Jenny L Donovan

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. pmc Optimising recruitment and informed consent in randomised controlled trials: the development and implementation of the Quintet Recruitment Intervention (QRI)
    Jenny L Donovan
    School of Social and Community Medicine, University of Bristol, Bristol, BS8 2PR, UK
    Trials 17:283. 2016
  2. pmc Time to be BRAVE: is educating surgeons the key to unlocking the potential of randomised clinical trials in surgery? A qualitative study
    Shelley Potter
    Bristol Centre for Surgical Research, School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
    Trials 15:80. 2014
  3. pmc The By-Band study: gastric bypass or adjustable gastric band surgery to treat morbid obesity: study protocol for a multi-centre randomised controlled trial with an internal pilot phase
    Chris A Rogers
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Trials 15:53. 2014
  4. pmc The intellectual challenges and emotional consequences of equipoise contributed to the fragility of recruitment in six randomized controlled trials
    Jenny L Donovan
    School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK Electronic address
    J Clin Epidemiol 67:912-20. 2014
  5. pmc Clear obstacles and hidden challenges: understanding recruiter perspectives in six pragmatic randomised controlled trials
    Jenny L Donovan
    School of Social and Community Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PS, UK
    Trials 15:5. 2014
  6. pmc Presenting treatment options to men with clinically localized prostate cancer: the acceptability of active surveillance/monitoring
    Jenny L Donovan
    School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol, UK
    J Natl Cancer Inst Monogr 2012:191-6. 2012
  7. pmc A review of reporting of participant recruitment and retention in RCTs in six major journals
    Merran Toerien
    Department of Sociology, The University of York, Heslington, York, YO10 4PS, UK
    Trials 10:52. 2009
  8. pmc Public involvement in suicide prevention: understanding and strengthening lay responses to distress
    Christabel Owens
    Peninsula Medical School Universities of Exeter and Plymouth, Wonford House, Dryden Road, Exeter, Devon, EX2 5AF, UK
    BMC Public Health 9:308. 2009
  9. doi Development of a complex intervention improved randomization and informed consent in a randomized controlled trial
    Jenny L Donovan
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR, UK
    J Clin Epidemiol 62:29-36. 2009
  10. pmc Screening for prostate cancer. The case against
    Jenny L Donovan
    University of Bristol, UK
    Ann R Coll Surg Engl 87:90-1; discussion 88. 2005

Detail Information

Publications99

  1. pmc Optimising recruitment and informed consent in randomised controlled trials: the development and implementation of the Quintet Recruitment Intervention (QRI)
    Jenny L Donovan
    School of Social and Community Medicine, University of Bristol, Bristol, BS8 2PR, UK
    Trials 17:283. 2016
    ..The 'QuinteT Recruitment Intervention' (QRI) aims to facilitate informed decision making by patients about RCT participation and to increase recruitment. This paper presents the development and implementation of the QRI...
  2. pmc Time to be BRAVE: is educating surgeons the key to unlocking the potential of randomised clinical trials in surgery? A qualitative study
    Shelley Potter
    Bristol Centre for Surgical Research, School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
    Trials 15:80. 2014
    ..Our aim in this qualitative study was to investigate surgeons' preferences regarding the feasibility of surgical RCTs and their understanding of study design issues using breast reconstruction surgery as a case study...
  3. pmc The By-Band study: gastric bypass or adjustable gastric band surgery to treat morbid obesity: study protocol for a multi-centre randomised controlled trial with an internal pilot phase
    Chris A Rogers
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Trials 15:53. 2014
    ..Laparoscopic adjustable gastric band and Roux-en-Y gastric bypass surgery are the two main surgical procedures performed...
  4. pmc The intellectual challenges and emotional consequences of equipoise contributed to the fragility of recruitment in six randomized controlled trials
    Jenny L Donovan
    School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK Electronic address
    J Clin Epidemiol 67:912-20. 2014
    ..The aim of the study was to investigate how doctors considered and experienced the concept of equipoise while recruiting patients to randomized controlled trials (RCTs)...
  5. pmc Clear obstacles and hidden challenges: understanding recruiter perspectives in six pragmatic randomised controlled trials
    Jenny L Donovan
    School of Social and Community Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PS, UK
    Trials 15:5. 2014
    ..This study aimed i) to understand the recruitment process from the perspective of recruiters actively recruiting RCT participants in six pragmatic RCTs, and ii) to identify opportunities for interventions to improve recruitment...
  6. pmc Presenting treatment options to men with clinically localized prostate cancer: the acceptability of active surveillance/monitoring
    Jenny L Donovan
    School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol, UK
    J Natl Cancer Inst Monogr 2012:191-6. 2012
    ....
