Susana Campino

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Mendelian and complex genetics of susceptibility and resistance to parasitic infections
    Susana Campino
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Semin Immunol 18:411-22. 2006
  2. pmc TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression
    Susana Campino
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Malar J 8:44. 2009
  3. pmc Association of the GNAS locus with severe malaria
    Sarah Auburn
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK
    Hum Genet 124:499-506. 2008
  4. pmc Lack of association of interferon regulatory factor 1 with severe malaria in affected child-parental trio studies across three African populations
    Valentina D Mangano
    Childhood Infection Group, The Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
    PLoS ONE 4:e4206. 2009
  5. pmc Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations
    Taane G Clark
    Wellcome Trust Centre for Human Genetics, University of Oxford, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Infect Dis 199:569-75. 2009
  6. pmc Validating discovered Cis-acting regulatory genetic variants: application of an allele specific expression approach to HapMap populations
    Susana Campino
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    PLoS ONE 3:e4105. 2008
  7. pmc Identification of common genetic variation that modulates alternative splicing
    Jeremy Hull
    University Department of Paediatrics, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS Genet 3:e99. 2007
  8. pmc Localization of a long-range cis-regulatory element of IL13 by allelic transcript ratio mapping
    Julian T Forton
    Department of Paediatrics, Oxford University, Oxford OX3 7BN, United Kingdom
    Genome Res 17:82-7. 2007
  9. pmc Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes
    Andrew E Fry
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 18:2683-92. 2009
  10. pmc Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility
    Taane G Clark
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Eur J Hum Genet 17:1080-5. 2009

Detail Information

Publications15

  1. ncbi request reprint Mendelian and complex genetics of susceptibility and resistance to parasitic infections
    Susana Campino
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Semin Immunol 18:411-22. 2006
    ..With new technologies and statistical tools for whole-genome association analysis, the next few years are likely to see acceleration in the rate of gene discovery, which has the potential to greatly assist drug and vaccine development...
  2. pmc TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression
    Susana Campino
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Malar J 8:44. 2009
    ..Although TLR9 activation by malaria parasites is well reported, the implication to the susceptibility to severe malaria is not clear. The aim of this study was to assess the contribution of genetic variation at TLR9 to severe malaria...
  3. pmc Association of the GNAS locus with severe malaria
    Sarah Auburn
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK
    Hum Genet 124:499-506. 2008
    ..88 (0.81-0.96), P = 0.005 and OR = 1.12 (1.03-1.20), P = 0.005]. The evidence presented here indicates that the influence of G-alpha-s on erythrocyte invasion efficacy may, indeed, alter individual susceptibility to disease...
  4. pmc Lack of association of interferon regulatory factor 1 with severe malaria in affected child-parental trio studies across three African populations
    Valentina D Mangano
    Childhood Infection Group, The Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
    PLoS ONE 4:e4206. 2009
    ..Our results offer no evidence that the molecular pathways regulated by the transcription factor IRF-1 are involved in the immune-based pathogenesis of severe malaria...
  5. pmc Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations
    Taane G Clark
    Wellcome Trust Centre for Human Genetics, University of Oxford, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Infect Dis 199:569-75. 2009
    ..Therefore, more-detailed mapping of variants across TNF/LTA genes and their flanking regions in the Gambian and allied populations may need to be undertaken to find any causal polymorphisms...
  6. pmc Validating discovered Cis-acting regulatory genetic variants: application of an allele specific expression approach to HapMap populations
    Susana Campino
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    PLoS ONE 3:e4105. 2008
    ..A complementary approach is to use an Allele-Specific Expression (ASE) assay, which is more robust to the effects of environmental variation and trans-acting genetic factors...
  7. pmc Identification of common genetic variation that modulates alternative splicing
    Jeremy Hull
    University Department of Paediatrics, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS Genet 3:e99. 2007
    ..Our findings suggest that phenotypic variation in splicing patterns is determined by the presence of SNPs within flanking introns or exons. Effects on splicing may represent an important mechanism by which SNPs influence gene function...
  8. pmc Localization of a long-range cis-regulatory element of IL13 by allelic transcript ratio mapping
    Julian T Forton
    Department of Paediatrics, Oxford University, Oxford OX3 7BN, United Kingdom
    Genome Res 17:82-7. 2007
    ..As this method is unaffected by other sources of variation, such as environmental and trans-acting genetic factors, it provides a tractable approach for dissecting the complexities of genetic variation in gene regulation...
  9. pmc Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes
    Andrew E Fry
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 18:2683-92. 2009
    ..98). These results suggest a range of possible explanations including the existence of alternative selection pressures on CD36, co-evolution between host and parasite or confounding caused by allelic heterogeneity of CD36 deficiency...
  10. pmc Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility
    Taane G Clark
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Eur J Hum Genet 17:1080-5. 2009
    ..Our results highlight some of the consequences of allelic heterogeneity, particularly the increased type I error. They also suggest that G6PD-deficient male hemizygotes and female heterozygotes are protected from severe malaria...
  11. pmc Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
    Olivo Miotto
    Medical Research Council MRC Centre for Genomics and Global Health, University of Oxford, Oxford, UK
    Nat Genet 45:648-55. 2013
    ..These data provide a population-level genetic framework for investigating the biological origins of artemisinin resistance and for defining molecular markers to assist in its elimination...
  12. pmc A genetic association study in the Gambia using tagging polymorphisms in the major histocompatibility complex class III region implicates a HLA-B associated transcript 2 polymorphism in severe malaria susceptibility
    Mahamadou Diakite
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Hum Genet 125:105-9. 2009
    ..An analysis of 2,162 case-controls demonstrated the first evidence of association between a BAT2 polymorphism (rs1046089) and severe malaria...
  13. pmc SnoopCGH: software for visualizing comparative genomic hybridization data
    Jacob Almagro-Garcia
    Wellcome Trust Sanger Institute, Hinxton, The Weatherall Institute of Molecular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Bioinformatics 25:2732-3. 2009
    ..Availability and implementation: SnoopCGH is written in java and is available from http://snoopcgh.sourceforge.net/..
  14. pmc Identification of two cerebral malaria resistance loci using an inbred wild-derived mouse strain
    Sébastien Bagot
    Unité Immunophysiopathologie Infectieuse, Institut Pasteur, Centre National de la Recherche Scientifique, Unité de Recherche Associée 1961, and Universite Pierre et Marie Curie, 75005 Paris, France
    Proc Natl Acad Sci U S A 99:9919-23. 2002
    ..These data provide the first evidence of loci associated with resistance to murine cerebral malaria, which may have important implications for the search for genetic factors controlling cerebral malaria in humans...
  15. ncbi request reprint Unique genetic variation revealed by a microsatellite polymorphism survey in ten wild-derived inbred strains
    Susana Campino
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande, 6, Oeiras, Portugal
    Genomics 79:618-20. 2002
    ....