Bhismadev Chakrabarti

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Variations in the human cannabinoid receptor (CNR1) gene modulate striatal responses to happy faces
    Bhismadev Chakrabarti
    Autism Research Centre, Douglas House, 18 B, Trumpington Road, Cambridge CB2 2AH, UK
    Eur J Neurosci 23:1944-8. 2006
  2. ncbi request reprint Empathizing: neurocognitive developmental mechanisms and individual differences
    Bhismadev Chakrabarti
    Autism Research Centre, University of Cambridge, Psychiatry Department, Douglas House, 18b Trumpington Rd, Cambridge CB2 2AH, UK
    Prog Brain Res 156:403-17. 2006
  3. doi request reprint Empathizing with basic emotions: common and discrete neural substrates
    Bhismadev Chakrabarti
    Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, UK
    Soc Neurosci 1:364-84. 2006
  4. pmc Fetal programming effects of testosterone on the reward system and behavioral approach tendencies in humans
    Michael V Lombardo
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 72:839-47. 2012
  5. pmc Biological sex affects the neurobiology of autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18B, Trumpington Road, Cambridge CB2 8AH, UK
    Brain 136:2799-815. 2013
  6. pmc Cognition in males and females with autism: similarities and differences
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e47198. 2012
  7. pmc Individual differences in brain structure underpin empathizing-systemizing cognitive styles in male adults
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge Douglas House, 18B, Trumpington Road, Cambridge CB2 8AH, UK
    Neuroimage 61:1347-54. 2012
  8. pmc A behavioral comparison of male and female adults with high functioning autism spectrum conditions
    Meng Chuan Lai
    Department of Psychiatry, Autism Research Centre, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e20835. 2011
  9. doi request reprint A shift to randomness of brain oscillations in people with autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, United Kingdom
    Biol Psychiatry 68:1092-9. 2010
  10. pmc Fetal testosterone influences sexually dimorphic gray matter in the human brain
    Michael V Lombardo
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge CB2 8AH, UK
    J Neurosci 32:674-80. 2012

Detail Information

Publications31

  1. ncbi request reprint Variations in the human cannabinoid receptor (CNR1) gene modulate striatal responses to happy faces
    Bhismadev Chakrabarti
    Autism Research Centre, Douglas House, 18 B, Trumpington Road, Cambridge CB2 2AH, UK
    Eur J Neurosci 23:1944-8. 2006
    ..This has implications for medical conditions involving hypo-responsivity to emotional and social stimuli, such as autism...
  2. ncbi request reprint Empathizing: neurocognitive developmental mechanisms and individual differences
    Bhismadev Chakrabarti
    Autism Research Centre, University of Cambridge, Psychiatry Department, Douglas House, 18b Trumpington Rd, Cambridge CB2 2AH, UK
    Prog Brain Res 156:403-17. 2006
    ....
  3. doi request reprint Empathizing with basic emotions: common and discrete neural substrates
    Bhismadev Chakrabarti
    Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, UK
    Soc Neurosci 1:364-84. 2006
    ..This pattern of results is interpreted using a modification of Haxby et al.'s model of face perception...
  4. pmc Fetal programming effects of testosterone on the reward system and behavioral approach tendencies in humans
    Michael V Lombardo
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 72:839-47. 2012
    ....
  5. pmc Biological sex affects the neurobiology of autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18B, Trumpington Road, Cambridge CB2 8AH, UK
    Brain 136:2799-815. 2013
    ..Future research should stratify by biological sex to reduce heterogeneity and to provide greater insight into the neurobiology of autism. ..
  6. pmc Cognition in males and females with autism: similarities and differences
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e47198. 2012
    ..However, in specific non-social cognitive domains, performance within ASC depends on sex. This suggests that in specific domains, cognitive profiles in ASC are modulated by sex...
  7. pmc Individual differences in brain structure underpin empathizing-systemizing cognitive styles in male adults
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge Douglas House, 18B, Trumpington Road, Cambridge CB2 8AH, UK
    Neuroimage 61:1347-54. 2012
    ..These results suggest an underlying neuroanatomical basis linked to the discrepancy between these two important dimensions of individual differences in cognitive style...
