Bhismadev Chakrabarti

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. doi request reprint Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome
    B Chakrabarti
    Autism Research Centre, Department of Psychiatry, Cambridge University, UK
    Autism Res 2:157-77. 2009
  2. pmc Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces
    Bhismadev Chakrabarti
    Centre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, Whiteknights, Reading RG6 6AL, UK
    Mol Autism 2:10. 2011
  3. pmc Fetal programming effects of testosterone on the reward system and behavioral approach tendencies in humans
    Michael V Lombardo
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 72:839-47. 2012
  4. pmc Biological sex affects the neurobiology of autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18B, Trumpington Road, Cambridge CB2 8AH, UK
    Brain 136:2799-815. 2013
  5. pmc Cognition in males and females with autism: similarities and differences
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e47198. 2012
  6. pmc Individual differences in brain structure underpin empathizing-systemizing cognitive styles in male adults
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge Douglas House, 18B, Trumpington Road, Cambridge CB2 8AH, UK
    Neuroimage 61:1347-54. 2012
  7. doi request reprint Specialization of right temporo-parietal junction for mentalizing and its relation to social impairments in autism
    Michael V Lombardo
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK
    Neuroimage 56:1832-8. 2011
  8. pmc A behavioral comparison of male and female adults with high functioning autism spectrum conditions
    Meng Chuan Lai
    Department of Psychiatry, Autism Research Centre, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e20835. 2011
  9. doi request reprint A shift to randomness of brain oscillations in people with autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, United Kingdom
    Biol Psychiatry 68:1092-9. 2010
  10. doi request reprint Autistic traits modulate mimicry of social but not nonsocial rewards
    Anthony Haffey
    Centre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, UK
    Autism Res 6:614-20. 2013

