Steven W Edwards

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. doi request reprint Inhibition of pre-B cell colony-enhancing factor (PBEF/NAMPT/visfatin) decreases the ability of human neutrophils to generate reactive oxidants but does not impair bacterial killing
    Kate J Roberts
    1 Biosciences Bldg, Crown St, Liverpool L69 7ZB, UK
    J Leukoc Biol 94:481-92. 2013
  2. ncbi request reprint Regulation of neutrophil apoptosis
    Steven W Edwards
    School of Biological Sciences, University of Liverpool, Liverpool, UK
    Chem Immunol Allergy 83:204-24. 2003
  3. ncbi request reprint The dual effects of TNFalpha on neutrophil apoptosis are mediated via differential effects on expression of Mcl-1 and Bfl-1
    Andrew Cross
    School of Biological Sciences, University of Liverpool, UK
    Blood 111:878-84. 2008
  4. ncbi request reprint Sodium salicylate promotes neutrophil apoptosis by stimulating caspase-dependent turnover of Mcl-1
    Mathieu Derouet
    School of Biological Sciences, University of Liverpool, United Kingdom
    J Immunol 176:957-65. 2006
  5. ncbi request reprint Neutrophil apoptosis in rheumatoid arthritis is regulated by local oxygen tensions within joints
    Andrew Cross
    Department of Medicine, School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, UK
    J Leukoc Biol 80:521-8. 2006
  6. doi request reprint Changes in expression of membrane TNF, NF-{kappa}B activation and neutrophil apoptosis during active and resolved inflammation
    Helen L Wright
    Biosciences Building, Crown Street, University of Liverpool, Liverpool L69 7ZB, UK
    Ann Rheum Dis 70:537-43. 2011
  7. ncbi request reprint Granulocyte macrophage colony-stimulating factor signaling and proteasome inhibition delay neutrophil apoptosis by increasing the stability of Mcl-1
    Mathieu Derouet
    School of Biological Sciences, Biosciences Building and Department of Medicine, University of Liverpool, Liverpool L69 7ZB, United Kingdom
    J Biol Chem 279:26915-21. 2004
  8. ncbi request reprint Secretion of oncostatin M by neutrophils in rheumatoid arthritis
    Andrew Cross
    Academic Rheumatology Unit, University of Liverpool, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK
    Arthritis Rheum 50:1430-6. 2004
  9. ncbi request reprint The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis
    Gianluca Fossati
    Department of Medicine, School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, UK
    J Immunol 170:1964-72. 2003
  10. pmc RNA-seq reveals activation of both common and cytokine-specific pathways following neutrophil priming
    Helen L Wright
    Institute of Integrative Biology, University of Liverpool, Liverpool, Merseyside, United Kingdom
    PLoS ONE 8:e58598. 2013

Collaborators

  • Robert J Moots
  • Andrew R Cross
  • C A Hart
  • Angela Midgley
  • Michael W Beresford
  • Jack Satsangi
  • Barry J Campbell
  • Batsi Chikura
  • Zerai Woldehiwet
  • Marco A Cassatella
  • C Akgul
  • Helen L Wright
  • Theresa C Barnes
  • Huw B Thomas
  • Francesca Tamarozzi
  • Luke W Thomas
  • Roger C Bucknall
  • Direkrit Chiewchengchol
  • Marina E Anderson
  • Mathieu Derouet
  • David G Spiller
  • Paul K Flanagan
  • Gianluca Fossati
  • Mark J Taylor
  • Kate J Roberts
  • Jagdish R Nair
  • Jonathan M Rhodes
  • Connie Lam
  • Sreedhar Subramanian
  • Michael R H White
  • Emma J Naylor
  • Chiedzo M Mpofu
  • Luke Thomas
  • Dale A Moulding
  • Fatima A Makki
  • Kelly L Johnston
  • Joseph D Turner
  • Helena Scaife
  • Ana F Guimarães
  • Nicolas Pionnier
  • Trevor Cox
  • Ruth Murphy
  • Abdullah Alswied
  • Jung Hwan Yoon
  • Olga Vasieva
  • Richard E Clark
  • Bob Thong
  • Carol L Roberts
  • Peter Calverley
  • Stuart Marshall-Clarke
  • Adrian McGoldrick
  • Mark Biffen
  • Stephen Scott
  • Denise Bakstad
  • Gregory J Gores
  • Hajime Higuchi
  • Nathan W Werneburg
  • Ali E Canbay
  • Scott H Kaufmann

Detail Information

Publications35

  1. doi request reprint Inhibition of pre-B cell colony-enhancing factor (PBEF/NAMPT/visfatin) decreases the ability of human neutrophils to generate reactive oxidants but does not impair bacterial killing
    Kate J Roberts
    1 Biosciences Bldg, Crown St, Liverpool L69 7ZB, UK
    J Leukoc Biol 94:481-92. 2013
    ..These data indicate that therapeutic NAMPT inhibition is unlikely to have deleterious effects on host protection against infections, in spite of this ability to down-regulate neutrophil respiratory burst activity significantly. ..
