia Camilla Varnier
    Department of Rheumatology, Institute of Child Health, Great Ormond Street Hospital, 30 Guilford Street, London, WC1N 1EH, UK
    Clin Rheumatol 35:2369-72. 2016
    ....
  19. pmc Mitochondrial and oxidative stress genes are differentially expressed in neutrophils of sJIA patients treated with tocilizumab: a pilot microarray study
    Ebun Omoyinmi
    Infection, Inflammation and Rheumatology Section, Institute of Child Health, UCL, London, UK
    Pediatr Rheumatol Online J 14:7. 2016
    ..We therefore studied the gene profile in both PBMC and neutrophils of sJIA patients treated with tocilizumab...
  20. doi request reprint Vasculitis in children
    Despina Eleftheriou
    Paediatric and Adolescent Rheumatology, UCL Institute of Child Health, London, UK
    Nephrol Dial Transplant 30:i94-103. 2015
    ..The continuation of unmet needs as well as the exploration of potential therapeutic avenues and considerations in the design of future trials are also discussed. ..
  21. doi request reprint Takayasu arteritis in childhood: retrospective experience from a tertiary referral centre in the UK
    Despina Eleftheriou
    UCL Institute of Child Health, ARUK centre for adolescent rheumatology and Great Ormond Street Hospital for children NHS Foundation Trust, London, UK
    Arthritis Res Ther 17:545. 2015
    ..Although the disease rarely affects children, it does occur, even in infants. The objective of this study was to evaluate the clinical features, disease activity, treatment and outcome of childhood TA in a tertiary UK centre...
  22. doi request reprint Radiologic Improvement After Early Medical Intervention in Localised Facial Morphea
    Muhammad Amjad Khan
    Paediatric Dermatology, Great Ormond Street Hospital, London, UK
    Pediatr Dermatol 33:e95-8. 2016
    ..This is one of the few reported cases of neuroradiologic improvement after immunosuppressive treatment in a child with en coup de sabre. ..
  23. pmc Therapeutic advances in the treatment of vasculitis
    Despina Eleftheriou
    ARUK centre for Paediatric and Adolescent Rheumatology, Institute of Child Health and Great Ormond St Hospital NHS Foundation Trust, 30 Guilford Street, London, WC1N 1EH, UK
    Pediatr Rheumatol Online J 14:26. 2016
    ....
  24. pmc Screening assays for primary haemophagocytic lymphohistiocytosis in children presenting with suspected macrophage activation syndrome
    Mary Cruikshank
    Departments of Rheumatology, Great Ormond Street Hospital NHS Foundation Trust, London, UK
    Pediatr Rheumatol Online J 12:48. 2015
    ..The objective of this study was to describe their diagnostic and prognostic relevance in children who had presented to paediatric rheumatology and had undergone investigative work up for MAS...
  25. doi request reprint Polyarticular septic arthritis in an 11-year-old child
    Raquel Campanilho-Marques
    Paediatric Rheumatology Department, Great Ormond Street Hospital NHS Foundation Trust and UCL Institute of Child Health, London, UK
    Clin Rheumatol 33:1181-2. 2014
    ..This case underlines the importance of early aggressive therapy and the role of PCR/16S ribosomal bacterial DNA amplification to detect the causative microorganisms in septic arthritis when cultures remain negative. ..
  26. pmc Brief Report: whole-exome sequencing revealing somatic NLRP3 mosaicism in a patient with chronic infantile neurologic, cutaneous, articular syndrome
    Ebun Omoyinmi
    University College London, London, UK
    Arthritis Rheumatol 66:197-202. 2014
    ....
  27. doi request reprint Inflammatory lesions of the orbit: a single paediatric rheumatology centre experience
    Emily L Boulter
    Rheumatology Department, Great Ormond Street Hospital, Great Ormond Street, Bloomsbury, London WC1N 3JH, UK
    Rheumatology (Oxford) 51:1070-5. 2012
    ..To describe the clinical, laboratory, histopathological presentations and final diagnoses for children presenting to a tertiary paediatric rheumatology service with an inflammatory lesion of the orbit...
  28. pmc An unusual case of epidermolysis bullosa complicated by persistent oligoarticular juvenile idiopathic arthritis; lessons to be learned
    Despoina Maritsi
    Rheumatology Department, Great Ormond Street Hospital NHS Trust, London, UK
    Pediatr Rheumatol Online J 9:13. 2011
    ..This report, besides presenting a unique case, also highlights the important issues that need to be taken into account when assessing and managing patients with such complex conditions...
  29. pmc Infliximab for the treatment of intravenous immunoglobulin resistant Kawasaki disease complicated by coronary artery aneurysms: a case report
    Robert J Brogan
    Department of Paediatric Rheumatology, UCL Institute of Child Health and Great Ormond Street Hospital, 30 Guilford Street, London, UK
    Pediatr Rheumatol Online J 7:3. 2009
    ..This case report describes an 8 year old boy with IVIG resistant Kawasaki disease complicated by severe bilateral coronary artery aneurysms successfully treated with infliximab, a monoclonal antibody against tumour necrosis factor alpha...