Adam F Cunningham

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi request reprint Tubercle bacilli generate a novel cell wall-associated pigment after long-term anaerobic culture
    Adam F Cunningham
    Birmingham Centre for Immune Regulation, University of Birmingham, Birmingham B15 2TT, UK
    FEMS Microbiol Lett 235:191-8. 2004
  2. ncbi request reprint Salmonella induces a switched antibody response without germinal centers that impedes the extracellular spread of infection
    Adam F Cunningham
    Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
    J Immunol 178:6200-7. 2007
  3. pmc Loss of CD154 impairs the Th2 extrafollicular plasma cell response but not early T cell proliferation and interleukin-4 induction
    Adam F Cunningham
    University of Birmingham, Medical Research Council Centre for Immune Regulation, Birmingham, UK
    Immunology 113:187-93. 2004
  4. ncbi request reprint Characterization of human humoral responses to the major outer membrane protein and OMP2 of Chlamydophila pneumoniae
    Adam F Cunningham
    Department of Molecular Microbiology, University of Southampton, Tremona Rd, Southampton, SO16 6YD, UK
    FEMS Microbiol Lett 227:73-9. 2003
  5. ncbi request reprint Responses to the soluble flagellar protein FliC are Th2, while those to FliC on Salmonella are Th1
    Adam F Cunningham
    MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK
    Eur J Immunol 34:2986-95. 2004
  6. pmc IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro, but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo
    Karine Serre
    MRC Centre for Immune Regulation, The IBR, School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Mol Immunol 47:1914-22. 2010
  7. doi request reprint T-zone localized monocyte-derived dendritic cells promote Th1 priming to Salmonella
    Adriana Flores-Langarica
    Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Eur J Immunol 41:2654-65. 2011
  8. doi request reprint Early simultaneous production of intranodal CD4 Th2 effectors and recirculating rapidly responding central-memory-like CD4 T cells
    Karine Serre
    MRC Centre for Immune Regulation, The IBR, Department of Immunology, University of Birmingham, Birmingham, UK
    Eur J Immunol 39:1573-86. 2009
  9. doi request reprint CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines
    Karine Serre
    Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom
    Blood 120:4552-9. 2012
  10. doi request reprint Molecular differences between the divergent responses of ovalbumin-specific CD4 T cells to alum-precipitated ovalbumin compared to ovalbumin expressed by Salmonella
    Karine Serre
    MRC Centre for Immune Regulation, University of Birmingham, Medical School, Birmingham, UK
    Mol Immunol 45:3558-66. 2008

Detail Information

Publications54

  1. ncbi request reprint Tubercle bacilli generate a novel cell wall-associated pigment after long-term anaerobic culture
    Adam F Cunningham
    Birmingham Centre for Immune Regulation, University of Birmingham, Birmingham B15 2TT, UK
    FEMS Microbiol Lett 235:191-8. 2004
    ..We termed this pigment APP1, anaerobically produced pigment 1, the first pigment identified in M. tuberculosis...
  2. ncbi request reprint Salmonella induces a switched antibody response without germinal centers that impedes the extracellular spread of infection
    Adam F Cunningham
    Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
    J Immunol 178:6200-7. 2007
    ..These results may explain why attenuated Salmonella-induced B cell responses are protective in secondary, but not primary infections...
  3. pmc Loss of CD154 impairs the Th2 extrafollicular plasma cell response but not early T cell proliferation and interleukin-4 induction
    Adam F Cunningham
    University of Birmingham, Medical Research Council Centre for Immune Regulation, Birmingham, UK
    Immunology 113:187-93. 2004
    ..Thus functional CD154 ligation during the first encounter of T cells and B cells in the T zone is critical for follicular and extrafollicular antibody responses...
  4. ncbi request reprint Characterization of human humoral responses to the major outer membrane protein and OMP2 of Chlamydophila pneumoniae
    Adam F Cunningham
    Department of Molecular Microbiology, University of Southampton, Tremona Rd, Southampton, SO16 6YD, UK
    FEMS Microbiol Lett 227:73-9. 2003
    ..Peptides from MOMP, unlike OMP2, were not strongly recognized. Two of these epitopes when linked to an inert carrier reacted strongly with high-titer anti-C. pneumoniae sera...
  5. ncbi request reprint Responses to the soluble flagellar protein FliC are Th2, while those to FliC on Salmonella are Th1
    Adam F Cunningham
    MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK
    Eur J Immunol 34:2986-95. 2004
    ....
