- Suppression of mitochondrial electron transport chain function in the hypoxic human placenta: a role for miRNA-210 and protein synthesis inhibitionFrancesca Colleoni
Department of Physiology, Development and Neuroscience, and Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom
PLoS ONE 8:e55194. 2013..Our results demonstrate that mitochondrial function is altered in hypoxic human placentas, with specific suppression of complexes I and IV compromising energy metabolism and potentially contributing to impaired fetal growth...
- Cryopreservation of placental biopsies for mitochondrial respiratory analysisF Colleoni
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
Placenta 33:122-3. 2012..We found no impairments in respiration following cryopreservation in the delivery suite, with enhanced coupling, as indicated by higher respiratory control ratios, than in fresh placental samples transported to the laboratory on ice...
- Influence of speed of sample processing on placental energetics and signalling pathways: implications for tissue collectionH W Yung
Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK Electronic address
Placenta 35:103-8. 2014..Therefore, this study aimed to elucidate the effects of ischaemia ex vivo as may occur during tissue collection on phosphorylation of placental proteins and kinases involved in growth and cell survival, and on mitochondrial complexes...