Marek Czosnyka

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. doi request reprint Monitoring of cerebral autoregulation
    Marek Czosnyka
    Department of Clinical Neurosciences, Division of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Box 167, Cambridge, CB2 2QQ, UK
    Neurocrit Care 21:S95-102. 2014
  2. doi request reprint Cerebrovascular time constant: dependence on cerebral perfusion pressure and end-tidal carbon dioxide concentration
    Marek Czosnyka
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Neurol Res 34:17-24. 2012
  3. ncbi request reprint Monitoring of cerebral autoregulation in head-injured patients
    M Czosnyka
    Medical Research Council Cambridge Center for Brain Repair, Addenbrooke s Hospital, UK
    Stroke 27:1829-34. 1996
  4. pmc Contribution of mathematical modelling to the interpretation of bedside tests of cerebrovascular autoregulation
    M Czosnyka
    Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, UK
    J Neurol Neurosurg Psychiatry 63:721-31. 1997
  5. pmc Laboratory testing of the Spiegelberg brain pressure monitor: a technical report
    M Czosnyka
    The UK Shunt Evaluation Laboratory, Addenbrooke s Hospital, Cambridge, UK
    J Neurol Neurosurg Psychiatry 63:732-5. 1997
  6. ncbi request reprint Vascular components of cerebrospinal fluid compensation
    M Czosnyka
    Medical Research Council Cambridge Centre for Brain Repair and Academic Neurosurgical Unit, Addenbrooke s Hospital, United Kingdom
    J Neurosurg 90:752-9. 1999
  7. pmc Critical closing pressure in cerebrovascular circulation
    M Czosnyka
    Wolfson Brain Imaging Centre, MRC Cambridge Centre for Brain Repair and Academic Neurosurgical Unit, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    J Neurol Neurosurg Psychiatry 66:606-11. 1999
  8. ncbi request reprint Hemodynamic characterization of intracranial pressure plateau waves in head-injury patients
    M Czosnyka
    Academic Neurosurgical Unit and Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 91:11-9. 1999
  9. ncbi request reprint Association between arterial and intracranial pressures
    M Czosnyka
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Br J Neurosurg 14:127-8. 2000
  10. ncbi request reprint Age dependence of cerebrospinal pressure-volume compensation in patients with hydrocephalus
    M Czosnyka
    Academic Neurosurgical Unit and Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 94:482-6. 2001

Detail Information

Publications164 found, 100 shown here

  1. doi request reprint Monitoring of cerebral autoregulation
    Marek Czosnyka
    Department of Clinical Neurosciences, Division of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Box 167, Cambridge, CB2 2QQ, UK
    Neurocrit Care 21:S95-102. 2014
    ..While further studies are needed, these data suggest that monitoring of autoregulation could aid prognostication and may help identify optimal CPP levels in individual patients. ..
  2. doi request reprint Cerebrovascular time constant: dependence on cerebral perfusion pressure and end-tidal carbon dioxide concentration
    Marek Czosnyka
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Neurol Res 34:17-24. 2012
    ..We studied the relationship between τ, ABP, intracranial pressure (ICP), and end-tidal carbon dioxide concentration (EtCO2)...
  3. ncbi request reprint Monitoring of cerebral autoregulation in head-injured patients
    M Czosnyka
    Medical Research Council Cambridge Center for Brain Repair, Addenbrooke s Hospital, UK
    Stroke 27:1829-34. 1996
    ..Using transcranial Doppler ultrasonography, we investigated whether hemodynamic responses to spontaneous variations of cerebral perfusion pressure (CPP) provide reliable information on cerebral autoregulatory reserve...
  4. pmc Contribution of mathematical modelling to the interpretation of bedside tests of cerebrovascular autoregulation
    M Czosnyka
    Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, UK
    J Neurol Neurosurg Psychiatry 63:721-31. 1997
    ....
  5. pmc Laboratory testing of the Spiegelberg brain pressure monitor: a technical report
    M Czosnyka
    The UK Shunt Evaluation Laboratory, Addenbrooke s Hospital, Cambridge, UK
    J Neurol Neurosurg Psychiatry 63:732-5. 1997
    ..To provide a rigorous bench comparison of the Spiegelberg monitor with the Camino pressure monitor an evaluation programme has been carried out in the UK Shunt Evaluation Laboratory...
  6. ncbi request reprint Vascular components of cerebrospinal fluid compensation
    M Czosnyka
    Medical Research Council Cambridge Centre for Brain Repair and Academic Neurosurgical Unit, Addenbrooke s Hospital, United Kingdom
    J Neurosurg 90:752-9. 1999
    ..The aim of the study was to assess how cerebrospinal fluid (CSF) pressure-volume compensation depends on cerebrovascular tone...