  6. pmc IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro, but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo
    Karine Serre
    MRC Centre for Immune Regulation, The IBR, School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Mol Immunol 47:1914-22. 2010
    ....
  7. doi request reprint T-zone localized monocyte-derived dendritic cells promote Th1 priming to Salmonella
    Adriana Flores-Langarica
    Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Eur J Immunol 41:2654-65. 2011
    ..Thus, optimal Th1 development to Salmonella requires the rapid accumulation of moDCs within T zones and their collaboration with cDCs...
  8. doi request reprint Early simultaneous production of intranodal CD4 Th2 effectors and recirculating rapidly responding central-memory-like CD4 T cells
    Karine Serre
    MRC Centre for Immune Regulation, The IBR, Department of Immunology, University of Birmingham, Birmingham, UK
    Eur J Immunol 39:1573-86. 2009
    ..Thus intranodal effector cells and recirculating, rapidly responding central-memory-like cells emerged simultaneously from the third day of a primary Th2 response...
  9. doi request reprint CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines
    Karine Serre
    Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom
    Blood 120:4552-9. 2012
    ..This model clarifies how precursors of long-lived AFCs and memory B cells acquire CXCR3 that causes their migration to inflammatory foci...
  10. doi request reprint Molecular differences between the divergent responses of ovalbumin-specific CD4 T cells to alum-precipitated ovalbumin compared to ovalbumin expressed by Salmonella
    Karine Serre
    MRC Centre for Immune Regulation, University of Birmingham, Medical School, Birmingham, UK
    Mol Immunol 45:3558-66. 2008
    ..Finally, IL-17RB is strongly associated with OVA-specific CD4 T cells responding to alumOVA, suggesting that alum may promote Th2 immune response through a role for the IL-25/IL-17RB pathway...
  11. doi request reprint Soluble flagellin, FliC, induces an Ag-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella typhimurium infection
    Saeeda Bobat
    MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK
    Eur J Immunol 41:1606-18. 2011
    ..This suggests that designing Th1-inducing subunit vaccines may not always be necessary since this can occur naturally during subsequent infection...
  12. ncbi request reprint Pinpointing IL-4-independent acquisition and IL-4-influenced maintenance of Th2 activity by CD4 T cells
    Adam F Cunningham
    The Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, GB
    Eur J Immunol 34:686-94. 2004
    ....
  13. doi request reprint Systemic flagellin immunization stimulates mucosal CD103+ dendritic cells and drives Foxp3+ regulatory T cell and IgA responses in the mesenteric lymph node
    Adriana Flores-Langarica
    Medical Research Council Centre for Immune Regulation, Division of Immunity and Infection, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Immunol 189:5745-54. 2012
    ..Therefore, systemic sFliC immunization targets CD103(+) DCs and drives distinct mucosal T and B cell responses. This offers a potential "Trojan horse" approach to modulate mucosal immunity by systemically immunizing with sFliC...
  14. doi request reprint Dendritic cells and monocyte/macrophages that create the IL-6/APRIL-rich lymph node microenvironments where plasmablasts mature
    Elodie Mohr
    Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom
    J Immunol 182:2113-23. 2009
    ..The distribution of these myeloid cell subsets correlates with a gradient of AFC maturation assessed by progressive loss of Ki67 as AFC pass from the B cell follicle along the perivascular areas to the medullary cords...
  15. pmc Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression
    Karine Serre
    School of Immunity and Infection, MRC Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Birmingham, England, United Kingdom
    PLoS ONE 6:e20731. 2011
    ..Thus, mechanism(s), different from the in vitro pathway for Th2-induction, contribute to in vivo Th2-differentiation. The pathway for in vivo IL-4-independent Th2-differentiation has yet to be characterized...
  16. pmc IFN-{gamma} produced by CD8 T cells induces T-bet-dependent and -independent class switching in B cells in responses to alum-precipitated protein vaccine
    Elodie Mohr
    Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Proc Natl Acad Sci U S A 107:17292-7. 2010
    ..Thus, T-bet dependence identifies distinct transcriptional pathways in B cells that regulate IFN-γ-induced switching to different IgG isotypes...
  17. pmc Rapid development of Th2 activity during T cell priming
    Adam F Cunningham
    University of Birmingham, Medical Research Council Centre for Immune Regulation, Birmingham B15 2TT, UK
    Clin Dev Immunol 10:1-6. 2003
    ..This contrasts with the critical role of the cytokines in reinforcing the Th-phenotype and selectively expanding T helper clones...