Collaborators

Detail Information

Publications35

  1. doi request reprint Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome
    B Chakrabarti
    Autism Research Centre, Department of Psychiatry, Cambridge University, UK
    Autism Res 2:157-77. 2009
    ..05). This is the first candidate-gene association study of AS and of autistic traits. The most promising candidate genes require independent replication and fine mapping...
  2. pmc Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces
    Bhismadev Chakrabarti
    Centre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, Whiteknights, Reading RG6 6AL, UK
    Mol Autism 2:10. 2011
    ..The striatum is involved in guiding gaze to rewarding aspects of a visual scene. We aimed to validate and extend this result in another sample using a different technique (gaze tracking)...
  3. pmc Fetal programming effects of testosterone on the reward system and behavioral approach tendencies in humans
    Michael V Lombardo
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 72:839-47. 2012
    ....
  4. pmc Biological sex affects the neurobiology of autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18B, Trumpington Road, Cambridge CB2 8AH, UK
    Brain 136:2799-815. 2013
    ..Future research should stratify by biological sex to reduce heterogeneity and to provide greater insight into the neurobiology of autism. ..
  5. pmc Cognition in males and females with autism: similarities and differences
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e47198. 2012
    ..However, in specific non-social cognitive domains, performance within ASC depends on sex. This suggests that in specific domains, cognitive profiles in ASC are modulated by sex...
  6. pmc Individual differences in brain structure underpin empathizing-systemizing cognitive styles in male adults
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge Douglas House, 18B, Trumpington Road, Cambridge CB2 8AH, UK
    Neuroimage 61:1347-54. 2012
    ..These results suggest an underlying neuroanatomical basis linked to the discrepancy between these two important dimensions of individual differences in cognitive style...
  7. doi request reprint Specialization of right temporo-parietal junction for mentalizing and its relation to social impairments in autism
    Michael V Lombardo
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK
    Neuroimage 56:1832-8. 2011
    ....
  8. pmc A behavioral comparison of male and female adults with high functioning autism spectrum conditions
    Meng Chuan Lai
    Department of Psychiatry, Autism Research Centre, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e20835. 2011
    ..We discuss the importance of the superficially better socio-communication ability in adult females with ASC in terms of why females with ASC may more often go under-recognized, and receive their diagnosis later, than males...
  9. doi request reprint A shift to randomness of brain oscillations in people with autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, United Kingdom
    Biol Psychiatry 68:1092-9. 2010
    ..5) to ordered (H = 1). Shifts in fractal scaling of physiological time series have been associated with neurological and cardiac conditions...
  10. doi request reprint Autistic traits modulate mimicry of social but not nonsocial rewards
    Anthony Haffey
    Centre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, UK
    Autism Res 6:614-20. 2013
    ..This evidence suggests a potential role for the reward system in underlying the atypical social behavior in individuals with ASC, who constitute the extreme end of the spectrum of autistic traits...
  11. pmc Fetal testosterone influences sexually dimorphic gray matter in the human brain
    Michael V Lombardo
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge CB2 8AH, UK
    J Neurosci 32:674-80. 2012
    ..These results bridge a long-standing gap between human and nonhuman species by showing that FT acts as an organizing mechanism for the development of regional sexual dimorphism in the human brain...
  12. pmc Neuroanatomy of Individual Differences in Language in Adult Males with Autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge CB2 8AH, UK Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei 10051, Taiwan
    Cereb Cortex 25:3613-28. 2015
    ..This underscores the importance of including both developmental and current language as specifiers for ASC, to help clarify heterogeneity. ..
  13. pmc Atypically rightward cerebral asymmetry in male adults with autism stratifies individuals with and without language delay
    Dorothea L Floris
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Hum Brain Mapp 37:230-53. 2016
    ..We conclude that atypical cerebral structural asymmetry is a potential candidate neurophenotype of ASC...
  14. pmc A Pooled Genome-Wide Association Study of Asperger Syndrome
    Varun Warrier
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 10:e0131202. 2015
    ..The effect sizes of the variants were modest, indicating that our study was not sufficiently powered to identify causal variants with precision. ..
  15. doi request reprint Empathizing with basic emotions: common and discrete neural substrates
    Bhismadev Chakrabarti
    Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, UK
    Soc Neurosci 1:364-84. 2006
    ..This pattern of results is interpreted using a modification of Haxby et al.'s model of face perception...
  16. doi request reprint How reward modulates mimicry: EMG evidence of greater facial mimicry of more rewarding happy faces
    Thomas B Sims
    Centre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, Whiteknights, Reading, UK
    Psychophysiology 49:998-1004. 2012
    ..This suggests a link between reward and spontaneous mimicry and provides a possible underlying mechanism for the reduced response to social rewards seen in autism...
  17. doi request reprint Atypical neural self-representation in autism
    Michael V Lombardo
    Autism Research Centre, Douglas House, Cambridge CB2 8AH, UK
    Brain 133:611-24. 2010
    ..These observations reveal that the atypical organization of neural circuitry preferentially coding for self-information is a key mechanism at the heart of both self-referential and social impairments in autism...
  18. pmc Why are autism spectrum conditions more prevalent in males?
    Simon Baron-Cohen
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 9:e1001081. 2011
    ..Ultimately, as these theories are not mutually exclusive and ASC is multi-factorial, they may help explain the male prevalence of ASC...
  19. doi request reprint Organizational effects of fetal testosterone on human corpus callosum size and asymmetry
    Lindsay R Chura
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK
    Psychoneuroendocrinology 35:122-32. 2010