  7. pmc Critical closing pressure in cerebrovascular circulation
    M Czosnyka
    Wolfson Brain Imaging Centre, MRC Cambridge Centre for Brain Repair and Academic Neurosurgical Unit, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    J Neurol Neurosurg Psychiatry 66:606-11. 1999
    ..The correlation of CCP with ICP, cerebral autoregulation, and other clinical and haemodynamic modalities in patients with head injury was evaluated...
  8. ncbi request reprint Hemodynamic characterization of intracranial pressure plateau waves in head-injury patients
    M Czosnyka
    Academic Neurosurgical Unit and Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 91:11-9. 1999
    ..The aim of this study was to investigate both the hemodynamic profile and the clinical consequences of plateau waves...
  9. ncbi request reprint Association between arterial and intracranial pressures
    M Czosnyka
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Br J Neurosurg 14:127-8. 2000
    ....
  10. ncbi request reprint Age dependence of cerebrospinal pressure-volume compensation in patients with hydrocephalus
    M Czosnyka
    Academic Neurosurgical Unit and Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 94:482-6. 2001
    ..The aim of this study was to investigate whether CSF compensatory parameters are dependent on age in patients who have symptoms of hydrocephalus and apparently normal intracranial pressure (ICP)...
  11. ncbi request reprint Cerebral autoregulation following head injury
    M Czosnyka
    Department of Neurosurgery, Wolfson Brain Imaging Centre, University of Cambridge, United Kingdom
    J Neurosurg 95:756-63. 2001
    ....
  12. ncbi request reprint Hydrodynamic properties of extraventricular drainage systems
    Marek Czosnyka
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, England
    Neurosurgery 52:619-23; discussion 623. 2003
    ..We tested five commercially available EVDs to assess their fundamental hydrodynamic properties, which determine the quality of this control...
  13. ncbi request reprint Continuous assessment of cerebral autoregulation: clinical and laboratory experience
    M Czosnyka
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 86:581-5. 2003
    ..00002). This method can be used in many clinical scenarios for continuous monitoring of cerebral autoregulation, predicting outcome and optimising treatment strategies...
  14. pmc Monitoring and interpretation of intracranial pressure
    M Czosnyka
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, UK
    J Neurol Neurosurg Psychiatry 75:813-21. 2004
    ..Some of these parameters allow prediction of prognosis of survival following head injury and optimisation of "CPP-guided therapy". In hydrocephalus CSF dynamic tests aid diagnosis and subsequent monitoring of shunt function...
  15. ncbi request reprint Cerebrospinal fluid dynamics
    Marek Czosnyka
    Department of Neurosciences, Addenbrooke s Hospital, Cambridge, UK
    Physiol Meas 25:R51-76. 2004
    ..The descriptions of multiple forms of measurement along with clinical illustrations are mainly based on in-house experience of a multidisciplinary group of scientists and clinicians from Cambridge, UK...
  16. ncbi request reprint Age, intracranial pressure, autoregulation, and outcome after brain trauma
    Marek Czosnyka
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 102:450-4. 2005
    ..The object of this study was to investigate whether a failure of cerebrovascular autoregulation contributes to the relationship between age and outcome in patients following head injury...
  17. ncbi request reprint Concept of "true ICP" in monitoring and prognostication in head trauma
    M Czosnyka
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:341-4. 2005
    ..To propose a new coefficient, which contains information about both the absolute ICP and the position of the 'working point' on the pressure-volume curve...
  18. ncbi request reprint Monitoring and interpretation of intracranial pressure after head injury
    M Czosnyka
    Department of Clinical Neurosciences, Neurosurgical Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:114-8. 2006
    ..To investigate the relationships between long-term computer-assisted monitoring of intracranial pressure (ICP) and indices derived from its waveform versus outcome, age, and sex...
  19. ncbi request reprint Pulse pressure waveform in hydrocephalus: what it is and what it isn't
    Marek Czosnyka
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, United Kingdom
    Neurosurg Focus 22:E2. 2007
    ..The authors reviewed their experience with the measurement and interpretation of ICP pulse amplitude by referring to a database of recordings in hydrocephalic patients...
  20. ncbi request reprint Intracranial pressure: more than a number
    Marek Czosnyka
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, United Kingdom
    Neurosurg Focus 22:E10. 2007
    ..However, the use of secondary ICP indices remains to be confirmed in clinical trials...
  21. doi request reprint An assessment of dynamic autoregulation from spontaneous fluctuations of cerebral blood flow velocity: a comparison of two models, index of autoregulation and mean flow index
    Marek Czosnyka
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Anesth Analg 106:234-9, table of contents. 2008
    ..We studied the association between the dynamic index of autoregulation (ARI) and time correlation index (mean flow index, Mx) in a group of patients after head injury...
  22. doi request reprint A synopsis of brain pressures: which? when? are they all useful?
    Marek Czosnyka
    Academic Neurosurgery Unit, Department of Neurosciences, University of Cambridge, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Neurol Res 29:672-9. 2007
    ....