  7. pmc A review of reporting of participant recruitment and retention in RCTs in six major journals
    Merran Toerien
    Department of Sociology, The University of York, Heslington, York, YO10 4PS, UK
    Trials 10:52. 2009
    ..This paper aims: (i) to update and extend previous reviews evaluating reporting of participant recruitment and retention in RCTs; (ii) to quantify the level of participation throughout RCTs...
  8. pmc Public involvement in suicide prevention: understanding and strengthening lay responses to distress
    Christabel Owens
    Peninsula Medical School Universities of Exeter and Plymouth, Wonford House, Dryden Road, Exeter, Devon, EX2 5AF, UK
    BMC Public Health 9:308. 2009
    ....
  9. doi Development of a complex intervention improved randomization and informed consent in a randomized controlled trial
    Jenny L Donovan
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR, UK
    J Clin Epidemiol 62:29-36. 2009
    ..Systematic reviews failed to identify robust strategies to improve recruitment. We developed and evaluated a complex intervention to increase levels of randomization and informed consent...
  10. pmc Screening for prostate cancer. The case against
    Jenny L Donovan
    University of Bristol, UK
    Ann R Coll Surg Engl 87:90-1; discussion 88. 2005
  11. pmc The case against
    Jenny L Donovan
    University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Ann R Coll Surg Engl 87:90-1. 2005
  12. pmc Impact of Helicobacter pylori eradication on dyspepsia, health resource use, and quality of life in the Bristol helicobacter project: randomised controlled trial
    J Athene Lane
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR
    BMJ 332:199-204. 2006
    ..To determine the impact of a community based Helicobacter pylori screening and eradication programme on the incidence of dyspepsia, resource use, and quality of life, including a cost consequences analysis...
  13. pmc 'The trial is owned by the team, not by an individual': a qualitative study exploring the role of teamwork in recruitment to randomised controlled trials in surgical oncology
    Sean Strong
    Centre for Surgical Research, School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, BS8 2PS, Bristol, UK
    Trials 17:212. 2016
    ..The aim of this study was to explore how teamwork influences recruitment to a multicentre randomised controlled trial (RCT) involving interventions delivered by different clinical specialties...
  14. pmc Validating the use of Hospital Episode Statistics data and comparison of costing methodologies for economic evaluation: an end-of-life case study from the Cluster randomised triAl of PSA testing for Prostate cancer (CAP)
    Joanna C Thorn
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    BMJ Open 6:e011063. 2016
    ..To evaluate the accuracy of routine data for costing inpatient resource use in a large clinical trial and to investigate costing methodologies...
  15. pmc Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort
    Carolina Bonilla
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    BMC Med 14:66. 2016
    ..To obtain causal estimates, we examined the role of pubertal development in prostate cancer using genetic polymorphisms associated with Tanner stage in adolescent boys in a Mendelian randomization (MR) approach...
  16. pmc Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer
    Jenny L Donovan
    From the School of Social and Community Medicine J L D, J A L, C M, E W, J M B, M D, E L T, R M M, Bristol Randomised Trials Collaboration J A L, C M, and the School of Clinical Sciences T J P, University of Bristol, National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care West at University Hospitals Bristol NHS Foundation Trust J L D, and Bristol Urological Institute, North Bristol NHS Trust L B, E S, D G, E R, Bristol, Nuffield Department of Surgical Sciences, University of Oxford, Oxford F C H, P Holding, D E N, The School of Medicine, University of Cardiff M M, and the Department of Urology, Cardiff and Vale University Health Board A J, S T, H K, Cardiff, The Department of Urology, University Hospitals Leicester, Leicester S B, Department of Biochemistry
    N Engl J Med 375:1425-1437. 2016
    ..Funded by the U.K. National Institute for Health Research Health Technology Assessment Program; ProtecT Current Controlled Trials number, ISRCTN20141297 ; ClinicalTrials.gov number, NCT02044172 .)...
  17. doi Prostate-specific antigen testing and prostate biopsy: are self-reported lower urinary tract symptoms and health-related quality of life associated with the decision to undergo these investigations?
    Kerry N L Avery
    Department of Social Medicine, University of Bristol, Bristol, UK
    BJU Int 102:1629-33. 2008
    ..To investigate whether men's self-reported health-related quality of life and lower urinary tract symptoms (LUTS) are associated with acceptance of prostate-specific antigen (PSA) testing and subsequent prostate biopsy...
  18. doi Predictors of attendance for prostate-specific antigen screening tests and prostate biopsy
    Kerry N L Avery
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Eur Urol 62:649-55. 2012
    ..Little is known about factors influencing men's decisions to undergo screening and diagnostic tests for prostate cancer (PCa)...
  19. ncbi Who can best recruit to randomized trials? Randomized trial comparing surgeons and nurses recruiting patients to a trial of treatments for localized prostate cancer (the ProtecT study)
    Jenny L Donovan
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    J Clin Epidemiol 56:605-9. 2003
    ..In a randomized trial nested within a trial of treatments for localized prostate cancer, we investigated the comparative effectiveness and cost-effectiveness of nurses and surgeons in recruiting patients...
