M S Cooke

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. ncbi request reprint Urinary measurement of 8-OxodG, 8-OxoGua, and 5HMUra: a noninvasive assessment of oxidative damage to DNA
    Ryszard Olinski
    Department of Clinical Biochemistry, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Poland
    Antioxid Redox Signal 8:1011-9. 2006
  2. doi request reprint Role of dietary antioxidants in the prevention of in vivo oxidative DNA damage
    M S Cooke
    Oxidative Stress Group, Division of Chemical Pathology, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester LE2 7LX, UK
    Nutr Res Rev 15:19-42. 2002
  3. pmc Sources of extracellular, oxidatively-modified DNA lesions: implications for their measurement in urine
    Marcus S Cooke
    Radiation and Oxidative Stress Section, Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Bilding, University of Leicester, LE2 7LX, UK
    J Clin Biochem Nutr 45:255-70. 2009
  4. pmc Rapid measurement of 8-oxo-7,8-dihydro-2'-deoxyguanosine in human biological matrices using ultra-high-performance liquid chromatography-tandem mass spectrometry
    Patricia M W Lam
    Oxidative Stress Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK
    Free Radic Biol Med 52:2057-63. 2012
  5. ncbi request reprint Evidence that oxidative stress is a risk factor for the development of squamous cell carcinoma in renal transplant patients
    Marcus S Cooke
    Radiation and Oxidative Stress Group, Department of Cancer Studies and Molecular Medicine, Leicester LE2 7LX, UK
    Free Radic Biol Med 43:1328-34. 2007
  6. ncbi request reprint DNA repair is responsible for the presence of oxidatively damaged DNA lesions in urine
    Marcus S Cooke
    Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester LE2 7LX, UK
    Mutat Res 574:58-66. 2005
  7. ncbi request reprint Does measurement of oxidative damage to DNA have clinical significance?
    Marcus S Cooke
    Radiation and Oxidative Stress Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, LE2 7LX, UK
    Clin Chim Acta 365:30-49. 2006
  8. ncbi request reprint Evidence for attenuated cellular 8-oxo-7,8-dihydro-2'-deoxyguanosine removal in cancer patients
    Marcus S Cooke
    Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, LE2 7LX, UK
    Biol Chem 387:393-400. 2006
  9. doi request reprint Interlaboratory comparison of methodologies for the measurement of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine
    Marcus S Cooke
    Department of Cancer Studies and Molecular Medicine, Radiation and Oxidative Stress Section, University of Leicester, Leicester, UK
    Biomarkers 14:103-10. 2009
  10. ncbi request reprint Evaluation of enzyme-linked immunosorbent assay and liquid chromatography-tandem mass spectrometry methodology for the analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine in saliva and urine
    Marcus S Cooke
    Radiation and Oxidative Stress Group, Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Building, University of Leicester, Leicester, LE2 7LX, UK
    Free Radic Biol Med 41:1829-36. 2006

Detail Information

Publications43

  1. ncbi request reprint Urinary measurement of 8-OxodG, 8-OxoGua, and 5HMUra: a noninvasive assessment of oxidative damage to DNA
    Ryszard Olinski
    Department of Clinical Biochemistry, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Poland
    Antioxid Redox Signal 8:1011-9. 2006
    ..In the absence of these confounding factors, urinary measurements may be attributed entirely to the repair of DNA damage and suggests their possible use in studying associations between DNA repair and disease...
  2. doi request reprint Role of dietary antioxidants in the prevention of in vivo oxidative DNA damage
    M S Cooke
    Oxidative Stress Group, Division of Chemical Pathology, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester LE2 7LX, UK
    Nutr Res Rev 15:19-42. 2002
    ....
  3. pmc Sources of extracellular, oxidatively-modified DNA lesions: implications for their measurement in urine
    Marcus S Cooke
    Radiation and Oxidative Stress Section, Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Bilding, University of Leicester, LE2 7LX, UK
    J Clin Biochem Nutr 45:255-70. 2009
    ..Further studies are required to define the relative contributions of metabolism, disease and diet to oxidised nucleic acids and their metabolites in urine in order to develop urinalyis as a better tool for understanding human disease...
  4. pmc Rapid measurement of 8-oxo-7,8-dihydro-2'-deoxyguanosine in human biological matrices using ultra-high-performance liquid chromatography-tandem mass spectrometry
    Patricia M W Lam
    Oxidative Stress Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK
    Free Radic Biol Med 52:2057-63. 2012
    ....