  18. pmc Thymic function is maintained during Salmonella-induced atrophy and recovery
    Ewan A Ross
    Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute for Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom
    J Immunol 189:4266-74. 2012
    ..Thus, thymic atrophy does not necessarily result in a matching dysfunctional T cell output, and thymic homeostasis can constantly adjust to systemic infection to ensure that naive T cell output is maintained...
  19. pmc Size and conformation limits to secretion of disulfide-bonded loops in autotransporter proteins
    Denisse L Leyton
    School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Biol Chem 286:42283-91. 2011
    ..These latter data strongly support the hairpin mode of autotransporter biogenesis...
  20. ncbi request reprint Critical synergy of CD30 and OX40 signals in CD4 T cell homeostasis and Th1 immunity to Salmonella
    Fabrina Gaspal
    Medical Research Council Centre for Immune Regulation, Division of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom
    J Immunol 180:2824-9. 2008
    ..Finally, Salmonella and lymphopenia are shown to act synergistically in selectively depleting CD4 T cells deficient in OX40 and CD30. Collectively these findings identify a novel mechanism by which Th1 responses are sustained...
  21. doi request reprint Selective effects of NF-κB1 deficiency in CD4⁺ T cells on Th2 and TFh induction by alum-precipitated protein vaccines
    Karine Serre
    MRC Centre for Immune Regulation, IBR, School of Immunity and Infection, University of Birmingham, Birmingham, UK
    Eur J Immunol 41:1573-82. 2011
    ..Altogether, these results suggest that NF-κB1 regulates the expression of CXCR5 on CD4(+) T cells primed in vivo, and thus selectively controls the T-cell-dependent germinal center component of B-cell response to alumOVA...
  22. pmc CD31 is required on CD4+ T cells to promote T cell survival during Salmonella infection
    Ewan A Ross
    Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Immunol 187:1553-65. 2011
    ..This identifies a novel role for CD31 in regulating CD4 T cell homeostasis...
  23. pmc A generalised module for the selective extracellular accumulation of recombinant proteins
    Yanina R Sevastsyanovich
    School of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    Microb Cell Fact 11:69. 2012
    ..It is widely believed that laboratory strains of Escherichia coli, including those used for industrial production of proteins, do not secrete proteins to the extracellular milieu...
  24. pmc Ligation of CD11c during vaccination promotes germinal centre induction and robust humoral responses without adjuvant
    Ann L White
    Tenovus Research Laboratory, Cancer Sciences Division, Southampton University School of Medicine, General Hospital, Southampton, UK
    Immunology 131:141-51. 2010
    ..They also point to an interesting role for CR4 on DC in triggering B cells during humoral immunity...
  25. doi request reprint Differential timing of antibody-mediated phagocytosis and cell-free killing of invasive African Salmonella allows immune evasion
    Matthew K Siggins
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, UK Novartis Vaccines Institute for Global Health, Siena, Italy
    Eur J Immunol 44:1093-8. 2014
    ....
  26. doi request reprint Early B blasts acquire a capacity for Ig class switch recombination that is lost as they become plasmablasts
    Jennifer L Marshall
    MRC Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham, UK
    Eur J Immunol 41:3506-12. 2011
    ..CSR in this extrafollicular response is confined to B blasts, because NP-specific plasmablasts, identified by expressing CD138 and Blimp-1, no longer express AID and cannot undergo CSR...
  27. doi request reprint Death receptor 3 is essential for generating optimal protective CD4⁺ T-cell immunity against Salmonella
    Sarah L Buchan
    Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    Eur J Immunol 42:580-8. 2012
    ..These data establish for the first time a role for DR3 in a host defence response...
  28. ncbi request reprint Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13, and B cells
    Adam F Cunningham
    University of Birmingham, Medical Research Council Centre for Immune Regulation, Birmingham, United Kingdom
    J Immunol 169:2900-6. 2002
    ..These early events that direct virgin T cells toward Th2 differentiation contrast with the critical later role of Th2 cytokines in selectively expanding Th2 clones and driving further IL-4 synthesis...
  29. doi request reprint Laboratory adapted Escherichia coli K-12 becomes a pathogen of Caenorhabditis elegans upon restoration of O antigen biosynthesis
    Douglas F Browning
    School of Immunity and Infection, University of Birmingham, Birmingham, UK
    Mol Microbiol 87:939-50. 2013
    ..coli. We show killing is associated with bacterial resistance to mechanical shear and persistence in the C. elegans gut. These results suggest C. elegans is not an effective model of human-pathogenic E. coli infectious disease...