  23. pmc Investigation of the hydrodynamic properties of a new MRI-resistant programmable hydrocephalus shunt
    David M Allin
    Shunt Evaluation Laboratory and Academic Neurosurgical Unit, Addenbrooke s Hospital, P, O, Box 167, Hills Road, Cambridge CB2 2QQ, UK
    Cerebrospinal Fluid Res 5:8. 2008
    ..The aim of this study was to bench test the properties of the Polaris shunt, independently of the manufacturer...
  24. doi request reprint Monitoring of cerebrovascular autoregulation: facts, myths, and missing links
    Marek Czosnyka
    Department of Clinical Neurosciences, Neurosurgical Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neurocrit Care 10:373-86. 2009
    ..We review a methodology and clinical application of indices useful for monitoring cerebral autoregulation and pressure-reactivity in various scenarios of neuro-critical care...
  25. ncbi request reprint Gender-related differences in intracranial hypertension and outcome after traumatic brain injury
    Marek Czosnyka
    Academic Neurosurgical Unit, Box 167, Addenbrooke s Hospital, Cambridge CB20 QQ, UK
    Acta Neurochir Suppl 102:25-8. 2008
    ..The results were always close to the limit of significance so that to achieve greater statistical power we have continued recruitment of patients for further 5 years...
  26. doi request reprint Impact of duration of symptoms on CSF dynamics in idiopathic normal pressure hydrocephalus
    Z Czosnyka
    Neurosurgical Unit, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurol Scand 123:414-8. 2011
    ..Is CSF compensation dependent on duration of symptoms in idiopathic normal pressure hydrocephalus (iNPH)?..
  27. doi request reprint Modeling of CSF dynamics: legacy of Professor Anthony Marmarou
    Marek Czosnyka
    Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK
    Acta Neurochir Suppl 113:9-14. 2012
    ..Professor Marmarou's work has had a direct impact in the field of contemporary clinical neurosciences, and many of his ideas are still being investigated actively today...
  28. doi request reprint Programmable Shunt Assistant tested in Cambridge shunt evaluation laboratory
    Marek Czosnyka
    Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    Acta Neurochir Suppl 113:71-6. 2012
    ..The system can be in vivo adjusted magnetically, and this adjustability is supposed to affect CSF drainage only in the vertical body position...
  29. ncbi request reprint Assessment of cerebrovascular autoregulation in head-injured patients: a validation study
    Luzius A Steiner
    Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, UK
    Stroke 34:2404-9. 2003
    ..Cerebrovascular autoregulation is frequently measured in head-injured patients. We attempted to validate 4 bedside methods used for assessment of autoregulation...
  30. doi request reprint Plateau waves in head injured patients requiring neurocritical care
    Gianluca Castellani
    Academic Neurosurgical Unit, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Neurocrit Care 11:143-50. 2009
    ..The aim of this study was to analyze the occurrence of plateau waves in head injured patients requiring neurocritical care, their relation with cerebral autoregulation and impact on outcome...
  31. doi request reprint A comparison study of cerebral autoregulation assessed with transcranial Doppler and cortical laser Doppler flowmetry
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, UK
    Neurol Res 32:425-8. 2010
    ....
  32. doi request reprint Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients
    Ivan Timofeev
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Brain 134:484-94. 2011
    ..Whether treatment-related improvement in biochemistry translates into better outcome remains to be established...
  33. doi request reprint The limitations of near-infrared spectroscopy to assess cerebrovascular reactivity: the role of slow frequency oscillations
    Jennifer Diedler
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, United Kingdom
    Anesth Analg 113:849-57. 2011
    ..In the current study, we investigated the role of slow oscillations of total hemoglobin for NIRS-based cerebrovascular reactivity monitoring...
  34. ncbi request reprint Direct comparison of cerebrovascular effects of norepinephrine and dopamine in head-injured patients
    Luzius A Steiner
    Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 32:1049-54. 2004
    ..To directly compare the cerebrovascular effects of norepinephrine and dopamine in patients with acute traumatic brain injury...
  35. doi request reprint Time constant of the cerebral arterial bed in normal subjects
    Magdalena Kasprowicz
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, United Kingdom
    Ultrasound Med Biol 38:1129-37. 2012
    ..C(a) was negatively correlated with mean ABP (R(partial) = -0.68, p < 0.000001). In summary, the time constant shortens with increasing EtCO(2). Its potential role in cerebrovascular investigations needs further studies...
  36. doi request reprint Transient changes in brain tissue oxygen in response to modifications of cerebral perfusion pressure: an observational study
    Danila K Radolovich
    Academic Neurosurgical Unit, Department of Clinical Neuroscience, University of Cambridge, Cambridge CB2 2QQ, UK
    Anesth Analg 110:165-73. 2010
    ..However, only a few of them analyzed fast (few minutes) and transient behavior of PbtO(2) in response to variations (waves) of intracranial pressure (ICP) and cerebral perfusion pressure (CPP)...