  20. doi Do the risk factors of age, family history of prostate cancer or a higher prostate specific antigen level raise anxiety at prostate biopsy?
    Rhiannon C Macefield
    Department of Social Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
    Eur J Cancer 45:2569-73. 2009
    ....
  21. ncbi 10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer
    Freddie C Hamdy
    From the Nuffield Department of Surgical Sciences, University of Oxford, Oxford F C H, P H, D E N, the School of Social and Community Medicine J L D, J A L, C M, M D, E L T, R M M, E W, the Bristol Randomized Trials Collaboration J A L, C M, and School of Clinical Sciences T J P, University of Bristol, the National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care West, University Hospitals Bristol NHS Foundation Trust J L D, The Department of Cellular Pathology, North Bristol NHS Trust J O, and the Department of Urology, Southmead Hospital and Bristol Urological Institute D G, E R, Bristol, the School of Medicine M M and Division of Cancer and Genetics, School of Medicine J S, Cardiff University, and the Department of Urology, Cardiff and Vale University Health Board H K, Cardiff, The Department of Cellular Pathology, Royal Victoria Infirmary M R, and the Department of Urology, Freeman Hospital P P
    N Engl J Med 375:1415-1424. 2016
    ..Funded by the National Institute for Health Research; ProtecT Current Controlled Trials number, ISRCTN20141297 ; ClinicalTrials.gov number, NCT02044172 .)...
  22. doi Factors distinguishing general practitioners who more readily participated in a large randomized trial were identified
    Liz Down
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    J Clin Epidemiol 62:67-73. 2009
    ..To investigate factors associated with the successful recruitment of general practices to a randomized controlled trial...
  23. doi Men with prostate cancer make positive dietary changes following diagnosis and treatment
    Kerry N L Avery
    School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Clifton, Bristol, BS8 2PS, UK
    Cancer Causes Control 24:1119-28. 2013
    ..This study examined dietary changes in men before and after treatment for PC within the prostate testing for cancer and treatment randomized trial...
  24. pmc Circulating folate, vitamin B12, homocysteine, vitamin B12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis
    Simon M Collin
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:1632-42. 2010
    ..Disturbed folate metabolism is associated with an increased risk of some cancers. Our objective was to determine whether blood levels of folate, vitamin B(12), and related metabolites were associated with prostate cancer risk...
  25. ncbi A comparison of socio-demographic and psychological factors between patients consenting to randomisation and those selecting treatment (the ProtecT study)
    Nicola Mills
    Department of Social Medicine, University of Bristol, UK
    Contemp Clin Trials 27:413-9. 2006
    ..Moreover, randomising patients with a preference may affect treatment efficacy and threaten internal validity...
  26. doi It's not just what you say, it's also how you say it: opening the 'black box' of informed consent appointments in randomised controlled trials
    Julia Wade
    Department of Social Medicine, University of Bristol, 39 Whatley Road, Clifton, Bristol BS8 2PS, United Kingdom
    Soc Sci Med 68:2018-28. 2009
    ..Use of these techniques is necessary to make potential participants' understanding of key issues and their position regarding equipoise explicit in order to facilitate truly informed consent...
  27. doi Associations of sexual dysfunction symptoms with PSA-detected localised and advanced prostate cancer: a case-control study nested within the UK population-based ProtecT (Prostate testing for cancer and Treatment) study
    Simon M Collin
    Department of Social Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PS, UK
    Eur J Cancer 45:3254-61. 2009
    ..Conversely, among men with raised prostate-specific antigen (PSA) levels, a negative association might be expected if sexual dysfunction was symptomatic of benign, rather than malignant, prostatic disease...
  28. pmc Incorporating Known Genetic Variants Does Not Improve the Accuracy of PSA Testing to Identify High Risk Prostate Cancer on Biopsy
    Rebecca Gilbert
    School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    PLoS ONE 10:e0136735. 2015
    ..We investigate whether incorporating information on the PSA-SNPs improves the discrimination achieved by a single PSA threshold in men with raised PSA levels...
  29. doi Associations of lifestyle factors and anthropometric measures with repeat PSA levels during active surveillance/monitoring
    Anya J Burton
    MRC Centre for Causal Analysis in Translational Epidemiology, University of Bristol, Bristol, UK
    Cancer Epidemiol Biomarkers Prev 21:1877-85. 2012
    ..Factors that influence PSA growth, however, are unclear. We evaluated associations of anthropometric and lifestyle factors with age-related PSA growth...
  30. pmc Exploring treatment preferences facilitated recruitment to randomized controlled trials
    Nicola Mills
    School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
    J Clin Epidemiol 64:1127-36. 2011
    ..To explore how patients' treatment preferences were expressed and justified during recruitment to a randomized controlled trial (RCT) and how they influenced participation and treatment decisions...
