Genomes and Genes
James R Edwards
Affiliation: University of Oxford
- Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodelingJames R Edwards
Vanderbilt Center for Bone Biology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Bone Miner Res 28:960-9. 2013..These findings support the notion that SirT1 is a genetic determinant of bone mass, acting in a cell-autonomous manner in both osteoblasts and osteoclasts, through control of NF-κB and bone cell differentiation...
- Osteoclasts: malefactors of disease and targets for treatmentJames R Edwards
Institute of Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford OX3 7LD, United Kingdom
Discov Med 13:201-10. 2012..This review will summarize current literature describing normal and pathological osteoclast biology and highlight the benefits of osteoclast-targeted therapy to combat skeletal disorders...
- Advances in osteoclast biology: old findings and new insights from mouse modelsJames R Edwards
Institute of Musculoskeletal Sciences, University of Oxford, Nuffield Orthopedic Center, Windmill Road, Oxford OX3 7LD, UK
Nat Rev Rheumatol 7:235-43. 2011....
- Osteoclasts in multiple myeloma are derived from Gr-1+CD11b+myeloid-derived suppressor cellsJunling Zhuang
Department of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
PLoS ONE 7:e48871. 2012..Collectively, these data provide in vitro and in vivo evidence that tumor-induced MDSCs exacerbate cancer-associated bone destruction by directly serving as osteoclast precursors...
- Host-derived adiponectin is tumor-suppressive and a novel therapeutic target for multiple myeloma and the associated bone diseaseJessica A Fowler
Vanderbilt Center for Bone Biology, Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA
Blood 118:5872-82. 2011..Furthermore, we have established the potential therapeutic benefit of increasing adiponectin for the treatment of myeloma and the associated bone disease...
- Inhibition of TGF-β signaling by 1D11 antibody treatment increases bone mass and quality in vivoJames R Edwards
Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Bone Miner Res 25:2419-26. 2010....
- Advances in the biology of bone metastasis: how the skeleton affects tumor behaviorJulie A Sterling
Center for Bone Biology, Vanderbilt University, Nashville, TN, USA
Bone 48:6-15. 2011..Taken together, these continually emerging areas of study suggest new potential pathways important in the pathogenesis of bone metastasis and potential areas for targeting therapeutics...
- Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivoClaire M Edwards
Department of Cancer Biology, Vanderbilt Center for Bone Biology, Vanderbilt University, Nashville, TN 37232, USA
Blood 111:2833-42. 2008....
- Lymphatics and boneJames R Edwards
Department of Pathology, Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, Oxford, OX3 7LD, UK
Hum Pathol 39:49-55. 2008..These findings also suggest that lymphangiogenesis is not involved in the disease progression of most primary bone tumors and that carcinomatous metastasis to bone does not occur via lymphatics...
- Activation of NF-kappa B signaling promotes growth of prostate cancer cells in boneRenjie Jin
Vanderbilt Prostate Cancer Center and Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
PLoS ONE 8:e60983. 2013....
- The osteoclast-not always guiltyGregory R Mundy
Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center, Nashville, TN 37232 0575, USA
Cell Metab 6:157-9. 2007....
- Osteoclast differentiation and bone resorption in multicentric reticulohistiocytosisIannis E Adamopoulos
Department of Pathology, University of Oxford, OX3 7LD Oxford, UK
Hum Pathol 37:1176-85. 2006..Inhibitors of osteoclast formation and resorption activity may be of use in preventing the severe joint destruction that commonly occurs in MR...
- Aging mechanisms in arthritic diseasePradeep K Sacitharan
Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, United Kingdom
Discov Med 14:345-52. 2012..As a significant global link exists between aging and the onset of arthritis, this review will consider whether factors known to affect lifespan may also play a role in arthritic disease...
- PTH-related peptide (PTHrP) in hypercalcemiaGregory R Mundy
Vanderbilt Center for Bone Biology, 1235 Medical Research Building IV, Nashville, TN 37232 0575, USA
J Am Soc Nephrol 19:672-5. 2008....