  30. pmc CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration
    Sian Lax
    Rheumatology Research Group, Institute of Biomedical Research, University of Birmingham, UK MRC Centre for Immune Regulation, University of Birmingham, UK
    FEBS Open Bio 2:187-90. 2012
    ..In CD248(-/-) mice the thymus is hypocellular and regeneration is poorer, with significant loss of all thymocyte populations. This identifies the requirement of CD248 to maintain optimal thymic cellularity post-partum and infection...
  31. pmc The essential β-barrel assembly machinery complex components BamD and BamA are required for autotransporter biogenesis
    Amanda E Rossiter
    School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Bacteriol 193:4250-3. 2011
    ..In this report, we detail the role of the other BAM components (BamB-E). We identify the importance of BamD in autotransporter biogenesis and show that BamB, BamC, and BamE are not required...
  32. pmc Cross-species chimeras reveal BamA POTRA and β-barrel domains must be fine-tuned for efficient OMP insertion
    Douglas F Browning
    Institute of Microbiology and Infection, University of Birmingham, Birmingham, B15 2TT, UK
    Mol Microbiol 97:646-59. 2015
    ..We show that defects in the orthologous POTRA domains can be rescued by compensatory mutations within the β-barrel. These data reveal that the POTRA and barrel domains must be precisely aligned to ensure efficient OMP insertion. ..
  33. pmc Mutational and topological analysis of the Escherichia coli BamA protein
    Douglas F Browning
    Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 8:e84512. 2013
    ..We show that the surface-exposed loops of the BamA β-barrel are essential. ..
  34. pmc The capsular polysaccharide Vi from Salmonella typhi is a B1b antigen
    Jennifer L Marshall
    Medical Research Council Centre for Immune Regulation, School of Immunity and Infection, Institute for Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Immunol 189:5527-32. 2012
    ..This work therefore suggests that, in mice, B1b cells contribute to the protection induced by Vi Ag, and targeting non-Vi Ags as subunit vaccines may offer an attractive strategy to augment current Vi-based vaccine strategies...
  35. pmc Soluble flagellin coimmunization attenuates Th1 priming to Salmonella and clearance by modulating dendritic cell activation and cytokine production
    Adriana Flores-Langarica
    Division of Immunity and Infection, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Eur J Immunol 45:2299-311. 2015
    ..This has marked implications for understanding how limits in Th1 priming can be achieved during infection-induced, Th1-mediated inflammation...
  36. pmc The porin OmpD from nontyphoidal Salmonella is a key target for a protective B1b cell antibody response
    Cristina Gil-Cruz
    School of Immunity and Infection and Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Proc Natl Acad Sci U S A 106:9803-8. 2009
    ..OmpD is a strong candidate vaccine target and may, in part, explain the lack of cross-protection between Salmonella Typhi and STm infections...
  37. doi request reprint Absent bactericidal activity of mouse serum against invasive African nontyphoidal Salmonella results from impaired complement function but not a lack of antibody
    Matthew K Siggins
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Immunol 186:2365-71. 2011
    ..This difference in Ab-dependent immunity to Salmonella in mice and men must be considered when applying findings from the mouse model of Salmonella disease and vaccination response to man...
  38. pmc Dysregulated humoral immunity to nontyphoidal Salmonella in HIV-infected African adults
    Calman A MacLennan
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, University of Birmingham, Birmingham, UK
    Science 328:508-12. 2010
    ....
  39. pmc Resolving Salmonella infection reveals dynamic and persisting changes in murine bone marrow progenitor cell phenotype and function
    Ewan A Ross
    MRC Centre for Immune Regulation, Institute for Microbiology and Infection, School of Immunity and Infection, Institute for Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham, UK
    Eur J Immunol 44:2318-30. 2014
    ..Better understanding of this process could offer novel therapeutic opportunities to modulate BM functionality and promote healthy aging...
  40. ncbi request reprint Extrafollicular antibody responses
    Ian C M MacLennan
    MRC Center for Immune Regulation, University of Birmingham, Birmingham, UK
    Immunol Rev 194:8-18. 2003
    ..All types of naïve and memory B cells can be recruited into extrafollicular responses. These responses are associated with immunoglobulin class switching but, at the most, only low-level hypermutation...
  41. pmc Increased severity of respiratory infections associated with elevated anti-LPS IgG2 which inhibits serum bactericidal killing
    Timothy J Wells
    Institute of Microbiology and Infection, School of Immunity and Infection, School Clinical and Experimental Medicine, University of Birmingham, Birmingham B15 2TT, England, UK Institute of Microbiology and Infection, School of Immunity and Infection, School Clinical and Experimental Medicine, University of Birmingham, Birmingham B15 2TT, England, UK
    J Exp Med 211:1893-904. 2014
    ..These findings have marked implications for our understanding of protection generated by natural infection and for the design of vaccines, which should avoid inducing such blocking antibodies. ..