  8. pmc A behavioral comparison of male and female adults with high functioning autism spectrum conditions
    Meng Chuan Lai
    Department of Psychiatry, Autism Research Centre, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e20835. 2011
    ..We discuss the importance of the superficially better socio-communication ability in adult females with ASC in terms of why females with ASC may more often go under-recognized, and receive their diagnosis later, than males...
  9. doi request reprint A shift to randomness of brain oscillations in people with autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, United Kingdom
    Biol Psychiatry 68:1092-9. 2010
    ..5) to ordered (H = 1). Shifts in fractal scaling of physiological time series have been associated with neurological and cardiac conditions...
  10. pmc Fetal testosterone influences sexually dimorphic gray matter in the human brain
    Michael V Lombardo
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge CB2 8AH, UK
    J Neurosci 32:674-80. 2012
    ..These results bridge a long-standing gap between human and nonhuman species by showing that FT acts as an organizing mechanism for the development of regional sexual dimorphism in the human brain...
  11. pmc Neuroanatomy of Individual Differences in Language in Adult Males with Autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge CB2 8AH, UK Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei 10051, Taiwan
    Cereb Cortex 25:3613-28. 2015
    ..This underscores the importance of including both developmental and current language as specifiers for ASC, to help clarify heterogeneity. ..
  12. pmc A Pooled Genome-Wide Association Study of Asperger Syndrome
    Varun Warrier
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 10:e0131202. 2015
    ..The effect sizes of the variants were modest, indicating that our study was not sufficiently powered to identify causal variants with precision. ..
  13. pmc Atypically rightward cerebral asymmetry in male adults with autism stratifies individuals with and without language delay
    Dorothea L Floris
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Hum Brain Mapp 37:230-53. 2016
    ..We conclude that atypical cerebral structural asymmetry is a potential candidate neurophenotype of ASC...
  14. doi request reprint Specialization of right temporo-parietal junction for mentalizing and its relation to social impairments in autism
    Michael V Lombardo
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK
    Neuroimage 56:1832-8. 2011
    ....
  15. pmc Why are autism spectrum conditions more prevalent in males?
    Simon Baron-Cohen
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 9:e1001081. 2011
    ..Ultimately, as these theories are not mutually exclusive and ASC is multi-factorial, they may help explain the male prevalence of ASC...
  16. pmc Sex/gender differences and autism: setting the scene for future research
    Meng Chuan Lai
    National Taiwan University Hospital and College of Medicine, Taipei, Taiwan and the Autism Research Centre, University of Cambridge, Cambridge, UK Electronic address
    J Am Acad Child Adolesc Psychiatry 54:11-24. 2015
    ..To better understand the implications from existing research and to help design future studies, we propose a 4-level conceptual framework to clarify the embedded themes...
  17. pmc Are power calculations useful? A multicentre neuroimaging study
    John Suckling
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom Cambridge and Peterborough Foundation NHS Trust, Cambridge, United Kingdom
    Hum Brain Mapp 35:3569-77. 2014
    ..In summary, power calculations offer a validated, quantitative means of making informed choices on important factors that influence the outcome of studies that consume significant resources...
  18. doi request reprint Atypical neural self-representation in autism
    Michael V Lombardo
    Autism Research Centre, Douglas House, Cambridge CB2 8AH, UK
    Brain 133:611-24. 2010
    ..These observations reveal that the atypical organization of neural circuitry preferentially coding for self-information is a key mechanism at the heart of both self-referential and social impairments in autism...
  19. doi request reprint Organizational effects of fetal testosterone on human corpus callosum size and asymmetry
    Lindsay R Chura
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK
    Psychoneuroendocrinology 35:122-32. 2010
    ..We suggest that this possible organizational effect of FT on callosal asymmetry may also play a role in shaping sexual dimorphism in functional and structural brain development, cognition, and behavior...
  20. doi request reprint Shared neural circuits for mentalizing about the self and others
    Michael V Lombardo
    University of Cambridge, United Kingdom
    J Cogn Neurosci 22:1623-35. 2010
    ....
  21. pmc STX1A and Asperger syndrome: a replication study
    Jaroslava Durdiakova
    Autism Research Centre, Department of Psychiatry, University of Cambridge, 18b Trumpington Road, Cambridge CB2 8AH, UK
    Mol Autism 5:14. 2014
    ..Syntaxin 1A (STX1A) encodes a protein involved in regulation of serotonergic and GABAergic systems and its expression is altered in autism...
