Alexander D Douglas
Affiliation: University of Oxford
- A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeysAlexander D Douglas
Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK Electronic address
Cell Host Microbe 17:130-9. 2015..These data suggest that PfRH5-based vaccines have potential to achieve strain-transcending efficacy in humans...
- Comparison of modeling methods to determine liver-to-blood inocula and parasite multiplication rates during controlled human malaria infectionAlexander D Douglas
Jenner Institute, University of Oxford, UK
J Infect Dis 208:340-5. 2013..We find that the parameters estimated by these models are closely correlated, and their predictive accuracy for omitted data points was similar. We propose that future studies include the linear model...
- The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibodyAlexander D Douglas
Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
Nat Commun 2:601. 2011..falciparum is a degenerate process involving a series of parallel redundant pathways...
- Substantially reduced pre-patent parasite multiplication rates are associated with naturally acquired immunity to Plasmodium falciparumA D Douglas
Jenner Institute, Nuffield Department of Medicine, University of Oxford, UK
J Infect Dis 203:1337-40. 2011..This supports the view that a blood-stage vaccine capable of emulating the disease-reducing effect of natural immunity could achieve a detectable effect during the prepatent period...
- Tailoring subunit vaccine immunogenicity: maximizing antibody and T cell responses by using combinations of adenovirus, poxvirus and protein-adjuvant vaccines against Plasmodium falciparum MSP1Alexander D Douglas
Jenner Institute, Oxford University, Oxford, UK
Vaccine 28:7167-78. 2010....
- The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessmentAnna L Goodman
The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
Sci Rep 3:1706. 2013..An improved understanding of the mechanisms responsible for protection, or failure of protection, against P. berghei merozoites could guide the development of an efficacious vaccine against P. falciparum...
- Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigensAndrew R Williams
The Jenner Institute, University of Oxford, Oxford, United Kingdom
PLoS Pathog 8:e1002991. 2012..falciparum antigens and should help to guide the rational development of future multi-antigen vaccines...
- Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5Alexander D Douglas
Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom
J Immunol 192:245-58. 2014..These data provide important insight into the mechanisms of broadly neutralizing anti-malaria Abs and further encourage anti-PfRH5-based malaria prevention efforts. ..
- ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humansSusanne H Sheehy
Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford, Churchill Hospital, Oxford, UK
Mol Ther 20:2355-68. 2012..These data call into question the utility of T cell-inducing blood-stage malaria vaccines and suggest that the focus should remain on high-titer antibody induction against susceptible antigen targets...
- The requirement for potent adjuvants to enhance the immunogenicity and protective efficacy of protein vaccines can be overcome by prior immunization with a recombinant adenovirusSimone C de Cassan
The Jenner Institute, University of Oxford, Headington, Oxford OX3 7DQ, United Kingdom
J Immunol 187:2602-16. 2011....
- Assessment of antibody-dependent respiratory burst activity from mouse neutrophils on Plasmodium yoelii malaria challenge outcomeDavid Llewellyn
1 University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK
J Leukoc Biol 95:369-82. 2014..falciparum arises following repeated natural exposure. ..
- Standardization of the antibody-dependent respiratory burst assay with human neutrophils and Plasmodium falciparum malariaDavid Llewellyn
The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK
Sci Rep 5:14081. 2015..The development of the ADRB assay complements the use of cell-independent assays in blood-stage malaria, such as the assay of growth inhibitory activity, and provides an important standardized cell-based assay in the field...
- Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909Christopher J A Duncan
Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom
PLoS ONE 6:e22271. 2011..Here we report the first study to examine the relationship between in vivo Plasmodium falciparum growth rates and in vitro GIA in humans experimentally infected with blood-stage malaria...
- Combining viral vectored and protein-in-adjuvant vaccines against the blood-stage malaria antigen AMA1: report on a phase 1a clinical trialSusanne H Hodgson
1 The Jenner Institute Laboratories, University of Oxford, Oxford, UK 2 Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford, Churchill Hospital, Oxford, UK
Mol Ther 22:2142-54. 2014....
- Increased sample volume and use of quantitative reverse-transcription PCR can improve prediction of liver-to-blood inoculum size in controlled human malaria infection studiesSusanne H Hodgson
The Jenner Institute, University of Oxford, Oxford, UK
Malar J 14:33. 2015....
- Blood-stage challenge for malaria vaccine efficacy trials: a pilot study with discussion of safety and potential valueFrances Sanderson
Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom
Am J Trop Med Hyg 78:878-83. 2008..This finding may provide greater power to detect partial efficacy of many blood-stage candidate vaccines. We discuss the potential utility of blood-stage challenge studies in accelerating malaria vaccine development...
- Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodiesKatherine E Wright
Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
Nature 515:427-30. 2014..This provides the first structural insight into erythrocyte binding by the Plasmodium RH protein family and identifies novel inhibitory epitopes to guide design of a new generation of vaccines against the blood-stage parasite. ..