  2. ncbi request reprint Regulation of neutrophil apoptosis
    Steven W Edwards
    School of Biological Sciences, University of Liverpool, Liverpool, UK
    Chem Immunol Allergy 83:204-24. 2003
  3. ncbi request reprint The dual effects of TNFalpha on neutrophil apoptosis are mediated via differential effects on expression of Mcl-1 and Bfl-1
    Andrew Cross
    School of Biological Sciences, University of Liverpool, UK
    Blood 111:878-84. 2008
    ....
  4. ncbi request reprint Sodium salicylate promotes neutrophil apoptosis by stimulating caspase-dependent turnover of Mcl-1
    Mathieu Derouet
    School of Biological Sciences, University of Liverpool, United Kingdom
    J Immunol 176:957-65. 2006
    ..These data thus shed important new insights into the dynamic and highly regulated control of neutrophil apoptosis that is effected by modification in the rate of Mcl-1 turnover...
  5. ncbi request reprint Neutrophil apoptosis in rheumatoid arthritis is regulated by local oxygen tensions within joints
    Andrew Cross
    Department of Medicine, School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, UK
    J Leukoc Biol 80:521-8. 2006
    ..These experiments also highlight the importance of performing in vitro experiments under laboratory conditions that closely mimic those that occur in vivo; otherwise, misleading conclusions may be drawn...
  6. doi request reprint Changes in expression of membrane TNF, NF-{kappa}B activation and neutrophil apoptosis during active and resolved inflammation
    Helen L Wright
    Biosciences Building, Crown Street, University of Liverpool, Liverpool L69 7ZB, UK
    Ann Rheum Dis 70:537-43. 2011
    ..Tumour necrosis factor (TNF) is central to the pathophysiological process of rheumatoid arthritis (RA), whether as soluble cytokine or membrane-expressed pro-TNF (mTNF)...
  7. ncbi request reprint Granulocyte macrophage colony-stimulating factor signaling and proteasome inhibition delay neutrophil apoptosis by increasing the stability of Mcl-1
    Mathieu Derouet
    School of Biological Sciences, Biosciences Building and Department of Medicine, University of Liverpool, Liverpool L69 7ZB, United Kingdom
    J Biol Chem 279:26915-21. 2004
    ..These observations indicate that profound changes in the rate of neutrophil apoptosis following cytokine signaling occur via dynamic changes in the rate of Mcl-1 turnover via the proteasome...
  8. ncbi request reprint Secretion of oncostatin M by neutrophils in rheumatoid arthritis
    Andrew Cross
    Academic Rheumatology Unit, University of Liverpool, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK
    Arthritis Rheum 50:1430-6. 2004
    ..The objective of this study was to determine whether neutrophils express oncostatin M (OSM), a member of the interleukin-6 family of cytokines that has been implicated in the pathogenesis of inflammatory joint disease...
  9. ncbi request reprint The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis
    Gianluca Fossati
    Department of Medicine, School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, UK
    J Immunol 170:1964-72. 2003
    ..These data shed important insights into the hitherto unrecognized importance of mitochondria in the function of neutrophils during infection and inflammation...
  10. pmc RNA-seq reveals activation of both common and cytokine-specific pathways following neutrophil priming
    Helen L Wright
    Institute of Integrative Biology, University of Liverpool, Liverpool, Merseyside, United Kingdom
    PLoS ONE 8:e58598. 2013
    ..This may provide an important, new approach to define the molecular properties of neutrophils after in vivo activation during inflammation...
  11. doi request reprint Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy
    Helen L Wright
    University of Liverpool, Liverpool, UK
    Rheumatology (Oxford) 51:451-9. 2012
    ....
  12. pmc Relative α₁-anti-trypsin deficiency in systemic sclerosis
    Theresa C Barnes
    Department of Rheumatology, Institute of Chronic Disease and Ageing, University of Liverpool, Clinical Sciences Centre, Aintree University Hospital, Longmoor Lane, Liverpool L9 7AL, UK
    Rheumatology (Oxford) 50:1373-8. 2011
    ..This study examines the role of neutrophil elastase in SSc, a systemic CTD that is typified by vascular dysfunction, tissue fibrosis and inflammation...