  37. doi request reprint Time constant of the cerebral arterial bed
    Magdalena Kasprowicz
    Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 114:17-21. 2012
    ..62, p = 0.001). In controls, τ was independent of age. Further study during cerebrovascular reactivity tests is needed to establish the usefulness of τ for quantitative estimation of haemodynamics in cerebrovascular disease...
  38. ncbi request reprint Predictive value of initial computerized tomography scan, intracranial pressure, and state of autoregulation in patients with traumatic brain injury
    Magdalena Hiler
    Academic Neurosurgical Unit, Department of Clinical Neuroscience, University of Cambridge, Addenbrooke s NHS Trust, Cambridge, United Kingdom
    J Neurosurg 104:731-7. 2006
    ....
  39. ncbi request reprint Is there a direct link between cerebrovascular activity and cerebrospinal fluid pressure-volume compensation?
    Christina Haubrich
    Department of Academic Neurosurgery, Box 167 Addenbrooke s Hospital, Cambridge, UK
    Stroke 38:2677-80. 2007
    ..This study focused on the question whether ICP has an independent impact on slow waves of FV within the normal cerebral perfusion pressures range...
  40. pmc Critical closing pressure determined with a model of cerebrovascular impedance
    Georgios V Varsos
    Neurosurgical Unit, Department of Clinical Neurosciences, Division of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 33:235-43. 2013
    ....
  41. doi request reprint Transcranial Doppler pulsatility index: what it is and what it isn't
    Nicolas de Riva
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Hills Road, Box 167, Cambridge, CB2 0QQ, UK
    Neurocrit Care 17:58-66. 2012
    ..We sought to evaluate the relationship between PI and CVR in situations, where CVR increases (mild hypocapnia) and decreases (plateau waves of intracranial pressure-ICP)...
  42. pmc Changes in cerebral compartmental compliances during mild hypocapnia in patients with traumatic brain injury
    Emmanuel Carrera
    Academic Neurosurgery Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom
    J Neurotrauma 28:889-96. 2011
    ..Further studies are needed to determine whether monitoring of arterial and CSF compartment compliances may detect and prevent an adverse ischemic event during hyperventilation...
  43. doi request reprint Continuous monitoring of cerebrovascular pressure reactivity in patients with head injury
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, United Kingdom
    Neurosurg Focus 25:E2. 2008
    ..A cerebrovascular pressure reactivity index (PRx) can be determined as the moving correlation coefficient between mean intracranial pressure (ICP) and mean arterial blood pressure...
  44. doi request reprint Reactivity of brain tissue oxygen to change in cerebral perfusion pressure in head injured patients
    Danila K Radolovich
    Academic Neurosurgical Unit, Department of Clinical Neuroscience, University of Cambridge, Addenbrooke s Hospital, P O Box 167, Cambridge, CB2 2QQ, UK
    Neurocrit Care 10:274-9. 2009
    ..We aimed to compare similar indices describing interaction between changes in intracranial pressure (ICP), arterial blood pressure (ABP), and brain tissue oxygen to verify their clinical utility in patients after traumatic brain injury...
  45. doi request reprint Critical closing pressure: comparison of three methods
    Jorge A López-Magaña
    Department of Clinical Neurosciences, Neurosurgery Unit, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    J Cereb Blood Flow Metab 29:987-93. 2009
    ..However, predictions of CCP using TCD waveform analysis show substantial differences from values of CCP recorded during cardiac arrest...
  46. doi request reprint Continuous assessment of cerebral autoregulation with near-infrared spectroscopy in adults after subarachnoid hemorrhage
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, UK
    Stroke 41:1963-8. 2010
    ..In this study, we compared near-infrared spectroscopy-based indices of cerebral autoregulation (TOx) with Mx in patients with subarachnoid hemorrhage...
  47. doi request reprint Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, United Kingdom
    J Neurotrauma 27:1951-8. 2010
    ..THx may be of diagnostic value to optimize therapy oriented toward restoration and continuity of cerebrovascular reactivity, especially in patients for whom direct ICP monitoring is not feasible...
  48. doi request reprint Doppler flow velocity and intra-cranial pressure: responses to short-term mild hypocapnia help to assess the pressure-volume relationship after head injury
    Christina Haubrich
    Department of Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Ultrasound Med Biol 39:1521-6. 2013
    ..01). Results suggest that a test that combines the responses of two intra-cranial compartments may provide consistent information about intra-cranial p/v compliance, even if the parameters derived from ICP monitoring are inconclusive. ..
  49. doi request reprint Critical closing pressure during intracranial pressure plateau waves
    Georgios V Varsos
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Hills Road, Cambridge CB2 0QQ, UK
    Neurocrit Care 18:341-8. 2013
    ..The aim of this study is to describe the behavior of CCP and WT during spontaneous increases of ICP, termed plateau waves, in order to quantify ischemic risk...
  50. doi request reprint Monitoring cerebral autoregulation after head injury. Which component of transcranial Doppler flow velocity is optimal?