  5. ncbi request reprint Evidence that oxidative stress is a risk factor for the development of squamous cell carcinoma in renal transplant patients
    Marcus S Cooke
    Radiation and Oxidative Stress Group, Department of Cancer Studies and Molecular Medicine, Leicester LE2 7LX, UK
    Free Radic Biol Med 43:1328-34. 2007
    ..02). These results demonstrate, for the first time, that a subpopulation of renal transplant patients is under greater oxidative burden, and it is this population that is particularly predisposed to skin cancer...
  6. ncbi request reprint DNA repair is responsible for the presence of oxidatively damaged DNA lesions in urine
    Marcus S Cooke
    Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester LE2 7LX, UK
    Mutat Res 574:58-66. 2005
    ..Taken together, these data would appear to rule out various confounding factors, leaving DNA repair pathways as the principal source of urinary purine, if not DNA, lesions enabling such measurements to be used as indicators of repair...
  7. ncbi request reprint Does measurement of oxidative damage to DNA have clinical significance?
    Marcus S Cooke
    Radiation and Oxidative Stress Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, LE2 7LX, UK
    Clin Chim Acta 365:30-49. 2006
    ..We conclude that further validation of biomarkers of oxidative DNA damage, along with further elucidation of the role of damage in disease, may allow these biomarkers to become potentially useful clinical tools...
  8. ncbi request reprint Evidence for attenuated cellular 8-oxo-7,8-dihydro-2'-deoxyguanosine removal in cancer patients
    Marcus S Cooke
    Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, LE2 7LX, UK
    Biol Chem 387:393-400. 2006
    ..Furthermore, analysis of DNA and urinary 8-oxodG in cancer patients and controls suggested reduced repair activity towards this lesion marker in these patients...
  9. doi request reprint Interlaboratory comparison of methodologies for the measurement of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine
    Marcus S Cooke
    Department of Cancer Studies and Molecular Medicine, Radiation and Oxidative Stress Section, University of Leicester, Leicester, UK
    Biomarkers 14:103-10. 2009
    ..0001). While it is reassuring to note good agreement between chromatographic assays, this study reveals significant short-comings in the ELISA, which brings into question its continued use in its present form...
  10. ncbi request reprint Evaluation of enzyme-linked immunosorbent assay and liquid chromatography-tandem mass spectrometry methodology for the analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine in saliva and urine
    Marcus S Cooke
    Radiation and Oxidative Stress Group, Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Building, University of Leicester, Leicester, LE2 7LX, UK
    Free Radic Biol Med 41:1829-36. 2006
    ..Ongoing investigation in our laboratories aims to identify the basis of the discrepancy between ELISA and LC-MS/MS...
  11. pmc 8-Oxo-deoxyguanosine: reduce, reuse, recycle?
    Marcus S Cooke
    Radiation and Oxidative Stress Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, United Kingdom
    Proc Natl Acad Sci U S A 104:13535-6. 2007
  12. doi request reprint Measurement and meaning of oxidatively modified DNA lesions in urine
    Marcus S Cooke
    Radiation and Oxidative Stress Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:3-14. 2008
    ..The noninvasive assessment of such damage, i.e., in urine, and application to large-scale human studies are vital to understanding this role and devising intervention strategies...
  13. doi request reprint Combination of azathioprine and UVA irradiation is a major source of cellular 8-oxo-7,8-dihydro-2'-deoxyguanosine
    Marcus S Cooke
    Radiation and Oxidative Stress Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK
    DNA Repair (Amst) 7:1982-9. 2008
    ..However, as oxidative stress is unlikely to be involved in the therapeutic effects of Aza, intercepting ROS production in the skin could be a viable route by which this side effect may be minimised...
  14. ncbi request reprint Immunochemical detection of UV-induced DNA damage and repair
    Marcus S Cooke
    Oxidative Stress Group, Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Building, University of Leicester, Leicester Royal Infirmary, PO Box 65, Leicester LE2 7LX, UK
    J Immunol Methods 280:125-33. 2003
    ..Moreover, the subsequent removal of this damage, as evidenced by a reduction in antiserum staining, was noted in sections of biopsies taken in the hours following irradiation...
  15. ncbi request reprint Oxidative DNA damage: mechanisms, mutation, and disease
    Marcus S Cooke
    Oxidative Stress Group, Department of Clinical Biochemistry, University of Leicester, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, LE2 7LX, UK
    FASEB J 17:1195-214. 2003
    ....
  16. ncbi request reprint Induction and excretion of ultraviolet-induced 8-oxo-2'-deoxyguanosine and thymine dimers in vivo: implications for PUVA
    M S Cooke
    Oxidative Stress Group, Division of Chemical Pathology, University of Leicester, RKCSB, Leicester Royal Infirmary NHS Trust, PO Box 65, Leicester LE2 7LX, UK
    J Invest Dermatol 116:281-5. 2001
    ....