  42. pmc The stability of complement-mediated bactericidal activity in human serum against Salmonella
    Colette M O'Shaughnessy
    Medical Research Council Centre for Immune Regulation and Clinical Immunology Service, Institute of Biomedical Research, School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 7:e49147. 2012
    ..The study provides a scheme for determining the requirements for serum handling in relation to functional activity of complement in other systems...
  43. pmc Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium
    Natalie A Roberts
    MRC Centre for Immune Regulation, University of Birmingham, Birmingham, B15 2TT, UK
    Immunity 36:427-37. 2012
    ....
  44. pmc SadA, a trimeric autotransporter from Salmonella enterica serovar Typhimurium, can promote biofilm formation and provides limited protection against infection
    Dhaarini Raghunathan
    School of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Infect Immun 79:4342-52. 2011
    ..Therefore, despite SadA having pleiotropic functions, it is not a dominant, protective antigen for antibody-mediated protection against Salmonella...
  45. pmc Genome sequence of the emerging pathogen Aeromonas caviae
    Scott A Beatson
    School of Immunity and Infection, University of Birmingham, Birmingham, UK
    J Bacteriol 193:1286-7. 2011
    ..Here we present the first genome sequence of an A. caviae strain that was isolated as the sole pathogen from a child with profuse diarrhea...
  46. pmc Differential Killing of Salmonella enterica Serovar Typhi by Antibodies Targeting Vi and Lipopolysaccharide O:9 Antigen
    Peter J Hart
    School of Immunity and Infection, College of Medicine and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 11:e0145945. 2016
    ..Our findings support a protective role for Vi capsule in preventing complement and phagocyte killing of Salmonella that can be overcome by specific anti-Vi antibodies, but only to a limited extent by anti-O:9 antibodies. ..
  47. pmc Inflammation-induced formation of fat-associated lymphoid clusters
    Cécile Bénézech
    School of Immunity and Infection, IBR MRC Centre for Immune Regulation, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Nat Immunol 16:819-28. 2015
    ..Thus, FALCs supported and coordinated the activation of innate B cells and T cells during serosal immune responses. ..
  48. pmc Natural and vaccine-mediated immunity to Salmonella Typhimurium is impaired by the helminth Nippostrongylus brasiliensis
    Saeeda Bobat
    MRC Centre for Immune Regulation, Institute of Microbiology and Infection, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS Negl Trop Dis 8:e3341. 2014
    ....
  49. ncbi request reprint CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair
    Sian Lax
    Division of Immunity and Infection, Institute for Biomedical Research, MRC Centre for Immune Regulation, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    FEBS Lett 581:3550-6. 2007
    ..These results suggest that CD248 expression helps define a subset of LT stromal cells which play a role in remodelling during tissue development, infection and repair...
  50. doi request reprint Transcription of the plasmid-encoded toxin gene from enteroaggregative Escherichia coli is regulated by a novel co-activation mechanism involving CRP and Fis
    Amanda E Rossiter
    School of Immunity and Infection School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Mol Microbiol 81:179-91. 2011
    ..This study complements previous findings that establish Fis as a key virulence regulator in EAEC 042...
  51. pmc Structure and function of BamE within the outer membrane and the β-barrel assembly machine
    Timothy J Knowles
    School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    EMBO Rep 12:123-8. 2011
    ....
  52. ncbi request reprint CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells
    Michelle R Tourigny
    Department of Pathology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Immunity 17:179-89. 2002
    ..Cell cycle arrest mediated by p18(INK4C) is therefore requisite for the generation of functional plasma cells...
  53. ncbi request reprint Recirculating CD4 memory T cells mount rapid secondary responses without major contributions from follicular CD4 effectors and B cells
    Sanjiv A Luther
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Eur J Immunol 37:1476-84. 2007
    ..Accelerated memory CD4 T cell responses were also seen in B cell-deficient mice...
  54. pmc Homeostatic cell-cycle control by BLyS: Induction of cell-cycle entry but not G1/S transition in opposition to p18INK4c and p27Kip1
    Xiangao Huang
    Department of Pathology and Graduate Program in Immunology and Microbial Pathogenesis, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:17789-94. 2004
    ..Antagonistic cell-cycle regulation by BLyS and p18(INK4c) is functionally linked to apoptotic control and conserved from B cell activation in vitro to antibody response in vivo, further indicating a physiologic role in homeostasis...