  31. doi Psychological distress and prostate specific antigen levels in men with and without prostate cancer
    Emma L Turner
    Department of Social Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
    Brain Behav Immun 23:1073-8. 2009
    ..These analyses highlight the need for further investigations into the possible role of depressed mood in the onset of prostate cancer and, in particular, research examining the biological basis for these relationships...
  32. doi Validation of the Hospital Episode Statistics Outpatient Dataset in England
    Joanna C Thorn
    School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK
    Pharmacoeconomics 34:161-8. 2016
    ..This study assesses the validity of coverage in the HES outpatient dataset...
  33. pmc Conveying Equipoise during Recruitment for Clinical Trials: Qualitative Synthesis of Clinicians' Practices across Six Randomised Controlled Trials
    Leila Rooshenas
    School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    PLoS Med 13:e1002147. 2016
    ....
  34. pmc Adherence to dietary and lifestyle recommendations and prostate cancer risk in the prostate testing for cancer and treatment (ProtecT) trial
    Vanessa Er
    School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom National Institute for Health Research NIHR Bristol Nutrition Biomedical Research Unit, Bristol, United Kingdom
    Cancer Epidemiol Biomarkers Prev 23:2066-77. 2014
    ..We investigated whether adherence to the WCRF/AICR recommendations and a prostate cancer dietary index is associated with prostate cancer risk...
  35. pmc Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: a nested case-control study
    Rebecca Gilbert
    School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK
    Cancer Causes Control 26:205-18. 2015
    ..We investigated associations of sixteen SNPs across seven genes with prostate-specific antigen-detected prostate cancer...
  36. pmc Detection of prostate cancer in unselected young men: prospective cohort nested within a randomised controlled trial
    J Athene Lane
    Department of Social Medicine, University of Bristol
    BMJ 335:1139. 2007
    ..To investigate the feasibility of testing for prostate cancer and the prevalence and characteristics of the disease in unselected young men...
  37. ncbi Decision-making about PSA testing and prostate biopsies: a qualitative study embedded in a primary care randomised trial
    Kerry N L Avery
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Eur Urol 53:1186-93. 2008
    ..The overall aim was to increase understanding of men's decision-making about prostate-specific antigen (PSA) testing and subsequent biopsy...
  38. pmc Contemporary accuracy of death certificates for coding prostate cancer as a cause of death: Is reliance on death certification good enough? A comparison with blinded review by an independent cause of death evaluation committee
    Emma L Turner
    School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
    Br J Cancer 115:90-4. 2016
    ..Accurate cause of death assignment is crucial for prostate cancer epidemiology and trials reporting prostate cancer-specific mortality outcomes...
  39. ncbi Longitudinal prostate-specific antigen reference ranges: Choosing the underlying model of age-related changes
    Andrew J Simpkin
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Stat Methods Med Res 25:1875-1891. 2016
    ..Second, it must be able to make accurate predictions about new PSA observations for an individual and about the entire PSA trajectory for a new individual...
  40. pmc Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels
    Carolina Bonilla
    School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    Int J Cancer 139:1520-33. 2016
    ..low grade disease as 1.14 (95% CI: 1.00, 1.31). Because of the potential for pleiotropy of the genetic instruments, these findings can only causally implicate the IGF pathway in general, not any one specific biomarker. ..
  41. pmc Establishing nurse-led active surveillance for men with localised prostate cancer: development and formative evaluation of a model of care in the ProtecT trial
    Julia Wade
    School of Social and Community Medicine, University of Bristol, UK
    BMJ Open 5:e008953. 2015
    ..Nurse-led care, comprising an explicit nurse-led protocol with support from urologists, was developed as part of the AM arm of the Prostate testing for cancer and Treatment (ProtecT) trial...
  42. pmc Patient-reported outcomes in the ProtecT randomized trial of clinically localized prostate cancer treatments: study design, and baseline urinary, bowel and sexual function and quality of life
    Athene Lane
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    BJU Int 118:869-879. 2016
    ....
  43. doi Suicide and the Internet: Changes in the accessibility of suicide-related information between 2007 and 2014
    Lucy Biddle
    School of Social and Community Medicine, University of Bristol, United Kingdom
    J Affect Disord 190:370-5. 2016
    ..Following the ongoing concerns about cyber-suicide, we investigate changes between 2007 and 2014 in material likely to be accessed by suicidal individuals searching for methods of suicide...
  44. doi Systematic Review and Meta-analysis of Factors Determining Change to Radical Treatment in Active Surveillance for Localized Prostate Cancer
    Andrew J Simpkin
    School of Social and Community Medicine, University of Bristol, Bristol, UK Electronic address
    Eur Urol 67:993-1005. 2015
    ..Many men with clinically localized prostate cancer are being monitored as part of active surveillance (AS) programs, but little is known about reasons for receiving radical treatment...