    Karol P Budohoski
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Hills Road, Cambridge CB2 0QQ, UK
    Neurocrit Care 17:211-8. 2012
    ..Systolic and diastolic FV have been explored in other diseases. This study aims to evaluate the systolic, mean and diastolic FV for monitoring autoregulation and predicting outcome after TBI...
  51. ncbi request reprint Reliability of the blood flow velocity pulsatility index for assessment of intracranial and cerebral perfusion pressures in head-injured patients
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Department of Clinical Neurosciences, Addenbrooke s Hospital, Cambridge, United Kingdom
    Neurosurgery 71:853-61. 2012
    ..It has been postulated that the Gosling pulsatility index (PI) assessed with transcranial Doppler (TCD) has a diagnostic value for noninvasive estimation of intracranial pressure (ICP) and cerebral perfusion pressure (CPP)...
  52. pmc Interaction between brain chemistry and physiology after traumatic brain injury: impact of autoregulation and microdialysis catheter location
    Ivan Timofeev
    Division of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurotrauma 28:849-60. 2011
    ..Decreases in perfusion and oxygenation were associated with deteriorating neurochemistry and these effects were more pronounced in perilesional tissue and when cerebrovascular reactivity was impaired...
  53. doi request reprint How does moderate hypocapnia affect cerebral autoregulation in response to changes in perfusion pressure in TBI patients?
    Christina Haubrich
    Department of Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 114:153-6. 2012
    ..Our study showed that short-term moderate HC may optimize the autoregulatory response to spontaneous CPP fluctuations with only a small CPP increase. Patients with impaired autoregulation seemed to benefit the most...
  54. doi request reprint A microdialysis study of oral vigabatrin administration in head injury patients: preliminary evaluation of multimodality monitoring
    Keri L H Carpenter
    Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    Acta Neurochir Suppl 114:271-6. 2012
    ....
  55. ncbi request reprint Responses of posttraumatic pericontusional cerebral blood flow and blood volume to an increase in cerebral perfusion pressure
    Luzius A Steiner
    Wolfson Brain Imaging Centre, University Department of Anesthesia, Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 23:1371-7. 2003
    ..Pericontusional oedema on computed tomography was associated with lower absolute values of CBF and CBV but did not differ from nonoedematous tissue in the relative response to CPP elevation...
  56. ncbi request reprint Asymmetry of pressure autoregulation after traumatic brain injury
    Eric A Schmidt
    Academic Neurosurgery Unit, Department of Anaesthesiology, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurosurg 99:991-8. 2003
    ..The aim of this study was to assess the asymmetry of autoregulation between the left and right sides of the brain by using bilateral transcranial Doppler ultrasonography in a cohort of patients with head injuries...
  57. ncbi request reprint Changes in cerebral blood flow during cerebrospinal fluid pressure manipulation in patients with normal pressure hydrocephalus: a methodological study
    Brian K Owler
    Academic Neurosurgery Unit, Addenbrooke s Hospital, University of Cambridge, Cambridge, United Kingdom
    J Cereb Blood Flow Metab 24:579-87. 2004
    ....
  58. doi request reprint Cerebrospinal compensation of pulsating cerebral blood volume in hydrocephalus
    Dong Joo Kim
    Academic Neurosurgical Unit, Addenbrooke s Hosptal, University of Cambridge, Cambridge CB2 2QQ, UK
    Neurol Res 32:587-92. 2010
    ..The method was verified using clinical recordings performed during infusion studies in a group of patients diagnosed with hydrocephalus...
  59. ncbi request reprint Enhancement of cerebral blood flow using systemic hypertonic saline therapy improves outcome in patients with poor-grade spontaneous subarachnoid hemorrhage
    Ming Yuan Tseng
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, United Kingdom
    J Neurosurg 107:274-82. 2007
    ..Whether the increment of change in CBF correlates with changes in autoregulation of CBF or outcome at discharge remains unknown...
  60. doi request reprint Impairment of cerebral autoregulation predicts delayed cerebral ischemia after subarachnoid hemorrhage: a prospective observational study
    Karol P Budohoski
    Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, UK
    Stroke 43:3230-7. 2012
    ..We tested the hypothesis that early autoregulatory failure, detected using near-infrared spectroscopy-based index, TOxa and transcranial Doppler-based index, Sxa, can predict DCI...
  61. doi request reprint Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury
    Marcel J H Aries
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, and Neurosciences Critical Care Unit, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 40:2456-63. 2012
    ..We then validated the CPPopt algorithm by determining the association between outcome and the deviation of actual CPP from CPPopt...
  62. ncbi request reprint Biological effects of acute pravastatin treatment in patients after aneurysmal subarachnoid hemorrhage: a double-blind, placebo-controlled trial
    Ming Yuan Tseng
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, United Kingdom
    J Neurosurg 107:1092-100. 2007
    ..The object of this study was to continue to examine potential mechanisms of these beneficial effects...
