Christopher D Byrne
Affiliation: University of Southampton
- Randomised controlled feasibility trial of a web-based weight management intervention with nurse support for obese patients in primary careLucy Yardley
Centre for Applications of Health Psychology CAHP, Faculty of Social and Human Sciences, University of Southampton, Southampton, UK
Int J Behav Nutr Phys Act 11:67. 2014....
- Muscle microvascular dysfunction in central obesity is related to muscle insulin insensitivity but is not reversed by high-dose statin treatmentGeraldine F Clough
School of Medicine, University of Southampton, Southampton, UK
Diabetes 58:1185-91. 2009....
- Predicting incident fatty liver using simple cardio-metabolic risk factors at baselineKi Chul Sung
Division of Cardiology, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
BMC Gastroenterol 12:84. 2012....
- Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspringJunlong Zhang
Clinical Science Research Institute, Warwick Medical School, Clinical Sciences Building, University Hospital, Walsgrave Campus, Coventry, UK
BMC Genomics 10:478. 2009....
- Functional dilator capacity is independently associated with insulin sensitivity and age in central obesity and is not improved by high dose statin treatmentGeraldine F Clough
Institute of Developmental Sciences, School of Medicine, University of Southampton, Southampton General Hospital MP 887, Southampton, UK
Microcirculation 18:74-84. 2011....
- Nonalcoholic fatty liver disease and vascular riskLokpal S Bhatia
National Institute of Health Research Biomedical Research Unit, Southampton University Hospitals NHS Trust, Southampton, UK
Curr Opin Cardiol 27:420-8. 2012..However, given the shared features between NAFLD, the metabolic syndrome and traditional cardiovascular risk factors, uncertainty exists as to whether NAFLD is an independent risk factor for increased cardiovascular disease...
- Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male miceChristopher Torrens
Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
PLoS ONE 7:e50671. 2012..To determine the impact of maternal and post-weaning consumption of a high fat diet on endothelium-dependent vasorelaxation and redox regulation in adult male mouse offspring...
- Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor?Lokpal S Bhatia
National Institute of Health Research Biomedical Research Unit, Southampton University Hospitals NHS Trust, Southampton General Hospital, Tremona Road, Southampton, UK
Eur Heart J 33:1190-200. 2012....
- Ectopic fat, insulin resistance, and nonalcoholic fatty liver disease: implications for cardiovascular diseaseChristopher D Byrne
From Nutrition and Metabolism, Faculty of Medicine, University of Southampton, Southampton, United Kingdom C D B Southampton National Institute for Health Research Biomedical Research Centre, University Hospital Southampton, Southampton, United Kingdom C D B and Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy G T
Arterioscler Thromb Vasc Biol 34:1155-61. 2014..Articles published in languages other than English were excluded...
- Ectopic fat, insulin resistance and non-alcoholic fatty liver diseaseChristopher D Byrne
Endocrinology and Metabolism, Nutrition and Metabolism, Faculty of Medicine, University of Southampton, and Southampton National Institute for Health Research Biomedical Research Centre, University Hospital of Southampton, UK
Proc Nutr Soc 72:412-9. 2013..The review will also describe the relationships between NAFLD, type 2 diabetes and CVD...
- Non-Alcoholic Fatty Liver Disease (NAFLD): new challenge for general practitioners and important burden for health authorities?Mohamed H Ahmed
Chemical Pathology Department, Southampton University Hospital NHS Trust, Southampton, UK
Prim Care Diabetes 4:129-37. 2010....
- Fatty liver: role of inflammation and fatty acid nutritionChristopher D Byrne
Institute for Developmental Sciences, University of Southampton and Southampton University Hospitals Trust, Southampton, UK
Prostaglandins Leukot Essent Fatty Acids 82:265-71. 2010..The purpose of this review is to discuss the roles of inflammation, fatty acids and fatty acids in nutrition, in the pathogenesis and potential treatment of NAFLD...
- Daily energy expenditure, cardiorespiratory fitness and glycaemic control in people with type 1 diabetesJohn Joseph Valletta
Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom Bioengineering Science, Faculty of Engineering and the Environment, University of Southampton, Southampton, United Kingdom
PLoS ONE 9:e97534. 2014....
- Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expressionKimberley D Bruce
Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton, UK
Hepatology 50:1796-808. 2009..In addition, measurement of hepatic gene expression indicated that lipogenesis, oxidative stress, and inflammatory pathways were up-regulated in the 15-week-old HF/C and HF/HF offspring...
- Gaussian Process modelling of blood glucose response to free-living physical activity data in people with type 1 diabetesJohn Joseph Valletta
School of Engineering Sciences, Computational Engineering and Design Group, University of Southampton, Southampton, United Kingdom
Conf Proc IEEE Eng Med Biol Soc 2009:4913-6. 2009..In this paper, Gaussian Processes are used to model the glucose excursions in response to physical activity data, to study its effect on glycaemic control...