  45. pmc Role of information in preparing men for transrectal ultrasound guided prostate biopsy: a qualitative study embedded in the ProtecT trial
    Julia Wade
    School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Clifton, Bristol, BS8 2PS, UK
    BMC Health Serv Res 15:80. 2015
    ..The objectives were a) to understand men's experiences of biopsy as compared to their expectations; and b) to propose current evidence-based information for men undergoing TRUS-Bx...
  46. doi Associations of adiponectin and leptin with stage and grade of PSA-detected prostate cancer: the ProtecT study
    Anya Burton
    School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK
    Cancer Causes Control 24:323-34. 2013
    ..We examined associations of the adipokines leptin and adiponectin with the stage and grade of PSA-detected prostate cancer...
  47. pmc Young adults' perceptions of GPs as a help source for mental distress: a qualitative study
    Lucy Biddle
    Department of Social Medicine, University of Bristol, Bristol, UK
    Br J Gen Pract 56:924-31. 2006
    ..Few young adults with mental disorder seek help from a GP...
  48. ncbi Perceptions of equipoise are crucial to trial participation: a qualitative study of men in the ProtecT study
    Nicola Mills
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, United Kingdom
    Control Clin Trials 24:272-82. 2003
    ..A priority for future research is to focus on the provision and presentation of suitable and effective trial information, concentrating in particular on the neglected concept of clinical equipoise...
  49. pmc Training recruiters to randomized trials to facilitate recruitment and informed consent by exploring patients' treatment preferences
    Nicola Mills
    School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
    Trials 15:323. 2014
    ..We investigated how RCT recruiters reacted to patients' treatment preferences and identified key strategies to improve informed decision-making and trial recruitment...
  50. pmc The importance of dietary change for men diagnosed with and at risk of prostate cancer: a multi-centre interview study with men, their partners and health professionals
    Kerry N L Avery
    School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Clifton, Bristol BS8 2PS, UK
    BMC Fam Pract 15:81. 2014
    ..Focus groups also evaluated stakeholder opinion, including healthcare professionals, about the provision of dietary advice to PC patients...
  51. doi Active monitoring, radical prostatectomy, or radiotherapy for localised prostate cancer: study design and diagnostic and baseline results of the ProtecT randomised phase 3 trial
    J Athene Lane
    University of Bristol, Bristol, UK
    Lancet Oncol 15:1109-18. 2014
    ....
  52. pmc Key issues in recruitment to randomised controlled trials with very different interventions: a qualitative investigation of recruitment to the SPARE trial (CRUK/07/011)
    Sangeetha Paramasivan
    School of Social and Community Medicine, University of Bristol, 39 Canynge Hall, Whatley Road, Bristol BS8 2PS, UK
    Trials 12:78. 2011
    ....
  53. pmc Using genetic proxies for lifecourse sun exposure to assess the causal relationship of sun exposure with circulating vitamin d and prostate cancer risk
    Carolina Bonilla
    School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, United Kingdom
    Cancer Epidemiol Biomarkers Prev 22:597-606. 2013
    ....
  54. pmc Alcohol consumption and PSA-detected prostate cancer risk--a case-control nested in the ProtecT study
    Luisa Zuccolo
    MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom
    Int J Cancer 132:2176-85. 2013
    ....
  55. doi Associations of aspirin, nonsteroidal anti-inflammatory drug and paracetamol use with PSA-detected prostate cancer: findings from a large, population-based, case-control study (the ProtecT study)
    Ali S Murad
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Int J Cancer 128:1442-8. 2011
    ..Our conclusions are unlikely to be influenced by PSA detection bias because the inverse associations of aspirin, NSAID and paracetamol use with serum PSA would have attenuated (not generated) the observed positive associations...
  56. doi Association of diabetes mellitus with prostate cancer: nested case-control study (Prostate testing for cancer and treatment study)
    Emma L Turner
    Department of Social Medicine, University of Bristol, Bristol, UK
    Int J Cancer 128:440-6. 2011
    ..95). Diabetes is associated with a decreased risk of PSA-detected prostate cancer. These data add to the evidence of the association of diabetes with prostate cancer in the PSA era...
  57. ncbi Transurethral prostate resection, noncontact laser therapy or conservative management in men with symptoms of benign prostatic enlargement? An economic evaluation
    Sian M Noble
    Department of Social Medicine, Medical Research Council Health Services Research Collaboration, Department of Social Medicine, University of Bristol, United Kingdom
    J Urol 168:2476-82. 2002
    ..We evaluated the cost-effectiveness of noncontact laser therapy compared with transurethral prostate resection and conservative treatment in men with symptoms associated with benign prostatic enlargement...
  58. doi Seasonal variation in prostate-specific antigen levels: a large cross-sectional study of men in the UK
    Liz Down
    School of Social and Community Medicine, University of Bristol, Bristol, Oncology Centre, Addenbrooke s Hospital, Cambridge, and Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK
    BJU Int 108:1409-14. 2011
    ..To assess whether a seasonal change in prostate specific antigen (PSA) levels can be detected in men recruited to a large clinical trial...