  63. doi request reprint Index of cerebrospinal compensatory reserve in hydrocephalus
    Dong Joo Kim
    Academic Neurosurgical Unit, Addenbrooke s Hospital, University of Cambridge, Cambridge, England
    Neurosurgery 64:494-501; discussion 501-2. 2009
    ..We explore how RAP varies with different forms of physiological or nonphysiological intracranial volume loads in adult hydrocephalus, with and without a functioning cerebrospinal fluid (CSF) shunt...
  64. doi request reprint Acute systemic erythropoietin therapy to reduce delayed ischemic deficits following aneurysmal subarachnoid hemorrhage: a Phase II randomized, double-blind, placebo-controlled trial. Clinical article
    Ming Yuan Tseng
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, UK
    J Neurosurg 111:171-80. 2009
    ..In this trial, the authors explored the potential neuroprotective effects of acute EPO therapy following aSAH...
  65. doi request reprint Continuous monitoring of cerebrovascular reactivity using pulse waveform of intracranial pressure
    Marcel J H Aries
    Academic Neurosurgery Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    Neurocrit Care 17:67-76. 2012
    ....
  66. ncbi request reprint The relationship between cerebral blood flow autoregulation and cerebrovascular pressure reactivity after traumatic brain injury
    Karol P Budohoski
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Neurosurgery 71:652-60; discussion 660-1. 2012
    ..From a practical point of view, PRx can be monitored continuously, whereas Mx can only be monitored in short periods when transcranial Doppler probes can be applied...
  67. doi request reprint Short-term moderate hypocapnia augments detection of optimal cerebral perfusion pressure
    Christina Haubrich
    Department of Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, England
    J Neurotrauma 28:1133-7. 2011
    ..It appeared that short-term moderate HC augmented the detection of an optimum CPP, and may therefore usefully support CPP-guided therapy in patients with TBI...
  68. ncbi request reprint Impact of intracranial pressure and cerebral perfusion pressure on severe disability and mortality after head injury
    Marcella Balestreri
    Academic Neurosurgical Unit Addenbrooke s Hospital, Cambridge, UK
    Neurocrit Care 4:8-13. 2006
    ..To investigate the relationships between intracranial pressure (ICP), cerebral perfusion pressure (CPP), and outcome after traumatic brain injury...
  69. doi request reprint What shapes pulse amplitude of intracranial pressure?
    Emmanuel Carrera
    Academic Neurosurgical Unit, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
    J Neurotrauma 27:317-24. 2010
    ..Further clinical studies will reveal whether AMP(ICP) is a better indicator of clinical severity and outcome than mICP in TBI and NPH patients...
  70. doi request reprint "Optimal cerebral perfusion pressure" in poor grade patients after subarachnoid hemorrhage
    Philippe Bijlenga
    Academic Neurosurgical Unit, Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 0QQ, UK
    Neurocrit Care 13:17-23. 2010
    ..The study investigates the association between vasospasm, PRx, and CPPopt in poor grade patients (WFNS 4&5) after subarachnoid hemorrhage (SAH)...
  71. doi request reprint Slow vasogenic fluctuations of intracranial pressure and cerebral near infrared spectroscopy--an observational study
    Ruwan A Weerakkody
    University of Cambridge, Addenbrooke s Hospital, UK
    Acta Neurochir (Wien) 152:1763-9. 2010
    ..In this study, we attempted to describe synchronisation between slow waves of ICP and of near-infrared spectroscopy (NIRS) variables during controlled elevation of ICP...
  72. doi request reprint Non-invasively estimated ICP pulse amplitude strongly correlates with outcome after TBI
    Karol P Budohoski
    Department of Clinical Neurosciences, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 114:121-5. 2012
    ....
  73. ncbi request reprint Slight elevation of baseline intracranial pressure after fluid infusion into CSF space in patients with hydrocephalus
    Magdalena Kasprowicz
    Academic Neurosurgery Unit, University of Cambridge Cambridge, UK
    Neurol Res 26:628-31. 2004
    ..To investigate the elevation of resting cerebrospinal fluid (CSF) pressure recorded after a CSF infusion test in patients with hydrocephalus...
  74. ncbi request reprint Positron emission tomographic cerebral perfusion disturbances and transcranial Doppler findings among patients with neurological deterioration after subarachnoid hemorrhage
    Pawan S Minhas
    Wolfson Brain Imaging Centre and Academic Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, England
    Neurosurgery 52:1017-22; discussion 1022-4. 2003
    ..We studied cerebral perfusion patterns and associated TCD indices for 25 patients who developed clinical signs of delayed neurological deficits...
  75. ncbi request reprint The effects of large-dose propofol on cerebrovascular pressure autoregulation in head-injured patients
    Luzius A Steiner
    Academic Neurosurgery, University Department of Anaesthesia, Addenbrooke s Hospital, Cambridge, United Kingdom
    Anesth Analg 97:572-6, table of contents. 2003
    ..We propose that large doses of propofol should be used cautiously in head-injured patients, because there is the potential to increase the injured brain's vulnerability to secondary insults...