  13. ncbi request reprint Haemophilus influenzae induces neutrophil necrosis: a role in chronic obstructive pulmonary disease?
    Emma J Naylor
    School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, UK
    Am J Respir Cell Mol Biol 37:135-43. 2007
    ..However, the infiltrating neutrophils fail to kill the bacteria and instead release tissue-damaging products into the lung as they undergo necrosis. These results may help to explain the clinical picture in COPD...
  14. pmc Killing of Escherichia coli by Crohn's Disease Monocyte-derived Macrophages and Its Enhancement by Hydroxychloroquine and Vitamin D
    Paul K Flanagan
    Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom Immunology Unit and Center of Excellence in Immunology and Immune mediated Disease, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Edinburgh, Scotland and Department of Gastroenterology, Royal Liverpool University Hospital, Liverpool, United Kingdom
    Inflamm Bowel Dis 21:1499-510. 2015
    ..We compared CD and healthy control (HC) macrophages for their abilities to kill E. coli and generate neutrophil chemoattractants and also assessed the effects of hydroxychloroquine (HCQ) and vitamin D on killing of phagocytosed E. coli...
  15. pmc Serine 162, an essential residue for the mitochondrial localization, stability and anti-apoptotic function of Mcl-1
    Luke W Thomas
    Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 7:e45088. 2012
    ..These data identify a new molecular determinant of Mcl-1 function, localization and stability that may be important for understanding the role of this protein in disease...
  16. doi request reprint Neutrophil-derived reactive oxygen species in SSc
    Theresa C Barnes
    Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK
    Rheumatology (Oxford) 51:1166-9. 2012
    ..Neutrophils constitute a major source of ROS during inflammation. Here, we examined endogenous and stimulated ex vivo ROS production of SSc neutrophils compared with control neutrophils with and without prior priming with TNF-α...
  17. ncbi request reprint Synovial fluid neutrophils transcribe and express class II major histocompatibility complex molecules in rheumatoid arthritis
    Andrew Cross
    University of Liverpool, Liverpool, UK
    Arthritis Rheum 48:2796-806. 2003
    ....
  18. ncbi request reprint Microbial mannan inhibits bacterial killing by macrophages: a possible pathogenic mechanism for Crohn's disease
    Chiedzo M Mpofu
    Division of Gastroenterology, School of Clinical Science, University of Liverpool, Liverpool, United Kingdom
    Gastroenterology 133:1487-98. 2007
    ..Crohn's disease (CD) is mimicked by inherited phagocyte disorders and is associated with circulating antibodies against yeast mannan (anti-Saccharomyces cerevisiae antibody; ASCA). We speculated that mannans might impair phagocyte function...
  19. doi request reprint Neutrophil function in inflammation and inflammatory diseases
    Helen L Wright
    School of Biological Sciences, University of Liverpool, UK
    Rheumatology (Oxford) 49:1618-31. 2010
    ....
  20. ncbi request reprint Differential role of neutrophil Fcgamma receptor IIIB (CD16) in phagocytosis, bacterial killing, and responses to immune complexes
    Gianluca Fossati
    University of Liverpool, Liverpool, UK
    Arthritis Rheum 46:1351-61. 2002
    ....
  21. doi request reprint The role of neutrophil apoptosis in juvenile-onset systemic lupus erythematosus
    Angela Midgley
    Alder Hey Children s National Health Service Foundation Trust, Institute of Child Health, Royal Liverpool Children s Hospital Alder Hey, Liverpool University, Liverpool, UK
    Arthritis Rheum 60:2390-401. 2009
    ..This study aimed to determine whether neutrophil apoptosis is altered in patients with juvenile-onset SLE as compared with controls...
  22. pmc Wolbachia endosymbionts induce neutrophil extracellular trap formation in human onchocerciasis
    Francesca Tamarozzi
    Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place L3 5QA, Liverpool, UK
    Sci Rep 6:35559. 2016
    ....
  23. pmc Whose Gene Is It Anyway? The Effect of Preparation Purity on Neutrophil Transcriptome Studies
    Huw B Thomas
    Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 10:e0138982. 2015
    ....
  24. doi request reprint Interferon gene expression signature in rheumatoid arthritis neutrophils correlates with a good response to TNFi therapy
    Helen L Wright
    Institute of Integrative Biology, University of Liverpool and Institute of Ageing and Chronic Disease, University Hospital Aintree, Liverpool, Merseyside, UK
    Rheumatology (Oxford) 54:188-93. 2015
    ..The aim of this study was to use whole transcriptome sequencing (RNA-Seq) of RA neutrophils to identify pre-therapy gene expression signatures that correlate with disease activity or response to TNF inhibitor (TNFi) therapy...