  59. doi A Peer Review Intervention for Monitoring and Evaluating sites (PRIME) that improved randomized controlled trial conduct and performance
    J Athene Lane
    School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
    J Clin Epidemiol 64:628-36. 2011
    ..We aimed to develop a site monitoring process using peer reviewers to improve staff training, site performance, data collection, and GCP compliance...
  60. doi Population-based prostate-specific antigen testing in the UK leads to a stage migration of prostate cancer
    Alison L Moore
    Department of Social Medicine, University of Bristol, Bristol, UK
    BJU Int 104:1592-8. 2009
    ..To determine, within the UK, the stage and grade of prostate cancers that would be found through population-based prostate specific antigen (PSA) testing and biopsy...
  61. pmc Development of a new method for monitoring prostate-specific antigen changes in men with localised prostate cancer: a comparison of observational cohorts
    Kate Tilling
    Department of Social Medicine, Bristol University, Canynge Hall, Bristol, UK
    Eur Urol 57:446-52. 2010
    ..Prostate-specific antigen (PSA) measurements are increasingly used to monitor men with localised prostate cancer (PCa), but there is little consensus about the method to use...
  62. pmc An evaluation of a multi-component adult weight management on referral intervention in a community setting
    Kate Birnie
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    BMC Res Notes 9:104. 2016
    ..Funding was available for 600 places...
  63. pmc Comparing open and minimally invasive surgical procedures for oesophagectomy in the treatment of cancer: the ROMIO (Randomised Oesophagectomy: Minimally Invasive or Open) feasibility study and pilot trial
    Chris Metcalfe
    Bristol Randomised Trials Collaboration, University of Bristol, Bristol, UK
    Health Technol Assess 20:1-68. 2016
    ..Minimal-access surgery may accelerate recovery...
  64. pmc Characteristics of men responding to an invitation to undergo testing for prostate cancer as part of a randomised trial
    Eleanor I Walsh
    School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK
    Trials 17:497. 2016
    ....
  65. pmc A simple technique to identify key recruitment issues in randomised controlled trials: Q-QAT - Quanti-Qualitative Appointment Timing
    Sangeetha Paramasivan
    School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK
    Trials 16:88. 2015
    ....
  66. pmc Men's knowledge and attitudes towards dietary prevention of a prostate cancer diagnosis: a qualitative study
    Jeremy P Horwood
    School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
    BMC Cancer 14:812. 2014
    ..Qualitative interviews with men participating in the ProDiet study were undertaken to explore the feasibility of implementing dietary interventions for the prevention of prostate cancer...
  67. pmc "Let's get the best quality research we can": public awareness and acceptance of consent to use existing data in health research: a systematic review and qualitative study
    Elizabeth M Hill
    School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, UK
    BMC Med Res Methodol 13:72. 2013
    ..We also investigated the effect of the provision of detailed information about the potential effect of selection bias on public acceptability of the use of data for research...
  68. doi Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigen velocity in men with localized prostate cancer
    Simon M Collin
    School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:2833-8. 2010
    ..We investigated whether these and other elements of folate metabolism were associated with prostate-specific antigen (PSA) velocity (PSAV) as a proxy measure of prostate cancer progression in men with localized prostate cancer...
  69. pmc Standardisation of information submitted to an endpoint committee for cause of death assignment in a cancer screening trial – lessons learnt from CAP (Cluster randomised triAl of PSA testing for Prostate cancer)
    Naomi J Williams
    School of Social and Community Medicine, University of Bristol, based at Royal Hallamshire Hospital, Sheffield, S10 2JF, UK
    BMC Med Res Methodol 15:6. 2015
    ....
  70. pmc The effects of height and BMI on prostate cancer incidence and mortality: a Mendelian randomization study in 20,848 cases and 20,214 controls from the PRACTICAL consortium
    Neil M Davies
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Cancer Causes Control 26:1603-16. 2015
    ..To address uncertainty over the causal nature of previous observational findings, we investigated associations of height- and adiposity-related genetic variants with prostate cancer risk and mortality...
  71. doi A simple technique to identify key recruitment issues in randomised controlled trials: Q-QAT - quanti-qualitative appointment timing
    Sangeetha Paramasivan
    School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK
    Trials 16:617. 2015
    ....
  72. pmc The feasibility of a randomized controlled trial of esophagectomy for esophageal cancer--the ROMIO (Randomized Oesophagectomy: Minimally Invasive or Open) study: protocol for a randomized controlled trial
    Kerry N L Avery
    School of Social and Community Medicine, University of Bristol, 39 Whatley Road, BS8 2PS, Clifton Bristol, UK
    Trials 15:200. 2014
    ....