  17. ncbi request reprint Further evidence for a possible role of conformation in the immunogenicity and antigenicity of the oxidative DNA lesion, 8-oxo-2'deoxyguanosine
    M S Cooke
    Division of Chemical Pathology, Centre for Mechanisms of Human Toxicity, University of Leicester, UK
    Free Radic Res 28:459-69. 1998
    ....
  18. ncbi request reprint Monoclonal antibody to single-stranded DNA: a potential tool for DNA repair studies
    M S Cooke
    Oxidative Stress Group, Division of Chemical Pathology, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, United Kingdom
    Biochem Biophys Res Commun 284:232-8. 2001
    ....
  19. ncbi request reprint Urinary 8-oxo-2'-deoxyguanosine--source, significance and supplements
    M S Cooke
    Division of Chemical Pathology, University of Leicester, UK
    Free Radic Res 32:381-97. 2000
    ....
  20. ncbi request reprint Immunochemical quantitation of UV-induced oxidative and dimeric DNA damage to human keratinocytes
    M S Cooke
    Oxidative Stress Group, University of Leicester, Leicester Royal Infirmary, UK
    Free Radic Res 33:369-81. 2000
    ..These data support the emerging importance of oxidative DNA damage in UV-induced carcinogenesis...
  21. ncbi request reprint DNA repair: insights from urinary lesion analysis
    Marcus S Cooke
    Oxidative Stress Group, Department of Clinical Biochemistry, University of Leicester, RKCSB, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester LE2 7LX, UK
    Free Radic Res 36:929-32. 2002
    ....
  22. ncbi request reprint Progress in the analysis of urinary oxidative DNA damage
    Marcus S Cooke
    Oxidative Stress Group, Department of Clinical Biochemistry, University of Leicester, Leicester Royal Infirmary, Leicester, UK
    Free Radic Biol Med 33:1601-14. 2002
    ..Upon establishment of these details, urinary oxidative DNA damage measurements may become more than a reflection of generalized oxidative stress...
  23. ncbi request reprint Deoxycytidine glyoxal: lesion induction and evidence of repair following vitamin C supplementation in vivo
    Marcus S Cooke
    Oxidative Stress Group, Department of Clinical Biochemistry, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK
    Free Radic Biol Med 34:218-25. 2003
    ..These results are also consistent with our hypothesis for a role of vitamin C in an adaptive/repair response and indicate that nucleotide excision repair specifically may be affected...
  24. ncbi request reprint Novel repair action of vitamin C upon in vivo oxidative DNA damage
    M S Cooke
    Division of Chemical Pathology, Centre for Mechanisms of Human Toxicity, University of Leicester, UK
    FEBS Lett 439:363-7. 1998
    ....
  25. ncbi request reprint Discrepancies in the measurement of UVC-induced 8-oxo-2'-deoxyguanosine: implications for the analysis of oxidative DNA damage
    M D Evans
    Division of Chemical Pathology, CMHT, Hodgkin Building, University of Leicester, Leicester, LE1 9HN, United Kingdom
    Biochem Biophys Res Commun 259:374-8. 1999
    ..Irrespective of the exact mechanism, there will be significant implications for the analysis of oxidative DNA damage...
  26. ncbi request reprint Immunochemical detection of UV-induced DNA damage and repair
    Marcus S Cooke
    Department of Cancer Studies and Molecular Medicine, University of Leicester, UK
    Methods Mol Biol 314:215-28. 2006
    ....
  27. doi request reprint Oxidative damage to DNA in non-malignant disease: biomarker or biohazard?
    M D Evans
    Radiation and Oxidative Stress Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
    Genome Dyn 1:53-66. 2006
    ..Our general conclusion is that, dependent on the disease, oxidative DNA damage may be a biomarker, biohazard or both of these...
  28. doi request reprint First-trimester increase in oxidative stress and risk of small-for-gestational-age fetus
    N Potdar
    Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
    BJOG 116:637-42. 2009
    ..Investigation of increased oxidative stress in early pregnancy and association with an increased risk of small-for-gestational-age (SGA) fetus...
  29. ncbi request reprint Oxidative DNA damage and disease: induction, repair and significance
    Mark D Evans
    Oxidative Stress Group, Department of Clinical Biochemistry, University of Leicester, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, LE2 7LX, UK
    Mutat Res 567:1-61. 2004
    ..However, exact roles remain to be elucidated...
  30. doi request reprint Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a noninvasive biomarker of oxidative stress
    Mark D Evans
    Department of Cancer Studies, University of Leicester, Leicester, UK
    FASEB J 24:1249-60. 2010
    ..D., Olinski, R., Loft, S., Cooke, M. S. Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine as a noninvasive biomarker of oxidative stress...
