Genomes and Genes
R J Cox
Affiliation: University of Bristol
- Post-translational modification of heterologously expressed Streptomyces type II polyketide synthase acyl carrier proteinsR J Cox
School of Chemistry, University of Bristol, UK
FEBS Lett 405:267-72. 1997..Co-expression of act and gris ACPs with ACPS in E. coli led to high levels of production of active holo-ACPs and ACPS. We have also made the significant observation that ACPS is able to transfer acylated CoA moieties to act apo-ACP...
- Subtle temperature-induced changes in small molecule conformer dynamics - observed and quantified by NOE spectroscopyC R Jones
School of Chemistry, University of Bristol Cantocks Close, Bristol, BS8 1TS, UK
Chem Commun (Camb) 52:2920-3. 2016..5%/10 °C) - in good agreement with Boltzmann-predictions, illustrating the effectiveness of accurate NOE-distance measurements in obtaining high quality dynamics as well as structural information for small molecules. ..
- Peptide inhibitors of N-succinyl diaminopimelic acid aminotransferase (DAP-AT): a novel class of antimicrobial compoundsR J Cox
University of Bristol, School of Chemistry, UK
Bioorg Med Chem Lett 8:945-50. 1998..These compounds were tested in vitro as inhibitors of DAP-AT from E. coli and in vivo as antibiotics. The hydrazino-dipeptides showed potent slow binding slow binding inhibition of DAP-AT as well as antimicrobial activity...
- Design and utility of oligonucleotide gene probes for fungal polyketide synthasesT P Nicholson
School of Chemistry, University of Bristol, Cantock s Close, UK
Chem Biol 8:157-78. 2001..Genomic fragments amplified using these specific primer sequences can be used in blotting experiments and have high potential as aids for the eventual cloning of new fungal PKS gene clusters...