  73. doi Very low PSA concentrations and deletions of the KLK3 gene
    Santiago Rodriguez
    MRC Centre for Causal Analyses in Translational Epidemiology CAiTE and Bristol Genetic Epidemiology Laboratories BGEL, University of Bristol, Bristol, UK
    Clin Chem 59:234-44. 2013
    ..We hypothesized that very low PSA concentrations might reflect gene-inactivating mutations in KLK3 that lead to abnormally reduced gene expression...
  74. ncbi Satisfaction with care: an independent outcome measure in surgical oncology
    Kerry N L Avery
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol Royal Infirmary, BS8 2PR, United Kingdom
    Ann Surg Oncol 13:817-22. 2006
    ..This study examined how patient satisfaction related to surgical morbidity, treatment type, and QOL outcomes after inpatient treatment for upper gastrointestinal cancer...
  75. doi Behavior theory for dietary interventions for cancer prevention: a systematic review of utilization and effectiveness in creating behavior change
    Kerry N L Avery
    School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol BS8 2PS, UK
    Cancer Causes Control 24:409-20. 2013
    ..This systematic review examined application of behavior theory to dietary interventions aimed at preventing cancer to improve the design and interpretation of trials...
  76. ncbi A scored form of the Bristol Female Lower Urinary Tract Symptoms questionnaire: data from a randomized controlled trial of surgery for women with stress incontinence
    Sara T Brookes
    Department of Social Medicine, University of Bristol, UK
    Am J Obstet Gynecol 191:73-82. 2004
    ..This paper describes development and validation of a scored form BFLUTS questionnaire...
  77. pmc Novel ways to explore surgical interventions in randomised controlled trials: applying case study methodology in the operating theatre
    Natalie S Blencowe
    Centre for Surgical Research, School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol, BS8 2PS, UK
    Trials 16:589. 2015
    ..Methods were developed to transcribe and synchronise data from video recordings with observational data to identify key intervention components, which were then explored in the interviews with surgeons...
  78. pmc Exposure to, and searching for, information about suicide and self-harm on the Internet: Prevalence and predictors in a population based cohort of young adults
    Becky Mars
    School of Social and Community Medicine, University of Bristol, Oakfield House, Bristol BS8 2BN, United Kingdom Electronic address
    J Affect Disord 185:239-45. 2015
    ..However, little is known about the prevalence and patterns of suicide/self-harm related Internet use in the general population...
  79. ncbi Health-related quality of life during neoadjuvant treatment and surgery for localized esophageal carcinoma
    Jane M Blazeby
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Cancer 103:1791-9. 2005
    ..The current study examined HRQL during preoperative chemotherapy/chemoradiotherapy treatment and compared postoperative recovery of HRQL in patients undergoing combined treatment with patients undergoing surgery alone...
  80. pmc Sexual dysfunction in men after treatment for lower urinary tract symptoms: evidence from randomised controlled trial
    Sara T Brookes
    Department of Social Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PR
    BMJ 324:1059-61. 2002
    ..To examine the impact on sexual function of treatments for lower urinary tract symptoms in men...
  81. pmc Supporting adolescent emotional health in schools: a mixed methods study of student and staff views in England
    Judi Kidger
    Department of Social Medicine, University of Bristol, Canynge Hall, 39, Whatley Road, Bristol BS8 2PS, UK
    BMC Public Health 9:403. 2009
    ..Relatively little is known about student and staff views regarding current school-based emotional health provision and what they would like to see in the future, and this is what this study explored...
  82. ncbi Relationship between lower urinary tract symptoms and erectile dysfunction: results from the Boston Area Community Health Survey
    Sara T Brookes
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    J Urol 179:250-5; discussion 255. 2008
    ..We explored the association of lower urinary tract symptoms and erectile dysfunction in a racially and ethnically diverse random sample of men...
  83. pmc Patient advocacy and patient centredness in participant recruitment to randomized-controlled trials: implications for informed consent
    Zelda Tomlin
    Research Fellow, Department of Primary Care and Public Health, Cardiff University, CardiffResearch Fellow, School of Social and Community Medicine, University of Bristol, BristolResearch Fellow RCUK, Department of Sociology, University of York, York
    Health Expect 17:670-82. 2014
    ....
  84. pmc Comparing specialist medical care with specialist medical care plus the Lightning Process for chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME): study protocol for a randomised controlled trial (SMILE Trial)
    Esther Crawley
    Centre for Child and Adolescent Health, School of Social and Community Medicine, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK
    Trials 14:444. 2013
    ..Although over 250 children with CFS/ME attend LP courses each year, there are no reported studies on the effectiveness or cost-effectiveness...
  85. pmc Unstated factors in orthopaedic decision-making: a qualitative study
    Rachael Gooberman-Hill
    University of Bristol, School of Clinical Sciences, Southmead Hospital, Westbury on Trym, Bristol BS10 5NB, UK
    BMC Musculoskelet Disord 11:213. 2010
    ..However, we do not know what happens within orthopaedic practice and whether this reflects the shared model. Our study examined how decisions are made about TJR in orthopaedic consultations...
