Tessa Crompton

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Sonic hedgehog signalling in T-cell development and activation
    Tessa Crompton
    Immunobiology Unit, University College London Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Nat Rev Immunol 7:726-35. 2007
  2. doi request reprint Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation
    Susan V Outram
    Immunobiology Unit, University College London Institute of Child Health, London, United Kingdom
    Blood 113:2217-28. 2009
  3. pmc Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development
    Ekati Drakopoulou
    Immunobiology Unit, UCL Institute of Child Health, London, UK
    Cell Cycle 9:4144-52. 2010
  4. pmc Role of Hedgehog signalling at the transition from double-positive to single-positive thymocyte
    Anna L Furmanski
    Immunobiology Unit, Institute of Child Health, University College London, London, UK
    Eur J Immunol 42:489-99. 2012
  5. pmc Hedgehog Signalling in the Embryonic Mouse Thymus
    Alessandro Barbarulo
    Immunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK
    J Dev Biol 4:22. 2016
  6. pmc The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκB activity
    Anna L Furmanski
    Immunobiology Section, Institute of Child Health, University College London, London WC1N 1EH, UK
    J Cell Sci 128:2085-95. 2015
  7. pmc A genome wide transcriptional model of the complex response to pre-TCR signalling during thymocyte differentiation
    Hemant Sahni
    Institute of Child Health, University College London, London WC1N 1EH, UK
    Oncotarget 6:28646-60. 2015
  8. pmc Regulation of murine normal and stress-induced erythropoiesis by Desert Hedgehog
    Ching In Lau
    Immunobiology Unit, University College London Institute of Child Health, 30 Guilford St, London, United Kingdom
    Blood 119:4741-51. 2012
  9. doi request reprint The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms
    Ariadne L Hager-Theodorides
    Immunobiology Unit, University College London Institute of Child Health, London, United Kingdom
    J Immunol 183:3023-32. 2009
  10. pmc Tissue-derived hedgehog proteins modulate Th differentiation and disease
    Anna L Furmanski
    Immunobiology Unit, Institute of Child Health, University College London, London WC1N 1EH, United Kingdom
    J Immunol 190:2641-9. 2013

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Sonic hedgehog signalling in T-cell development and activation
    Tessa Crompton
    Immunobiology Unit, University College London Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Nat Rev Immunol 7:726-35. 2007
    ..We also review the influence of hedgehog signalling in peripheral T-cell activation...
  2. doi request reprint Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation
    Susan V Outram
    Immunobiology Unit, University College London Institute of Child Health, London, United Kingdom
    Blood 113:2217-28. 2009
    ..Analysis of Ihh conditional knockout and heterozygote adult mice showed that Ihh also influences thymocyte number in the adult...
  3. pmc Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development
    Ekati Drakopoulou
    Immunobiology Unit, UCL Institute of Child Health, London, UK
    Cell Cycle 9:4144-52. 2010
    ..In addition, introduction of a Class I-restricted transgenic TCR into the adult Gli1-deficient and embryonic Gli2-deficient thymus showed that both Gli1 and Gli2 influence its selection to the CD8 lineage...
  4. pmc Role of Hedgehog signalling at the transition from double-positive to single-positive thymocyte
    Anna L Furmanski
    Immunobiology Unit, Institute of Child Health, University College London, London, UK
    Eur J Immunol 42:489-99. 2012
    ..These data together suggest that Hh signalling may play a role in influencing the later stages of thymocyte development...
  5. pmc Hedgehog Signalling in the Embryonic Mouse Thymus
    Alessandro Barbarulo
    Immunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK
    J Dev Biol 4:22. 2016
    ..Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte-TEC cross-talk in the embryonic mouse thymus during the last week of gestation...
  6. pmc The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκB activity
    Anna L Furmanski
    Immunobiology Section, Institute of Child Health, University College London, London WC1N 1EH, UK
    J Cell Sci 128:2085-95. 2015
    ....
  7. pmc A genome wide transcriptional model of the complex response to pre-TCR signalling during thymocyte differentiation
    Hemant Sahni
    Institute of Child Health, University College London, London WC1N 1EH, UK
    Oncotarget 6:28646-60. 2015
    ..Our model thus placed known regulators in a temporal perspective, and in addition identified novel candidate regulators of thymocyte differentiation. ..
  8. pmc Regulation of murine normal and stress-induced erythropoiesis by Desert Hedgehog
    Ching In Lau
    Immunobiology Unit, University College London Institute of Child Health, 30 Guilford St, London, United Kingdom
    Blood 119:4741-51. 2012
    ..During recovery of hematopoiesis after irradiation, and under conditions of stress-induced erythropoiesis, erythrocyte differentiation was accelerated in both spleen and bone marrow of Dhh-deficient mice compared with WT...
  9. doi request reprint The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms
    Ariadne L Hager-Theodorides
    Immunobiology Unit, University College London Institute of Child Health, London, United Kingdom
    J Immunol 183:3023-32. 2009
    ..Overall our data indicate that Gli3 expressed in the thymus stroma regulates negative selection and TCR signal strength via Hh-dependent and -independent mechanisms, with implications for autoimmunity...
  10. pmc Tissue-derived hedgehog proteins modulate Th differentiation and disease
    Anna L Furmanski
    Immunobiology Unit, Institute of Child Health, University College London, London WC1N 1EH, United Kingdom
    J Immunol 190:2641-9. 2013
    ..Our data present an unexpected and novel role for tissue-derived morphogens in the regulation of fluid immune responses, with implications for allergy and tumor responses, suggesting new uses for anti-Hh therapeutics...