  76. ncbi request reprint Pattern of white matter regional cerebral blood flow and autoregulation in normal pressure hydrocephalus
    Shahan Momjian
    Academic Neurosurgery Unit, Addenbrooke s Hospital and Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK
    Brain 127:965-72. 2004
    ..These results are discussed in the light of previous hypotheses concerning the aetiology of periventricular CBF reduction in NPH...
  77. ncbi request reprint Pressure autoregulation and positron emission tomography-derived cerebral blood flow acetazolamide reactivity in patients with carotid artery stenosis
    Pawan S Minhas
    Wolfson Brain Imaging Centre and Academic Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, England
    Neurosurgery 55:63-7; discussion 67-8. 2004
    ..4 indicates diminished autoregulation. The objective of this study was to compare acetazolamide reactivity of positron emission tomography (PET)-derived cerebral blood flow (CBF) with Mx in patients with carotid arterial disease...
  78. ncbi request reprint Effects of acute treatment with statins on cerebral autoregulation in patients after aneurysmal subarachnoid hemorrhage
    Ming Yuan Tseng
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, United Kingdom
    Neurosurg Focus 21:E10. 2006
    ..In the current study, they test the hypothesis that these effects are associated with improvement in indices describing autoregulation of cerebral blood flow...
  79. ncbi request reprint Effects of acute pravastatin treatment on intensity of rescue therapy, length of inpatient stay, and 6-month outcome in patients after aneurysmal subarachnoid hemorrhage
    Ming Yuan Tseng
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Stroke 38:1545-50. 2007
    ..This study assesses the effects of pravastatin on the frequency and intensity for rescue therapy, length of inpatient stay, and long-term outcome at 6 months...
  80. ncbi request reprint Normal pressure hydrocephalus and cerebral blood flow: a PET study of baseline values
    Brian K Owler
    Academic Neurosurgery Unit, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 24:17-23. 2004
    ..The results suggest that the role of the basal ganglia and thalamus in NPH may be more prominent than currently appreciated. The implications for theories regarding the pathogenesis of NPH are discussed...
  81. doi request reprint The monitoring of relative changes in compartmental compliances of brain
    Dong Joo Kim
    Academic Neurosurgical Unit, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK Department of Engineering, University of Cambridge, Cambridge, UK
    Physiol Meas 30:647-59. 2009
    ..Plateau waves affect the balance between vascular and CSF compartments, which is reflected by the inverse change of compliance of the cerebral arterial bed and global compliance of the CSF space...
  82. doi request reprint Effect of hyper- and hypocapnia on cerebral arterial compliance in normal subjects
    Emmanuel Carrera
    Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Cambridge, United Kingdom
    J Neuroimaging 21:121-5. 2011
    ..However, the effects of changes in PaCO2 on cerebral arterial compliance (Ca) are unknown...
  83. doi request reprint Critical thresholds for transcranial Doppler indices of cerebral autoregulation in traumatic brain injury
    Enrico Sorrentino
    Department of Academic Neurosurgery, Addenbrooke s Hospital, Hills Rd, Cambridge, CB2 OQQ, UK
    Neurocrit Care 14:188-93. 2011
    ..Transcranial Doppler-derived indices of cerebral autoregulation are related to outcome after TBI. We analyzed our retrospective material to identify thresholds discriminative of outcome for these indices...
  84. ncbi request reprint Asymmetry of cerebral autoregulation following head injury
    E A Schmidt
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Wolfson Brain Imaging Centre, University of Cambridge, UK
    Acta Neurochir Suppl 81:133-4. 2002
    ..To investigate asymmetry of cerebra autoregulation in head-injured patients with lateral brain contusions...
  85. ncbi request reprint Association between outcome, cerebral pressure reactivity and slow ICP waves following head injury
    M Balestreri
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:25-8. 2005
    ..To investigate the relationships between slow vasogenic waves ('B waves') of intracranial pressure (ICP), pressure-reactivity and outcome after traumatic brain injury...
  86. ncbi request reprint Should we measure cerebral blood flow in head-injured patients?
    L A Steiner
    Academic Neurosurgery Unit, Addenbrooke s Hospital, Cambridge, UK
    Br J Neurosurg 16:429-39. 2002
    ....
  87. ncbi request reprint Decompressive craniectomy in traumatic brain injury: outcome following protocol-driven therapy
    I Timofeev
    Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:11-6. 2006
    ..Formal prospective randomized studies of decompressive craniectomy are now indicated...
  88. ncbi request reprint Use of ICM+ software for on-line analysis of intracranial and arterial pressures in head-injured patients
    K Guendling
    Academic Department of Clinical Neuroscience, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 96:108-13. 2006
    ..To summarize our experience from the first 2 years of use of the ICM+ software in our Neurocritical Care Unit (NCCU)...