    ..We suggest that this possible organizational effect of FT on callosal asymmetry may also play a role in shaping sexual dimorphism in functional and structural brain development, cognition, and behavior...
  20. pmc STX1A and Asperger syndrome: a replication study
    Jaroslava Durdiakova
    Autism Research Centre, Department of Psychiatry, University of Cambridge, 18b Trumpington Road, Cambridge CB2 8AH, UK
    Mol Autism 5:14. 2014
    ..Syntaxin 1A (STX1A) encodes a protein involved in regulation of serotonergic and GABAergic systems and its expression is altered in autism...
  21. pmc From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition
    Adam M H Young
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, UK School of Clinical Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, UK
    Mol Autism 7:9. 2016
    ..This is complemented with a number of neuroimaging and neuropathological studies describing microglial activation. Implications for treatment are discussed. ..
  22. pmc Subgrouping the autism "spectrum": reflections on DSM-5
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK
    PLoS Biol 11:e1001544. 2013
    ..But making progress in research, and ultimately improving clinical practice, will require identifying subgroups within the autism spectrum...
  23. pmc Self-referential and social cognition in a case of autism and agenesis of the corpus callosum
    Michael V Lombardo
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge CB2 8AH, UK
    Mol Autism 3:14. 2012
    ..Here we examine agenesis of the corpus callosum (AgCC) as a model at the level of neuroanatomy that may be relevant for understanding self-referential and social-cognitive difficulties in ASC...
  24. pmc Variation in the autism candidate gene GABRB3 modulates tactile sensitivity in typically developing children
    Teresa Tavassoli
    Department of Psychiatry, Autism Research Centre, University of Cambridge, Cambridge, UK
    Mol Autism 3:6. 2012
    ..To test this, we conducted two pilot genetic association studies in the general population, analysing two phenotypic measures of tactile sensitivity (a parent-report and a behavioural measure) for association with 43 SNPs in GABRB3...
  25. pmc Talent in autism: hyper-systemizing, hyper-attention to detail and sensory hypersensitivity
    Simon Baron-Cohen
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge CB2 8AH, UK
    Philos Trans R Soc Lond B Biol Sci 364:1377-83. 2009
    ..We conclude that the origins of the association between autism and talent begin at the sensory level, include excellent attention to detail and end with hyper-systemizing...
  26. pmc Genetic variation in GABRB3 is associated with Asperger syndrome and multiple endophenotypes relevant to autism
    Varun Warrier
    Department of Psychiatry, Autism Research Centre, University of Cambridge, Cambridgeshire, UK
    Mol Autism 4:48. 2013
    ..A key component of the GABA-ergic system is encoded by the GABRB3 gene, which has been previously implicated both in ASC and in individual differences in empathy...
  27. pmc Single nucleotide polymorphism rs6716901 in SLC25A12 gene is associated with Asperger syndrome
    Jaroslava Durdiakova
    Autism Research Centre, Department of Psychiatry, University of Cambridge, 18b Trumpington Road, Cambridge CB2 8AH, UK
    Mol Autism 5:25. 2014
    ..rs2056202 SNP in this gene has previously been associated with ASC. SNPs rs6716901 and rs3765166 analysed in this study have not been previously explored in association with AS...
  28. pmc Sex and STEM Occupation Predict Autism-Spectrum Quotient (AQ) Scores in Half a Million People
    Emily Ruzich
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom Cambridge Intellectual and Developmental Disabilities Research Group, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 10:e0141229. 2015
    ..These results support previous findings relating to sex and STEM careers in the largest set of individuals for which AQ scores have been reported and suggest the AQ is a useful self-report measure of autistic traits. ..
  29. pmc Autistic traits modulate frontostriatal connectivity during processing of rewarding faces
    Thomas B Sims
    Centre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, Reading RG6 6AL, UK
    Soc Cogn Affect Neurosci 9:2010-6. 2014
    ....
  30. doi request reprint Parameterising ecological validity and integrating individual differences within second-person neuroscience
    Bhismadev Chakrabarti
    Centre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, Reading RG6 6AL, United Kingdom
    Behav Brain Sci 36:414-5. 2013
    ..It then considers how individual differences at psychological and genetic levels can be integrated within the proposed framework. ..
  31. pmc A genome wide association study of mathematical ability reveals an association at chromosome 3q29, a locus associated with autism and learning difficulties: a preliminary study
    Simon Baron-Cohen
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridgeshire, United Kingdom CLASS Clinic, Cambridgeshire and Peterborough NHS Foundation Trust CPFT, Cambridgeshire, United Kingdom
    PLoS ONE 9:e96374. 2014
    ..To our knowledge, this is only the second study to investigate the association of genetic variants with mathematical ability, and it highlights a number of interesting markers for future study...
  32. ncbi request reprint Empathizing: neurocognitive developmental mechanisms and individual differences
    Bhismadev Chakrabarti
    Autism Research Centre, University of Cambridge, Psychiatry Department, Douglas House, 18b Trumpington Rd, Cambridge CB2 2AH, UK
    Prog Brain Res 156:403-17. 2006
    ....
  33. doi request reprint Increased serum androstenedione in adults with autism spectrum conditions
    Liliana Ruta
    Autism Research Centre, Department of Psychiatry, Cambridge University, Cambridge, UK
    Psychoneuroendocrinology 36:1154-63. 2011
    ..02). This result is discussed in terms of androstenedione being the immediate precursor of, and being converted into, testosterone, dihydrotestosterone, or estrogens in hormone-sensitive tissues and organs...
  34. pmc Spontaneous Facial Mimicry is Modulated by Joint Attention and Autistic Traits
    Janina Neufeld
    Centre for Integrative Neuroscience and Neurodynamics, School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK
    Autism Res 9:781-9. 2016
    ..Autism Res 2016, 9: 781-789. © 2015 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research. ..
  35. ncbi request reprint Variations in the human cannabinoid receptor (CNR1) gene modulate striatal responses to happy faces
    Bhismadev Chakrabarti
    Autism Research Centre, Douglas House, 18 B, Trumpington Road, Cambridge CB2 2AH, UK
    Eur J Neurosci 23:1944-8. 2006
    ..This has implications for medical conditions involving hypo-responsivity to emotional and social stimuli, such as autism...