- Aspirin resistance is more common in lacunar strokes than embolic strokes and is related to stroke severityNicola A Englyst
Endocrinology and Metabolism Unit, Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
J Cereb Blood Flow Metab 28:1196-203. 2008..765, P=0.005) as the outcome. In conclusion, aspirin resistance is related to stroke severity and aspirin resistance is more common in lacunar strokes than embolic strokes...
- Current treatment of non-alcoholic fatty liver diseaseMohamed H Ahmed
Chemical Pathology Department, Southampton University Hospitals NHS Trust, Southampton General Hospital, Southampton, UK
Diabetes Obes Metab 11:188-95. 2009..The potential benefit of bariatric surgery and the role of weight loss per se in treating NAFLD are also discussed...
- Vascular disease in the metabolic syndrome: do we need to target the microcirculation to treat large vessel disease?Andrew J Krentz
Institute of Developmental Sciences, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
J Vasc Res 46:515-26. 2009..The hypothesis that vascular events can be prevented, or at least deferred, through earlier therapeutic intervention in pre-diabetic subjects with glucose intolerance is amenable to testing in clinical trials...
- The housekeeping gene YWHAZ remains stable in a model of developmentally primed non-alcoholic fatty liver diseaseKimberley D Bruce
Human Development and Health, Institute of Developmental Sciences, University of Southampton Faculty of Medicine, Southampton, UK
Liver Int 32:1315-21. 2012..However, there is little existing data to show the effects of NAFLD on HKG expression...
- Age and cigarette smoking are independently associated with the cutaneous vascular response to local warmingMiriam R Avery
School of Medicine, University of Southampton, Southampton, UK
Microcirculation 16:725-34. 2009..To investigate the relative impacts of age and cigarette smoking on cutaneous blood flow and flow motion...
- Intensive glucose control and hypoglycaemia: a new cardiovascular risk factor?Omar A Rana
Department of Cardiology, University of Southampton and Southampton University Hospitals NHS Foundation Trust, Southampton, Hampshire, UK
Heart 100:21-7. 2014....
- Glucose metabolism in adult survivors of severe acute malnutritionPatrice M Francis-Emmanuel
Tropical Medicine Research Institute P M F E, D S T, A T B, T E F, M S B and Department of Surgery, Radiology, Anaesthesia, and Intensive Care A T B, The University of the West Indies, Mona, Kingston 7, Jamaica, West Indies Medical Research Council Lifecourse Epidemiology Unit C O, Institute of Developmental Sciences M A H and Nutrition and Metabolism Unit C D B, School of Medicine, University of Southampton, Southampton SO16 6YD, United Kingdom and Centre for Human Evolution, Adaptation, and Disease P D G, Liggins Institute, University of Auckland, Auckland 1142, New Zealand
J Clin Endocrinol Metab 99:2233-40. 2014..We hypothesized that resultant metabolic effects may persist into adulthood. We investigated whether marasmus survivors (MS) are more insulin resistant and glucose intolerant than kwashiorkor survivors (KS)...
- Bariatric surgery and renal function: a precarious balance between benefit and harmMohamed H Ahmed
Chemical Pathology Department, Southampton University Hospitals NHS Trust, Southampton, UK
Nephrol Dial Transplant 25:3142-7. 2010..The main risk factor for nephrolithiasis is increased excretion of urinary oxalate. In this review, we discuss the association between bariatric surgery, an increased risk of renal stone formation and oxalate nephropathy...
- Percentage of body fat and plasma glucose predict plasma sialic acid concentration in type 2 diabetes mellitusNicola A Englyst
Endocrinology and Metabolism Unit, University of Southampton, Southampton SO16 6YD, UK
Metabolism 55:1165-70. 2006..In conclusion, this is the first study to show that percentage of body fat predicts plasma sialic acid concentration and contributes toward higher levels of sialic acid in type 2 diabetes mellitus...
- Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged caucasian menJunlong Zhang
Endocrinology and Metabolism Unit, Developmental Origins of Health and Disease Division, University of Southampton, Level F, Central Block, Mailpoint 113, Southampton General Hospital, Southampton, SO16 6YD, UK
Diabetes Care 28:2058-60. 2005
- Long-chain n-3 fatty acid supplementation in men increases resistance to activated protein CNicola A Englyst
Endocrinology and Metabolism Unit, Developmental Origins of Health and Disease Division, Institute of Human Nutrition, University of Southampton, Southampton SO16 6YD, UK
Metabolism 56:547-51. 2007..These findings will need to be repeated in different disease states...