  89. ncbi request reprint The continuous assessment of cerebrovascular reactivity: a validation of the method in healthy volunteers
    S K Piechnik
    Wolfson Brain Imaging Centre, Cambridge Medical Research Council s Centre for Brain Repair and Academic Neurosurgery Unit, Addenbrooke s Hospital, United Kingdom
    Anesth Analg 89:944-9. 1999
    ..17/s for all volunteers and increased values of Mx (> 0.4 in 86% of volunteers) and Sx (> 0.2 in 79% of volunteers). Overall, there was a reasonably good correlation of both Mx and Sx with RoR (R2 = 0.65 and 0.58, respectively)...
  90. ncbi request reprint Intracranial hypertension: what additional information can be derived from ICP waveform after head injury?
    M Balestreri
    Department of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir (Wien) 146:131-41. 2004
    ..We have studied whether the value of ICP monitoring can be augmented by indices describing cerebrovascular pressure-reactivity and pressure-volume compensatory reserve derived from ICP and arterial blood pressure (ABP) waveforms...
  91. doi request reprint Cerebrospinal fluid dynamics: disturbances and diagnostics
    A Lavinio
    Addenbrooke s Hospital, Academic Neurosurgery, Cambridge, UK
    Eur J Anaesthesiol Suppl 42:137-41. 2008
    ..The technique is also helpful in the assessment of shunt malfunction, including posture-related over-drainage and shunt obstruction...
  92. ncbi request reprint Imaging of cerebral blood flow and metabolism in brain injury in the ICU
    J D Pickard
    Wolfson Brain Imaging Centre, University of Cambridge, Addenbrookes Hospital, Cambridge, UK
    Acta Neurochir Suppl 95:459-64. 2005
    ..New modelling and analytical approaches have been developed...
  93. ncbi request reprint Dynamic cerebral autoregulation: should intracranial pressure be taken into account?
    P M Lewis
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir (Wien) 149:549-55; discussion 555. 2007
    ..The aim of our project was to assess the discrepancies between methods of dynamic autoregulation testing based on CPP or ABP, and study possible differences in their prognostic value...
  94. ncbi request reprint Clinical significance of cerebral autoregulation
    M Czosnyka
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 81:117-9. 2002
    ..In the present study we have correlated these methods with clinical findings...
  95. ncbi request reprint Pressure-autoregulation, CO2 reactivity and asymmetry of haemodynamic parameters in patients with carotid artery stenotic disease. A clinical appraisal
    I Gooskens
    Academic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir (Wien) 145:527-32; discussion 532. 2003
    ..We evaluated the relationship between clinical status, CO2 reactivity, pressure-autoregulation and other haemodynamic variables derived from Transcranial Doppler ultrasonography in patients with carotid artery disease...
  96. ncbi request reprint Cerebral autoregulation among patients with symptoms of hydrocephalus
    Zofia H Czosnyka
    Academic Neurosurgical Unit and Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, England
    Neurosurgery 50:526-32; discussion 532-3. 2002
    ..To study the relationship between the resistance to cerebrospinal fluid (CSF) outflow and cerebral autoregulation...
  97. ncbi request reprint Continuous monitoring of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic brain injury
    Luzius A Steiner
    Academic Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Crit Care Med 30:733-8. 2002
    ..To test the hypothesis that patients with poor outcome were managed at a cerebral perfusion pressure (CPP) differing more from their CPPOPT than were patients with good outcome...
  98. ncbi request reprint A case study of hemispatial neglect using finite element analysis and positron emission tomography
    Alonso Pena
    Academic Neurosurgery Unit, Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Department of Engineering, University of Cambridge, United Kingdom
    J Neuroimaging 12:360-7. 2002
    ..As symptoms evolved in parallel with brain shift over the subsequent months, the authors hypothesized that the disorder was associated with the appearance of mechanical stresses in the cerebral mantle...
  99. ncbi request reprint Symmetry of cerebral hemodynamic indices derived from bilateral transcranial Doppler
    Eric A Schmidt
    Academic Neurosurgery Unit, PO Box 167, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, United Kingdom
    J Neuroimaging 13:248-54. 2003
    ..The authors evaluated with bilateral transcranial Doppler (TCD) ultrasonography the norm of interhemispheric difference for several cerebrovascular hemodynamic parameters...
  100. ncbi request reprint Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic deficits after aneurysmal subarachnoid hemorrhage: a phase II randomized placebo-controlled trial
    Ming Yuan Tseng
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
    Stroke 36:1627-32. 2005
    ....
  101. ncbi request reprint Hydrocephalus, ventriculomegaly and the vegetative state: a review
    John D Pickard
    University of Cambridge, Academic Neurosurgery Unit, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ
    Neuropsychol Rehabil 15:224-36. 2005
    ..These techniques are reviewed together with the limited literature available that documents the effect of CSF diversion on outcome in "vegetative" patients...