  11. ncbi request reprint KLF13 influences multiple stages of both B and T cell development
    Susan V Outram
    Immunobiology Unit, Institute of Child Health, University College, London, United Kingdom
    Cell Cycle 7:2047-55. 2008
    ..Thus KLF13 is involved at multiple different checkpoints in development that require signalling through the TCR, pre-BCR or mature BCR...
  12. pmc T-cell reconstitution after thymus xenotransplantation induces hair depigmentation and loss
    Anna L Furmanski
    Immunobiology Unit, Institute of Child Health, University College London, London, UK
    J Invest Dermatol 133:1221-30. 2013
    ..Our data raise interesting questions about the mechanisms underlying tissue-specific tolerance to skin antigens...
  13. ncbi request reprint A novel role for Hedgehog in T-cell receptor signaling: implications for development and immunity
    Nicola J Rowbotham
    Immunobiology Unit, UCL Institute of Child Health, London, UK
    Cell Cycle 6:2138-42. 2007
    ..Modulation of TCR signal strength by Hh pathway activation has importance for immunity as the presence or absence of Hh in the environment in which a T cell is activated would shape the immune response...
  14. ncbi request reprint Reduced thymocyte development in sonic hedgehog knockout embryos
    Divya K Shah
    Department of Biological Sciences, Imperial College London, London, United Kingdom
    J Immunol 172:2296-306. 2004
    ....
  15. doi request reprint Splenomegaly and modified erythropoiesis in KLF13-/- mice
    Adele R Gordon
    Section of Cardiovascular Biology, Department of Biochemistry, University of Cambridge, Downing Site, Cambridge, CB2 1QW, United Kingdom
    J Biol Chem 283:11897-904. 2008
    ..A higher proportion of the Ter119(med)CD71(hi) cells were proliferating, indicating that the mice were under a degree of erythropoietic stress. These data indicate that KLF13 is involved in the normal control of erythropoiesis...
  16. pmc Beta-selection: abundance of TCRbeta-/gammadelta- CD44- CD25- (DN4) cells in the foetal thymus
    Ariadne L Hager-Theodorides
    Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, London, UK
    Eur J Immunol 37:487-500. 2007
    ..Our data demonstrate in vivo differentiation from DN3 to DN4 cell in the absence of TCRbeta/gammadelta expression in the foetal thymus, and after hydrocortisone treatment of adult mice...
  17. pmc Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation
    Nicola J Rowbotham
    Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London, UK
    Blood 109:3757-66. 2007
    ..In peripheral T cells, Gli2DeltaN(2) expression attenuated T-cell activation and proliferation, by a mechanism upstream of ERK phosphorylation...
  18. pmc The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes
    Ariadne L Hager-Theodorides
    Division of Cell and Molecular Biology, Faculty of Life Sciences, Imperial College London, Sir Alexander Fleming Bldg, South Kensington Campus, London SW7 2AZ, United Kingdom
    Blood 106:1296-304. 2005
    ..The effect of Gli3 was dose dependent, suggesting its direct involvement in the transcriptional regulation of genes controlling T-cell differentiation during fetal development...
  19. ncbi request reprint Expression and function of the Eph A receptors and their ligands ephrins A in the rat thymus
    Juan J Muñoz
    Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain
    J Immunol 169:177-84. 2002
    ....
  20. ncbi request reprint Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation
    Ariadne L Hager-Theodorides
    Department of Biological Sciences, Imperial College of Science Technology and Medicine, London SW7 2AZ, UK
    J Immunol 169:5496-504. 2002
    ..Our study suggests that the BMP2/4 pathway may function in thymic homeostasis by regulating T cell lineage commitment and differentiation...
  21. ncbi request reprint The role of morphogens in T-cell development
    Alberto Varas
    Department of Cell Biology, Faculty of Biology, Complutense University, 28040 Madrid, Spain
    Trends Immunol 24:197-206. 2003
    ....
  22. pmc Expression of hedgehog proteins in the human thymus
    Rosa Sacedon
    Department of Cell Biology, Faculty of Medicine, Complutense University, 28040 Madrid, Spain
    J Histochem Cytochem 51:1557-66. 2003
    ....
  23. ncbi request reprint Repression of hedgehog signal transduction in T-lineage cells increases TCR-induced activation and proliferation
    Nicola J Rowbotham
    Immunobiology Unit, UCL Institute of Child Health, London, United Kingdom
    Cell Cycle 7:904-8. 2008
    ..Thus, as negative regulators of TCR-dependent events, Hh proteins provide an environmental influence on T-cell fate...
  24. ncbi request reprint Sonic hedgehog regulates early human thymocyte differentiation by counteracting the IL-7-induced development of CD34+ precursor cells
    Cruz Gutiérrez-Frías
    Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain
    J Immunol 173:5046-53. 2004
    ..Therefore, Shh may function as a maintenance factor for intrathymic CD34+ precursor cells...
  25. pmc Diacylglycerol kinase alpha activity promotes survival of CD4+ 8+ double positive cells during thymocyte development
    Susan V Outram
    Department of Biology, Imperial College of Science, Technology and Medicine, Imperial College Road, London SW7 2AZ, UK
    Immunology 105:391-8. 2002
    ..Thus we report a novel activity of DGKalpha in survival of thymocytes immediately after entry into the DP stage in development...