  25. pmc Anaplasma phagocytophilum reduces neutrophil apoptosis in vivo
    Helena Scaife
    School of Biological Sciences, Life Sciences Building, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Infect Immun 71:1995-2001. 2003
    ..phagocytophilum results in changes in rates of apoptosis of infected immune cells. This may help explain how these bacteria replicate in these normally short-lived cells...
  26. pmc Endothelial activation and apoptosis mediated by neutrophil-dependent interleukin 6 trans-signalling: a novel target for systemic sclerosis?
    Theresa C Barnes
    School of Clinical Sciences, University of Liverpool, Liverpool, UK
    Ann Rheum Dis 70:366-72. 2011
    ..Endothelial cell activation and apoptosis are thought to be pivotal in the pathogenesis of this disease, but the mechanisms that mediate this remain unknown...
  27. ncbi request reprint Neutrophil biomarkers predict response to therapy with tumor necrosis factor inhibitors in rheumatoid arthritis
    Helen L Wright
    Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
    J Leukoc Biol . 2016
    ..We also show that in RA, there is great plasticity in neutrophil phenotype, with circulating cells expressing genes normally only expressed in more immature cells...
  28. ncbi request reprint Low-density granulocytes: functionally distinct, immature neutrophils in rheumatoid arthritis with altered properties and defective TNF signalling
    Helen L Wright
    Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom and
    J Leukoc Biol . 2016
    ..Their enhanced survival properties and decreased TNF signaling are likely to have important consequences for disease pathology and response to therapy...
  29. doi request reprint A lack of confirmation with alternative assays questions the validity of IL-17A expression in human neutrophils using immunohistochemistry
    Francesca Tamarozzi
    Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK
    Immunol Lett 162:194-8. 2014
    ..However, we could not detect IL-17A using a range of alternative assays. Our data question the IL-17A antibody specificity and the ability of human neutrophils to express IL-17A. ..
  30. doi request reprint The multifactorial role of neutrophils in rheumatoid arthritis
    Helen L Wright
    Institute of Integrative Biology, Biosciences Building, Crown Street, University of Liverpool, Liverpool L69 7ZB, UK
    Nat Rev Rheumatol 10:593-601. 2014
    ..Thus, in addition to their cytotoxic and immunoregulatory role in RA, neutrophils may be a source of the autoantigens that drive the autoimmune processes underlying this disease. ..
  31. doi request reprint Effects of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo
    Helen L Wright
    Institute of Integrative Biology, University of Liverpool and Institute of Ageing and Chronic Disease, University Hospital Aintree, Liverpool, UK
    Rheumatology (Oxford) 53:1321-31. 2014
    ..This study investigated interactions between IL-6, the anti-IL-6 receptor agent tocilizumab (TCZ) and neutrophils in vitro and in vivo...
  32. doi request reprint Mcl-1; the molecular regulation of protein function
    Luke W Thomas
    School of Biological Sciences, University of Liverpool, Liverpool, UK
    FEBS Lett 584:2981-9. 2010
    ....
  33. pmc Mucocutaneous manifestations in juvenile-onset systemic lupus erythematosus: a review of literature
    Direkrit Chiewchengchol
    Institute of Translational Medicine, Alder Hey Children s NHS Foundation Trust, University of Liverpool, Liverpool, UK Institute of Integrative Biology, University of Liverpool, Liverpool, UK Immunology Unit and Center of Excellence in Immunology and Immune mediated Disease, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    Pediatr Rheumatol Online J 13:1. 2015
    ..They will often improve as lupus is adequately controlled and their reappearance is often the first indicator of a disease flare. ..
  34. doi request reprint Mavrilimumab, a human monoclonal GM-CSF receptor-α antibody for the management of rheumatoid arthritis: a novel approach to therapy
    Jagdish R Nair
    Aintree University Hospital, Rheumatology, Longmoor Lane, Liverpool, UK
    Expert Opin Biol Ther 12:1661-8. 2012
    ....
  35. ncbi request reprint Bile acids inhibit Mcl-1 protein turnover via an epidermal growth factor receptor/Raf-1-dependent mechanism
    Jung Hwan Yoon
    Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic, and Foundation, Rochester, Minnesota 55905, USA
    Cancer Res 62:6500-5. 2002
    ..Raf-1 inhibitors block this increase of Mcl-1 and render the cells more susceptible to apoptosis, a potential therapeutic strategy for cholangiocarcinomas...