  22. pmc From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition
    Adam M H Young
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, UK School of Clinical Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, UK
    Mol Autism 7:9. 2016
    ..This is complemented with a number of neuroimaging and neuropathological studies describing microglial activation. Implications for treatment are discussed. ..
  23. pmc Subgrouping the autism "spectrum": reflections on DSM-5
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK
    PLoS Biol 11:e1001544. 2013
    ..But making progress in research, and ultimately improving clinical practice, will require identifying subgroups within the autism spectrum...
  24. pmc Variation in the autism candidate gene GABRB3 modulates tactile sensitivity in typically developing children
    Teresa Tavassoli
    Department of Psychiatry, Autism Research Centre, University of Cambridge, Cambridge, UK
    Mol Autism 3:6. 2012
    ..To test this, we conducted two pilot genetic association studies in the general population, analysing two phenotypic measures of tactile sensitivity (a parent-report and a behavioural measure) for association with 43 SNPs in GABRB3...
  25. pmc Self-referential and social cognition in a case of autism and agenesis of the corpus callosum
    Michael V Lombardo
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge CB2 8AH, UK
    Mol Autism 3:14. 2012
    ..Here we examine agenesis of the corpus callosum (AgCC) as a model at the level of neuroanatomy that may be relevant for understanding self-referential and social-cognitive difficulties in ASC...
  26. pmc Single nucleotide polymorphism rs6716901 in SLC25A12 gene is associated with Asperger syndrome
    Jaroslava Durdiakova
    Autism Research Centre, Department of Psychiatry, University of Cambridge, 18b Trumpington Road, Cambridge CB2 8AH, UK
    Mol Autism 5:25. 2014
    ..rs2056202 SNP in this gene has previously been associated with ASC. SNPs rs6716901 and rs3765166 analysed in this study have not been previously explored in association with AS...
  27. pmc Genetic variation in GABRB3 is associated with Asperger syndrome and multiple endophenotypes relevant to autism
    Varun Warrier
    Department of Psychiatry, Autism Research Centre, University of Cambridge, Cambridgeshire, UK
    Mol Autism 4:48. 2013
    ..A key component of the GABA-ergic system is encoded by the GABRB3 gene, which has been previously implicated both in ASC and in individual differences in empathy...
  28. pmc Sex and STEM Occupation Predict Autism-Spectrum Quotient (AQ) Scores in Half a Million People
    Emily Ruzich
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom Cambridge Intellectual and Developmental Disabilities Research Group, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 10:e0141229. 2015
    ..These results support previous findings relating to sex and STEM careers in the largest set of individuals for which AQ scores have been reported and suggest the AQ is a useful self-report measure of autistic traits. ..
  29. pmc A genome wide association study of mathematical ability reveals an association at chromosome 3q29, a locus associated with autism and learning difficulties: a preliminary study
    Simon Baron-Cohen
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridgeshire, United Kingdom CLASS Clinic, Cambridgeshire and Peterborough NHS Foundation Trust CPFT, Cambridgeshire, United Kingdom
    PLoS ONE 9:e96374. 2014
    ..To our knowledge, this is only the second study to investigate the association of genetic variants with mathematical ability, and it highlights a number of interesting markers for future study...
  30. doi request reprint Increased serum androstenedione in adults with autism spectrum conditions
    Liliana Ruta
    Autism Research Centre, Department of Psychiatry, Cambridge University, Cambridge, UK
    Psychoneuroendocrinology 36:1154-63. 2011
    ..02). This result is discussed in terms of androstenedione being the immediate precursor of, and being converted into, testosterone, dihydrotestosterone, or estrogens in hormone-sensitive tissues and organs...
  31. pmc Talent in autism: hyper-systemizing, hyper-attention to detail and sensory hypersensitivity
    Simon Baron-Cohen
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge CB2 8AH, UK
    Philos Trans R Soc Lond B Biol Sci 364:1377-83. 2009
    ..We conclude that the origins of the association between autism and talent begin at the sensory level, include excellent attention to detail and end with hyper-systemizing...