Affiliation: University of Plymouth
- A few important points about dopamine's role in neural network dynamicsD Durstewitz
Centre for Theoretical and Computational Neuroscience, University of Plymouth, United Kingdom
Pharmacopsychiatry 39:S72-5. 2006..These properties could be crucial for understanding dopamine's functional role...
- Dynamical basis of irregular spiking in NMDA-driven prefrontal cortex neuronsDaniel Durstewitz
Centre for Theoretical and Computational Neuroscience, University of Plymouth, Plymouth, UK
Cereb Cortex 17:894-908. 2007..The nonlinearity of NMDA conductances was crucial for inducing this regime. NMDA-induced irregular dynamics may have important implications for computational processes during working memory and neural coding...
- The dual-state theory of prefrontal cortex dopamine function with relevance to catechol-o-methyltransferase genotypes and schizophreniaDaniel Durstewitz
Centre for Theoretical and Computational Neuroscience, Faculty of Science, University of Plymouth, Plymouth, United Kingdom
Biol Psychiatry 64:739-49. 2008....
- Computational significance of transient dynamics in cortical networksDaniel Durstewitz
Centre for Theoretical and Computational Neuroscience, University of Plymouth, Portland Square, Drake Circus, Plymouth PL4 8AA, UK
Eur J Neurosci 27:217-27. 2008..Neural computation has to exploit the itinerant dynamics between these states...
- Beyond bistability: biophysics and temporal dynamics of working memoryD Durstewitz
Centre for Theoretical and Computational Neuroscience, University of Plymouth, A 220 Portland Square, Drake Circus, Plymouth PL4 8AA, UK
Neuroscience 139:119-33. 2006..Together such findings may lay the foundations for highly dynamical theories of working memory based on biophysical principles...
- The ability of the mesocortical dopamine system to operate in distinct temporal modesChristopher C Lapish
Department of Neurosciences, Medical University of South Carolina, Suite 430 BSB 173 Ashley, Charleston, SC, USA
Psychopharmacology (Berl) 191:609-25. 2007..This review discusses evidence that cells in the mesocortical dopamine (DA) system influence information processing in target areas across three distinct temporal domains...
- Successful choice behavior is associated with distinct and coherent network states in anterior cingulate cortexChristopher C Lapish
Department of Psychiatry and Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5
Proc Natl Acad Sci U S A 105:11963-8. 2008..These results point to an underlying functional organization into cell assemblies in the ACC that may monitor choices, outcomes, and task contexts, thus tracking the animal's progression through "task space."..
- Self-organizing neural integrator predicts interval times through climbing activityDaniel Durstewitz
Department of Biopsychology, Ruhr University Bochum, D 44780 Bochum, Germany
J Neurosci 23:5342-53. 2003..Thus, specific mechanisms are proposed for (1) how neurons might represent interval times of variable length and (2) how neurons could acquire the biophysical properties that enable them to work as timers...
- Neural representation of interval timeDaniel Durstewitz
Institute for Cognitive Neuroscience, GAFO 04 991, Ruhr University Bochum, D 44780 Bochum, Germany
Neuroreport 15:745-9. 2004..Various neural mechanisms for producing climbing activity with variable slopes, representing the length of learned intervals, are discussed...
- The computational role of dopamine D1 receptors in working memoryDaniel Durstewitz
AE Biopsychologie, Facultät für Psychologie, Ruhr Universitat Bochum, Germany
Neural Netw 15:561-72. 2002..In this manner, D1 receptor stimulation might regulate the extent to which PFC network activity is focused on a particular goal state versus being open to new goals or information unrelated to the current goal...