- Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal deathLisa Chakrabarti
Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
Mol Brain 2:24. 2009..However, our results support a role for dysregulated autophagy activation in pcd, and suggest that increased or aberrant mitophagy contributes to the Purkinje cell degeneration in pcd mice...
- A mitochondrial location for haemoglobins--dynamic distribution in ageing and Parkinson's diseaseFreya Shephard
School of Veterinary Medicine and Science, Faculty of Medicine and Health Sciences, University of Nottingham, LE12 5RD, United Kingdom
Mitochondrion 14:64-72. 2014..One explanation could be a specific loss of cells containing mitochondria loaded with Hb proteins. Our study opens the door to an examination of the role of Hb function, within the context of the mitochondrion-in health and disease...
- The zinc-binding domain of Nna1 is required to prevent retinal photoreceptor loss and cerebellar ataxia in Purkinje cell degeneration (pcd) miceLisa Chakrabarti
Department of Laboratory Medicine, University of Washington Medical Center, Seattle, WA, USA
Vision Res 48:1999-2005. 2008..In conclusion, Nna1 is required for survival of retinal photoreceptors and other neuron populations that degenerate in pcd mice. A functional zinc-binding domain is crucial for Nna1 to support neuron survival...
- The Purkinje cell degeneration 5J mutation is a single amino acid insertion that destabilizes Nna1 proteinLisa Chakrabarti
Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195 7110, USA
Mamm Genome 17:103-10. 2006....