  86. ncbi Research in black and white
    Joy Adamson
    Joint Medical Research Council, Department of Health, University of Bristol, UK
    Qual Health Res 12:816-25. 2002
    ..The authors believe that qualitative research should be judged by the plausibility of the findings and by a critical evaluation of the way in which the research was conducted and the reflexivity of the researcher...
  87. pmc Factors influencing help seeking in mentally distressed young adults: a cross-sectional survey
    Lucy Biddle
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Br J Gen Pract 54:248-53. 2004
    ..Young adults, especially men, are among those least likely to consult healthcare professionals when mentally distressed or suicidal...
  88. ncbi A placebo-controlled randomized trial of eradication of Helicobacter pylori in the general population: study design and response rates of the Bristol Helicobacter Project
    J Athene Lane
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Control Clin Trials 23:321-32. 2002
    ..In the Bristol Helicobacter Project the rate of participation varied inversely with both social deprivation and the prevalence of the infection...
  89. ncbi Inverse relationship between alcohol consumption and active Helicobacter pylori infection: the Bristol Helicobacter project
    Liam J Murray
    The Queen s University of Belfast, United Kingdom
    Am J Gastroenterol 97:2750-5. 2002
    ..The aim of this study was to examine whether smoking or consumption of alcohol or coffee is associated with active Helicobacter pylori (H. pylori) infection...
  90. pmc Randomised controlled trial of effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux: Bristol helicobacter project
    Richard F Harvey
    Frenchay Hospital, North Bristol NHS Trust, Bristol BS16 1LE
    BMJ 328:1417. 2004
    ..To investigate the effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux...
  91. ncbi "Why don't they just tell me straight, why allocate it?" The struggle to make sense of participating in a randomised controlled trial
    Katie Featherstone
    Cardiff School of Social Sciences, Cardiff University, Wales, UK
    Soc Sci Med 55:709-19. 2002
    ..The provision of clearer written information or time to discuss the trial with particular individuals might be beneficial, although greater public understanding of trials is also needed...
  92. ncbi Measuring the psychosocial impact of population-based prostate-specific antigen testing for prostate cancer in the UK
    Lucy A Brindle
    School of Nursing and Midwifery, University of Southampton, Southampton, UK
    BJU Int 98:777-82. 2006
    ....
  93. ncbi Remapping the body: learning to eat again after surgery for esophageal cancer
    David Wainwright
    University of Bath, United Kingdom
    Qual Health Res 17:759-71. 2007
    ..The authors report findings from in-depth interviews with 11 esophageal cancer patients, documenting their experiences as they struggle to achieve a process of adaptation that is at once physiological, psychological, and social...
  94. ncbi Contribution of a single repeat PSA test to prostate cancer risk assessment: experience from the ProtecT study
    Derek J Rosario
    University of Sheffield, Sheffield, United Kingdom
    Eur Urol 53:777-84. 2008
    ..To examine whether a single repeat prostate-specific antigen (PSA) helps discriminate cancer from non-cancer-related PSA elevation...
  95. pmc Ethics of clinical trials from bayesian perspective: randomisation to clinical trials may solve dilemma of treatment choice in prostate cancer
    Freddie C Hamdy
    BMJ 326:1456. 2003
  96. ncbi Serum insulin-like growth factor-I is positively associated with serum prostate-specific antigen in middle-aged men without evidence of prostate cancer
    Steven E Oliver
    Department of Health Sciences, University of York, and The Hull York Medical School, Heslington, York, UK
    Cancer Epidemiol Biomarkers Prev 13:163-5. 2004
    ..Greater rates of cell proliferation induced by IGF-I may be a key biological pathway underlying these disorders...
  97. ncbi A patient-centered approach to developing a comprehensive symptom and quality of life assessment of anal incontinence
    Nikki Cotterill
    Bristol Urological Institute, Southmead Hospital, Westbury on Trym, Bristol, United Kingdom
    Dis Colon Rectum 51:82-7. 2008
    ..This study was designed to identify question items required for a comprehensive symptom and quality of life assessment for individuals with anal incontinence...
  98. doi Multiple newly identified loci associated with prostate cancer susceptibility
    Rosalind A Eeles
    The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK
    Nat Genet 40:316-21. 2008
    ..7 x 10(-29)). We confirmed previous reports of common loci associated with prostate cancer at 8q24 and 17q. Moreover, we found that three of the newly identified loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK3...
  99. pmc Multiple loci with different cancer specificities within the 8q24 gene desert
    Maya Ghoussaini
    Cancer Research UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, CB1 8RN, Cambridge, UK
    J Natl Cancer Inst 100:962-6. 2008
    ..We conclude that there are at least five separate functional variants in this region...