  31. ncbi request reprint Factors contributing to the outcome of oxidative damage to nucleic acids
    Mark D Evans
    Genome Instability Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, UK
    Bioessays 26:533-42. 2004
    ..This review will survey these aspects of oxidative damage to nucleic acids and their implication for disease...
  32. doi request reprint Analysis of urinary 8-oxo-7,8-dihydro-purine-2'-deoxyribonucleosides by LC-MS/MS and improved ELISA
    Mark D Evans
    Department of Cancer, Radiation and Oxidative Stress Section, Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, University Hospitals of Leicester, Leicester, UK
    Free Radic Res 42:831-40. 2008
    ..Urinary 8-oxodA is either not present or below the limit of detection of the instrumentation...
  33. ncbi request reprint 17 beta-Oestradiol attenuates nucleotide excision repair
    Mark D Evans
    Oxidative Stress Group, Department of Clinical Biochemistry, P O Box 65, Robert Kilpatrick Clinical Sciences Building, University of Leicester, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester LE2 7LX, UK
    FEBS Lett 535:153-8. 2003
    ..In contrast, treatment with 17 alpha-oestradiol had no effect. Mechanisms are proposed for this effect of E2, which may contribute to its carcinogenic potential...
  34. ncbi request reprint Urinary 8-oxo-2'-deoxyguanosine: redox regulation of DNA repair in vivo?
    Joseph Lunec
    Oxidative Stress Group, Department of Clinical Biochemistry, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester LE2 7LX, UK
    Free Radic Biol Med 33:875-85. 2002
    ..We also propose that redox-active components of the diet, such as vitamin C, may promote such repair, affecting NER specifically...
  35. doi request reprint DNA repair and the origins of urinary oxidized 2'-deoxyribonucleosides
    Mark D Evans
    Radiation and Oxidative Stress Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE1 7RH, UK
    Mutagenesis 25:433-42. 2010
    ....
  36. doi request reprint Analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine by liquid chromatography-tandem mass spectrometry
    Mark D Evans
    Radiation and Oxidative Stress Group, Department of Cancer Studies, University of Leicester, Leicester, UK
    Methods Mol Biol 610:341-51. 2010
    ..Subsequent analysis by liquid chromatography-tandem mass spectrometry has the advantages of sensitivity, internal standardisation and robust peak identification...
  37. ncbi request reprint Quantification of UVR-induced DNA damage: global- versus gene-specific levels of thymine dimers
    Aikaterini Karakoula
    Oxidative Stress Group, Department of Clinical Biochemistry, University of Leicester, RKCSB, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, PO Box 65, LE2 7LX, Leicester, UK
    J Immunol Methods 277:27-37. 2003
    ..These findings demonstrate the suitability of this approach to the detection of UVR-induced DNA damage at the level of individual genes...
  38. doi request reprint Gene expression profiling reveals new protective roles for vitamin C in human skin cells
    Tiago L Duarte
    Department of Cancer Studies and Molecular Medicine, University of Leicester, UK
    Free Radic Biol Med 46:78-87. 2009
    ....
  39. doi request reprint Antiserum detection of reactive carbonyl species-modified DNA in human colonocytes
    Nalini Mistry
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
    Free Radic Res 42:344-53. 2008
    ..These results fully support a potential role for dietary lipid peroxidation products in the development of sporadic colon cancer...
  40. doi request reprint Cytotoxicity and gene expression profiling of two hydroxylated polybrominated diphenyl ethers in human H295R adrenocortical carcinoma cells
    Renfang Song
    Department of Cancer Studies and Molecular Medicine, University of Leicester, University Road, Leicester LE1 7RH, UK
    Toxicol Lett 185:23-31. 2009
    ..We discuss whether OH-PBDE bioaccumulation could result in impairment of the adrenocortical secretory function...
  41. ncbi request reprint Neutrophils in induced sputum from healthy children: role of interleukin-8 and oxidative stress
    Neeta Kulkarni
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE2 7LX, UK
    Respir Med 101:2108-12. 2007
    ....
  42. doi request reprint Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker?
    Steffen Loft
    Institute of Public Health, University of Copenhagen, Copenhagen, Denmark
    Eur J Nutr 47:19-28. 2008
    ..Although firm conclusions cannot be reached, there appears to be links between ingestion of antioxidants, oxidative damage to DNA, and risk of cancer...
  43. ncbi request reprint Case 3-2007: a boy with respiratory insufficiency
    Jonathan Grigg
    N Engl J Med 356:2329-30; author reply 2330. 2007